{"data":{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:30497457", "kind": "science-record", "revision": 6, "content_hash": "sha256:351dab985d0b62ea6ecc1ab330803fadecf3b284d55fed5e5350ce026d22b1d0", "created_at": "2026-11-01T15:40:39Z", "updated_at": "2026-11-01T21:21:47Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol.", "doi": "10.1186/s12906-018-2383-6", "pmid": "30497457", "authors": ["Jen-Kit Tan", "Faizul Jaafar", "Suzana Makpol"], "journal": "BMC complementary and alternative medicine", "year": 2018, "abstract": "BACKGROUND: Replicative senescence of human diploid fibroblasts (HDFs) has been used as a model to study mechanisms of cellular aging. Gamma-tocotrienol (γT3) is one of the members of vitamin E family which has been shown to increase proliferation of senescent HDFs. However, the modulation of protein expressions by γT3 in senescent HDFs remains to be elucidated. Therefore, this study aimed to determine the differentially expressed proteins (DEPs) in young and senescent HDFs; and in vehicle- and γT3-treated senescent HDFs using label-free quantitative proteomics.\nMETHODS: Whole proteins were extracted and digested in-gel with trypsin. Peptides were detected by Orbitrap liquid chromatography mass spectrometry. Mass spectra were identified and quantitated by MaxQuant software. The data were further filtered and analyzed statistically using Perseus software to identify DEPs. Functional annotations of DEPs were performed using Panther Classification System.\nRESULTS: A total of 1217 proteins were identified in young and senescent cells, while 1218 proteins in vehicle- and γT3-treated senescent cells. 11 DEPs were found in young and senescent cells which included downregulation of platelet-derived growth factor (PDGF) receptor beta and upregulation of tubulin beta-2A chain protein expressions in senescent cells. 51 DEPs were identified in vehicle- and γT3-treated senescent cells which included upregulation of 70 kDa heat shock protein, triosephosphate isomerase and malate dehydrogenase protein expressions in γT3-treated senescent cells.\nCONCLUSIONS: PDGF signaling and cytoskeletal structure may be dysregulated in senescent HDFs. The pro-proliferative effect of γT3 on senescent HDFs may be mediated through the stimulation of cellular response to stress and carbohydrate metabolism. The expressions and roles of these proteins in relation to cellular senescence are worth further investigations. 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with the dataset identifier PXD009933.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The mass spectrometry proteomic data have been deposited to the ProteomeXchange Consortium via the PRIDE [21] partner repository with the dataset identifier PXD009933.", "access_statement_kind": "data_availability_statement", "sample_accessions": [], "sample_count": null, "group_sizes": null, "group_sizes_basis": null, "platform": null, "taxon": null, "title": "proteomic analysis of gamma-tocotienol(GT3)-treated human diploid fibroblasts (HDFs)", "resolution_checked_at": "2026-10-31T18:35:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:30497457:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:754381659d4ab4ec7e3653c2994c2f9f09151b8576f328725573fb46139ae30c", "bytes": 805, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[11]/table-wrap[1]#Tab1", "version": null, "note": "List of differentially expressed proteins in young and senescent cells", "structure": {"pmcid": "PMC6267793", "section_index": 11, "section_title": "LFQ analysis", "row_count": 14, "column_count": 2}, "table": {"label": "Table 1", "caption": "List of differentially expressed proteins in young and senescent cells", "rows": [["Protein ID", "Protein name (symbol)"], ["Upregulated"], ["Q01518", "Adenylyl cyclase-associated protein 1 (CAP1)"], ["O43852", "Calumenin (CALU)"], ["Q13561", "Dynactin subunit 2 (DCTN2)"], ["Q92734", "Protein TFG (TFG)"], ["Q9Y3A5", "Ribosome maturation protein SBDS (SBDS)"], ["P09486", "SPARC (SPARC)"], ["Q9NPQ8", "Synembryn-A (RIC8A)"], ["Q13885", "Tubulin beta-2A chain (TUBB2A)"], ["P45880", "Voltage-dependent anion-selective channel protein 2 (VDAC2)"], ["Downregulated"], ["Q13308", "Inactive tyrosine-protein kinase 7 (PTK7)"], ["P09619", "Platelet-derived growth factor receptor beta (PDGFRB)"]], "row_count": 14, "column_count": 2, "numeric_cells": 14, "header_rows": 1, "locator": "section[11]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:30497457:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:380fd0e08dc311117fd0d12c040eb4718e6aeed0e7bacd847268748bc36f33dd", "bytes": 3372, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[11]/table-wrap[2]#Tab2", "version": null, "note": "List of differentially expressed proteins in vehicle- and γT3-treated senescent cells", "structure": {"pmcid": "PMC6267793", "section_index": 11, "section_title": "LFQ analysis", "row_count": 54, "column_count": 2}, "table": {"label": "Table 2", "caption": "List of differentially expressed proteins in vehicle- and γT3-treated senescent cells", "rows": [["Protein ID", "Protein name (symbol)"], ["Upregulated"], ["O00487", "26S proteasome non-ATPase regulatory subunit 14 (PSMD14)"], ["P08865", "40S ribosomal protein SA (RPSA)"], ["Q969Q0", "60S ribosomal protein L36a-like (RPL36AL)"], ["P30533", "Alpha-2-macroglobulin receptor-associated protein (LRPAP1)"], ["P40222", "Alpha-taxilin (TXLNA)"], ["P07355;A6NMY6", "Annexin A2 (ANXA2);Putative annexin A2-like protein (ANXA2P2)"], ["P08758", "Annexin A5 (ANXA5)"], ["Q9NUU7;Q9UMR2", "ATP-dependent RNA helicase DDX19A (DDX19A);ATP-dependent RNA helicase DDX19B (DDX19B)"], ["Q05682", "Caldesmon (CALD1)"], ["P17612;P22694", "cAMP-dependent protein kinase catalytic subunit alpha (PRKACA);cAMP-dependent protein kinase catalytic subunit beta (PRKACB)"], ["P17812", "CTP synthase 1 (CTPS1)"], ["P54886", "Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)"], ["Q9NZN3", "EH domain-containing protein 3 (EHD3)"], ["O94905", "Erlin-2 (ERLIN2)"], ["O75822", "Eukaryotic translation initiation factor 3 subunit J (EIF3J)"], ["Q9Y262", "Eukaryotic translation initiation factor 3 subunit L (EIF3L)"], ["P14324", "Farnesyl pyrophosphate synthase (FDPS)"], ["P14314", "Glucosidase 2 subunit beta (PRKCSH)"], ["Q06210", "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1)"], ["Q9UBQ7", "Glyoxylate reductase/hydroxypyruvate reductase (GRHPR)"], ["P0DMV9;P0DMV8", "Heat shock 70 kDa protein 1B (HSPA71B);Heat shock 70 kDa protein 1A (HSPA71A)"], ["Q14103", "Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)"], ["O14979", "Heterogeneous nuclear ribonucleoprotein D-like (HNRNDL)"], ["P31942", "Heterogeneous nuclear ribonucleoprotein H3 (HNRNH3)"], ["P22626", "Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)"], ["Q16850", "Lanosterol 14-alpha demethylase (CYP51A1)"], ["Q96AG4", "Leucine-rich repeat-containing protein 59 (LRRC59)"], ["P40926", "Malate dehydrogenase, mitochondrial (MDH2)"], ["P29966", "Myristoylated alanine-rich C-kinase substrate (MARCKS)"], ["Q96AY3", "Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)"], ["P48739", "Phosphatidylinositol transfer protein beta isoform (PITPNB)"], ["O60568", "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3)"], ["Q99623", "Prohibitin-2 (PHB2)"], ["Q86UE4", "Protein LYRIC (MTDH)"], ["Q96M27", "Protein PRRC1 (PRRC1)"], ["Q15436", "Protein transport protein Sec23A (SEC23A)"], ["P35241", "Radixin (RDX)"], ["Q9UN86", "Ras GTPase-activating protein-binding protein 2 (G3BP2)"], ["Q15019", "Septin-2 (SEPT2)"], ["P62136", "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)"], ["Q9BWM7", "Sideroflexin-3 (SFXN3)"], ["P08240", "Signal recognition particle receptor subunit alpha (SRPRA)"], ["O43765", "Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA)"], ["Q9Y5X3", "Sorting nexin-5 (SNX5)"], ["Q8WZ42", "Titin (TTN)"], ["P60174", "Triosephosphate isomerase (TPI1)"], ["P09493", "Tropomyosin alpha-1 chain (TPM1)"], ["P06753", "Tropomyosin alpha-3 chain (TPM3)"], ["Q96FW1", "Ubiquitin thioesterase (OTUB1)"], ["Downregulated"], ["Q15435", "Protein phosphatase 1 regulatory subunit 7 (PPP1R7)"], ["Q59GN2;P62891", "Putative 60S ribosomal protein L39-like 5 (RPL39P5);60S ribosomal protein L39 (RPL39)"]], "row_count": 54, "column_count": 2, "numeric_cells": 73, "header_rows": 1, "locator": "section[11]/table-wrap[2]#Tab2"}}], "gaps": ["asset:data:geo:PXD009933 not downloaded", "asset:data:geo:PXD009933 licence not read"]}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "principal_component_analysis", "specific": "pca", "label": "Principal component analysis", "dsl_operations": ["pca_fit"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["wide_numeric_matrix"], "evidence": {"score": 0.8, "band": "high", "quote": "PCA"}}, {"id": "method-2", "family": "clustering", "specific": "hierarchical", "label": "Clustering", "dsl_operations": ["hierarchical_cluster"], "missing_operations": [], 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The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["PXD009933"], "resolved_accessions": ["PXD009933"], "statements": ["The mass spectrometry proteomic data have been deposited to the ProteomeXchange Consortium via the PRIDE [21] partner repository with the dataset identifier PXD009933."], "basis": "The paper names PXD009933 in ProteomeXchange Consortium via the PRIDE partner repository and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["pca_fit"], "assets": ["source:pmid:30497457", "data:geo:PXD009933", "asset:table:pmid:30497457:1", "asset:table:pmid:30497457:2"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:PXD009933"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:12:58Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 29835, "completion_tokens": 833, "cached_tokens": 784}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:30497457", "type": "paper", "label": "pmid:30497457"}, {"id": "source:pmid:30497457", "type": "manuscript", "label": "PMID 30497457 full text"}, {"id": "data:geo:PXD009933", "type": "dataset", "label": "GEO PXD009933"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:30497457", "type": "paper", "label": "pmid:30497457"}, {"id": "source:pmid:30497457", "type": "manuscript", "label": "PMID 30497457 full text"}, {"id": "data:geo:PXD009933", "type": "dataset", "label": "GEO PXD009933"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-30497457", "type": "extraction", "used": ["source:pmid:30497457"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-PXD009933", "type": "accession_resolution", "used": ["data:geo:PXD009933"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:30497457", "parent_hash": "sha256:9842ad069824d0277034c5b2a221e52eff119cabeab5e6cf9d748980025b286d", "fork_of": null, "generation": 5}, "gaps": ["asset:data:geo:PXD009933 licence not read", "asset:data:geo:PXD009933 not downloaded", "execution.not_run", "method.reader_named_unmapped", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "mass_spectrometry", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["Proteomic profiling of senescent human diploid fibrobl", "senescent HDFs using label-free quantitative proteomics. METHODS: Whole proteins were extracted and", "of data and materials The mass spectrometry proteomic data have been deposited to the ProteomeXcha", "e detected by Orbitrap liquid chromatography mass spectrometry. Mass spectra were identified and quantitate"], "order_basis": "paper_text_order:0", "id": "assay:1"}, {"role": "analysis", "definition_id": "principal_component_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["pca_fit"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 0.8, "evidence": ["PCA"], "order_basis": "consumes_earlier_output", "id": "assay:2"}]},"meta":{"api_version":"v1","automation_ladder_snapshot":"ba34b49490d9bfaf","automation_ladder_caveats":["Method extraction is rule-based and has no hand-judged accuracy sample. Evidence bands order textual support; method agreement intervals are null (n=0), never probabilities. Work-type validation does not validate methods.","Operation coverage describes only explicitly named methods. It does not prove a complete protocol, compatible parameters, successful compilation or re-execution. Unrecognised or ambiguous methods require review.","Data reachability is a textual accession or public-data statement. No dataset was downloaded or checked for access, completeness or licence.","Capabilities are planning states seeded from the dated equipment register. No bench ownership, completed quote or partner booking is inferred. Procurement counts are dependencies, not guaranteed replications or financial returns.","Tier and blocker counts are deterministic assessments of this corpus, not measured agreement. R3 is reserved for procurement; unresolved methods and data require human work (R4). The most restrictive axis wins, with capability, method, data as tie-breaks. Resolving one blocker can leave another at the same tier."],"engine":"corpus_engine","engine_provider":"rule_based_v1+lex99e1195c7d6f","run_id":"run-20261023T122449232913","source":"esearch","source_detail":"PubMed mirror biomed_pubmed (read-only)","run_status":"complete","imported_at":"2026-11-03T20:16:52+00:00","generated_at":"2026-11-04T02:45:43+00:00","total_papers":5529,"total_assays_tracked":29,"automatable_assay_families":6,"validated":true,"caveat_count":9,"blocking_caveats":5,"caveats":[{"code":"low_evidence_dominates","basis":["4,152 of 5,529 classifications (75.1%) matched no cue evidence and sit at the 0.05 floor.","34 of 230 data_only calls (14.8%) are in that group."],"claim":"Work type and confidence bands","gloss":"Most records were classified from their title and framing alone, with assay-cue coverage at zero.","detail":"Most classifications in this run rest on no matched evidence at all. At the evidence floor the work type comes from title framing and a fixed prior, not from anything in the paper, so the published work-type split should be read as a rough triage signal rather than a measured distribution. The impact is bounded but not removed: since 2026-10-23 the engine excludes floor-confidence records from the shortlist entirely and publishes them separately as held out, so the recommendation is unaffected even though the census is.","status":"unverified","severity":"high"},{"code":"runtime_is_modelled","basis":["Runtime is summed from published per-assay hour figures. Timing awaits the first executed replication.","4,407 of 5,529 records (79.7%) model to 0.00 hours because no assay was matched, which the ranking then reads as \"cheapest\".","0 of 10 shortlisted records carry a 0.00-hour estimate."],"claim":"Estimated replication runtime","gloss":"The hour figures are estimates built from assay mentions; timing awaits the first executed replication.","detail":"The hour figures are a cost model derived from the bench steps implied by each matched assay family. The first executed replication will supply measured timing. Records without an assay match currently receive a zero-hour model value.","status":"unverified","severity":"high"},{"code":"signal_score_without_citations","basis":["5,529 of 5,529 records (100.0%) have no citation count from the source metadata."],"claim":"Signal score","gloss":"The signal score uses publication-type weight because the mirror supplied zero citation counts.","detail":"The source supplied no citation counts for any record in this run, so the signal score is publication-type weight only. The citation term of the ranking is inert here, and the shortlist is ordered by publication type alone.","status":"unverified","severity":"high"},{"code":"abstract_absent","basis":["1,667 of 5,529 records (30.2%) carry no abstract at all."],"claim":"Evidence base for classification","gloss":"Some records contain a title and publication type only, defining the available classification evidence.","detail":"Where the mirror contains a title and publication types only, those fields define the classifier evidence. A methods section is required for fuller automated and human review.","status":"unverified","severity":"medium"},{"code":"classifier_agreement_measured","basis":["Published two-way decision agreement 77.7% (310 of 399 decidable records) from a stratified hand-check of 438 real records.","Three-way diagnostic agreement 73.9% (288 of 390 decidable records).","data_only agreement 75.2% (100 of 133 decidable).","48 record(s) could not be decided from title and abstract and were excluded from the denominator.","56 analysis-only records were published under another work type, so the data_only share is not an upper bound."],"claim":"Published automatable decision","gloss":"This figure has been checked against a human reading the same papers, so we know how often it is right.","detail":"The published automatable / not-automatable distribution comes from a rule-based classifier that was hand-checked against a fixed ground-truth definition. The agreement rates below are measured, not estimated. The three-way work type remains a diagnostic and is reported separately.","status":"measured","severity":"high"},{"code":"llm_comparison_not_measured","basis":["rule_based_v1+lex99e1195c7d6f produced 5,529 of 5,529 classifications.","Measured on 438 labelled records; these are RULE-BASED figures, not model results."],"claim":"Rule-based versus LLM agreement","gloss":"Every number here is the rule engine’s own. Model comparison begins when a working API credential is connected and measured.","detail":"The published two-way decision agreed with a human reading on 310 of 399 decidable records (77.7%). The diagnostic three-way label agreed on 288 of 390 decidable records (73.9%). Every percentage in this run belongs to the rule engine. Model comparison begins when a working API credential is connected and measured.","status":"not_measured","severity":"high"},{"code":"confidence_is_a_band","basis":["low band: 135 of 210 hand-judged records were correct, 64.3% [57.6, 70.5] (95% CI).","medium band: 80 of 104 hand-judged records were correct, 76.9% [68.0, 84.0] (95% CI).","high band: 73 of 76 hand-judged records were correct, 96.0% [89.0, 98.7] (95% CI).","A fitted calibrated probability was built, measured and withdrawn: it overstated held-out accuracy and reorders nothing."],"claim":"Confidence band and evidence score","gloss":"The confidence band carries a measured accuracy interval; 0.85 represents relative rank strength.","detail":"Confidence on this run is a BAND plus its measured accuracy interval. The number stored alongside each record is a monotone evidence score that orders records; 0.85 represents relative rank strength. A fitted probability was withdrawn after it overstated held-out accuracy. Threshold on the band.","status":"measured","severity":"medium"},{"code":"three_way_split_is_diagnostic","basis":["The corpus is published at the two-way decision: automatable or not-automatable. The three-way split (data_only / physical / mixed) is published as a diagnostic with its measured reliability attached, not as a claim, because the rule engine's `mixed` call cannot be defended.","The engine called 22 record(s) mixed; 10 matched the human judgement (45.5%, 95% CI 26.9-65.3).","The engine's `mixed` call is right on 10/22 hand-judged records (45.5%, 95% CI 26.9%-65.3%); a constant `physical` guess scores 36.4%.","The engine's `mixed` call does not reliably beat a constant `physical` guess on the hand-judged records it labels mixed.","The sign of that difference flips between two independent samples, so the three-way refinement is not demonstrably informative.","The mixed stratum contributes a disproportionate share of errors relative to its size.","At title-only depth the physical/mixed split collapses: a title says that work was done, not whether it was also analysed."],"claim":"The published decision is two-way","gloss":"The three-way split is shown for diagnosis only. The published split is two ways.","detail":"Count and filter the corpus on automatable versus not-automatable. The data_only / physical / mixed split remains an internal engine diagnostic because the mixed call has lower measured reliability.","status":"measured","severity":"medium"},{"code":"automatable_flag_unproven","basis":["6 of 29 assay families are marked automatable now: meta_analysis, machine_learning, survival_analysis, pca, molecular_docking, differential_expression.","The flag is a rule over assay family and work type; validation begins with the first executed replication.","It inherits the 75.2% data_only agreement rate, because the flag requires the record to be analysis-only."],"claim":"Automatable now","gloss":"This flag marks assay families the rules classify as data-only. The first executed replication will validate it.","detail":"This flag marks families the rules consider replicable from data alone. Its validity depends on the analysis-only classification and will be measured through an executed replication.","status":"unverified","severity":"medium"}],"confidence_policy":"band_with_measured_interval","confidence_contract":{"policy":"band_with_measured_interval","summary":"Confidence is reported as a BAND with a measured accuracy interval. The raw evidence score supplies monotone ordering. A fitted point estimate was withdrawn after it overstated held-out accuracy.","evidence_score":"A monotone evidence score in [0,1] built from cue mass, axis separation and text coverage. Use it to order records. Interpret 0.85 as relative rank strength.","confidence_band":"low | medium | high. Consumers threshold on this value.","band_accuracy":"Wilson 95% interval on the measured agreement of the hand-judged records in this band.","calibrated_confidence":"WITHDRAWN. Reintroduction requires held-out evidence demonstrating reliable estimates across every bin."},"band_accuracy":{"low":{"n":210,"low":0.576,"band":"low","high":0.7046,"agree":135,"accuracy":0.6429},"high":{"n":76,"low":0.8903,"band":"high","high":0.9865,"agree":73,"accuracy":0.9605},"medium":{"n":104,"low":0.6795,"band":"medium","high":0.8397,"agree":80,"accuracy":0.7692}},"provider":"rule_based_v1+lex99e1195c7d6f","lexicon_id":"99e1195c7d6f","contract_published_at":"2026-10-23T12:25:29.022232+00:00","confidence_is_band":true,"confidence_is_probability":false,"decision_taxonomy":"two_way","decidable_fraction_two_way":0.8854,"decidable_fraction_two_way_low":0.8565,"decidable_fraction_two_way_high":0.9143,"decidable_fraction_three_way":0.8586,"decidable_fraction_three_way_low":0.8287,"decidable_fraction_three_way_high":0.8884,"decidable_population":5529,"validation_sample_size":438,"three_way_cost_fraction":0.0268,"three_way_cost_records":148,"decision_counts":{"automatable":230,"not_automatable":5299},"decision_split":{"automatable":{"count":230,"share":0.04159884246699222},"not_automatable":{"count":5299,"share":0.9584011575330078}},"diagnostic_work_type_counts":{"mixed":24,"physical":5275,"data_only":230}}}