{"data":{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:29552626", "kind": "science-record", "revision": 9, "content_hash": "sha256:8aae2da988ee763a7ae659f35fd18662748696f9a028363428b19d437471fde4", "created_at": "2026-11-01T15:40:32Z", "updated_at": "2026-11-01T22:43:19Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Neutrophil-Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis.", "doi": "10.1016/j.jcmgh.2018.01.003", "pmid": "29552626", "authors": ["Zhou Zhou", "Ming-Jiang Xu", "Yan Cai", "Wei Wang", "Joy X Jiang", "Zoltan V Varga", "Dechun Feng", "Pal Pacher", "George Kunos", "Natalie J Torok", "Bin Gao"], "journal": "Cellular and molecular gastroenterology and hepatology", "year": 2018, "abstract": "BACKGROUND & AIMS: Hepatic infiltration of neutrophils is a hallmark of steatohepatitis; however, the role of neutrophils in the progression of steatohepatitis remains unknown.\nMETHODS: A clinically relevant mouse model of steatohepatitis induced by high-fat diet (HFD) plus binge ethanol feeding was used. Liver fibrosis was examined. In vitro cell culture was used to analyze the interaction of hepatic stellate cells (HSCs) and neutrophils.\nRESULTS: HFD plus one binge ethanol (HFD+1B) feeding induced significant hepatic neutrophil infiltration, liver injury, and fibrosis. HFD plus multiple binges of ethanol (HFD+mB) caused more pronounced liver fibrosis. Microarray analyses showed that the most highly activated signaling pathway in this HFD+1B model was related to liver fibrosis and HSC activation. Blockade of chemokine (C-X-C motif) ligand 1 or intercellular adhesion molecule-1 expression reduced hepatic neutrophil infiltration and ameliorated liver injury and fibrosis. Disruption of the p47phox gene (also called neutrophil cytosolic factor 1), a critical component of reactive oxygen species producing nicotinamide adenine dinucleotide phosphate-oxidase in neutrophils, diminished HFD+1B-induced liver injury and fibrosis. Co-culture of HSCs with neutrophils, but not with neutrophil apoptotic bodies, induced HSC activation and prolonged neutrophil survival. Mechanistic studies showed that activated HSCs produce granulocyte-macrophage colony-stimulating factor and interleukin-15 to prolong the survival of neutrophils, which may serve as a positive forward loop to promote liver damage and fibrosis.\nCONCLUSIONS: The current data from a mouse model of HFD plus binge ethanol feeding suggest that obesity and binge drinking synergize to promote liver fibrosis, which is partially mediated via the interaction of neutrophils and HSCs. Microarray data in this article have been uploaded to NCBI's Gene Expression Omnibus (GEO accession number: GSE98153).", "claims": [{"id": "claim-method", "statement": "Data from 2 groups were compared with an unpaired t test. Data from multiple groups were compared with 1-way analysis of variance followed by the Tukey post hoc test.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:29552626", "locator": "sections[17] \"Statistical Analysis\" paragraph 2", "quote": "Data from 2 groups were compared with an unpaired t test. Data from multiple groups were compared with 1-way analysis of variance followed by the Tukey post hoc test."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Full microarray data have been uploaded to NCBI’s Gene Expression Omnibus (GEO accession number: GSE98153).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:29552626", "locator": "sections[8] \"Microarray Analyses of Mouse Liver Samples\" paragraph 2", "quote": "Full microarray data have been uploaded to NCBI’s Gene Expression Omnibus (GEO accession number: GSE98153)."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Headline result: Obesity and binge drinking synergistically promote liver fibrosis, partially through interactions between neutrophils and hepatic stellate cells. Statistical method: two-group comparisons used an unpaired t test; multiple-group comparisons used one-way analysis of variance followed by the Tukey post hoc test, with P < .05 considered significant. Route to source data: the microarray data were uploaded to NCBI’s Gene Expression Omnibus under accession GSE98153, and all authors had access to the study data.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:29552626", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "The current data from a mouse model of HFD plus binge ethanol feeding suggest that obesity and binge drinking synergize to promote liver fibrosis, which is partially mediated via the interaction of neutrophils and HSCs."}, {"asset": "source:pmid:29552626", "locator": "sections[17] \"Statistical Analysis\" paragraph 2", "quote": "Data are shown as means ± SEM. Data from 2 groups were compared with an unpaired t test. Data from multiple groups were compared with 1-way analysis of variance followed by the Tukey post hoc test. P < .05 was considered a significant difference."}, {"asset": "source:pmid:29552626", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "Microarray data in this article have been uploaded to NCBI’s Gene Expression Omnibus (GEO accession number: GSE98153)."}, {"asset": "source:pmid:29552626", "locator": "sections[18] \"Data\" paragraph 2", "quote": "All authors had access to the study data and reviewed and approved the final manuscript."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Headline result: Obesity and binge drinking synergistically promote liver fibrosis, partially through interactions between neutrophils and hepatic stellate cells. Statistical method: two-group comparisons used an unpaired t test; multiple-group comparisons used one-way analysis of variance followed by the Tukey post hoc test, with P < .05 considered significant. Route to source data: the microarray data were uploaded to NCBI’s Gene Expression Omnibus under accession GSE98153, and all authors had access to the study data.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:29552626"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE98153"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE98153"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:29552626", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1016/j.jcmgh.2018.01.003", "sha256": "sha256:acb0a1a863a5c4eae2a1cd6682bb9647dbb11ea2547a3df3492e6f3c5b14096c", "bytes": 55043, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1016/j.jcmgh.2018.01.003", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC5852390", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE98153", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98153", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE98153", "version": null, "note": "Full microarray data have been uploaded to NCBI’s Gene Expression Omnibus (GEO accession number: GSE98153).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Full microarray data have been uploaded to NCBI’s Gene Expression Omnibus (GEO accession number: GSE98153).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM2588732", "GSM2588733", "GSM2588734", "GSM2588735", "GSM2588736", "GSM2588737", "GSM2588738", "GSM2588739", "GSM2588740", "GSM2588741", "GSM2588742", "GSM2588743", "GSM2588744", "GSM2588745", "GSM2588746", "GSM2588747", "GSM2588748"], "sample_count": 17, "group_sizes": null, "group_sizes_basis": null, "platform": "7202", "taxon": "Mus musculus", "title": "Interaction of neutrophils and hepatic stellate cells promotes fibrosis in a mouse model of steatohepatitis", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:29552626:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:d8caa93335b250a9d80f99d0218bdc3d8720b3c8b963801972178cd0dc02dc3a", "bytes": 1365, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[16]/table-wrap[1]#tbl1", "version": null, "note": "Real-Time Quantitative PCR Primer Sequence Used in the Present Study", "structure": {"pmcid": "PMC5852390", "section_index": 16, "section_title": "Real-Time Quantitative PCR", "row_count": 19, "column_count": 3}, "table": {"label": "Table 1", "caption": "Real-Time Quantitative PCR Primer Sequence Used in the Present Study", "rows": [["Gene name", "Forward", "Reverse"], ["Acta2 (encodes α-SMA)", "TCCTGACGCTGAAGTATCCGATA", "GGTGCCAGATCTTTTCCATGTC"], ["collagen 1a1", "TAGGCCATTGTGTATGCAGC", "ACATGTTCAGCTTTGTGGACC"], ["collagen 1a2", "GGTGAGCCTGGTCAAACGG", "ACTGTGTCCTTTCACGCCTTT"], ["collagen 3a1", "TAGGACTGACCAAGGTGGCT", "GGAACCTGGTTTCTTCTCACC"], ["collagen 4a1", "CACATTTTCCACAGCCAGAG", "GTCTGGCTTCTGCTGCTCTT"], ["collagen 5a2", "CATGGAGAAGGTTTCCAAATG", "AAAGCCCAGGAACAAGAGAA"], ["collagen 12a1", "TGAGGTCTGGGTAAAGGCAA", "GTATGAGGTCACCGTCCAGG"], ["Ly6g", "TGCGTTGCTCTGGAGATAGA", "CAGAGTAGTGGGGCAGATG"], ["Csf2 (encodes GM-CSF)", "CTGCTCTTCTCCACGCTACTG", "GAGACTCGCCGGTGTATCC"], ["Csf3 (encodes G-CSF)", "CTGATCTTCTTGCTACTCCCCA", "GGTGTAGTTCAAGTGAGGCAG"], ["IL3", "GGGATACCCACCGTTTAACCA", "AGGTTTACTCTCCGAAAGCTCTT"], ["IL15", "ACATCCATCTCGTGCTACTTGT", "GCCTCTGTTTTAGGGAGACCT"], ["Egf", "AGCATCTCTCGGATTGACCCA", "CCTGTCCCGTTAAGGAAAACTCT"], ["Hgf", "ATGTGGGGGACCAAACTTCTG", "GGATGGCGACATGAAGCAG"], ["IL17a", "TTTAACTCCCTTGGCGCAAAA", "CTTTCCCTCCGCATTGACAC"], ["IL17f", "TGCTACTGTTGATGTTGGGAC", "AATGCCCTGGTTTTGGTTGAA"], ["Ly6g", "TGCGTTGCTCTGGAGATAGA", "CAGAGTAGTGGGGCAGATGG"], ["18s", "GTAACCCGTTGAACCCCATT", "CCATCCAATCGGTAGTAGCG"]], "row_count": 19, "column_count": 3, "numeric_cells": 10, "header_rows": 1, "locator": "section[16]/table-wrap[1]#tbl1"}}], "gaps": ["asset:data:geo:GSE98153 not downloaded", "asset:data:geo:GSE98153 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "group_comparison", "specific": "anova", "label": "Group comparison", "dsl_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["two_or_more_groups_continuous"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "Data from 2 groups were compared with an unpaired t test. Data from multiple groups were compared with 1-way analysis of variance followed by the Tukey post hoc test."}}], "targets": [], "gaps": []}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: anova."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE98153"], "resolved_accessions": ["GSE98153"], "statements": ["Full microarray data have been uploaded to NCBI’s Gene Expression Omnibus (GEO accession number: GSE98153)."], "basis": "The paper names GSE98153 in NCBI’s Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "assets": ["source:pmid:29552626", "data:geo:GSE98153", "asset:table:pmid:29552626:1"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE98153"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:34:15Z", "independence": "same_provider"}, "evidence_check": {"method": "verbatim", "availability": null}, "calls": 8, "usage": {"prompt_tokens": 114393, "completion_tokens": 2962, "cached_tokens": 1560}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:29552626", "type": "paper", "label": "pmid:29552626"}, {"id": "source:pmid:29552626", "type": "manuscript", "label": "PMID 29552626 full text"}, {"id": "data:geo:GSE98153", "type": "dataset", "label": "GEO GSE98153"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:29552626", "type": "paper", "label": "pmid:29552626"}, {"id": "source:pmid:29552626", "type": "manuscript", "label": "PMID 29552626 full text"}, {"id": "data:geo:GSE98153", "type": "dataset", "label": "GEO GSE98153"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-29552626", "type": "extraction", "used": ["source:pmid:29552626"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE98153", "type": "accession_resolution", "used": ["data:geo:GSE98153"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:29552626", "parent_hash": "sha256:58baff2016486dee9f652aa48adfdd214065ce2f2d04a5f36c60ae3b36c2e082", "fork_of": null, "generation": 8}, "gaps": ["asset:data:geo:GSE98153 licence not read", "asset:data:geo:GSE98153 not downloaded", "execution.not_run", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "animal_model", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["ains unknown. METHODS: A clinically relevant mouse model of steatohepatitis induced by high-fat diet", "brosis. CONCLUSIONS: The current data from a mouse model of HFD plus binge ethanol feeding suggest th", "ains unknown. METHODS: A clinically relevant mouse model of steatohepatitis induced by high-fat", "brosis. CONCLUSIONS: The current data from a mouse model of HFD plus binge ethanol feeding sugg"], "order_basis": "paper_text_order:259", "id": "assay:1"}, {"role": "data_generation", "definition_id": "microarray", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["D+mB) caused more pronounced liver fibrosis. Microarray analyses showed that the most highly activat", "via the interaction of neutrophils and HSCs. Microarray data in this article have been uploaded to N", "Materials and Methods Microarray Analyses of Mouse Liver Samples Total RNAs w", "bridized to an Agilent 44K mouse 60-meroligo microarray (Agilent Technologies, Santa Clara, CA). The"], "order_basis": "paper_text_order:713", "id": "assay:2"}, {"role": "data_generation", "definition_id": "elisa", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["on Omnibus (GEO accession number: GSE98153). Enzyme-Linked Immunosorbent Assay Analysis of GM-CSF The concentration of GM-C", "pernatant of HSCs was measured with a GM-CSF enzyme-linked immunosorbent assay kit (R&D) according to the manufacturer's in"], "order_basis": "paper_text_order:3105", "id": "assay:3"}, {"role": "analysis", "definition_id": "group_comparison", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["Data from 2 groups were compared with an unpaired t test. Data from multiple groups were compared with 1-way analysis of variance followed by the Tukey post hoc test."], "order_basis": "consumes_earlier_output", "id": "assay:4"}]},"meta":{"api_version":"v1","automation_ladder_snapshot":"ba34b49490d9bfaf","automation_ladder_caveats":["Method extraction is rule-based and has no hand-judged accuracy sample. Evidence bands order textual support; method agreement intervals are null (n=0), never probabilities. Work-type validation does not validate methods.","Operation coverage describes only explicitly named methods. It does not prove a complete protocol, compatible parameters, successful compilation or re-execution. Unrecognised or ambiguous methods require review.","Data reachability is a textual accession or public-data statement. No dataset was downloaded or checked for access, completeness or licence.","Capabilities are planning states seeded from the dated equipment register. No bench ownership, completed quote or partner booking is inferred. Procurement counts are dependencies, not guaranteed replications or financial returns.","Tier and blocker counts are deterministic assessments of this corpus, not measured agreement. R3 is reserved for procurement; unresolved methods and data require human work (R4). The most restrictive axis wins, with capability, method, data as tie-breaks. Resolving one blocker can leave another at the same tier."],"engine":"corpus_engine","engine_provider":"rule_based_v1+lex99e1195c7d6f","run_id":"run-20261023T122449232913","source":"esearch","source_detail":"PubMed mirror biomed_pubmed (read-only)","run_status":"complete","imported_at":"2026-11-03T20:16:52+00:00","generated_at":"2026-11-04T02:52:05+00:00","total_papers":5529,"total_assays_tracked":29,"automatable_assay_families":6,"validated":true,"caveat_count":9,"blocking_caveats":5,"caveats":[{"code":"low_evidence_dominates","basis":["4,152 of 5,529 classifications (75.1%) matched no cue evidence and sit at the 0.05 floor.","34 of 230 data_only calls (14.8%) are in that group."],"claim":"Work type and confidence bands","gloss":"Most records were classified from their title and framing alone, with assay-cue coverage at zero.","detail":"Most classifications in this run rest on no matched evidence at all. At the evidence floor the work type comes from title framing and a fixed prior, not from anything in the paper, so the published work-type split should be read as a rough triage signal rather than a measured distribution. The impact is bounded but not removed: since 2026-10-23 the engine excludes floor-confidence records from the shortlist entirely and publishes them separately as held out, so the recommendation is unaffected even though the census is.","status":"unverified","severity":"high"},{"code":"runtime_is_modelled","basis":["Runtime is summed from published per-assay hour figures. Timing awaits the first executed replication.","4,407 of 5,529 records (79.7%) model to 0.00 hours because no assay was matched, which the ranking then reads as \"cheapest\".","0 of 10 shortlisted records carry a 0.00-hour estimate."],"claim":"Estimated replication runtime","gloss":"The hour figures are estimates built from assay mentions; timing awaits the first executed replication.","detail":"The hour figures are a cost model derived from the bench steps implied by each matched assay family. The first executed replication will supply measured timing. Records without an assay match currently receive a zero-hour model value.","status":"unverified","severity":"high"},{"code":"signal_score_without_citations","basis":["5,529 of 5,529 records (100.0%) have no citation count from the source metadata."],"claim":"Signal score","gloss":"The signal score uses publication-type weight because the mirror supplied zero citation counts.","detail":"The source supplied no citation counts for any record in this run, so the signal score is publication-type weight only. The citation term of the ranking is inert here, and the shortlist is ordered by publication type alone.","status":"unverified","severity":"high"},{"code":"abstract_absent","basis":["1,667 of 5,529 records (30.2%) carry no abstract at all."],"claim":"Evidence base for classification","gloss":"Some records contain a title and publication type only, defining the available classification evidence.","detail":"Where the mirror contains a title and publication types only, those fields define the classifier evidence. A methods section is required for fuller automated and human review.","status":"unverified","severity":"medium"},{"code":"classifier_agreement_measured","basis":["Published two-way decision agreement 77.7% (310 of 399 decidable records) from a stratified hand-check of 438 real records.","Three-way diagnostic agreement 73.9% (288 of 390 decidable records).","data_only agreement 75.2% (100 of 133 decidable).","48 record(s) could not be decided from title and abstract and were excluded from the denominator.","56 analysis-only records were published under another work type, so the data_only share is not an upper bound."],"claim":"Published automatable decision","gloss":"This figure has been checked against a human reading the same papers, so we know how often it is right.","detail":"The published automatable / not-automatable distribution comes from a rule-based classifier that was hand-checked against a fixed ground-truth definition. The agreement rates below are measured, not estimated. The three-way work type remains a diagnostic and is reported separately.","status":"measured","severity":"high"},{"code":"llm_comparison_not_measured","basis":["rule_based_v1+lex99e1195c7d6f produced 5,529 of 5,529 classifications.","Measured on 438 labelled records; these are RULE-BASED figures, not model results."],"claim":"Rule-based versus LLM agreement","gloss":"Every number here is the rule engine’s own. Model comparison begins when a working API credential is connected and measured.","detail":"The published two-way decision agreed with a human reading on 310 of 399 decidable records (77.7%). The diagnostic three-way label agreed on 288 of 390 decidable records (73.9%). Every percentage in this run belongs to the rule engine. Model comparison begins when a working API credential is connected and measured.","status":"not_measured","severity":"high"},{"code":"confidence_is_a_band","basis":["low band: 135 of 210 hand-judged records were correct, 64.3% [57.6, 70.5] (95% CI).","medium band: 80 of 104 hand-judged records were correct, 76.9% [68.0, 84.0] (95% CI).","high band: 73 of 76 hand-judged records were correct, 96.0% [89.0, 98.7] (95% CI).","A fitted calibrated probability was built, measured and withdrawn: it overstated held-out accuracy and reorders nothing."],"claim":"Confidence band and evidence score","gloss":"The confidence band carries a measured accuracy interval; 0.85 represents relative rank strength.","detail":"Confidence on this run is a BAND plus its measured accuracy interval. The number stored alongside each record is a monotone evidence score that orders records; 0.85 represents relative rank strength. A fitted probability was withdrawn after it overstated held-out accuracy. Threshold on the band.","status":"measured","severity":"medium"},{"code":"three_way_split_is_diagnostic","basis":["The corpus is published at the two-way decision: automatable or not-automatable. The three-way split (data_only / physical / mixed) is published as a diagnostic with its measured reliability attached, not as a claim, because the rule engine's `mixed` call cannot be defended.","The engine called 22 record(s) mixed; 10 matched the human judgement (45.5%, 95% CI 26.9-65.3).","The engine's `mixed` call is right on 10/22 hand-judged records (45.5%, 95% CI 26.9%-65.3%); a constant `physical` guess scores 36.4%.","The engine's `mixed` call does not reliably beat a constant `physical` guess on the hand-judged records it labels mixed.","The sign of that difference flips between two independent samples, so the three-way refinement is not demonstrably informative.","The mixed stratum contributes a disproportionate share of errors relative to its size.","At title-only depth the physical/mixed split collapses: a title says that work was done, not whether it was also analysed."],"claim":"The published decision is two-way","gloss":"The three-way split is shown for diagnosis only. The published split is two ways.","detail":"Count and filter the corpus on automatable versus not-automatable. The data_only / physical / mixed split remains an internal engine diagnostic because the mixed call has lower measured reliability.","status":"measured","severity":"medium"},{"code":"automatable_flag_unproven","basis":["6 of 29 assay families are marked automatable now: meta_analysis, machine_learning, survival_analysis, pca, molecular_docking, differential_expression.","The flag is a rule over assay family and work type; validation begins with the first executed replication.","It inherits the 75.2% data_only agreement rate, because the flag requires the record to be analysis-only."],"claim":"Automatable now","gloss":"This flag marks assay families the rules classify as data-only. The first executed replication will validate it.","detail":"This flag marks families the rules consider replicable from data alone. Its validity depends on the analysis-only classification and will be measured through an executed replication.","status":"unverified","severity":"medium"}],"confidence_policy":"band_with_measured_interval","confidence_contract":{"policy":"band_with_measured_interval","summary":"Confidence is reported as a BAND with a measured accuracy interval. The raw evidence score supplies monotone ordering. A fitted point estimate was withdrawn after it overstated held-out accuracy.","evidence_score":"A monotone evidence score in [0,1] built from cue mass, axis separation and text coverage. Use it to order records. Interpret 0.85 as relative rank strength.","confidence_band":"low | medium | high. Consumers threshold on this value.","band_accuracy":"Wilson 95% interval on the measured agreement of the hand-judged records in this band.","calibrated_confidence":"WITHDRAWN. Reintroduction requires held-out evidence demonstrating reliable estimates across every bin."},"band_accuracy":{"low":{"n":210,"low":0.576,"band":"low","high":0.7046,"agree":135,"accuracy":0.6429},"high":{"n":76,"low":0.8903,"band":"high","high":0.9865,"agree":73,"accuracy":0.9605},"medium":{"n":104,"low":0.6795,"band":"medium","high":0.8397,"agree":80,"accuracy":0.7692}},"provider":"rule_based_v1+lex99e1195c7d6f","lexicon_id":"99e1195c7d6f","contract_published_at":"2026-10-23T12:25:29.022232+00:00","confidence_is_band":true,"confidence_is_probability":false,"decision_taxonomy":"two_way","decidable_fraction_two_way":0.8854,"decidable_fraction_two_way_low":0.8565,"decidable_fraction_two_way_high":0.9143,"decidable_fraction_three_way":0.8586,"decidable_fraction_three_way_low":0.8287,"decidable_fraction_three_way_high":0.8884,"decidable_population":5529,"validation_sample_size":438,"three_way_cost_fraction":0.0268,"three_way_cost_records":148,"decision_counts":{"automatable":230,"not_automatable":5299},"decision_split":{"automatable":{"count":230,"share":0.04159884246699222},"not_automatable":{"count":5299,"share":0.9584011575330078}},"diagnostic_work_type_counts":{"mixed":24,"physical":5275,"data_only":230}}}