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pmid:25126520
Gene expression signatures affected by ethanol and/or nicotine in normal human normal oral keratinocytes (NHOKs).
Jeffrey J Kim · Omar Khalid · Lewei Duan · Reuben Kim · David Elashoff · Yong Kim
Genomics data · 2014 doi:10.1016/j.gdata.2014.06.021
Paper
complete
Experiment
complete
Data
partial
Analysis
partial
Execution
absent
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Complete file
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The aim of this study is to determine the molecular mechanisms of nicotine/alcohol-induced epigenetic alterations and their mechanistic roles in transcriptional regulation in human adult stem cells. We hypothesized that nicotine/alcohol induces deregulation of epigenetic machinery and leads to epigenetic alterations, which subsequently affect transcriptional regulation in oral epithelial stem cells. As an initiating step we have profiled transcriptomic alterations induced by combinatory administration of EtOH and nicotine in primary normal human oral keratinocytes. Here we provide detailed experimental methods, analysis and information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE57634. 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Columns three to ten are user defined depending on the user's specific hypothesis. 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