A 10-gene expression signature of Notch pathway predicts recurrence in ovarian carcinoma.

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A 10-gene signature (FZD4, HES1, PSEN2, JAG2, PPARG, FOS, HEY1, CDC16, MFNG, and EP300) was identified and validated that is associated with recurrence-free survival time, but not with overall survival time, in the TCGA dataset and in other two independent datasets, GSE9891 and GSE30161. This gene signature gave a significant performance in discriminating patients at high risk of recurrence from those at low risk, as measured by the area under the receiver operating characteristic curve. Cox proportional hazards regression analyses demonstrated that the prognostic value of this 10-gene set is independent of other clinical variables in all three datasets. The potential as a biomarker for predicting high- and low-risk subgroups for recurrence in ovarian cancer patients deserves further investigation in prospective patient cohorts in the future.", "claims": [{"id": "claim-method", "statement": "Cox proportional hazards regression analyses demonstrated that the prognostic value of this 10-gene set is independent of other clinical variables in all three datasets.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:26622736", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Cox proportional hazards regression analyses demonstrated that the prognostic value of this 10-gene set is independent of other clinical variables in all three datasets."}], "state": "complete"}, {"id": "claim-data-access", "statement": "In the present study, 81 Notch pathway genes were selected to find recurrence-related genes in The Cancer Genome Atlas dataset.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:26622736", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "In the present study, 81 Notch pathway genes were selected to find recurrence-related genes in The Cancer Genome Atlas dataset."}], "state": "complete"}, {"id": "claim-target-result", "statement": "A 10-gene signature was identified and validated as associated with recurrence-free survival time in the TCGA dataset and in two independent datasets, GSE9891 and GSE30161.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:26622736", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "A 10-gene signature (FZD4, HES1, PSEN2, JAG2, PPARG, FOS, HEY1, CDC16, MFNG, and EP300) was identified and validated that is associated with recurrence-free survival time, but not with overall survival time, in the TCGA dataset and in other two independent datasets, GSE9891 and GSE30161."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "A 10-gene signature was identified and validated as associated with recurrence-free survival time in the TCGA dataset and in two independent datasets, GSE9891 and GSE30161.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:26622736"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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