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pmid:26484249

Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia.

Li Sun · Zaohuo Cheng · Fuquan Zhang · Yong Xu

Genomics data · 2015 doi:10.1016/j.gdata.2015.04.022

Paper

complete

Experiment

complete

Data

partial

Analysis

partial

Execution

absent

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Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia.
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10.1016/j.gdata.2015.04.022
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Li Sun
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Zaohuo Cheng
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Fuquan Zhang
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Yong Xu
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Genomics data
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2015
abstract
Schizophrenia (SZ) is a severe chronic psychiatric disorder with wide prevalence and high morbidity. We know little about SZ's etiology and pathophysiology at present. The study of gene expression profile is useful for us to identify potential biomarkers at molecular level and explain possible pathogenesis of SZ. Therefore we recently compared gene expression profiles in PMBCs from EOS cases and healthy controls using microarrays. Here we will describe in detail the contents and quality control of the microarray experiment. The raw microarray data are accessible through GEO series accession number GSE54913.
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Identification of differentially expressed genes between SZ cases and controls was made using R package genefilter [6].We identified 84 differentially expressed genes through fold change and P value filtering (FC ≥ 2 and Padjusted < 0.05) listed in Table 1.
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Identification of differentially expressed genes between SZ cases and controls was made using R package genefilter [6].We identified 84 differentially expressed genes through fold change and P value filtering (FC ≥ 2 and Padjusted < 0.05) listed in Table 1.
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mRNA expression in blood of 18 schizophrenia patients and 12 healthy controls
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Identification of differentially expressed genes between SZ cases and controls was made using R package genefilter [6].We identified 84 differentially expressed genes through fold change and P value filtering (FC ≥ 2 and Padjusted < 0.05) listed in Table 1.
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