{"data":{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:31758680", "kind": "science-record", "revision": 6, "content_hash": "sha256:1f2b5d936f347ef3421acf6fffc533687d711206d112f560598fa30f1ef9d3bf", "created_at": "2026-11-01T15:40:52Z", "updated_at": "2026-11-01T21:22:39Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Identification of Hub Genes Using Co-Expression Network Analysis in Breast Cancer as a Tool to Predict Different Stages.", "doi": "10.12659/MSM.919046", "pmid": "31758680", "authors": ["Yun Fu", "Qu-Zhi Zhou", "Xiao-Lei Zhang", "Zhen-Zhen Wang", "Peng Wang"], "journal": "Medical science monitor : international medical journal of experimental and clinical research", "year": 2019, "abstract": "BACKGROUND Breast cancer has a high mortality rate and is the most common cancer of women worldwide. Our gene co-expression network analysis identified the genes closely related to the pathological stage of breast cancer. MATERIAL AND METHODS We performed weighted gene co-expression network analysis (WGCNA) from the Gene Expression Omnibus (GEO) database, and performed pathway enrichment analysis on genes from significant modules. RESULTS A non-metastatic sample (374) of breast cancer from GSE102484 was used to construct the gene co-expression network. All 49 hub genes have been shown to be upregulated, and 19 of the 49 hub genes are significantly upregulated in breast cancer tissue. The roles of the genes CASC5, CKAP2L, FAM83D, KIF18B, KIF23, SKA1, GINS1, CDCA5, and MCM6 in breast cancer are unclear, so in order to better reveal the staging of breast cancer markers, it is necessary to study those hub genes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes indicated that 49 hub genes were enriched to sister chromatid cohesion, spindle midzone, microtubule motor activity, cell cycle, and something else. Additionally, there is an independent data set - GSE20685 - for module preservation analysis, survival analysis, and gene validation. CONCLUSIONS This study identified 49 hub genes that were associated with pathologic stage of breast cancer, 19 of which were significantly upregulated in breast cancer. Risk stratification, therapeutic decision making, and prognosis predication might be improved by our study results. This study provides new insights into biomarkers of breast cancer, which might influence the future direction of breast cancer research.", "claims": [{"id": "claim-method", "statement": "To assess the relationship between hub genes and breast cancer patients, the Kaplan-Meier survival analysis and log-rank test using the “survival” package of R software were conducted.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31758680", "locator": "sections[8] \"Survival analysis\" paragraph 2", "quote": "To assess the relationship between hub genes and breast cancer patients, the Kaplan-Meier survival analysis and log-rank test using the “survival” package of R software were conducted."}], "state": "complete"}, {"id": "claim-data-access", "statement": "All data and material are available in the GEO database.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31758680", "locator": "sections[19] \"Footnotes\" paragraph 2", "quote": "All data and material are available in the GEO database."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31758680"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE102484"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE102484"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:31758680", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.12659/MSM.919046", "sha256": "sha256:8d7371caebfc08342aa7ea35cbeec9aa3f51a85d3ca5282ce47649b9b15b8361", "bytes": 37061, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.12659/MSM.919046", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC6886326", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE102484", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE102484", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE102484", "version": null, "note": "All data and material are available in the GEO database.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "All data and material are available in the GEO database.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM2738656", "GSM2738657", "GSM2738658", "GSM2738659", "GSM2738660", "GSM2738661", "GSM2738662", "GSM2738663", "GSM2738664", "GSM2738665", "GSM2738666", "GSM2738667", "GSM2738668", "GSM2738669", "GSM2738670", "GSM2738671", "GSM2738672", "GSM2738673", "GSM2738674", "GSM2738675", "GSM2738676", "GSM2738677", "GSM2738678", "GSM2738679", "GSM2738680", "GSM2738681", "GSM2738682", "GSM2738683", "GSM2738684", "GSM2738685", "GSM2738686", "GSM2738687", "GSM2738688", "GSM2738689", "GSM2738690", "GSM2738691", "GSM2738692", "GSM2738693", "GSM2738694", "GSM2738695", "GSM2738696", "GSM2738697", "GSM2738698", "GSM2738699", "GSM2738700", "GSM2738701", "GSM2738702", "GSM2738703", "GSM2738704", "GSM2738705", "GSM2738706", "GSM2738707", "GSM2738708", "GSM2738709", "GSM2738710", "GSM2738711", "GSM2738712", "GSM2738713", "GSM2738714", "GSM2738715", "GSM2738716", "GSM2738717", "GSM2738718", "GSM2738719", "GSM2738720", "GSM2738721", "GSM2738722", "GSM2738723", "GSM2738724", "GSM2738725", "GSM2738726", "GSM2738727", "GSM2738728", "GSM2738729", "GSM2738730", "GSM2738731", "GSM2738732", "GSM2738733", "GSM2738734", "GSM2738735", "GSM2738736", "GSM2738737", "GSM2738738", "GSM2738739", "GSM2738740", "GSM2738741", "GSM2738742", "GSM2738743", "GSM2738744", "GSM2738745", "GSM2738746", "GSM2738747", "GSM2738748", "GSM2738749", "GSM2738750", "GSM2738751", "GSM2738752", "GSM2738753", "GSM2738754", "GSM2738755", "GSM2738756", "GSM2738757", "GSM2738758", "GSM2738759", "GSM2738760", "GSM2738761", "GSM2738762", "GSM2738763", "GSM2738764", "GSM2738765", "GSM2738766", "GSM2738767", "GSM2738768", "GSM2738769", "GSM2738770", "GSM2738771", "GSM2738772", "GSM2738773", "GSM2738774", "GSM2738775", "GSM2738776", "GSM2738777", "GSM2738778", "GSM2738779", "GSM2738780", "GSM2738781", "GSM2738782", "GSM2738783", "GSM2738784", "GSM2738785", "GSM2738786", "GSM2738787", "GSM2738788", "GSM2738789", "GSM2738790", "GSM2738791", "GSM2738792", "GSM2738793", "GSM2738794", "GSM2738795", "GSM2738796", "GSM2738797", "GSM2738798", "GSM2738799", "GSM2738800", "GSM2738801", "GSM2738802", "GSM2738803", "GSM2738804", "GSM2738805", "GSM2738806", "GSM2738807", "GSM2738808", "GSM2738809", "GSM2738810", "GSM2738811", "GSM2738812", "GSM2738813", "GSM2738814", "GSM2738815", "GSM2738816", "GSM2738817", "GSM2738818", "GSM2738819", "GSM2738820", "GSM2738821", "GSM2738822", "GSM2738823", "GSM2738824", "GSM2738825", "GSM2738826", "GSM2738827", "GSM2738828", "GSM2738829", "GSM2738830", "GSM2738831", "GSM2738832", "GSM2738833", "GSM2738834", "GSM2738835", "GSM2738836", "GSM2738837", "GSM2738838", "GSM2738839", "GSM2738840", "GSM2738841", "GSM2738842", "GSM2738843", "GSM2738844", "GSM2738845", "GSM2738846", "GSM2738847", "GSM2738848", "GSM2738849", "GSM2738850", "GSM2738851", "GSM2738852", "GSM2738853", "GSM2738854", "GSM2738855", "GSM2738856", "GSM2738857", "GSM2738858", "GSM2738859", "GSM2738860", "GSM2738861", "GSM2738862", "GSM2738863", "GSM2738864", "GSM2738865", "GSM2738866", "GSM2738867", "GSM2738868", "GSM2738869", "GSM2738870", "GSM2738871", "GSM2738872", "GSM2738873", "GSM2738874", "GSM2738875", "GSM2738876", "GSM2738877", "GSM2738878", "GSM2738879", "GSM2738880", "GSM2738881", "GSM2738882", "GSM2738883", "GSM2738884", "GSM2738885", "GSM2738886", "GSM2738887", "GSM2738888", "GSM2738889", "GSM2738890", "GSM2738891", "GSM2738892", "GSM2738893", "GSM2738894", "GSM2738895", "GSM2738896", "GSM2738897", "GSM2738898", "GSM2738899", "GSM2738900", "GSM2738901", "GSM2738902", "GSM2738903", "GSM2738904", "GSM2738905", "GSM2738906", "GSM2738907", "GSM2738908", "GSM2738909", "GSM2738910", "GSM2738911", "GSM2738912", "GSM2738913", "GSM2738914", "GSM2738915", "GSM2738916", "GSM2738917", "GSM2738918", "GSM2738919", "GSM2738920", "GSM2738921", "GSM2738922", "GSM2738923", "GSM2738924", "GSM2738925", "GSM2738926", "GSM2738927", "GSM2738928", "GSM2738929", "GSM2738930", "GSM2738931", "GSM2738932", "GSM2738933", "GSM2738934", "GSM2738935", "GSM2738936", "GSM2738937", "GSM2738938", "GSM2738939", "GSM2738940", "GSM2738941", "GSM2738942", "GSM2738943", "GSM2738944", "GSM2738945", "GSM2738946", "GSM2738947", "GSM2738948", "GSM2738949", "GSM2738950", "GSM2738951", "GSM2738952", "GSM2738953", "GSM2738954", "GSM2738955", "GSM2738956", "GSM2738957", "GSM2738958", "GSM2738959", "GSM2738960", "GSM2738961", "GSM2738962", "GSM2738963", "GSM2738964", "GSM2738965", "GSM2738966", "GSM2738967", "GSM2738968", "GSM2738969", "GSM2738970", "GSM2738971", "GSM2738972", "GSM2738973", "GSM2738974", "GSM2738975", "GSM2738976", "GSM2738977", "GSM2738978", "GSM2738979", "GSM2738980", "GSM2738981", "GSM2738982", "GSM2738983", "GSM2738984", "GSM2738985", "GSM2738986", "GSM2738987", "GSM2738988", "GSM2738989", "GSM2738990", "GSM2738991", "GSM2738992", "GSM2738993", "GSM2738994", "GSM2738995", "GSM2738996", "GSM2738997", "GSM2738998", "GSM2738999", "GSM2739000", "GSM2739001", "GSM2739002", "GSM2739003", "GSM2739004", "GSM2739005", "GSM2739006", "GSM2739007", "GSM2739008", "GSM2739009", "GSM2739010", "GSM2739011", "GSM2739012", "GSM2739013", "GSM2739014", "GSM2739015", "GSM2739016", "GSM2739017", "GSM2739018", "GSM2739019", "GSM2739020", "GSM2739021", "GSM2739022", "GSM2739023", "GSM2739024", "GSM2739025", "GSM2739026", "GSM2739027", "GSM2739028", "GSM2739029", "GSM2739030", "GSM2739031", "GSM2739032", "GSM2739033", "GSM2739034", "GSM2739035", "GSM2739036", "GSM2739037", "GSM2739038", "GSM2739039", "GSM2739040", "GSM2739041", "GSM2739042", "GSM2739043", "GSM2739044", "GSM2739045", "GSM2739046", "GSM2739047", "GSM2739048", "GSM2739049", "GSM2739050", "GSM2739051", "GSM2739052", "GSM2739053", "GSM2739054", "GSM2739055", "GSM2739056", "GSM2739057", "GSM2739058", "GSM2739059", "GSM2739060", "GSM2739061", "GSM2739062", "GSM2739063", "GSM2739064", "GSM2739065", "GSM2739066", "GSM2739067", "GSM2739068", "GSM2739069", "GSM2739070", "GSM2739071", "GSM2739072", "GSM2739073", "GSM2739074", "GSM2739075", "GSM2739076", "GSM2739077", "GSM2739078", "GSM2739079", "GSM2739080", "GSM2739081", "GSM2739082", "GSM2739083", "GSM2739084", "GSM2739085", "GSM2739086", "GSM2739087", "GSM2739088", "GSM2739089", "GSM2739090", "GSM2739091", "GSM2739092", "GSM2739093", "GSM2739094", "GSM2739095", "GSM2739096", "GSM2739097", "GSM2739098", "GSM2739099", "GSM2739100", "GSM2739101", "GSM2739102", "GSM2739103", "GSM2739104", "GSM2739105", "GSM2739106", "GSM2739107", "GSM2739108", "GSM2739109", "GSM2739110", "GSM2739111", "GSM2739112", "GSM2739113", "GSM2739114", "GSM2739115", "GSM2739116", "GSM2739117", "GSM2739118", "GSM2739119", "GSM2739120", "GSM2739121", "GSM2739122", "GSM2739123", "GSM2739124", "GSM2739125", "GSM2739126", "GSM2739127", "GSM2739128", "GSM2739129", "GSM2739130", "GSM2739131", "GSM2739132", "GSM2739133", "GSM2739134", "GSM2739135", "GSM2739136", "GSM2739137", "GSM2739138", "GSM2739139", "GSM2739140", "GSM2739141", "GSM2739142", "GSM2739143", "GSM2739144", "GSM2739145", "GSM2739146", "GSM2739147", "GSM2739148", "GSM2739149", "GSM2739150", "GSM2739151", "GSM2739152", "GSM2739153", "GSM2739154", "GSM2739155", "GSM2739156", "GSM2739157", "GSM2739158", "GSM2739159", "GSM2739160", "GSM2739161", "GSM2739162", "GSM2739163", "GSM2739164", "GSM2739165", "GSM2739166", "GSM2739167", "GSM2739168", "GSM2739169", "GSM2739170", "GSM2739171", "GSM2739172", "GSM2739173", "GSM2739174", "GSM2739175", "GSM2739176", "GSM2739177", "GSM2739178", "GSM2739179", "GSM2739180", "GSM2739181", "GSM2739182", "GSM2739183", "GSM2739184", "GSM2739185", "GSM2739186", "GSM2739187", "GSM2739188", "GSM2739189", "GSM2739190", "GSM2739191", "GSM2739192", "GSM2739193", "GSM2739194", "GSM2739195", "GSM2739196", "GSM2739197", "GSM2739198", "GSM2739199", "GSM2739200", "GSM2739201", "GSM2739202", "GSM2739203", "GSM2739204", "GSM2739205", "GSM2739206", "GSM2739207", "GSM2739208", "GSM2739209", "GSM2739210", "GSM2739211", "GSM2739212", "GSM2739213", "GSM2739214", "GSM2739215", "GSM2739216", "GSM2739217", "GSM2739218", "GSM2739219", "GSM2739220", "GSM2739221", "GSM2739222", "GSM2739223", "GSM2739224", "GSM2739225", "GSM2739226", "GSM2739227", "GSM2739228", "GSM2739229", "GSM2739230", "GSM2739231", "GSM2739232", "GSM2739233", "GSM2739234", "GSM2739235", "GSM2739236", "GSM2739237", "GSM2739238", "GSM2739239", "GSM2739240", "GSM2739241", "GSM2739242", "GSM2739243", "GSM2739244", "GSM2739245", "GSM2739246", "GSM2739247", "GSM2739248", "GSM2739249", "GSM2739250", "GSM2739251", "GSM2739252", "GSM2739253", "GSM2739254", "GSM2739255", "GSM2739256", "GSM2739257", "GSM2739258", "GSM2739259", "GSM2739260", "GSM2739261", "GSM2739262", "GSM2739263", "GSM2739264", "GSM2739265", "GSM2739266", "GSM2739267", "GSM2739268", "GSM2739269", "GSM2739270", "GSM2739271", "GSM2739272", "GSM2739273", "GSM2739274", "GSM2739275", "GSM2739276", "GSM2739277", "GSM2739278", "GSM2739279", "GSM2739280", "GSM2739281", "GSM2739282", "GSM2739283", "GSM2739284", "GSM2739285", "GSM2739286", "GSM2739287", "GSM2739288", "GSM2739289", "GSM2739290", "GSM2739291", "GSM2739292", "GSM2739293", "GSM2739294", "GSM2739295", "GSM2739296", "GSM2739297", "GSM2739298", "GSM2739299", "GSM2739300", "GSM2739301", "GSM2739302", "GSM2739303", "GSM2739304", "GSM2739305", "GSM2739306", "GSM2739307", "GSM2739308", "GSM2739309", "GSM2739310", "GSM2739311", "GSM2739312", "GSM2739313", "GSM2739314", "GSM2739315", "GSM2739316", "GSM2739317", "GSM2739318", "GSM2739319", "GSM2739320", "GSM2739321", "GSM2739322", "GSM2739323", "GSM2739324", "GSM2739325", "GSM2739326", "GSM2739327", "GSM2739328", "GSM2739329", "GSM2739330", "GSM2739331", "GSM2739332", "GSM2739333", "GSM2739334", "GSM2739335", "GSM2739336", "GSM2739337", "GSM2739338"], "sample_count": 683, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Expression data from invasive breast cancer patient", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE20685", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20685", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE20685", "version": null, "note": "All data and material are available in the GEO database.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "All data and material are available in the GEO database.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM519117", "GSM519118", "GSM519119", "GSM519120", "GSM519121", "GSM519122", "GSM519123", "GSM519124", "GSM519125", "GSM519126", "GSM519127", "GSM519128", "GSM519129", "GSM519130", "GSM519131", "GSM519132", "GSM519133", "GSM519134", "GSM519135", "GSM519136", "GSM519137", "GSM519138", "GSM519139", "GSM519140", "GSM519141", "GSM519142", "GSM519143", "GSM519144", "GSM519145", "GSM519146", "GSM519147", "GSM519148", "GSM519149", "GSM519150", "GSM519151", "GSM519152", "GSM519153", "GSM519154", "GSM519155", "GSM519156", "GSM519157", "GSM519158", "GSM519159", "GSM519160", "GSM519161", "GSM519162", "GSM519163", "GSM519164", "GSM519165", "GSM519166", "GSM519167", "GSM519168", "GSM519169", "GSM519170", "GSM519171", "GSM519172", "GSM519173", "GSM519174", "GSM519175", "GSM519176", "GSM519177", "GSM519178", "GSM519179", "GSM519180", "GSM519181", "GSM519182", "GSM519183", "GSM519184", "GSM519185", "GSM519186", "GSM519187", "GSM519188", "GSM519189", "GSM519190", "GSM519191", "GSM519192", "GSM519193", "GSM519194", "GSM519195", "GSM519196", "GSM519197", "GSM519198", "GSM519199", "GSM519200", "GSM519201", "GSM519202", "GSM519203", "GSM519204", "GSM519205", "GSM519206", "GSM519207", "GSM519208", "GSM519209", "GSM519210", "GSM519211", "GSM519212", "GSM519213", "GSM519214", "GSM519215", "GSM519216", "GSM519217", "GSM519218", "GSM519219", "GSM519220", "GSM519221", "GSM519222", "GSM519223", "GSM519224", "GSM519225", "GSM519226", "GSM519227", "GSM519228", "GSM519229", "GSM519230", "GSM519231", "GSM519232", "GSM519233", "GSM519234", "GSM519235", "GSM519236", "GSM519237", "GSM519238", "GSM519239", "GSM519240", "GSM519241", "GSM519242", "GSM519243", "GSM519244", "GSM519245", "GSM519246", "GSM519247", "GSM519248", "GSM519249", "GSM519250", "GSM519251", "GSM519252", "GSM519253", "GSM519254", "GSM519255", "GSM519256", "GSM519257", "GSM519258", "GSM519259", "GSM519260", "GSM519261", "GSM519262", "GSM519263", "GSM519264", "GSM519265", "GSM519266", "GSM519267", "GSM519268", "GSM519269", "GSM519270", "GSM519271", "GSM519272", "GSM519273", "GSM519274", "GSM519275", "GSM519276", "GSM519277", "GSM519278", "GSM519279", "GSM519280", "GSM519281", "GSM519282", "GSM519283", "GSM519284", "GSM519285", "GSM519286", "GSM519287", "GSM519288", "GSM519289", "GSM519290", "GSM519291", "GSM519292", "GSM519293", "GSM519294", "GSM519295", "GSM519296", "GSM519297", "GSM519298", "GSM519299", "GSM519300", "GSM519301", "GSM519302", "GSM519303", "GSM519304", "GSM519305", "GSM519306", "GSM519307", "GSM519308", "GSM519309", "GSM519310", "GSM519311", "GSM519312", "GSM519313", "GSM519314", "GSM519315", "GSM519316", "GSM519317", "GSM519318", "GSM519319", "GSM519320", "GSM519321", "GSM519322", "GSM519323", "GSM519324", "GSM519325", "GSM519326", "GSM519327", "GSM519328", "GSM519329", "GSM519330", "GSM519331", "GSM519332", "GSM519333", "GSM519334", "GSM519335", "GSM519336", "GSM519337", "GSM519338", "GSM519339", "GSM519340", "GSM519341", "GSM519342", "GSM519343", "GSM519344", "GSM519345", "GSM519346", "GSM519347", "GSM519348", "GSM519349", "GSM519350", "GSM519351", "GSM519352", "GSM519353", "GSM519354", "GSM519355", "GSM519356", "GSM519357", "GSM519358", "GSM519359", "GSM519360", "GSM519361", "GSM519362", "GSM519363", "GSM519364", "GSM519365", "GSM519366", "GSM519367", "GSM519368", "GSM519369", "GSM519370", "GSM519371", "GSM519372", "GSM519373", "GSM519374", "GSM519375", "GSM519376", "GSM519377", "GSM519378", "GSM519379", "GSM519380", "GSM519381", "GSM519382", "GSM519383", "GSM519384", "GSM519385", "GSM519386", "GSM519387", "GSM519388", "GSM519389", "GSM519390", "GSM519391", "GSM519392", "GSM519393", "GSM519394", "GSM519395", "GSM519396", "GSM519397", "GSM519398", "GSM519399", "GSM519400", "GSM519401", "GSM519402", "GSM519403", "GSM519404", "GSM519405", "GSM519406", "GSM519407", "GSM519408", "GSM519409", "GSM519410", "GSM519411", "GSM519412", "GSM519413", "GSM519414", "GSM519415", "GSM519416", "GSM519417", "GSM519418", "GSM519419", "GSM519420", "GSM519421", "GSM519422", "GSM519423", "GSM519424", "GSM519425", "GSM519426", "GSM519427", "GSM519428", "GSM519429", "GSM519430", "GSM519431", "GSM519432", "GSM519433", "GSM519434", "GSM519435", "GSM519436", "GSM519437", "GSM519438", "GSM519439", "GSM519440", "GSM519441", "GSM519442", "GSM519443"], "sample_count": 327, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Microarray-based molecular subtyping of breast cancer", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE29044", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29044", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE29044", "version": null, "note": "All data and material are available in the GEO database.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "All data and material are available in the GEO database.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM719634", "GSM719635", "GSM719636", "GSM719637", "GSM719638", "GSM719639", "GSM719640", "GSM719641", "GSM719642", "GSM719643", "GSM719644", "GSM719645", "GSM719646", "GSM719647", "GSM719648", "GSM719649", "GSM719650", "GSM719651", "GSM719652", "GSM719653", "GSM719654", "GSM719655", "GSM719656", "GSM719657", "GSM719658", "GSM719659", "GSM719660", "GSM719661", "GSM719662", "GSM719663", "GSM719664", "GSM719665", "GSM719666", "GSM719667", "GSM719668", "GSM719669", "GSM719670", "GSM719671", "GSM719672", "GSM719673", "GSM719674", "GSM719675", "GSM719676", "GSM719677", "GSM719678", "GSM719679", "GSM719680", "GSM719681", "GSM719682", "GSM719683", "GSM719684", "GSM719685", "GSM719686", "GSM719687", "GSM719688", "GSM719689", "GSM719690", "GSM719691", "GSM719692", "GSM719693", "GSM719694", "GSM719695", "GSM719696", "GSM719697", "GSM719698", "GSM719699", "GSM719700", "GSM719701", "GSM719702", "GSM719703", "GSM719704", "GSM719705", "GSM719706", "GSM719707", "GSM719708", "GSM719709", "GSM719710", "GSM719711", "GSM719712", "GSM719713", "GSM719714", "GSM719715", "GSM719716", "GSM719717", "GSM719718", "GSM719719", "GSM719720", "GSM719721", "GSM719722", "GSM719723", "GSM719724", "GSM719725", "GSM719726", "GSM719727", "GSM719728", "GSM719729", "GSM719730", "GSM719731", "GSM719732", "GSM719733", "GSM719734", "GSM719735", "GSM719736", "GSM719737", "GSM719738", "GSM719739", "GSM719740", "GSM719741", "GSM719742", "GSM736476", "GSM736477", "GSM736478", "GSM736479", "GSM736480", "GSM736481", "GSM736482", "GSM736483", "GSM736484", "GSM736485", "GSM736486", "GSM736487", "GSM736488", "GSM736489", "GSM736490", "GSM740839", "GSM740840", "GSM740841", "GSM740842", "GSM740843", "GSM740844", "GSM740845", "GSM740846", "GSM740847", "GSM740848", "GSM740849", "GSM740850", "GSM740851", "GSM740852"], "sample_count": 138, "group_sizes": null, "group_sizes_basis": null, "platform": "570;5175", "taxon": "Homo sapiens", "title": "Expression data from breast tumors  in different age-specific cohorts  and for different sequentional disease stages", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:31758680:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:0f0c3833238c859c9dee1cef17eb97a335dfa5de9b41786323d5917713a5c5ae", "bytes": 3144, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#t1-medscimonit-25-8873", "version": null, "note": "The 49 hub genes most associated with breast cancer.", "structure": {"pmcid": "PMC6886326", "section_index": 13, "section_title": "Hub genes identification, validation and functional annotation", "row_count": 50, "column_count": 5}, "table": {"label": "Table 1", "caption": "The 49 hub genes most associated with breast cancer.", "rows": [["Probe ID", "Gene symbol", "Entrez gene ID", "Gene module membership", "Gene trait significance"], ["209642_at", "BUB1", "699", "0.924293226", "0.235607323"], ["209408_at", "KIF2C", "11004", "0.92218934", "0.241907024"], ["210052_s_at", "TPX2", "22974", "0.914480792", "0.223144303"], ["224753_at", "CDCA5", "113130", "0.91205407", "0.259025302"], ["220651_s_at", "MCM10", "55388", "0.910563071", "0.208487817"], ["204822_at", "TTK", "7272", "0.907948229", "0.219457711"], ["204825_at", "MELK", "9833", "0.903514378", "0.231607588"], ["218726_at", "HJURP", "55355", "0.90328239", "0.22698554"], ["225687_at", "FAM83D", "81610", "0.899886619", "0.203016176"], ["218663_at", "NCAPG", "64151", "0.896054426", "0.205216007"], ["218755_at", "KIF20A", "10112", "0.895166941", "0.226348808"], ["202870_s_at", "CDC20", "991", "0.892240716", "0.239137318"], ["221520_s_at", "CDCA8", "55143", "0.89118746", "0.244566866"], ["206364_at", "KIF14", "9928", "0.890950252", "0.26234143"], ["209464_at", "AURKB", "9212", "0.890552966", "0.22142283"], ["203755_at", "BUB1B", "701", "0.888672889", "0.213901874"], ["218355_at", "KIF4A", "24137", "0.887945991", "0.228378944"], ["202954_at", "UBE2C", "11065", "0.887818368", "0.226938633"], ["203554_x_at", "PTTG1", "9232", "0.881155019", "0.213686403"], ["205046_at", "CENPE", "1062", "0.880069219", "0.22209321"], ["208079_s_at", "AURKA", "6790", "0.879152052", "0.218061231"], ["203358_s_at", "EZH2", "2146", "0.875743388", "0.207933283"], ["222608_s_at", "ANLN", "54443", "0.871339701", "0.234975449"], ["205339_at", "STIL", "6491", "0.869107261", "0.210922715"], ["205024_s_at", "RAD51", "5888", "0.867508527", "0.213183274"], ["228069_at", "MTFR2", "113115", "0.864955684", "0.211359463"], ["228868_x_at", "CDT1", "81620", "0.86478764", "0.229292335"], ["205733_at", "BLM", "641", "0.860785004", "0.217032378"], ["228323_at", "CASC5", "57082", "0.857092896", "0.202429723"], ["201710_at", "MYBL2", "4605", "0.85635078", "0.236329323"], ["206102_at", "GINS1", "9837", "0.856311574", "0.208385671"], ["222077_s_at", "RACGAP1", "29127", "0.853841921", "0.256705857"], ["204709_s_at", "KIF23", "9493", "0.851379193", "0.21561731"], ["229610_at", "CKAP2L", "150468", "0.85011016", "0.229596216"], ["204033_at", "TRIP13", "9319", "0.849593284", "0.202381238"], ["218009_s_at", "PRC1", "9055", "0.849581571", "0.221410912"], ["207746_at", "POLQ", "10721", "0.848529181", "0.247638427"], ["214804_at", "CENPI", "2491", "0.846773238", "0.207038989"], ["217640_x_at", "SKA1", "220134", "0.837739498", "0.203041011"], ["219650_at", "ERCC6L", "54821", "0.82821799", "0.202549981"], ["222039_at", "KIF18B", "146909", "0.825933796", "0.203151907"], ["207828_s_at", "CENPF", "1063", "0.818716418", "0.230482778"], ["228273_at", "PRR11", "55771", "0.815331726", "0.215057337"], ["204023_at", "RFC4", "5984", "0.815233799", "0.213293858"], ["213008_at", "FANCI", "55215", "0.810580105", "0.2165155"], ["204817_at", "ESPL1", "9700", "0.808284083", "0.211142978"], ["202107_s_at", "MCM2", "4171", "0.803926063", "0.207204313"], ["209680_s_at", "KIFC1", "3833", "0.801065976", "0.213650537"], ["201930_at", "MCM6", "4175", "0.800871266", "0.214708557"]], "row_count": 50, "column_count": 5, "numeric_cells": 206, "header_rows": 1, "locator": "section[13]/table-wrap[1]#t1-medscimonit-25-8873"}}, {"id": "asset:table:pmid:31758680:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:970bb9da7fd12a804aa21c64fa624a411df3faef6ce6088c123dcbd94b7e8a2e", "bytes": 3199, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#t2-medscimonit-25-8873", "version": null, "note": "The node degree, betweenness, stress, closeness, and clustering coefficient of 49 hub genes in brown module.", "structure": {"pmcid": "PMC6886326", "section_index": 13, "section_title": "Hub genes identification, validation and functional annotation", "row_count": 50, "column_count": 6}, "table": {"label": "Table 2", "caption": "The node degree, betweenness, stress, closeness, and clustering coefficient of 49 hub genes in brown module.", "rows": [["Gene", "Node degree", "Betweenness", "Stress", "Closeness", "Clustering coefficient"], ["AURKA", "50", "0.01994251", "556", "1", "0.77306122"], ["TPX2", "49", "0.00885408", "464", "0.98039216", "0.80272109"], ["BUB1", "49", "0.00885408", "464", "0.98039216", "0.80272109"], ["BUB1B", "49", "0.00885408", "464", "0.98039216", "0.80272109"], ["CDCA8", "49", "0.00885408", "464", "0.98039216", "0.80272109"], ["KIF2C", "49", "0.01860824", "508", "0.98039216", "0.78401361"], ["TTK", "49", "0.00885408", "464", "0.98039216", "0.80272109"], ["NCAPG", "49", "0.00885408", "464", "0.98039216", "0.80272109"], ["KIF20A", "48", "0.0078717", "418", "0.96153846", "0.81471631"], ["MELK", "48", "0.0078717", "418", "0.96153846", "0.81471631"], ["CDC20", "47", "0.00599724", "352", "0.94339623", "0.83718779"], ["AURKB", "47", "0.00603083", "352", "0.94339623", "0.83718779"], ["MCM10", "47", "0.01567858", "408", "0.94339623", "0.81128585"], ["CENPF", "47", "0.00603083", "352", "0.94339623", "0.83718779"], ["UBE2C", "47", "0.00730838", "386", "0.94339623", "0.82146161"], ["KIF4A", "47", "0.00538752", "336", "0.94339623", "0.84458834"], ["RACGAP1", "46", "0.00583064", "326", "0.92592593", "0.84251208"], ["KIF23", "46", "0.00457007", "294", "0.92592593", "0.85797101"], ["CENPE", "45", "0.00420229", "268", "0.90909091", "0.86464646"], ["PRC1", "44", "0.00395004", "248", "0.89285714", "0.86892178"], ["CDCA5", "44", "0.00448217", "252", "0.89285714", "0.86680761"], ["HJURP", "44", "0.00449643", "262", "0.89285714", "0.8615222"], ["TRIP13", "43", "0.00307517", "204", "0.87719298", "0.88704319"], ["PTTG1", "41", "0.00319721", "176", "0.84745763", "0.89268293"], ["ANLN", "41", "0.00234005", "160", "0.84745763", "0.90243902"], ["FANCI", "41", "0.00240147", "160", "0.84745763", "0.90243902"], ["CDT1", "40", "0.00249934", "158", "0.83333333", "0.89871795"], ["MCM2", "40", "0.00238095", "152", "0.83333333", "0.9025641"], ["ESPL1", "40", "0.00218884", "142", "0.83333333", "0.90897436"], ["KIF14", "40", "0.00258938", "152", "0.83333333", "0.9025641"], ["RAD51", "38", "0.00218296", "138", "0.80645161", "0.90184922"], ["MCM6", "36", "0.00155343", "98", "0.78125", "0.92222222"], ["CASC5", "36", "7.88E-04", "58", "0.78125", "0.95396825"], ["SKA1", "36", "0.00155359", "96", "0.78125", "0.92380952"], ["KIF18B", "36", "0.00151695", "98", "0.78125", "0.92222222"], ["KIFC1", "36", "0.00120015", "80", "0.78125", "0.93650794"], ["ERCC6L", "36", "0.00174436", "110", "0.78125", "0.91269841"], ["CKAP2L", "35", "0.00166605", "94", "0.76923077", "0.9210084"], ["RFC4", "34", "0.00115046", "74", "0.75757576", "0.93404635"], ["MYBL2", "34", "0.00150041", "82", "0.75757576", "0.92691622"], ["POLQ", "33", "0.00670463", "108", "0.74626866", "0.89772727"], ["EZH2", "33", "8.32E-04", "54", "0.74626866", "0.94886364"], ["CENPI", "32", "4.99E-04", "36", "0.73529412", "0.96370968"], ["FAM83D", "29", "2.09E-04", "16", "0.70422535", "0.98029557"], ["STIL", "29", "2.24E-04", "16", "0.70422535", "0.98029557"], ["BLM", "26", "6.48E-04", "44", "0.67567568", "0.93230769"], ["GINS1", "26", "3.55E-04", "26", "0.67567568", "0.96"], ["PRR11", "18", "5.66E-05", "4", "0.6097561", "0.9869281"], ["MTFR2", "15", "0", "0", "0.58823529", "1"]], "row_count": 50, "column_count": 6, "numeric_cells": 255, "header_rows": 1, "locator": "section[13]/table-wrap[2]#t2-medscimonit-25-8873"}}, {"id": "asset:table:pmid:31758680:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:e8decc6ed5ed770812d6fc424a42019cd630f8f3c9f0287c420d5c2a9abefc1b", "bytes": 5453, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[3]#t3-medscimonit-25-8873", "version": null, "note": "GO function annotation of 49 hub genes.", "structure": {"pmcid": "PMC6886326", "section_index": 13, "section_title": "Hub genes identification, validation and functional annotation", "row_count": 31, "column_count": 7}, "table": {"label": "Table 3", "caption": "GO function annotation of 49 hub genes.", "rows": [["Series", "Name", "P value", "Adjusted P value", "Z score", "Combined score", "Genes"], ["GO Cellular Component", "Spindle midzone (GO: 0051233)", "7.05E-22", "9.03E-20", "−2.19", "106.46", "KIF14; BUB1B; CDCA8; TTK; KIF23; AURKB; AURKA; CDC20; TPX2; CENPF; RACGAP1; PRC1; KIF20A"], ["GO Cellular Component", "Mitotic spindle (GO: 0072686)", "4.49E-18", "2.37E-16", "−2.3", "91.68", "CDC20; TPX2; CENPF; RACGAP1; ESPL1; CKAP2L; PRC1; TTK; KIF23; KIF20A; AURKB; AURKA"], ["GO Cellular Component", "Mitotic spindle midzone (GO: 1990023)", "5.56E-18", "2.37E-16", "−2.06", "81.88", "TPX2; CENPE; RACGAP1; ESPL1; CKAP2L; KIF14; BUB1B; CDCA8; KIF23; AURKB; AURKA"], ["GO Biological Process", "Sister chromatid cohesion (GO: 0007062)", "6.67E-18", "1.35E-15", "−2.76", "109.02", "CDC20; CENPE; CENPF; ERCC6L; CENPI; CDCA5; BUB1B; CDCA8; KIF2C; BUB1; AURKB; SKA1"], ["GO Cellular Component", "Spindle microtubule (GO: 0005876)", "1.69E-17", "5.42E-16", "−2.32", "89.73", "KIF14; TTK; KIF23; AURKB; SKA1; AURKA; CDC20; TPX2; CENPE; CENPF; PRC1; KIF4A; KIF20A"], ["GO Cellular Component", "Spindle (GO: 0005819)", "2.60E-16", "6.67E-15", "−2.45", "88.06", "TTK; KIF23; AURKB; SKA1; AURKA; CDC20; TPX2; CENPE; CENPF; PRC1; KIF2C; KIF20A; MCM2"], ["GO Cellular Component", "Mitotic spindle microtubule (GO: 1990498)", "1.87E-15", "3.99E-14", "−2.1", "71.08", "TPX2; RACGAP1; ESPL1; CKAP2L; PRC1; KIF4A; KIF23; AURKB; SKA1; AURKA"], ["GO Biological Process", "Mitotic cell cycle (GO: 0000278)", "9.03E-15", "9.17E-13", "−2.82", "91.31", "CDT1; TPX2; CENPE; CENPF; KIF18B; CDCA5; BUB1B; KIF2C; SKA1; AURKA"], ["GO Cellular Component", "Meiotic spindle (GO: 0072687)", "1.20E-14", "2.20E-13", "−1.98", "63.49", "CDC20; TPX2; CENPF; PRC1; TTK; KIF23; KIF20A; AURKB; AURKA"], ["GO Biological Process", "Microtubule-based movement (GO: 0007018)", "2.69E-14", "1.82E-12", "−2.46", "76.95", "CENPE; KIF18B; RACGAP1; KIFC1; KIF4A; KIF14; KIF2C; KIF23; KIF20A"], ["GO Cellular Component", "Spindle pole (GO: 0000922)", "6.45E-14", "1.03E-12", "−2.19", "66.53", "CDC20; TPX2; CENPF; PRC1; TTK; KIF23; AUNIP; KIF20A; AURKB; AURKA"], ["GO Cellular Component", "Kinesin complex (GO: 0005871)", "9.68E-14", "1.13E-12", "−1.72", "51.51", "CENPE; KIF18B; KIFC1; KIF4A; KIF14; KIF2C; KIF23; KIF20A"], ["GO Cellular Component", "Kinesin I complex (GO: 0016938)", "9.68E-14", "1.13E-12", "−1.68", "50.33", "CENPE; KIF18B; KIFC1; KIF4A; KIF14; KIF2C; KIF23; KIF20A"], ["GO Molecular Function", "ATP-dependent microtubule motor activity (GO: 1990939)", "5.81E-13", "1.22E-10", "−1.91", "53.71", "CENPE; KIF18B; KIFC1; KIF4A; KIF14; KIF2C; KIF23; KIF20A"], ["GO Molecular Function", "Microtubule motor activity (GO: 0003777)", "2.84E-12", "2.98E-10", "−2.06", "54.82", "CENPE; KIF18B; KIFC1; KIF4A; KIF14; KIF2C; KIF23; KIF20A"], ["GO Molecular Function", "ATP-dependent microtubule motor activity, plus-end-directed| (GO: 0008574)", "7.36E-11", "5.15E-09", "−2.59", "60.38", "CENPE; BLM; KIF18B; KIFC1; KIF4A; KIF14; KIF2C; KIF23; KIF20A"], ["GO Biological Process", "Mitotic metaphase plate congression (GO: 0007080)", "4.10E-10", "2.08E-08", "−2.79", "60.28", "CENPE; KIFC1; CDCA5; KIF14; CDCA8; KIF2C"], ["GO Molecular Function", "Protein-DNA unloading ATPase activity (GO: 0140083)", "1.11E-09", "4.14E-08", "−2.51", "51.79", "CENPE; BLM; KIF18B; KIFC1; KIF14; KIF2C; KIF23; KIF20A"], ["GO Molecular Function", "ATPase activity, uncoupled (GO: 0042624)", "1.18E-09", "4.14E-08", "−2.56", "52.69", "CENPE; BLM; KIF18B; KIFC1; KIF14; KIF2C; KIF23; KIF20A"], ["GO Molecular Function", "ATP-dependent microtubule motor activity, minus-end-directed (GO: 0008569)", "1.33E-09", "4.14E-08", "−2.54", "51.86", "CENPE; BLM; KIF18B; KIFC1; KIF14; KIF2C; KIF23; KIF20A"], ["GO Molecular Function", "ATPase activity, coupled (GO: 0042623)", "1.49E-09", "4.14E-08", "−2.61", "53.06", "CENPE; BLM; KIF18B; KIFC1; KIF14; KIF2C; KIF23; KIF20A"], ["GO Molecular Function", "ATPase activity (GO: 0016887)", "1.58E-09", "4.14E-08", "−2.53", "51.31", "CENPE; BLM; KIF18B; KIFC1; KIF14; KIF2C; KIF23; KIF20A"], ["GO Molecular Function", "Intracellular ATPase-gated chloride channel activity (GO: 0005260)", "5.56E-09", "1.30E-07", "−2.63", "50.06", "CENPE; BLM; KIF18B; KIFC1; KIF14; KIF2C; KIF23; KIF20A"], ["GO Biological Process", "Mitotic spindle midzone assembly (GO: 0051256)", "6.60E-09", "2.68E-07", "−2.1", "39.62", "RACGAP1; KIF4A; KIF23; AURKB"], ["GO Biological Process", "Metaphase plate congression (GO: 0051310)", "1.04E-08", "3.51E-07", "−2.44", "44.81", "CENPE; CENPF; KIF2C; FAM83D"], ["GO Biological Process", "Anaphase-promoting complex-dependent catabolic process (GO: 0031145)", "4.13E-08", "0.000001197", "−2.51", "42.73", "CDC20; PTTG1; UBE2C; BUB1B; AURKB; AURKA"], ["GO Biological Process", "Chromosome segregation (GO: 0007059)", "1.13E-07", "0.000002705", "−2.33", "37.27", "CDT1; CENPE; CENPF; HJURP; SKA1"], ["GO Biological Process", "Spindle organization (GO: 0007051)", "1.20E-07", "0.000002705", "−2.13", "33.93", "TTK; AUNIP; AURKB; AURKA"], ["GO Biological Process", "Protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO: 0042787)", "5.14E-07", "0.00001043", "−2.89", "41.83", "CDC20; PTTG1; UBE2C; BUB1B; AURKB; AURKA"], ["GO Molecular Function", "Microtubule plus-end binding (GO: 0051010)", "7.81E-07", "1.64E-05", "−2.32", "32.66", "RACGAP1; KIF14; KIF2C; KIF23; FAM83D; SKA1"]], "row_count": 31, "column_count": 7, "numeric_cells": 178, "header_rows": 1, "locator": "section[13]/table-wrap[3]#t3-medscimonit-25-8873"}}, {"id": "asset:table:pmid:31758680:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:97560037d96b8fef5c80daea4fa7e203f6e166c2ca7fb867c7d23bc39efa1b60", "bytes": 858, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[4]#t4-medscimonit-25-8873", "version": null, "note": "KEGG enrichment analysis of 49 hub genes.", "structure": {"pmcid": "PMC6886326", "section_index": 13, "section_title": "Hub genes identification, validation and functional annotation", "row_count": 7, "column_count": 6}, "table": {"label": "Table 4", "caption": "KEGG enrichment analysis of 49 hub genes.", "rows": [["Name", "P value", "Adjusted P value", "Z score", "Combined score", "Genes"], ["Cell cycle", "6.34E-10", "1.01E-08", "−5.14", "108.9", "CDC20; PTTG1; ESPL1; BUB1B; TTK; MCM6; BUB1; MCM2"], ["Oocyte meiosis", "0.00001346", "0.0001077", "−27.81", "311.96", "CDC20; PTTG1; ESPL1; BUB1; AURKA"], ["DNA replication", "0.00009322", "0.0004972", "−49.47", "459.08", "RFC4; MCM6; MCM2"], ["Fanconi anemia pathway", "0.0003139", "0.001256", "−42.68", "344.27", "FANCI; BLM; RAD51"], ["Human T-cell leukemia virus 1 infection", "0.002015", "0.006448", "−19.4", "120.41", "CDC20; PTTG1; ESPL1; BUB1B"], ["Homologous recombination", "0.004537", "0.0121", "−49.65", "267.88", "BLM; RAD51"]], "row_count": 7, "column_count": 6, "numeric_cells": 30, "header_rows": 1, "locator": "section[13]/table-wrap[4]#t4-medscimonit-25-8873"}}], "gaps": ["asset:data:geo:GSE102484 not downloaded", "asset:data:geo:GSE102484 licence not read", "asset:data:geo:GSE20685 not downloaded", "asset:data:geo:GSE20685 licence not read", "asset:data:geo:GSE29044 not downloaded", "asset:data:geo:GSE29044 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": "log_rank_test", "label": "Survival analysis", "dsl_operations": ["logrank_test"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "To assess the relationship between hub genes and breast cancer patients, the Kaplan-Meier survival analysis and log-rank test using the “survival” package of R software were conducted."}}, {"id": "method-2", "family": "survival_analysis", "specific": "kaplan_meier", "label": "Survival analysis", "dsl_operations": ["survival_km"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "Kaplan-Meier"}}, {"id": "method-3", "family": "clustering", "specific": "hierarchical", "label": "Clustering", "dsl_operations": ["hierarchical_cluster"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["feature_matrix"], "evidence": {"score": 0.8, "band": "high", "quote": "dendrogram"}}, {"id": "method-4", "family": "network_analysis", "specific": "pathway_enrichment", "label": "Network / pathway analysis", "dsl_operations": ["pathway_enrich"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["edge_list"], "evidence": {"score": 0.7, "band": "medium", "quote": "pathway enrichment"}}], "targets": [], "gaps": []}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["logrank_test"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: log_rank_test."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE102484", "GSE20685", "GSE29044"], "resolved_accessions": ["GSE102484", "GSE20685", "GSE29044"], "statements": ["All data and material are available in the GEO database."], "basis": "The paper names GSE102484, GSE20685, GSE29044 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["logrank_test"], "assets": ["source:pmid:31758680", "data:geo:GSE102484", "asset:table:pmid:31758680:1", "asset:table:pmid:31758680:2", "asset:table:pmid:31758680:3", "asset:table:pmid:31758680:4"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE102484"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:16:55Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 28003, "completion_tokens": 1387, "cached_tokens": 792}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:31758680", "type": "paper", "label": "pmid:31758680"}, {"id": "source:pmid:31758680", "type": "manuscript", "label": "PMID 31758680 full text"}, {"id": "data:geo:GSE102484", "type": "dataset", "label": "GEO GSE102484"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:31758680", "type": "paper", "label": "pmid:31758680"}, {"id": "source:pmid:31758680", "type": "manuscript", "label": "PMID 31758680 full text"}, {"id": "data:geo:GSE102484", "type": "dataset", "label": "GEO GSE102484"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-31758680", "type": "extraction", "used": ["source:pmid:31758680"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE102484", "type": "accession_resolution", "used": ["data:geo:GSE102484"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:31758680", "parent_hash": "sha256:58dc99f9a9951d0031e494daf1b7db2dc81124973500cf9909bcffc8e5440e58", "fork_of": null, "generation": 5}, "gaps": ["asset:data:geo:GSE102484 licence not read", "asset:data:geo:GSE102484 not downloaded", "asset:data:geo:GSE20685 licence not read", "asset:data:geo:GSE20685 not downloaded", "asset:data:geo:GSE29044 licence not read", "asset:data:geo:GSE29044 not downloaded", "execution.not_run", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["logrank_test"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["To assess the relationship between hub genes and breast cancer patients, the Kaplan-Meier survival analysis and log-rank test using the “survival” package of R software were conducted."], "order_basis": "analysis_only", "id": "assay:1"}]},"meta":{"api_version":"v1","automation_ladder_snapshot":"ba34b49490d9bfaf","automation_ladder_caveats":["Method extraction is rule-based and has no hand-judged accuracy sample. Evidence bands order textual support; method agreement intervals are null (n=0), never probabilities. Work-type validation does not validate methods.","Operation coverage describes only explicitly named methods. It does not prove a complete protocol, compatible parameters, successful compilation or re-execution. Unrecognised or ambiguous methods require review.","Data reachability is a textual accession or public-data statement. No dataset was downloaded or checked for access, completeness or licence.","Capabilities are planning states seeded from the dated equipment register. No bench ownership, completed quote or partner booking is inferred. Procurement counts are dependencies, not guaranteed replications or financial returns.","Tier and blocker counts are deterministic assessments of this corpus, not measured agreement. R3 is reserved for procurement; unresolved methods and data require human work (R4). The most restrictive axis wins, with capability, method, data as tie-breaks. Resolving one blocker can leave another at the same tier."],"engine":"corpus_engine","engine_provider":"rule_based_v1+lex99e1195c7d6f","run_id":"run-20261023T122449232913","source":"esearch","source_detail":"PubMed mirror biomed_pubmed (read-only)","run_status":"complete","imported_at":"2026-11-03T20:16:52+00:00","generated_at":"2026-11-04T03:39:59+00:00","total_papers":5529,"total_assays_tracked":29,"automatable_assay_families":6,"validated":true,"caveat_count":9,"blocking_caveats":5,"caveats":[{"code":"low_evidence_dominates","basis":["4,152 of 5,529 classifications (75.1%) matched no cue evidence and sit at the 0.05 floor.","34 of 230 data_only calls (14.8%) are in that group."],"claim":"Work type and confidence bands","gloss":"Most records were classified from their title and framing alone, with assay-cue coverage at zero.","detail":"Most classifications in this run rest on no matched evidence at all. At the evidence floor the work type comes from title framing and a fixed prior, not from anything in the paper, so the published work-type split should be read as a rough triage signal rather than a measured distribution. The impact is bounded but not removed: since 2026-10-23 the engine excludes floor-confidence records from the shortlist entirely and publishes them separately as held out, so the recommendation is unaffected even though the census is.","status":"unverified","severity":"high"},{"code":"runtime_is_modelled","basis":["Runtime is summed from published per-assay hour figures. Timing awaits the first executed replication.","4,407 of 5,529 records (79.7%) model to 0.00 hours because no assay was matched, which the ranking then reads as \"cheapest\".","0 of 10 shortlisted records carry a 0.00-hour estimate."],"claim":"Estimated replication runtime","gloss":"The hour figures are estimates built from assay mentions; timing awaits the first executed replication.","detail":"The hour figures are a cost model derived from the bench steps implied by each matched assay family. The first executed replication will supply measured timing. Records without an assay match currently receive a zero-hour model value.","status":"unverified","severity":"high"},{"code":"signal_score_without_citations","basis":["5,529 of 5,529 records (100.0%) have no citation count from the source metadata."],"claim":"Signal score","gloss":"The signal score uses publication-type weight because the mirror supplied zero citation counts.","detail":"The source supplied no citation counts for any record in this run, so the signal score is publication-type weight only. The citation term of the ranking is inert here, and the shortlist is ordered by publication type alone.","status":"unverified","severity":"high"},{"code":"abstract_absent","basis":["1,667 of 5,529 records (30.2%) carry no abstract at all."],"claim":"Evidence base for classification","gloss":"Some records contain a title and publication type only, defining the available classification evidence.","detail":"Where the mirror contains a title and publication types only, those fields define the classifier evidence. A methods section is required for fuller automated and human review.","status":"unverified","severity":"medium"},{"code":"classifier_agreement_measured","basis":["Published two-way decision agreement 77.7% (310 of 399 decidable records) from a stratified hand-check of 438 real records.","Three-way diagnostic agreement 73.9% (288 of 390 decidable records).","data_only agreement 75.2% (100 of 133 decidable).","48 record(s) could not be decided from title and abstract and were excluded from the denominator.","56 analysis-only records were published under another work type, so the data_only share is not an upper bound."],"claim":"Published automatable decision","gloss":"This figure has been checked against a human reading the same papers, so we know how often it is right.","detail":"The published automatable / not-automatable distribution comes from a rule-based classifier that was hand-checked against a fixed ground-truth definition. The agreement rates below are measured, not estimated. The three-way work type remains a diagnostic and is reported separately.","status":"measured","severity":"high"},{"code":"llm_comparison_not_measured","basis":["rule_based_v1+lex99e1195c7d6f produced 5,529 of 5,529 classifications.","Measured on 438 labelled records; these are RULE-BASED figures, not model results."],"claim":"Rule-based versus LLM agreement","gloss":"Every number here is the rule engine’s own. Model comparison begins when a working API credential is connected and measured.","detail":"The published two-way decision agreed with a human reading on 310 of 399 decidable records (77.7%). The diagnostic three-way label agreed on 288 of 390 decidable records (73.9%). Every percentage in this run belongs to the rule engine. Model comparison begins when a working API credential is connected and measured.","status":"not_measured","severity":"high"},{"code":"confidence_is_a_band","basis":["low band: 135 of 210 hand-judged records were correct, 64.3% [57.6, 70.5] (95% CI).","medium band: 80 of 104 hand-judged records were correct, 76.9% [68.0, 84.0] (95% CI).","high band: 73 of 76 hand-judged records were correct, 96.0% [89.0, 98.7] (95% CI).","A fitted calibrated probability was built, measured and withdrawn: it overstated held-out accuracy and reorders nothing."],"claim":"Confidence band and evidence score","gloss":"The confidence band carries a measured accuracy interval; 0.85 represents relative rank strength.","detail":"Confidence on this run is a BAND plus its measured accuracy interval. The number stored alongside each record is a monotone evidence score that orders records; 0.85 represents relative rank strength. A fitted probability was withdrawn after it overstated held-out accuracy. Threshold on the band.","status":"measured","severity":"medium"},{"code":"three_way_split_is_diagnostic","basis":["The corpus is published at the two-way decision: automatable or not-automatable. The three-way split (data_only / physical / mixed) is published as a diagnostic with its measured reliability attached, not as a claim, because the rule engine's `mixed` call cannot be defended.","The engine called 22 record(s) mixed; 10 matched the human judgement (45.5%, 95% CI 26.9-65.3).","The engine's `mixed` call is right on 10/22 hand-judged records (45.5%, 95% CI 26.9%-65.3%); a constant `physical` guess scores 36.4%.","The engine's `mixed` call does not reliably beat a constant `physical` guess on the hand-judged records it labels mixed.","The sign of that difference flips between two independent samples, so the three-way refinement is not demonstrably informative.","The mixed stratum contributes a disproportionate share of errors relative to its size.","At title-only depth the physical/mixed split collapses: a title says that work was done, not whether it was also analysed."],"claim":"The published decision is two-way","gloss":"The three-way split is shown for diagnosis only. The published split is two ways.","detail":"Count and filter the corpus on automatable versus not-automatable. The data_only / physical / mixed split remains an internal engine diagnostic because the mixed call has lower measured reliability.","status":"measured","severity":"medium"},{"code":"automatable_flag_unproven","basis":["6 of 29 assay families are marked automatable now: meta_analysis, machine_learning, survival_analysis, pca, molecular_docking, differential_expression.","The flag is a rule over assay family and work type; validation begins with the first executed replication.","It inherits the 75.2% data_only agreement rate, because the flag requires the record to be analysis-only."],"claim":"Automatable now","gloss":"This flag marks assay families the rules classify as data-only. The first executed replication will validate it.","detail":"This flag marks families the rules consider replicable from data alone. Its validity depends on the analysis-only classification and will be measured through an executed replication.","status":"unverified","severity":"medium"}],"confidence_policy":"band_with_measured_interval","confidence_contract":{"policy":"band_with_measured_interval","summary":"Confidence is reported as a BAND with a measured accuracy interval. The raw evidence score supplies monotone ordering. A fitted point estimate was withdrawn after it overstated held-out accuracy.","evidence_score":"A monotone evidence score in [0,1] built from cue mass, axis separation and text coverage. Use it to order records. Interpret 0.85 as relative rank strength.","confidence_band":"low | medium | high. Consumers threshold on this value.","band_accuracy":"Wilson 95% interval on the measured agreement of the hand-judged records in this band.","calibrated_confidence":"WITHDRAWN. Reintroduction requires held-out evidence demonstrating reliable estimates across every bin."},"band_accuracy":{"low":{"n":210,"low":0.576,"band":"low","high":0.7046,"agree":135,"accuracy":0.6429},"high":{"n":76,"low":0.8903,"band":"high","high":0.9865,"agree":73,"accuracy":0.9605},"medium":{"n":104,"low":0.6795,"band":"medium","high":0.8397,"agree":80,"accuracy":0.7692}},"provider":"rule_based_v1+lex99e1195c7d6f","lexicon_id":"99e1195c7d6f","contract_published_at":"2026-10-23T12:25:29.022232+00:00","confidence_is_band":true,"confidence_is_probability":false,"decision_taxonomy":"two_way","decidable_fraction_two_way":0.8854,"decidable_fraction_two_way_low":0.8565,"decidable_fraction_two_way_high":0.9143,"decidable_fraction_three_way":0.8586,"decidable_fraction_three_way_low":0.8287,"decidable_fraction_three_way_high":0.8884,"decidable_population":5529,"validation_sample_size":438,"three_way_cost_fraction":0.0268,"three_way_cost_records":148,"decision_counts":{"automatable":230,"not_automatable":5299},"decision_split":{"automatable":{"count":230,"share":0.04159884246699222},"not_automatable":{"count":5299,"share":0.9584011575330078}},"diagnostic_work_type_counts":{"mixed":24,"physical":5275,"data_only":230}}}