Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis

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The statistical significance of pooled ORs was assessed by the Z-test. Heterogeneity was assessed by the I 2 statistic, which was documented for the percentage of the observed between-study variability due to heterogeneity rather than chance with the ranges of 0 to 100% [I 2 = 0–25%, no heterogeneity; I 2 = 25–50%, moderate heterogeneity; I 2 = 50–75%, large heterogeneity; I 2 = 75–100%, extreme heterogeneity] [12]. When the Q test was significant (P<0.05) or I 2>50%, indicating the presence of heterogeneity, a random-effects model (the DerSimonian & Laird method) was used [13]; otherwise, the fixed-effects model (the Mantel-Haenszel method) was used [14]. Sensitivity analysis was performed by excluding the studies that the genotype distribution in controls was not in HWE or which did not provide the three genotypes in controls to evaluate the stability of the results. 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