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pmid:23688397

PLANEX: the plant co-expression database.

Won Cheol Yim · Yongbin Yu · Kitae Song · Cheol Seong Jang · Byung-Moo Lee

BMC plant biology · 2013 doi:10.1186/1471-2229-13-83

Paper

complete

Experiment

partial

Data

partial

Analysis

partial

Execution

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title
PLANEX: the plant co-expression database.
doi
10.1186/1471-2229-13-83
pmid
23688397
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[0]
Won Cheol Yim
[1]
Yongbin Yu
[2]
Kitae Song
[3]
Cheol Seong Jang
[4]
Byung-Moo Lee
journal
BMC plant biology
year
2013
abstract
BACKGROUND: The PLAnt co-EXpression database (PLANEX) is a new internet-based database for plant gene analysis. PLANEX (http://planex.plantbioinformatics.org) contains publicly available GeneChip data obtained from the Gene Expression Omnibus (GEO) of the National Center for Biotechnology Information (NCBI). PLANEX is a genome-wide co-expression database, which allows for the functional identification of genes from a wide variety of experimental designs. It can be used for the characterization of genes for functional identification and analysis of a gene's dependency among other genes. Gene co-expression databases have been developed for other species, but gene co-expression information for plants is currently limited. DESCRIPTION: We constructed PLANEX as a list of co-expressed genes and functional annotations for Arabidopsis thaliana, Glycine max, Hordeum vulgare, Oryza sativa, Solanum lycopersicum, Triticum aestivum, Vitis vinifera and Zea mays. PLANEX reports Pearson's correlation coefficients (PCCs; r-values) that distribute from a gene of interest for a given microarray platform set corresponding to a particular organism. To support PCCs, PLANEX performs an enrichment test of Gene Ontology terms and Cohen's Kappa value to compare functional similarity for all genes in the co-expression database. PLANEX draws a cluster network with co-expressed genes, which is estimated using the k-mean method. To construct PLANEX, a variety of datasets were interpreted by the IBM supercomputer Advanced Interactive eXecutive (AIX) in a supercomputing center. CONCLUSION: PLANEX provides a correlation database, a cluster network and an interpretation of enrichment test results for eight plant species. A typical co-expressed gene generates lists of co-expression data that contain hundreds of genes of interest for enrichment analysis. Also, co-expressed genes can be identified and cataloged in terms of comparative genomics by using the 'Co-expression gene compare' feature. This type of analysis will help interpret experimental data and determine whether there is a common term among genes of interest.
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Cohen’s Kappa statistics were used to compare co-expression data between species [34].
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