{"data":{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:31545476", "kind": "science-record", "revision": 8, "content_hash": "sha256:4549a003f1cabd025789cbafebac466b0a3a050d41cad31b4b22fabf683231c2", "created_at": "2026-11-01T15:40:49Z", "updated_at": "2026-11-01T22:44:13Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Microarray‑based analysis of COL11A1 and TWIST1 as important differentially‑expressed pathogenic genes between left and right‑sided colon cancer.", "doi": "10.3892/mmr.2019.10667", "pmid": "31545476", "authors": ["Chen Su", "Jiabao Zhao", "Xinya Hong", "Sijiu Yang", "Ying Jiang", "Jingjing Hou"], "journal": "Molecular medicine reports", "year": 2019, "abstract": "Colonic cancer has become a main reason of mortality associated with cancer; however, left and right‑sided colonic cancer have diverse outcomes in terms of epidemiological, histological, clinical parameters and prognosis. We aimed to examine the discrepancies between these two types of colon cancers to identify potential therapeutic targets. In the present study, three gene expression profiles (GSE44076, GSE31595, GSE26906) from Gene Expression Omnibus (GEO) database were downloaded and further analyzed. A PPI (protein‑protein interaction) network of the differentially‑expressed genes (DEGs) of GSE44076 between tumor and normal was established with the Search Tool for the Retrieval of Interacting Genes database. Then, the DEGs of these two colon cancers (left, right) samples were identified. Subsequently, the intersection of DEGs of left and right‑sided colon cancer samples obtained from three databases, and DEGs of tumor and normal samples were analyzed. Collagen type XI α1 chain (COL11A1), Twist family bHLH transcription factor 1 (TWIST1), insulin‑like 5 and chromogranin A were upregulated proteins, while 3β‑hydroxysteroid dehydrogenase was downregulated protein in right colon cancer than in left‑sided tumor samples. Through further experimental verification, we revealed that COL11A1 and TWIST1 were significantly upregulated at the mRNA and protein levels within right‑sided colon cancer compared with in left‑sided colon cancer samples (P<0.05), consistent with bioinformatical analysis. Furthermore, a positive correlation between COL11A1 and TWIST1 protein expression was observed (P<0.0276). Collectively, our data showed that COL11A1 and TWIST1 may be potential prognostic indicators and molecular targets for the treatment of right‑sided colon cancer.", "claims": [{"id": "claim-method", "statement": "Subsequently, the DEGs between left and right-sided colonic cancer of three separate datasets were conducted by utilizing the limma package (37) in R.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31545476", "locator": "sections[6] \"Data pre-processing and DEG analysis\" paragraph 2", "quote": "Subsequently, the DEGs between left and right-sided colonic cancer of three separate datasets were conducted by utilizing the limma package (37) in R."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data of four original microarray datasets GSE44076, GSE31596 and GSE26906 were downloaded from NCBI-Gene Expression Omnibus database (Available online: http://www.ncbi.nlm.nih.gov/geo).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31545476", "locator": "sections[27] \"Availability of data and materials\" paragraph 2", "quote": "The data of four original microarray datasets GSE44076, GSE31596 and GSE26906 were downloaded from NCBI-Gene Expression Omnibus database (Available online: http://www.ncbi.nlm.nih.gov/geo)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31545476"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE26906"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE26906"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:31545476", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.3892/mmr.2019.10667", "sha256": "sha256:8ba82c7a33439242a547eb5475368801f08105a5eda484b4de6816517ec0b412", "bytes": 54826, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.3892/mmr.2019.10667", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC6797952", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE26906", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE26906", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE26906", "version": null, "note": "The data of four original microarray datasets GSE44076, GSE31596 and GSE26906 were downloaded from NCBI-Gene Expression Omnibus database (Available online: http://www.ncbi.nlm.nih.gov/geo).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The data of four original microarray datasets GSE44076, GSE31596 and GSE26906 were downloaded from NCBI-Gene Expression Omnibus database (Available online: http://www.ncbi.nlm.nih.gov/geo).", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM662633", "GSM662634", "GSM662635", "GSM662636", "GSM662637", "GSM662638", "GSM662639", "GSM662640", "GSM662641", "GSM662642", "GSM662643", "GSM662644", "GSM662645", "GSM662646", "GSM662647", "GSM662648", "GSM662649", "GSM662650", "GSM662651", "GSM662652", "GSM662653", "GSM662654", "GSM662655", "GSM662656", "GSM662657", "GSM662658", "GSM662659", "GSM662660", "GSM662661", "GSM662662", "GSM662663", "GSM662664", "GSM662665", "GSM662666", "GSM662667", "GSM662668", "GSM662669", "GSM662670", "GSM662671", "GSM662672", "GSM662673", "GSM662674", "GSM662675", "GSM662676", "GSM662677", "GSM662678", "GSM662679", "GSM662680", "GSM662681", "GSM662682", "GSM662683", "GSM662684", "GSM662685", "GSM662686", "GSM662687", "GSM662688", "GSM662689", "GSM662690", "GSM662691", "GSM662692", "GSM662693", "GSM662694", "GSM662695", "GSM662696", "GSM662697", "GSM662698", "GSM662699", "GSM662700", "GSM662701", "GSM662702", "GSM662703", "GSM662704", "GSM662705", "GSM662706", "GSM662707", "GSM662708", "GSM662709", "GSM662710", "GSM662711", "GSM662712", "GSM662713", "GSM662714", "GSM662715", "GSM662716", "GSM662717", "GSM662718", "GSM662719", "GSM662720", "GSM662721", "GSM662722"], "sample_count": 90, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "APC colon stage II", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE31595", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE31595", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE31595", "version": null, "note": "The data of four original microarray datasets GSE44076, GSE31596 and GSE26906 were downloaded from NCBI-Gene Expression Omnibus database (Available online: http://www.ncbi.nlm.nih.gov/geo).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The data of four original microarray datasets GSE44076, GSE31596 and GSE26906 were downloaded from NCBI-Gene Expression Omnibus database (Available online: http://www.ncbi.nlm.nih.gov/geo).", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM782671", "GSM782674", "GSM784850", "GSM784851", "GSM784852", "GSM784853", "GSM784854", "GSM784855", "GSM784856", "GSM784857", "GSM784858", "GSM784860", "GSM784862", "GSM784865", "GSM784867", "GSM784871", "GSM784873", "GSM784875", "GSM784878", "GSM784881", "GSM784884", "GSM784885", "GSM784886", "GSM784887", "GSM784888", "GSM784889", "GSM784890", "GSM784891", "GSM784892", "GSM784893", "GSM784894", "GSM784901", "GSM784902", "GSM784903", "GSM784904", "GSM784905", "GSM784906"], "sample_count": 37, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene Expression Profiles in Stage II and III Colon Cancer. 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"", "", "0.633"], ["Tis +I", "2", "0", ""], ["II", "10", "8", ""], ["III", "4", "4", ""], ["IV", "1", "1", ""], ["Histology grade", "", "", "0.432"], ["Well + moderate", "12", "10", ""], ["Poor", "3", "3", ""], ["Mucinous adenocarcinoma", "2", "0", ""]], "row_count": 18, "column_count": 4, "numeric_cells": 28, "header_rows": 3, "locator": "section[4]/table-wrap[1]#tI-mmr-20-05-4202"}}, {"id": "asset:table:pmid:31545476:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:26ab7f246180e64f081908cdb3566f9fb417a3ea7d60378101c1f7fe3f65c746", "bytes": 1224, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[22]/table-wrap[1]#tV-mmr-20-05-4202", "version": null, "note": "Functional enrichment analysis for differentially-expressed genes between tumor and normal contained TWIST1 or COL11A1 based on GO.", "structure": {"pmcid": "PMC6797952", "section_index": 15, "section_title": "Functional enrichment analysis", "row_count": 8, "column_count": 5}, "table": {"label": "Table V.", "caption": "Functional enrichment analysis for differentially-expressed genes between tumor and normal contained TWIST1 or COL11A1 based on GO.", "rows": [["Category", "Term", "Description", "P-value", "Genes"], ["GOTERM_CC_DIRECT", "GO:0005578", "Proteinaceous extracellular matrix", "0.0022724", "MMP9, COMP, COL11A1, MMP1, COL10A1"], ["GOTERM_BP_DIRECT", "GO:0001649", "Osteoblast differentiation", "0.0028232", "MSX2, COL1A1, TWIST1, SPP1"], ["GOTERM_BP_DIRECT", "GO:0045944", "Positive regulation of transcription from RNA polymerase II promoter", "0.0096635", "CKAP2, FOXA2, ATAD2, BMP7, MYC, ETV4, TWIST1"], ["GOTERM_MF_DIRECT", "GO:0000981", "RNA polymerase II transcription factor activity, sequence-specific DNA binding", "0.0108839", "FOXA2, MYBL2, ETV4, TWIST1"], ["GOTERM_CC_DIRECT", "GO:0005581", "Collagen trimer", "0.0135131", "COL1A1, COL11A1, COL10A1"], ["GOTERM_BP_DIRECT", "GO:0002063", "Chondrocyte development", "0.04367", "MSX2, COL11A1"], ["GOTERM_CC_DIRECT", "GO:0005634", "Nucleus", "0.0498886", "FOXA2, NUF2, TPX2, MND1, ATAD2, UBE2C, MYBL2, CENPH, MSX2, SPC25, CDCA7, CENPA, MYC, ETV4, TWIST1"]], "row_count": 8, "column_count": 5, "numeric_cells": 18, "header_rows": 1, "locator": "section[22]/table-wrap[1]#tV-mmr-20-05-4202"}}, {"id": "asset:table:pmid:31545476:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:78592f6f683cbee7cdd391d4fc865375753e378995ffb12801ff829680f3cd1f", "bytes": 2149, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[18]/table-wrap[1]#tII-mmr-20-05-4202", "version": null, "note": "DEGs were identified from three profile datasets, including up-regulated genes and down-regulated genes in which the colon cancer tissues compared with normal colon tissues and right-sided colon cancer tissues compared to left-sided colon cancer.", "structure": {"pmcid": "PMC6797952", "section_index": 18, "section_title": "Screening of DEGs", "row_count": 5, "column_count": 3}, "table": {"label": "Table II.", "caption": "DEGs were identified from three profile datasets, including up-regulated genes and down-regulated genes in which the colon cancer tissues compared with normal colon tissues and right-sided colon cancer tissues compared to left-sided colon cancer.", "rows": [["DEGs", "Upregulated genes", "Downregulated genes"], ["GSE44076 tumor and normal", "IL8, MYC, MMP9, CCNB1, AGT, BUB1, CENPA, CXCL1, TPX2, CEP55, UBE2C, NUF2, CXCL11, CXCL5, GNG4, TIMP1, SPP1, MMP3, MND1, CXCL2, TRIP13, MMP7, ATAD2, MMP1, CXCL3, COL1A1, ANLN, ERCC6L, CENPH, SKA3, DSCC1, SPC25, SOX9, LGR5, CDCA7, CKAP2, BMP7, RNASEH2A, FOXA2, FAM54A, FCGR3A, MMP10, DIAPH3, COL11A1, TWIST1, ETV4, LCN2, MYBL2, SULT2B1, COMP, COL10A1, FABP6, MTHFD1L, ORC6L, MSX2, FAP", "CXCL12, SST, NPY, PYY, CCL19, GCG, ADRA2A, INSL5, CD36, CA2, CHGA, FABP4, CCL13, HSD3B2, VIP, KLF4, CCL23, PCSK2, PDE6A, FABP1, MUC2, PDE9A, HPGD, OASL, CTSG, RERGL, SGK1, AKR1C1, CFD, SLC4A4, DES, MMP28, HSD17B2, DARC, PCK1, UGT2B15, UGT2B17, ADH1B, MYH11, PTGDR"], ["GSE44076 right and left", "TTPA, TRIM54, PNLIPRP2, ELAVL2, G0S2, RBP2, MSLN, EREG, ZNF43, TNNC1, PRAC, ODAM, QPRT, PCP4, COL9A3, LY6G6D, BEX2, SLC26A3, GAL, CKMT2", "MB, HOXC6, HOXB6, ARX, AIM2, SLC28A3, B3GNT6, L1TD1, DMRTA2, GABRP, GBA3, ART3, CLDN2, FOXA1, CYP4X1, KRT6B, CA9, HEPACAM2, FOXD1, HOXB8, MS4A8B, C4BPA, DMBT1, MT1H, MUC1, IDO1, KLK1, PIGR"], ["GSE31595 right and left", "FGD1, PRAC1, C11orf70, HS3ST3A1, PKIA, PI3, INSL5, HOXB13, PHACTR3, ASB9, SYNE4, RLN2, FLJ41455, TWIST1, CKMT2, SLC35D3, CCDC113, COL11A1, PPBP, EPYC, CPE", "IL10, USP30-AS1, SLC51A, HAR1A, CRTAM, NKG7, NPY6R, NR1H4, TREH, BLNK, MEP1B, GDPD3, PITX2, CYP2C18, AIM2, PP7080, CD69, GBA3, GRAMD1C, CCL8, HSD3B2, CCL5, HMGCS2, RARRES3, SLC20A1"], ["GSE26906 right and left", "PRAC1, CLDN5, SERPINE2, PCDH19, CHGA, PRELP, SERPINA6, PLA1A, SCNN1B, STMN2, MAP7D2, CHRDL1, MUC12, PCP4, HSD17B6, MN1, ARMCX1, CHRDL2, CLDN10, CCL11, AOC3, CLC, BEX2", "PLA2G3, RIBC2, CAPN6, PIWIL1, SLC28A3, GMPR, TMEM171, REG3A, L1TD1, FOXD1, CLDN2"]], "row_count": 5, "column_count": 3, "numeric_cells": 12, "header_rows": 1, "locator": "section[18]/table-wrap[1]#tII-mmr-20-05-4202"}}, {"id": "asset:table:pmid:31545476:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:d7adbe18a4297032b751a77e3ca6fb8c4eb2b830fa04f151cdffd39eac758fa3", "bytes": 712, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[21]/table-wrap[1]#tIII-mmr-20-05-4202", "version": null, "note": "Clinicopathological characteristics and COL11A1 mRNA expression in colon cancer samples.", "structure": {"pmcid": "PMC6797952", "section_index": 21, "section_title": "Verification of the DEGs (COL11A1 and TWIST1) between left and right-sided colonic cancer with western blotting analysis and RT-qPCR", "row_count": 13, "column_count": 4}, "table": {"label": "Table III.", "caption": "Clinicopathological characteristics and COL11A1 mRNA expression in colon cancer samples.", "rows": [["Clinicopathological parameters", "No. of cases", "COL11A1 expression (2−ΔCq, mean)", "P-value"], ["Tumor location", "", "", ""], ["Left", "17", "1.1993", "<0.0001"], ["Right", "13", "2.7947", ""], ["TNM stage", "", "", ""], ["Tis + I", "2", "1.1530", "0.7026"], ["II", "18", "1.9950", ""], ["III", "8", "1.9223", ""], ["IV", "2", "1.5617", ""], ["Histology grade", "", "", ""], ["Well + moderate", "22", "1.8974", "0.4455"], ["Poor", "6", "2.1369", ""], ["Mucinous adenocarcinoma", "2", "1.0769", ""]], "row_count": 13, "column_count": 4, "numeric_cells": 22, "header_rows": 1, "locator": "section[21]/table-wrap[1]#tIII-mmr-20-05-4202"}}, {"id": "asset:table:pmid:31545476:5", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:a0b89769ab70681797a960392b2156808b22cd927713a86b93845a6b714eadaa", "bytes": 708, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[21]/table-wrap[2]#tIV-mmr-20-05-4202", "version": null, "note": "Clinicopathological characteristics and TWIST1 mRNA expression in colon cancer samples.", "structure": {"pmcid": "PMC6797952", "section_index": 21, "section_title": "Verification of the DEGs (COL11A1 and TWIST1) between left and right-sided colonic cancer with western blotting analysis and RT-qPCR", "row_count": 13, "column_count": 4}, "table": {"label": "Table IV.", "caption": "Clinicopathological characteristics and TWIST1 mRNA expression in colon cancer samples.", "rows": [["Clinicopathological parameters", "No. of cases", "TWIST1 expression (2−ΔCq, mean)", "P-value"], ["Tumor location", "", "", "<0.0001"], ["Left", "17", "1.1546", ""], ["Right", "13", "2.3867", ""], ["TNM stage", "", "", "0.7767"], ["Tis + I", "2", "1.2984", ""], ["II", "18", "1.7548", ""], ["III", "8", "1.7536", ""], ["IV", "2", "1.2214", ""], ["Histology grade", "", "", "0.3601"], ["Well + moderate", "22", "1.6988", ""], ["Poor", "6", "1.9118", ""], ["Mucinous adenocarcinoma", "2", "0.9055", ""]], "row_count": 13, "column_count": 4, "numeric_cells": 22, "header_rows": 1, "locator": "section[21]/table-wrap[2]#tIV-mmr-20-05-4202"}}, {"id": "asset:table:pmid:31545476:6", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:26ab7f246180e64f081908cdb3566f9fb417a3ea7d60378101c1f7fe3f65c746", "bytes": 1224, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[22]/table-wrap[1]#tV-mmr-20-05-4202", "version": null, "note": "Functional enrichment analysis for differentially-expressed genes between tumor and normal contained TWIST1 or COL11A1 based on GO.", "structure": {"pmcid": "PMC6797952", "section_index": 22, "section_title": "Functional enrichment analysis", "row_count": 8, "column_count": 5}, "table": {"label": "Table V.", "caption": "Functional enrichment analysis for differentially-expressed genes between tumor and normal contained TWIST1 or COL11A1 based on GO.", "rows": [["Category", "Term", "Description", "P-value", "Genes"], ["GOTERM_CC_DIRECT", "GO:0005578", "Proteinaceous extracellular matrix", "0.0022724", "MMP9, COMP, COL11A1, MMP1, COL10A1"], ["GOTERM_BP_DIRECT", "GO:0001649", "Osteoblast differentiation", "0.0028232", "MSX2, COL1A1, TWIST1, SPP1"], ["GOTERM_BP_DIRECT", "GO:0045944", "Positive regulation of transcription from RNA polymerase II promoter", "0.0096635", "CKAP2, FOXA2, ATAD2, BMP7, MYC, ETV4, TWIST1"], ["GOTERM_MF_DIRECT", "GO:0000981", "RNA polymerase II transcription factor activity, sequence-specific DNA binding", "0.0108839", "FOXA2, MYBL2, ETV4, TWIST1"], ["GOTERM_CC_DIRECT", "GO:0005581", "Collagen trimer", "0.0135131", "COL1A1, COL11A1, COL10A1"], ["GOTERM_BP_DIRECT", "GO:0002063", "Chondrocyte development", "0.04367", "MSX2, COL11A1"], ["GOTERM_CC_DIRECT", "GO:0005634", "Nucleus", "0.0498886", "FOXA2, NUF2, TPX2, MND1, ATAD2, UBE2C, MYBL2, CENPH, MSX2, SPC25, CDCA7, CENPA, MYC, ETV4, TWIST1"]], "row_count": 8, "column_count": 5, "numeric_cells": 18, "header_rows": 1, "locator": "section[22]/table-wrap[1]#tV-mmr-20-05-4202"}}], "gaps": ["asset:data:geo:GSE26906 not downloaded", "asset:data:geo:GSE26906 licence not read", "asset:data:geo:GSE31595 not downloaded", "asset:data:geo:GSE31595 licence not read", "asset:data:geo:GSE44076 not downloaded", "asset:data:geo:GSE44076 licence not read"]}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "differential_expression", "specific": "limma_voom", "label": "Differential expression analysis", "dsl_operations": ["normalise_counts", "differential_expression_fit", "fdr_bh"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["count_matrix_with_condition"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "Subsequently, the DEGs between left and right-sided colonic cancer of three separate datasets were conducted by utilizing the limma package (37) in R."}}, {"id": "method-2", "family": "group_comparison", "specific": "anova", "label": "Group comparison", "dsl_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["two_or_more_groups_continuous"], "evidence": {"score": 0.8, "band": "high", "quote": "ANOVA"}}, {"id": "method-3", "family": "network_analysis", "specific": "ppi_network", "label": "Network / pathway analysis", "dsl_operations": ["build_graph", "centrality_scores", "pathway_enrich"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["edge_list"], "evidence": {"score": 0.7, "band": "medium", "quote": "PPI"}}], "targets": [], "gaps": ["method.reader_differs_from_extractor"]}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["normalise_counts", "differential_expression_fit", "fdr_bh"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: limma_voom."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE44076", "GSE31595", "GSE26906"], "resolved_accessions": ["GSE44076", "GSE31595", "GSE26906"], "statements": ["The data of four original microarray datasets GSE44076, GSE31596 and GSE26906 were downloaded from NCBI-Gene Expression Omnibus database (Available online: http://www.ncbi.nlm.nih.gov/geo)."], "basis": "The paper names GSE44076, GSE31595, GSE26906 in Gene Expression Omnibus (GEO) database and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["normalise_counts", "differential_expression_fit", "fdr_bh"], "assets": ["source:pmid:31545476", "data:geo:GSE26906", "asset:table:pmid:31545476:1", "asset:table:pmid:31545476:2", "asset:table:pmid:31545476:3", "asset:table:pmid:31545476:4", "asset:table:pmid:31545476:5", "asset:table:pmid:31545476:6"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE26906"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:16:11Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 45677, "completion_tokens": 1764, "cached_tokens": 648}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:31545476", "type": "paper", "label": "pmid:31545476"}, {"id": "source:pmid:31545476", "type": "manuscript", "label": "PMID 31545476 full text"}, {"id": "data:geo:GSE26906", "type": "dataset", "label": "GEO GSE26906"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:31545476", "type": "paper", "label": "pmid:31545476"}, {"id": "source:pmid:31545476", "type": "manuscript", "label": "PMID 31545476 full text"}, {"id": "data:geo:GSE26906", "type": "dataset", "label": "GEO GSE26906"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-31545476", "type": "extraction", "used": ["source:pmid:31545476"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE26906", "type": "accession_resolution", "used": ["data:geo:GSE26906"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:31545476", "parent_hash": "sha256:24d025a0d470bfcef5f3551d2a183a619a8ca336d5dad3d6c46d413b1abae5ca", "fork_of": null, "generation": 7}, "gaps": ["asset:data:geo:GSE26906 licence not read", "asset:data:geo:GSE26906 not downloaded", "asset:data:geo:GSE31595 licence not read", "asset:data:geo:GSE31595 not downloaded", "asset:data:geo:GSE44076 licence not read", "asset:data:geo:GSE44076 not downloaded", "execution.not_run", "method.reader_differs_from_extractor", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "microarray", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["Microarray‑based analysis of COL11A1 and TWIST1 as impo", "data and materials The data of four original microarray datasets GSE44076, GSE31596 and GSE26906 wer"], "order_basis": "paper_text_order:0", "id": "assay:1"}, {"role": "data_generation", "definition_id": "transfection", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["blish the PPI network (40). Cell culture and transfection The colon cancer HCT116 cell line was purcha", "asmids (Public Protein/Plasmid Library) were transfected into HCT116 cells; after 36 h, the cells wer"], "order_basis": "paper_text_order:2486", "id": "assay:2"}, {"role": "data_generation", "definition_id": "cell_culture", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.77, "evidence": ["hased from the Institute of Cell Biology and cultured in RPMI-1640 (Gibco; Thermo Fisher Scientific,"], "order_basis": "paper_text_order:2586", "id": "assay:3"}, {"role": "analysis", "definition_id": "differential_expression", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["normalise_counts", "differential_expression_fit", "fdr_bh"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["Subsequently, the DEGs between left and right-sided colonic cancer of three separate datasets were conducted by utilizing the limma package (37) in R."], "order_basis": "consumes_earlier_output", "id": "assay:4"}]},"meta":{"api_version":"v1","automation_ladder_snapshot":"ba34b49490d9bfaf","automation_ladder_caveats":["Method extraction is rule-based and has no hand-judged accuracy sample. Evidence bands order textual support; method agreement intervals are null (n=0), never probabilities. Work-type validation does not validate methods.","Operation coverage describes only explicitly named methods. It does not prove a complete protocol, compatible parameters, successful compilation or re-execution. Unrecognised or ambiguous methods require review.","Data reachability is a textual accession or public-data statement. No dataset was downloaded or checked for access, completeness or licence.","Capabilities are planning states seeded from the dated equipment register. No bench ownership, completed quote or partner booking is inferred. Procurement counts are dependencies, not guaranteed replications or financial returns.","Tier and blocker counts are deterministic assessments of this corpus, not measured agreement. R3 is reserved for procurement; unresolved methods and data require human work (R4). The most restrictive axis wins, with capability, method, data as tie-breaks. Resolving one blocker can leave another at the same tier."],"engine":"corpus_engine","engine_provider":"rule_based_v1+lex99e1195c7d6f","run_id":"run-20261023T122449232913","source":"esearch","source_detail":"PubMed mirror biomed_pubmed (read-only)","run_status":"complete","imported_at":"2026-11-03T20:16:52+00:00","generated_at":"2026-11-04T00:39:29+00:00","total_papers":5529,"total_assays_tracked":29,"automatable_assay_families":6,"validated":true,"caveat_count":9,"blocking_caveats":5,"caveats":[{"code":"low_evidence_dominates","basis":["4,152 of 5,529 classifications (75.1%) matched no cue evidence and sit at the 0.05 floor.","34 of 230 data_only calls (14.8%) are in that group."],"claim":"Work type and confidence bands","gloss":"Most records were classified from their title and framing alone, with assay-cue coverage at zero.","detail":"Most classifications in this run rest on no matched evidence at all. At the evidence floor the work type comes from title framing and a fixed prior, not from anything in the paper, so the published work-type split should be read as a rough triage signal rather than a measured distribution. The impact is bounded but not removed: since 2026-10-23 the engine excludes floor-confidence records from the shortlist entirely and publishes them separately as held out, so the recommendation is unaffected even though the census is.","status":"unverified","severity":"high"},{"code":"runtime_is_modelled","basis":["Runtime is summed from published per-assay hour figures. Timing awaits the first executed replication.","4,407 of 5,529 records (79.7%) model to 0.00 hours because no assay was matched, which the ranking then reads as \"cheapest\".","0 of 10 shortlisted records carry a 0.00-hour estimate."],"claim":"Estimated replication runtime","gloss":"The hour figures are estimates built from assay mentions; timing awaits the first executed replication.","detail":"The hour figures are a cost model derived from the bench steps implied by each matched assay family. The first executed replication will supply measured timing. Records without an assay match currently receive a zero-hour model value.","status":"unverified","severity":"high"},{"code":"signal_score_without_citations","basis":["5,529 of 5,529 records (100.0%) have no citation count from the source metadata."],"claim":"Signal score","gloss":"The signal score uses publication-type weight because the mirror supplied zero citation counts.","detail":"The source supplied no citation counts for any record in this run, so the signal score is publication-type weight only. The citation term of the ranking is inert here, and the shortlist is ordered by publication type alone.","status":"unverified","severity":"high"},{"code":"abstract_absent","basis":["1,667 of 5,529 records (30.2%) carry no abstract at all."],"claim":"Evidence base for classification","gloss":"Some records contain a title and publication type only, defining the available classification evidence.","detail":"Where the mirror contains a title and publication types only, those fields define the classifier evidence. A methods section is required for fuller automated and human review.","status":"unverified","severity":"medium"},{"code":"classifier_agreement_measured","basis":["Published two-way decision agreement 77.7% (310 of 399 decidable records) from a stratified hand-check of 438 real records.","Three-way diagnostic agreement 73.9% (288 of 390 decidable records).","data_only agreement 75.2% (100 of 133 decidable).","48 record(s) could not be decided from title and abstract and were excluded from the denominator.","56 analysis-only records were published under another work type, so the data_only share is not an upper bound."],"claim":"Published automatable decision","gloss":"This figure has been checked against a human reading the same papers, so we know how often it is right.","detail":"The published automatable / not-automatable distribution comes from a rule-based classifier that was hand-checked against a fixed ground-truth definition. The agreement rates below are measured, not estimated. The three-way work type remains a diagnostic and is reported separately.","status":"measured","severity":"high"},{"code":"llm_comparison_not_measured","basis":["rule_based_v1+lex99e1195c7d6f produced 5,529 of 5,529 classifications.","Measured on 438 labelled records; these are RULE-BASED figures, not model results."],"claim":"Rule-based versus LLM agreement","gloss":"Every number here is the rule engine’s own. Model comparison begins when a working API credential is connected and measured.","detail":"The published two-way decision agreed with a human reading on 310 of 399 decidable records (77.7%). The diagnostic three-way label agreed on 288 of 390 decidable records (73.9%). Every percentage in this run belongs to the rule engine. Model comparison begins when a working API credential is connected and measured.","status":"not_measured","severity":"high"},{"code":"confidence_is_a_band","basis":["low band: 135 of 210 hand-judged records were correct, 64.3% [57.6, 70.5] (95% CI).","medium band: 80 of 104 hand-judged records were correct, 76.9% [68.0, 84.0] (95% CI).","high band: 73 of 76 hand-judged records were correct, 96.0% [89.0, 98.7] (95% CI).","A fitted calibrated probability was built, measured and withdrawn: it overstated held-out accuracy and reorders nothing."],"claim":"Confidence band and evidence score","gloss":"The confidence band carries a measured accuracy interval; 0.85 represents relative rank strength.","detail":"Confidence on this run is a BAND plus its measured accuracy interval. The number stored alongside each record is a monotone evidence score that orders records; 0.85 represents relative rank strength. A fitted probability was withdrawn after it overstated held-out accuracy. Threshold on the band.","status":"measured","severity":"medium"},{"code":"three_way_split_is_diagnostic","basis":["The corpus is published at the two-way decision: automatable or not-automatable. The three-way split (data_only / physical / mixed) is published as a diagnostic with its measured reliability attached, not as a claim, because the rule engine's `mixed` call cannot be defended.","The engine called 22 record(s) mixed; 10 matched the human judgement (45.5%, 95% CI 26.9-65.3).","The engine's `mixed` call is right on 10/22 hand-judged records (45.5%, 95% CI 26.9%-65.3%); a constant `physical` guess scores 36.4%.","The engine's `mixed` call does not reliably beat a constant `physical` guess on the hand-judged records it labels mixed.","The sign of that difference flips between two independent samples, so the three-way refinement is not demonstrably informative.","The mixed stratum contributes a disproportionate share of errors relative to its size.","At title-only depth the physical/mixed split collapses: a title says that work was done, not whether it was also analysed."],"claim":"The published decision is two-way","gloss":"The three-way split is shown for diagnosis only. The published split is two ways.","detail":"Count and filter the corpus on automatable versus not-automatable. The data_only / physical / mixed split remains an internal engine diagnostic because the mixed call has lower measured reliability.","status":"measured","severity":"medium"},{"code":"automatable_flag_unproven","basis":["6 of 29 assay families are marked automatable now: meta_analysis, machine_learning, survival_analysis, pca, molecular_docking, differential_expression.","The flag is a rule over assay family and work type; validation begins with the first executed replication.","It inherits the 75.2% data_only agreement rate, because the flag requires the record to be analysis-only."],"claim":"Automatable now","gloss":"This flag marks assay families the rules classify as data-only. The first executed replication will validate it.","detail":"This flag marks families the rules consider replicable from data alone. Its validity depends on the analysis-only classification and will be measured through an executed replication.","status":"unverified","severity":"medium"}],"confidence_policy":"band_with_measured_interval","confidence_contract":{"policy":"band_with_measured_interval","summary":"Confidence is reported as a BAND with a measured accuracy interval. The raw evidence score supplies monotone ordering. A fitted point estimate was withdrawn after it overstated held-out accuracy.","evidence_score":"A monotone evidence score in [0,1] built from cue mass, axis separation and text coverage. Use it to order records. Interpret 0.85 as relative rank strength.","confidence_band":"low | medium | high. Consumers threshold on this value.","band_accuracy":"Wilson 95% interval on the measured agreement of the hand-judged records in this band.","calibrated_confidence":"WITHDRAWN. Reintroduction requires held-out evidence demonstrating reliable estimates across every bin."},"band_accuracy":{"low":{"n":210,"low":0.576,"band":"low","high":0.7046,"agree":135,"accuracy":0.6429},"high":{"n":76,"low":0.8903,"band":"high","high":0.9865,"agree":73,"accuracy":0.9605},"medium":{"n":104,"low":0.6795,"band":"medium","high":0.8397,"agree":80,"accuracy":0.7692}},"provider":"rule_based_v1+lex99e1195c7d6f","lexicon_id":"99e1195c7d6f","contract_published_at":"2026-10-23T12:25:29.022232+00:00","confidence_is_band":true,"confidence_is_probability":false,"decision_taxonomy":"two_way","decidable_fraction_two_way":0.8854,"decidable_fraction_two_way_low":0.8565,"decidable_fraction_two_way_high":0.9143,"decidable_fraction_three_way":0.8586,"decidable_fraction_three_way_low":0.8287,"decidable_fraction_three_way_high":0.8884,"decidable_population":5529,"validation_sample_size":438,"three_way_cost_fraction":0.0268,"three_way_cost_records":148,"decision_counts":{"automatable":230,"not_automatable":5299},"decision_split":{"automatable":{"count":230,"share":0.04159884246699222},"not_automatable":{"count":5299,"share":0.9584011575330078}},"diagnostic_work_type_counts":{"mixed":24,"physical":5275,"data_only":230}}}