{"data":{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:31417870", "kind": "science-record", "revision": 6, "content_hash": "sha256:ac398a17cec5fa156dac4edbf39f6d78fc3c08674f8185a754c7e074c13f7247", "created_at": "2026-11-01T15:40:48Z", "updated_at": "2026-11-01T21:22:25Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "A Robust 8-Gene Prognostic Signature for Early-Stage Non-small Cell Lung Cancer.", "doi": "10.3389/fonc.2019.00693", "pmid": "31417870", "authors": ["Ru He", "Shuguang Zuo"], "journal": "Frontiers in oncology", "year": 2019, "abstract": "Background: The current staging system is imprecise for prognostic prediction of early-stage non-small cell lung cancer (NSCLC). This study aimed to develop a robust prognostic signature for early-stage NSCLC, allowing classification of patients with a high risk of poor outcome and specific treatment decision. Method: In the present study, a comprehensive genome-wide profiling analysis was conducted using a retrospective pool of early-stage NSCLC patient data from the previous datasets of Gene Expression Omnibus (GEO) including GSE31210, GSE37745, and GSE50081 and The Cancer Genome Atlas (TCGA). Cox proportional hazards models were implemented to determine the association between gene expression levels and overall patient survival in each dataset. The common genes among all datasets were selected as candidate prognostic genes. A risk score model was developed and validated using four independent datasets and the entire cohort. The Kaplan-Meier with log-rank test was used to assess survival difference. Results: A univariate Cox proportional hazards regression analysis for each dataset showed that a total of 2280 genes in GSE31210, 762 genes in GSE37745, 871 genes in GSE50081, and 666 genes in TCGA were identified as candidate protective genes, while overall 2131 genes in GSE31210, 913 in GSE37745, 1107 in GSE50081, and 997 in TCGA were identified as candidate risky genes. There were 8 common genes associated with overall survival, including 7 mRNA and 1 lncRNA. By using the Step-wise multivariate Cox analysis, an 8-gene prognostic signature (CDCP1, HMMR, TPX2, CIRBP, HLF, KBTBD7, SEC24B-AS1, and SH2B1) for early-stage NSCLC was developed. Patients in the high-risk group had shorter overall survival than those in the low-risk group. Multivariate regression and stratified analysis suggested that the prognostic power of the 8-gene signature was independent of other clinical factors. Furthermore, the 8-gene signature achieved AUC values of 0.726, 0.701, 0.725 and 0.650 in GSE31210, GSE37745, GSE50081 and TCGA, respectively. Moreover, the combination of the 8-gene signature and the stage resulted to a better patient classification for survival prediction and treatment decision. Conclusion: This study developed a robust gene signature with great value for prognostic prediction in early-stage NSCLC, which may contribute to patient classification and personalized treatment decisions.", "claims": [{"id": "claim-method", "statement": "A univariate Cox proportional hazard regression model was used to assess the association of gene expression with the overall survival of NSCLC patients in each cohort. The raw data of gene expression and corresponding clinical information of patients with early-stage NSCLC were downloaded from GEO and TCGA, respectively.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31417870", "locator": "sections[4] \"Prognostic Signature\" paragraph 2", "quote": "A univariate Cox proportional hazard regression model was used to assess the association of gene expression with the overall survival of NSCLC patients in each cohort."}, {"asset": "source:pmid:31417870", "locator": "sections[3] \"Patients and Study Design\" paragraph 2", "quote": "The raw data of gene expression and corresponding clinical information of patients with early-stage NSCLC were downloaded from GEO and TCGA, respectively."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31417870", "locator": "sections[15] \"Data Availability\" paragraph 2", "quote": "The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31417870"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE31210"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE31210"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:31417870", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.3389/fonc.2019.00693", "sha256": 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"Univariate regression analysis of 8 genes and overall survival of NSCLC patients in 4 datasets.", "rows": [["Genes", "GSE31210", "GSE37745", "GSE5008", "TCGA"], ["", "HR (95% CI)", "P", "HR (95% CI)", "P", "HR (95% CI)", "P", "HR (95% CI)", "P"], ["CDCP1", "2.17 (1.28–3.67)", "3.80E-03", "1.93 (1.42–2.63)", "2.40E-05", "1.42 (1.04–1.95)", "3.00E-02", "1.17 (1.02–1.35)", "2.20E-02"], ["CIRBP", "0.25 (0.13–0.48)", "3.00E-05", "0.65 (0.45–0.95)", "2.70E-02", "0.6 (0.39–0.93)", "2.30E-02", "0.67 (0.53–0.85)", "8.40E-04"], ["HLF", "0.7 (0.57–0.86)", "6.40E-04", "0.85 (0.74–0.99)", "3.40E-02", "0.76 (0.63–0.92)", "5.80E-03", "0.92 (0.85–0.99)", "3.10E-02"], ["HMMR", "1.61 (1.21–2.13)", "1.00E-03", "1.35 (1.1–1.66)", "3.80E-03", "1.29 (1.02–1.63)", "3.50E-02", "1.16 (1.01–1.33)", "3.60E-02"], ["KBTBD7", "0.39 (0.18–0.83)", "1.60E-02", "0.71 (0.52–0.97)", "3.20E-02", "0.64 (0.46–0.9)", "9.60E-03", "0.77 (0.61–0.97)", "2.40E-02"], ["SEC24B-AS1", "0.3 (0.17–0.55)", "9.90E-05", "0.62 (0.4–0.97)", "3.70E-02", "0.48 (0.24–0.95)", "3.50E-02", "0.78 (0.65–0.94)", "1.00E-02"], ["SH2B1", "0.34 (0.15–0.79)", "1.20E-02", "0.38 (0.19–0.74)", "4.70E-03", "0.32 (0.13–0.78)", "1.30E-02", "0.79 (0.65–0.96)", "1.70E-02"], ["TPX2", "1.49 (1.18–1.89)", "8.90E-04", "1.17 (1.01–1.35)", "3.70E-02", "1.27 (1.08–1.49)", "4.40E-03", "1.12 (1–1.24)", "5.00E-02"]], "row_count": 10, "column_count": 9, "numeric_cells": 72, "header_rows": 2, "locator": "section[7]/table-wrap[2]#T2"}}, {"id": "asset:table:pmid:31417870:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:b986a1fb357b977b3ded19c2e820ae82c484f70273a16a18f780dea53e4e1602", "bytes": 3401, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[9]/table-wrap[1]#T3", "version": null, "note": "Univariate and multivariate Cox regression analyses of the gene signature and overall survival of NSCLC patients in 4 independent datasets.", "structure": {"pmcid": "PMC6684755", "section_index": 9, "section_title": "The 8-Gene Prognostic Signature Is Independent of Other Clinicopathological Factors", "row_count": 40, "column_count": 7}, "table": {"label": "Table 3", "caption": "Univariate and multivariate Cox regression analyses of the gene signature and overall survival of NSCLC patients in 4 independent datasets.", "rows": [["Variables", "Patients (N)", "Univariate analysis", "Multivariate analysis"], ["", "", "", "HR (95% CI)", "P", "HR (95% CI)", "P"], ["GSE31210"], ["Age", "< = 65/>65", "176/50", "2.58 (1.31–5.08)", "6.00E-03", "2.71 (1.31–5.63)", "7.50E-03"], ["Gender", "Male/Female", "121/105", "1.52 (0.78–2.96)", "2.20E-01", "", ""], ["ALK fusion", "−/+", "215/11", "1.49 (0.36–6.24)", "5.80E-01", "", ""], ["EGFR mutation", "−/+", "99/127", "0.47 (0.24–0.93)", "3.00E-02", "0.77 (0.36–1.67)", "5.10E-01"], ["KRAS mutation", "−/+", "206/20", "0.87 (0.27–2.85)", "8.20E-01", "", ""], ["Myc", "Low/High", "207/17", "0.70 (0.17–2.90)", "6.20E-01", "", ""], ["Stage", "IA/IB", "114/54", "2.47 (0.95–6.40)", "6.30E-02", "1.69 (0.64–4.46)", "2.90E-01"], ["Stage", "IA/II", "114/58", "6.18 (2.68–14.26)", "1.90E-05", "4.89 (2.00–11.95)", "4.90E-04"], ["Smoking", "No/Yes", "115/111", "1.64 (0.84–3.20)", "1.50E-01", "", ""], ["Risk score", "Low/High", "113/113", "4.74 (2.07–10.87)", "2.40E-04", "3.51 (1.47–8.37)", "4.60E-03"], ["GSE37745"], ["Age", "< = 65/>65", "82/83", "1.51 (1.05–2.18)", "2.60E-02", "1.46 (1.00–2.13)", "4.80E-02"], ["Gender", "Male/Female", "74/91", "1.11 (0.77–1.60)", "5.90E-01", "", ""], ["Stage", "IA/IB", "40/90", "1.71 (1.07–2.73)", "2.50E-02", "1.69 (1.04–2.72)", "3.30E-02"], ["Stage", "IA/II", "40/35", "1.77 (1.02–3.06)", "4.30E-02", "1.81 (1.01–3.23)", "4.50E-02"], ["Histological type", "Adeno/Large", "89/21", "0.97 (0.54–1.73)", "9.10E-01", "", ""], ["Histological type", "Adeno/Squamous", "89/55", "1.25 (0.84–1.85)", "2.80E-01", "", ""], ["Performance status", "0/1", "87/66", "2.04 (1.39–2.98)", "2.40E-04", "2.26 (1.53–3.34)", "4.10E-05"], ["Performance status", "0/2–3", "87/12", "1.50 (0.74–3.04)", "2.60E-01", "1.47 (0.70–3.08)", "3.10E-01"], ["Risk score", "Low/High", "83/82", "2.23 (1.54–3.23)", "2.00E-05", "2.69 (1.82–3.97)", "6.00E-07"], ["GSE50081"], ["Age", "< = 65/>65", "59/122", "1.56 (0.93–2.61)", "9.00E-02", "1.30 (0.74–2.30)", "3.60E-01"], ["Gender", "Male/Female", "83/98", "1.93 (1.19–3.14)", "7.80E-03", "1.73 (0.99–3.00)", "5.30E-02"], ["Stage", "IA/IB", "48/79", "1.76 (0.93–3.34)", "8.20E-02", "1.78 (0.83–3.83)", "1.40E-01"], ["Stage", "IA/II", "48/54", "2.46 (1.27–4.78)", "7.80E-03", "3.13 (1.39–7.01)", "5.70E-03"], ["Histological type", "Adeno/Large", "127/7", "1.71 (0.62–4.74)", "3.00E-01", "", ""], ["Histological type", "Adeno/Other", "127/4", "1.84 (0.57–5.92)", "3.00E-01", "", ""], ["Histological type", "Adeno/Squamous", "127/43", "0.8 (0.46–1.39)", "4.30E-01", "", ""], ["Smoking", "No/Yes", "24/136", "1.39 (0.66–2.92)", "3.90E-01", "", ""], ["Risk score", "Low/High", "91/90", "2.33 (1.45–3.75)", "4.90E-04", "1.92 (1.10–3.37)", "2.20E-02"], ["TCGA"], ["Age", "< = 65/>65", "325/434", "1.29 (0.95–1.75)", "1.10E-01", "", ""], ["Gender", "Male/Female", "306/453", "0.96 (0.71–1.29)", "7.70E-01", "", ""], ["Stage", "IA/IB", "213/277", "1.31 (0.87–1.97)", "1.90E-01", "1.23 (0.82–1.85)", "3.20E-01"], ["Stage", "IA/II", "213/269", "2.04 (1.36–3.05)", "5.30E-04", "1.94 (1.28–2.92)", "1.60E-03"], ["Histological type", "Adeno/Squamous", "372/387", "1.18 (0.88–1.60)", "2.70E-01", "", ""], ["Risk score", "Low/High", "380/379", "1.59 (1.18–2.14)", "2.50E-03", "1.47 (1.08–2.00)", "1.40E-02"]], "row_count": 40, "column_count": 7, "numeric_cells": 151, "header_rows": 2, "locator": "section[9]/table-wrap[1]#T3"}}, {"id": "asset:table:pmid:31417870:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:88b0f3dca7c36ca1f1f56ede060a4ff5d5d830fbd72272618372c047721a5ae6", "bytes": 1114, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[9]/table-wrap[2]#T4", "version": null, "note": "Univariate and multivariate Cox regression analyses of the gene signature and overall survival of NSCLC patients in entire cohort.", "structure": {"pmcid": "PMC6684755", "section_index": 9, "section_title": "The 8-Gene Prognostic Signature Is Independent of Other Clinicopathological Factors", "row_count": 9, "column_count": 7}, "table": {"label": "Table 4", "caption": "Univariate and multivariate Cox regression analyses of the gene signature and overall survival of NSCLC patients in entire cohort.", "rows": [["Variables", "Patients (N)", "Univariate analysis", "Multivariate analysis"], ["", "", "", "HR (95% CI)", "P", "HR (95% CI)", "P"], ["Age", "< = 65/>65", "646/693", "1.85 (1.51–2.25)", "1.40E-09", "1.77 (1.44–2.17)", "4.00E-08"], ["Gender", "Male/Female", "591/749", "1.34 (1.10–1.63)", "3.90E-03", "1.11 (0.91–1.37)", "3.00E-01"], ["Stage", "I/II", "923/417", "1.75 (1.43–2.14)", "5.80E-08", "1.62 (1.32–1.99)", "3.80E-06"], ["Histological type", "Adeno/Large", "819/28", "1.61 (1.00–2.62)", "5.20E-02", "1.53 (0.94–2.49)", "8.70E-02"], ["Histological type", "Adeno/Other", "819/4", "2.10 (0.67–6.57)", "2.00E-01", "1.83 (0.58–5.76)", "3.00E-01"], ["Histological type", "Adeno/Squamous", "819/489", "1.76 (1.44–2.15)", "3.00E-08", "1.33 (1.08–1.64)", "7.80E-03"], ["Risk score", "Low/High", "671/669", "2.07 (1.69–2.53)", "1.60E-12", "1.90 (1.55–2.33)", "8.70E-10"]], "row_count": 9, "column_count": 7, "numeric_cells": 38, "header_rows": 2, "locator": "section[9]/table-wrap[2]#T4"}}], "gaps": ["asset:data:geo:GSE31210 not downloaded", "asset:data:geo:GSE31210 licence not read", "asset:data:geo:GSE37745 not downloaded", "asset:data:geo:GSE37745 licence not read", "asset:data:geo:GSE50081 not downloaded", 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The raw data of gene expression and corresponding clinical information of patients with early-stage NSCLC were downloaded from GEO and TCGA, respectively."}}, {"id": "method-2", "family": "survival_analysis", "specific": "kaplan_meier", "label": "Survival analysis", "dsl_operations": ["survival_km"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.7, "band": "medium", "quote": "Kaplan-Meier"}}, {"id": "method-3", "family": "survival_analysis", "specific": "log_rank_test", "label": "Survival analysis", "dsl_operations": ["logrank_test"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.7, "band": "medium", "quote": "log-rank"}}], "targets": [], "gaps": []}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["cox_ph"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: cox_proportional_hazards."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE31210", "GSE37745", "GSE50081"], "resolved_accessions": ["GSE31210", "GSE37745", "GSE50081"], "statements": ["The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request."], "basis": "The paper names GSE31210, GSE37745, GSE50081 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["cox_ph"], "assets": ["source:pmid:31417870", "data:geo:GSE31210", "asset:table:pmid:31417870:1", "asset:table:pmid:31417870:2", "asset:table:pmid:31417870:3", "asset:table:pmid:31417870:4"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE31210"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:15:57Z", "independence": "single_reader"}, "evidence_check": {"method": "reordered", "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 21405, "completion_tokens": 1569, "cached_tokens": 776}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:31417870", "type": "paper", "label": "pmid:31417870"}, {"id": "source:pmid:31417870", "type": "manuscript", "label": "PMID 31417870 full text"}, {"id": "data:geo:GSE31210", "type": "dataset", "label": "GEO GSE31210"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:31417870", "type": "paper", "label": "pmid:31417870"}, {"id": "source:pmid:31417870", "type": "manuscript", "label": "PMID 31417870 full text"}, {"id": "data:geo:GSE31210", "type": "dataset", "label": "GEO GSE31210"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-31417870", "type": "extraction", "used": ["source:pmid:31417870"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE31210", "type": "accession_resolution", "used": ["data:geo:GSE31210"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:31417870", "parent_hash": "sha256:0358dc757682594e61a6978aaa217f6bccdcbac5a11c9488bdc9f88595122f17", "fork_of": null, "generation": 5}, "gaps": ["asset:data:geo:GSE31210 licence not read", "asset:data:geo:GSE31210 not downloaded", "asset:data:geo:GSE37745 licence not read", "asset:data:geo:GSE37745 not downloaded", "asset:data:geo:GSE50081 licence not read", "asset:data:geo:GSE50081 not downloaded", "execution.not_run", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "microarray", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["s were generated by Affymetrix U133 Plus 2.0 microarray platform, while the TCGA data were analyzed", "of the three GEO datasets were generated by Affymetrix U133 Plus 2.0 microarray platform, while the"], "order_basis": "paper_text_order:3119", "id": "assay:1"}, {"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["cox_ph"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["A univariate Cox proportional hazard regression model was used to assess the association of gene expression with the overall survival of NSCLC patients in each cohort. The raw data of gene expression and corresponding clinical information of patients with early-stage NSCLC were downloaded from GEO and TCGA, respectively."], "order_basis": "consumes_earlier_output", "id": "assay:2"}]},"meta":{"api_version":"v1","automation_ladder_snapshot":"ba34b49490d9bfaf","automation_ladder_caveats":["Method extraction is rule-based and has no hand-judged accuracy sample. Evidence bands order textual support; method agreement intervals are null (n=0), never probabilities. Work-type validation does not validate methods.","Operation coverage describes only explicitly named methods. It does not prove a complete protocol, compatible parameters, successful compilation or re-execution. Unrecognised or ambiguous methods require review.","Data reachability is a textual accession or public-data statement. No dataset was downloaded or checked for access, completeness or licence.","Capabilities are planning states seeded from the dated equipment register. No bench ownership, completed quote or partner booking is inferred. Procurement counts are dependencies, not guaranteed replications or financial returns.","Tier and blocker counts are deterministic assessments of this corpus, not measured agreement. R3 is reserved for procurement; unresolved methods and data require human work (R4). The most restrictive axis wins, with capability, method, data as tie-breaks. Resolving one blocker can leave another at the same tier."],"engine":"corpus_engine","engine_provider":"rule_based_v1+lex99e1195c7d6f","run_id":"run-20261023T122449232913","source":"esearch","source_detail":"PubMed mirror biomed_pubmed (read-only)","run_status":"complete","imported_at":"2026-11-03T20:16:52+00:00","generated_at":"2026-11-04T01:22:14+00:00","total_papers":5529,"total_assays_tracked":29,"automatable_assay_families":6,"validated":true,"caveat_count":9,"blocking_caveats":5,"caveats":[{"code":"low_evidence_dominates","basis":["4,152 of 5,529 classifications (75.1%) matched no cue evidence and sit at the 0.05 floor.","34 of 230 data_only calls (14.8%) are in that group."],"claim":"Work type and confidence bands","gloss":"Most records were classified from their title and framing alone, with assay-cue coverage at zero.","detail":"Most classifications in this run rest on no matched evidence at all. At the evidence floor the work type comes from title framing and a fixed prior, not from anything in the paper, so the published work-type split should be read as a rough triage signal rather than a measured distribution. The impact is bounded but not removed: since 2026-10-23 the engine excludes floor-confidence records from the shortlist entirely and publishes them separately as held out, so the recommendation is unaffected even though the census is.","status":"unverified","severity":"high"},{"code":"runtime_is_modelled","basis":["Runtime is summed from published per-assay hour figures. Timing awaits the first executed replication.","4,407 of 5,529 records (79.7%) model to 0.00 hours because no assay was matched, which the ranking then reads as \"cheapest\".","0 of 10 shortlisted records carry a 0.00-hour estimate."],"claim":"Estimated replication runtime","gloss":"The hour figures are estimates built from assay mentions; timing awaits the first executed replication.","detail":"The hour figures are a cost model derived from the bench steps implied by each matched assay family. The first executed replication will supply measured timing. Records without an assay match currently receive a zero-hour model value.","status":"unverified","severity":"high"},{"code":"signal_score_without_citations","basis":["5,529 of 5,529 records (100.0%) have no citation count from the source metadata."],"claim":"Signal score","gloss":"The signal score uses publication-type weight because the mirror supplied zero citation counts.","detail":"The source supplied no citation counts for any record in this run, so the signal score is publication-type weight only. The citation term of the ranking is inert here, and the shortlist is ordered by publication type alone.","status":"unverified","severity":"high"},{"code":"abstract_absent","basis":["1,667 of 5,529 records (30.2%) carry no abstract at all."],"claim":"Evidence base for classification","gloss":"Some records contain a title and publication type only, defining the available classification evidence.","detail":"Where the mirror contains a title and publication types only, those fields define the classifier evidence. A methods section is required for fuller automated and human review.","status":"unverified","severity":"medium"},{"code":"classifier_agreement_measured","basis":["Published two-way decision agreement 77.7% (310 of 399 decidable records) from a stratified hand-check of 438 real records.","Three-way diagnostic agreement 73.9% (288 of 390 decidable records).","data_only agreement 75.2% (100 of 133 decidable).","48 record(s) could not be decided from title and abstract and were excluded from the denominator.","56 analysis-only records were published under another work type, so the data_only share is not an upper bound."],"claim":"Published automatable decision","gloss":"This figure has been checked against a human reading the same papers, so we know how often it is right.","detail":"The published automatable / not-automatable distribution comes from a rule-based classifier that was hand-checked against a fixed ground-truth definition. The agreement rates below are measured, not estimated. The three-way work type remains a diagnostic and is reported separately.","status":"measured","severity":"high"},{"code":"llm_comparison_not_measured","basis":["rule_based_v1+lex99e1195c7d6f produced 5,529 of 5,529 classifications.","Measured on 438 labelled records; these are RULE-BASED figures, not model results."],"claim":"Rule-based versus LLM agreement","gloss":"Every number here is the rule engine’s own. Model comparison begins when a working API credential is connected and measured.","detail":"The published two-way decision agreed with a human reading on 310 of 399 decidable records (77.7%). The diagnostic three-way label agreed on 288 of 390 decidable records (73.9%). Every percentage in this run belongs to the rule engine. Model comparison begins when a working API credential is connected and measured.","status":"not_measured","severity":"high"},{"code":"confidence_is_a_band","basis":["low band: 135 of 210 hand-judged records were correct, 64.3% [57.6, 70.5] (95% CI).","medium band: 80 of 104 hand-judged records were correct, 76.9% [68.0, 84.0] (95% CI).","high band: 73 of 76 hand-judged records were correct, 96.0% [89.0, 98.7] (95% CI).","A fitted calibrated probability was built, measured and withdrawn: it overstated held-out accuracy and reorders nothing."],"claim":"Confidence band and evidence score","gloss":"The confidence band carries a measured accuracy interval; 0.85 represents relative rank strength.","detail":"Confidence on this run is a BAND plus its measured accuracy interval. The number stored alongside each record is a monotone evidence score that orders records; 0.85 represents relative rank strength. A fitted probability was withdrawn after it overstated held-out accuracy. Threshold on the band.","status":"measured","severity":"medium"},{"code":"three_way_split_is_diagnostic","basis":["The corpus is published at the two-way decision: automatable or not-automatable. The three-way split (data_only / physical / mixed) is published as a diagnostic with its measured reliability attached, not as a claim, because the rule engine's `mixed` call cannot be defended.","The engine called 22 record(s) mixed; 10 matched the human judgement (45.5%, 95% CI 26.9-65.3).","The engine's `mixed` call is right on 10/22 hand-judged records (45.5%, 95% CI 26.9%-65.3%); a constant `physical` guess scores 36.4%.","The engine's `mixed` call does not reliably beat a constant `physical` guess on the hand-judged records it labels mixed.","The sign of that difference flips between two independent samples, so the three-way refinement is not demonstrably informative.","The mixed stratum contributes a disproportionate share of errors relative to its size.","At title-only depth the physical/mixed split collapses: a title says that work was done, not whether it was also analysed."],"claim":"The published decision is two-way","gloss":"The three-way split is shown for diagnosis only. The published split is two ways.","detail":"Count and filter the corpus on automatable versus not-automatable. The data_only / physical / mixed split remains an internal engine diagnostic because the mixed call has lower measured reliability.","status":"measured","severity":"medium"},{"code":"automatable_flag_unproven","basis":["6 of 29 assay families are marked automatable now: meta_analysis, machine_learning, survival_analysis, pca, molecular_docking, differential_expression.","The flag is a rule over assay family and work type; validation begins with the first executed replication.","It inherits the 75.2% data_only agreement rate, because the flag requires the record to be analysis-only."],"claim":"Automatable now","gloss":"This flag marks assay families the rules classify as data-only. The first executed replication will validate it.","detail":"This flag marks families the rules consider replicable from data alone. Its validity depends on the analysis-only classification and will be measured through an executed replication.","status":"unverified","severity":"medium"}],"confidence_policy":"band_with_measured_interval","confidence_contract":{"policy":"band_with_measured_interval","summary":"Confidence is reported as a BAND with a measured accuracy interval. The raw evidence score supplies monotone ordering. A fitted point estimate was withdrawn after it overstated held-out accuracy.","evidence_score":"A monotone evidence score in [0,1] built from cue mass, axis separation and text coverage. Use it to order records. Interpret 0.85 as relative rank strength.","confidence_band":"low | medium | high. Consumers threshold on this value.","band_accuracy":"Wilson 95% interval on the measured agreement of the hand-judged records in this band.","calibrated_confidence":"WITHDRAWN. Reintroduction requires held-out evidence demonstrating reliable estimates across every bin."},"band_accuracy":{"low":{"n":210,"low":0.576,"band":"low","high":0.7046,"agree":135,"accuracy":0.6429},"high":{"n":76,"low":0.8903,"band":"high","high":0.9865,"agree":73,"accuracy":0.9605},"medium":{"n":104,"low":0.6795,"band":"medium","high":0.8397,"agree":80,"accuracy":0.7692}},"provider":"rule_based_v1+lex99e1195c7d6f","lexicon_id":"99e1195c7d6f","contract_published_at":"2026-10-23T12:25:29.022232+00:00","confidence_is_band":true,"confidence_is_probability":false,"decision_taxonomy":"two_way","decidable_fraction_two_way":0.8854,"decidable_fraction_two_way_low":0.8565,"decidable_fraction_two_way_high":0.9143,"decidable_fraction_three_way":0.8586,"decidable_fraction_three_way_low":0.8287,"decidable_fraction_three_way_high":0.8884,"decidable_population":5529,"validation_sample_size":438,"three_way_cost_fraction":0.0268,"three_way_cost_records":148,"decision_counts":{"automatable":230,"not_automatable":5299},"decision_split":{"automatable":{"count":230,"share":0.04159884246699222},"not_automatable":{"count":5299,"share":0.9584011575330078}},"diagnostic_work_type_counts":{"mixed":24,"physical":5275,"data_only":230}}}