Microarray expression profile of circular RNAs in human pancreatic ductal adenocarcinoma.

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Circular RNAs (circRNAs) are an abundant, stable and conserved class of RNA molecules that exhibit tissue/developmental-stage-specific expression (Salzman et al., 2012; Jeck et al., 2013; Memczak et al., 2013). CircRNAs play a crucial role in disease, especially in cancer, and provide new potential diagnostic and therapeutic targets for disease (Hansen et al., 2013; Qu et al., 2015).This research was designed to explore the expression profile of circRNAs in PDAC to serve as new diagnosis and treatment strategies for PDAC. Microarray and sample annotation data were deposited in Gene Expression Omnibus (GEO) under accession number GSE69362.", "claims": [{"id": "claim-method", "statement": "CircRNAs differentially expressed between the two groups were conveniently estimated by fold-change filtering and Student's t-test.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:26484292", "locator": "sections[7] \"Microarray and quality control\" paragraph 2", "quote": "CircRNAs differentially expressed between the two groups were conveniently estimated by fold-change filtering and Student's t-test."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Microarray and sample annotation data were deposited in Gene Expression Omnibus (GEO) under accession number GSE69362.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:26484292", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Microarray and sample annotation data were deposited in Gene Expression Omnibus (GEO) under accession number GSE69362."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The circRNA expression signatures of PDAC were dysregulated; differentially expressed circRNAs were identified by fold-change filtering and Student's t-test, selecting circRNAs with fold changes ≥ 2.0 and p-values ≤ 0.05. 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