Time-course investigation of the gene expression profile during Fasciola hepatica infection: A microarray-based study.

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Despite there are several studies describing the immune response induced by Fasciola hepatica in the mammalian host, investigations aimed at identifying the expression profile of genes involved in inducing hepatic injury are currently scarce. Data presented here belong to a time-course investigation of the gene expression profile in the liver of BALB/c mice infected with F. hepatica metacercariae at 7 and 21 days after experimental infection. The data published here have been deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GSE69588, previously published by Rojas-Caraballo et al. 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Group 1 remains untreated and served as control; group 2 was orally infected with Fasciola hepatica metacercariae on day 0 and humanely euthanized and necropsied at 7 days post-infection; group 3 was infected as above and humanely euthanized and necropsied at 21 days post-infection. In necropsy, liver of each mouse was removed and the RNA isolated. 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