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pmid:26701646

Dog Tear Film Proteome In-Depth Analysis.

Mateusz Winiarczyk · Dagmara Winiarczyk · Tomasz Banach · Lukasz Adaszek · Jacek Madany · Jerzy Mackiewicz · Dorota Pietras-Ozga · Stanislaw Winiarczyk

PloS one · 2015 doi:10.1371/journal.pone.0144242

Paper

complete

Experiment

complete

Data

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Analysis

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Execution

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Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
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created_at
2026-11-01T15:40:15Z
updated_at
2026-11-01T18:47:55Z
generator object · 2 fields
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paper object · 10 fields
state
complete
title
Dog Tear Film Proteome In-Depth Analysis.
doi
10.1371/journal.pone.0144242
pmid
26701646
authors array · 8 items
[0]
Mateusz Winiarczyk
[1]
Dagmara Winiarczyk
[2]
Tomasz Banach
[3]
Lukasz Adaszek
[4]
Jacek Madany
[5]
Jerzy Mackiewicz
[6]
Dorota Pietras-Ozga
[7]
Stanislaw Winiarczyk
journal
PloS one
year
2015
abstract
In this study, mass spectrometry was used to explore the canine tear proteome. Tear samples were obtained from six healthy dogs, and one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis (1D SDS-PAGE) was used as a first step to separate intact proteins into 17 bands. Each fraction was then trypsin digested and analysed by matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF-MS/MS) to characterize the protein components in each fraction. In total, 125 tear proteins were identified, with MCA (Major Canine Allergen), Serum albumin, UPF0557 protein C10orf119 homolog, Collagen alpha-2(I) chain, Tyrosine -protein kinase Fer, Keratine type II cytoskeletal, Beta-crystallin B2, Interleukin-6 and Desmin occurring as the most confident ones with the highest scores. The results showed that the proteomic strategy used in this study was successful in the analysis of the dog tear proteome. To the best of our knowledge, this study is the first to report the comprehensive proteome profile of tears from healthy dogs by 1D SDS PAGE and MALDI-TOF. Data are available via ProteomeXchange with identifier PXD003124.
claims array · 2 items
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claim-data-access
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All relevant data are within the paper, and the mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003124.
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sections[7] "Data Availability" paragraph 2
quote
All relevant data are within the paper, and the mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003124.
state
complete
[1] object · 6 fields
id
claim-target-result
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Using 1D SDS-PAGE followed by MALDI-TOF-MS/MS, the study identified 125 tear proteins in healthy dogs; the mass-spectrometry proteomics data were deposited in ProteomeXchange under identifier PXD003124.
kind
qualitative
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null
evidence array · 4 items
[0] object · 3 fields
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source:pmid:26701646
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sections[0] "Abstract" paragraph 1
quote
In total, 125 tear proteins were identified, with MCA (Major Canine Allergen), Serum albumin, UPF0557 protein C10orf119 homolog, Collagen alpha-2(I) chain, Tyrosine -protein kinase Fer, Keratine type II cytoskeletal, Beta-crystallin B2, Interleukin-6 and Desmin occuring as the most confident ones with the highest scores.
[1] object · 3 fields
asset
source:pmid:26701646
locator
sections[0] "Abstract" paragraph 1
quote
Data are available via ProteomeXchange with identifier PXD003124.
[2] object · 3 fields
asset
source:pmid:26701646
locator
sections[5] "Results and Discussion" paragraph 3
quote
From the 17 bands, a total of 125 distinct/unique proteins were identified (Tables 1 and 2).
[3] object · 3 fields
asset
source:pmid:26701646
locator
sections[5] "Results and Discussion" paragraph 13
quote
The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium [26] via the PRIDE partner repository [27] with the dataset identifier PXD003124.
state
complete
gaps array · 0 items
experiment object · 8 fields
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complete
objective
Using 1D SDS-PAGE followed by MALDI-TOF-MS/MS, the study identified 125 tear proteins in healthy dogs; the mass-spectrometry proteomics data were deposited in ProteomeXchange under identifier PXD003124.
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Read the published estimate from the source
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The claim, method and evidence span published with the source article.
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the published estimate and its evidence
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Obtain the source data from the named repository
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The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.
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the source data with its repository provenance
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Apply the paper's statistical method to the resolved series and compare the result with the published target.
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https://doi.org/10.1371/journal.pone.0144242
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PMC4689550
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europe_pmc_fulltext
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data:geo:PXD003124
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All relevant data are within the paper, and the mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003124.
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GEO accession URL
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All relevant data are within the paper, and the mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003124.
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title
Dog tear film proteome in-depth analysis
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[2] object · 16 fields
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Summary of protein identification.
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PMC4689550
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5
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Results and Discussion
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126
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8
table object · 8 fields
label
Table 1
caption
Summary of protein identification.
rows array · 126 items
[0] array · 8 items
[0]
No.
[1]
Protein
[2]
Accession no.
[3]
Score
[4]
Matches
[5]
Gene name
[6]
Molecular function
[7]
Biological process
[1] array · 8 items
[0]
1
[1]
Tuftelin-interacting protein 11
[2]
Q29RR5
[3]
35
[4]
12
[5]
TFIP11
[6]
DNA binding
[7]
mRNA processing
[2] array · 8 items
[0]
2
[1]
Selenocysteine insertion sequence-binding protein 2-like
[2]
Q93073
[3]
34
[4]
4
[5]
SECISBP2L
[6]
RNA binding
[7]
unclassified
[3] array · 8 items
[0]
3
[1]
Visual system homeobox 2
[2]
P58304
[3]
51
[4]
6
[5]
VSX2
[6]
DNA binding
[7]
transcription
[4] array · 8 items
[0]
4
[1]
Tensin-1
[2]
Q9HBL0
[3]
61
[4]
11
[5]
TNS1
[6]
RNA binding
[7]
unclassified
[5] array · 8 items
[0]
5
[1]
Zinc finger protein 780A
[2]
O75290
[3]
34
[4]
4
[5]
ZNF780A
[6]
DNA binding
[7]
transcription
[6] array · 8 items
[0]
6
[1]
Putative homeodomain transcription factor 1
[2]
Q9UMS5
[3]
32
[4]
5
[5]
PHTF1
[6]
DNA binding
[7]
transcription
[7] array · 8 items
[0]
7
[1]
Transcription factor TFIIIB component B'' homologue
[2]
A6H8Y1
[3]
40
[4]
14
[5]
BDP1
[6]
DNA binding
[7]
transcription
[8] array · 8 items
[0]
8
[1]
Hepatoma-derived growth factor
[2]
Q8VHK7
[3]
37
[4]
5
[5]
Hdgf
[6]
DNA binding
[7]
transcription
[9] array · 8 items
[0]
9
[1]
Metastasis-associated protein MTA3
[2]
Q924K8
[3]
32
[4]
9
[5]
Mta3
[6]
DNA binding
[7]
cell cycle
[10] array · 8 items
[0]
10
[1]
Nuclear protein 14
[2]
Q8R3N1
[3]
33
[4]
13
[5]
Nop14
[6]
RNA binding
[7]
rRNA processing
[11] array · 8 items
[0]
11
[1]
Zinc finger protein 582
[2]
Q96NG8
[3]
34
[4]
9
[5]
ZNF582
[6]
DNA binding
[7]
transcription
[12] array · 8 items
[0]
12
[1]
Zinc finger protein 2
[2]
P08043
[3]
61
[4]
6
[5]
Zfp2
[6]
DNA binding
[7]
transcription
[13] array · 8 items
[0]
13
[1]
Eukaryotic translation initiation factor 3 subunit H
[2]
Q91WK2
[3]
54
[4]
7
[5]
Eif3h
[6]
RNA binding
[7]
protein biosynthesis
[14] array · 8 items
[0]
14
[1]
78 kDa glucose-regulated protein//Heat shock 70 kDa protein 5
[2]
Q0VCX2
[3]
62
[4]
10
[5]
HSPA5
[6]
nucleotide binding
[7]
unclassified
[15] array · 8 items
[0]
15
[1]
Splicing factor, proline- and glutamine-rich
[2]
P23246
[3]
37
[4]
4
[5]
SFPQ
[6]
nucleotide binding
[7]
unclassified
[16] array · 8 items
[0]
16
[1]
Putative fidgetin-like protein 2
[2]
A6NMB9
[3]
41
[4]
4
[5]
FIGNL2
[6]
nucleotide binding
[7]
unclassified
[17] array · 8 items
[0]
17
[1]
UPF0557 protein C10orf119 homolog
[2]
A5PJM5
[3]
51
[4]
10
[5]
MCMBP
[6]
chromatin binding
[7]
cell cycle
[18] array · 8 items
[0]
18
[1]
Guanine nucleotide-binding protein G(t) subunit alpha-2
[2]
P38400
[3]
30
[4]
5
[5]
GNAI2
[6]
transducer
[7]
cell cycle
[19] array · 8 items
[0]
19
[1]
Protein Spindly
[2]
Q08DR9
[3]
54
[4]
13
[5]
SPDL1
[6]
kinetochore binding
[7]
cell cycle
[20] array · 8 items
[0]
20
[1]
Cell division cycle protein 27 homolog
[2]
P30260
[3]
41
[4]
7
[5]
CDC27
[6]
phosphatase binding
[7]
cell cycle
[21] array · 8 items
[0]
21
[1]
Kinesin-like protein KIF11
[2]
P52732
[3]
55
[4]
9
[5]
KIF11
[6]
motor protein
[7]
cell cycle
[22] array · 8 items
[0]
22
[1]
Parafibromin
[2]
Q6P1J9
[3]
44
[4]
5
[5]
CDC73
[6]
RNA polymerase binding
[7]
cell cycle
[23] array · 8 items
[0]
23
[1]
G2/mitotic-specific cyclin-B3
[2]
Q659K0
[3]
19
[4]
5
[5]
CCNB3
[6]
cycline
[7]
cell cycle
[24] array · 8 items
[0]
24
[1]
Transcription factor 4
[2]
P15881
[3]
28
[4]
4
[5]
TCF4
[6]
activator
[7]
transcription
[25] array · 8 items
[0]
25
[1]
Cysteinyl-tRNA synthetase, cytoplasmic//Cysteine—tRNA ligase, cytoplasmic
[2]
Q9ER72
[3]
38 MS/MS
[4]
10
[5]
Cars
[6]
ligase
[7]
protein biosynthesis
[26] array · 8 items
[0]
26
[1]
Pinin
[2]
P79149
[3]
30
[4]
4
[5]
PNN
[6]
activator
[7]
transcription
[27] array · 8 items
[0]
27
[1]
C-C motif chemokine 25
[2]
Q68A93
[3]
47
[4]
4
[5]
CCL25
[6]
cytokine
[7]
inflammatory response
[28] array · 8 items
[0]
28
[1]
Interleukin-18
[2]
Q9XSR0
[3]
27
[4]
3
[5]
IL18
[6]
cytokine
[7]
immune response
[29] array · 8 items
[0]
29
[1]
Interleukin-12 subunit alpha
[2]
Q28267
[3]
41
[4]
4
[5]
IL12A
[6]
cytokine
[7]
immune response
[30] array · 8 items
[0]
30
[1]
Interleukin-1 family member 8//Interleukin-36 beta
[2]
Q9NZH7
[3]
46
[4]
4
[5]
IL36B
[6]
cytokine
[7]
immune response
[31] array · 8 items
[0]
31
[1]
Interleukin-6
[2]
P79341
[3]
79
[4]
7
[5]
IL6
[6]
cytokine
[7]
immune response
[32] array · 8 items
[0]
32
[1]
Ig heavy chain V-II region COR
[2]
P01815
[3]
37
[4]
3
[5]
N/A
[6]
antigen binding
[7]
immune response
[33] array · 8 items
[0]
33
[1]
Scavenger receptor cysteine-rich type 1 protein M130
[2]
Q2VLG6
[3]
23
[4]
5
[5]
CD163
[6]
scavenger receptor
[7]
inflammatory response
[34] array · 8 items
[0]
34
[1]
Ig heavy chain V region GOM
[2]
P01784
[3]
23 MS/MS
[4]
1
[5]
N/A
[6]
antigen binding
[7]
unclassified
[35] array · 8 items
[0]
35
[1]
Zinc finger BED domain-containing protein 5
[2]
A4Z944
[3]
33
[4]
6
[5]
ZBED5
[6]
DNA and metal ion binding
[7]
unclassified
[36] array · 8 items
[0]
36
[1]
Desmoglein-1
[2]
Q9GKQ8
[3]
31
[4]
5
[5]
DSG1
[6]
ion binding
[7]
cell adhesion
[37] array · 8 items
[0]
37
[1]
Calcium uptake protein 1, mitochondrial
[2]
Q8VCX5
[3]
48
[4]
7
[5]
Micu1
[6]
ion binding
[7]
calcium transport
[38] array · 8 items
[0]
38
[1]
Cysteine and glycine-rich protein 2
[2]
Q32LE9
[3]
49
[4]
5
[5]
CSRP2
[6]
ion binding
[7]
differentiation
[39] array · 8 items
[0]
39
[1]
Alpha-fetoprotein
[2]
Q8MJU5
[3]
25
[4]
3
[5]
AFP
[6]
ion binding
[7]
transport
[40] array · 8 items
[0]
40
[1]
Ankyrin repeat domain-containing protein 5//Ankyrin repeat and EF-hand domain-containing protein 1
[2]
Q9NU02
[3]
42
[4]
5
[5]
ANKEF1
[6]
ion binding
[7]
unclassified
[41] array · 8 items
[0]
41
[1]
Zinc finger UFM1-specific peptidase domain protein
[2]
Q3T9Z9
[3]
50
[4]
7
[5]
Zufsp
[6]
ion binding
[7]
unclassified
[42] array · 8 items
[0]
42
[1]
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
[2]
P60529
[3]
Protein autopho
[4]
4
[5]
HBA
[6]
oxygen binding
[7]
oxygen transport
[43] array · 8 items
[0]
43
[1]
Haemoglobin subunit gamma
[2]
P02099
[3]
60
[4]
6
[5]
HBG
[6]
oxygen binding
[7]
transport
[44] array · 8 items
[0]
44
[1]
Myosin-Ic
[2]
Q63355
[3]
56
[4]
6
[5]
Myo1c
[6]
motor activity
[7]
transport
[45] array · 8 items
[0]
45
[1]
Drebrin-like protein
[2]
Q9UJU6
[3]
48
[4]
6
[5]
DBNL
[6]
actin binding
[7]
transport
[46] array · 8 items
[0]
46
[1]
Serum albumin
[2]
P49822
[3]
60
[4]
9
[5]
ALB
[6]
transport/carrier protein
[7]
unclassified
[47] array · 8 items
[0]
47
[1]
Major allergen Can f 1
[2]
O18873
[3]
95, 200 MS/MS
[4]
8
[5]
N/A
[6]
transport protein
[7]
unclassified
[48] array · 8 items
[0]
48
[1]
Gastrin/cholecystokinin type B receptor
[2]
F1Q0L4
[3]
40
[4]
3
[5]
CCKBR
[6]
gastrin receptor
[7]
unclassified
[49] array · 8 items
[0]
49
[1]
Growth hormone receptor
[2]
Q9TU69
[3]
25
[4]
4
[5]
GHR
[6]
receptor
[7]
endocytosis
[50] array · 8 items
[0]
50
[1]
Transferrin receptor protein
[2]
Q9GLD3
[3]
36
[4]
8
[5]
TFRC
[6]
receptor
[7]
endocytosis
[51] array · 8 items
[0]
51
[1]
Gastrin-releasing peptide receptor
[2]
P30550
[3]
15 MS/MS
[4]
1
[5]
GRPR
[6]
receptor
[7]
cell proliferation
[52] array · 8 items
[0]
52
[1]
Desmin
[2]
Q5XFN2
[3]
87
[4]
4
[5]
DES
[6]
muscle protein
[7]
cell structure
[53] array · 8 items
[0]
53
[1]
Beta-crystallin B2
[2]
P02522
[3]
76
[4]
6
[5]
CRYBB2
[6]
eye lens protein
[7]
cell structure
[54] array · 8 items
[0]
54
[1]
Keratin, type I microfibrillar 48kDa, component 8C-1
[2]
P02534
[3]
52
[4]
8
[5]
N/A
[6]
structural
[7]
cell structure
[55] array · 8 items
[0]
55
[1]
Collagen alpha-2(I) chain
[2]
O46392
[3]
58
[4]
10
[5]
COL1A2
[6]
matrix protein
[7]
cell structure
[56] array · 8 items
[0]
56
[1]
Adipocytes plasma membrane-associated protein
[2]
Q3T0E5
[3]
55
[4]
5
[5]
APMAP
[6]
structural
[7]
membrane protein
[57] array · 8 items
[0]
57
[1]
DnaJ homologue subfamily member 18
[2]
Q5EA26
[3]
54
[4]
7
[5]
DNAJC18
[6]
structural
[7]
membrane protein
[58] array · 8 items
[0]
58
[1]
Keratin, type II cytoskeletal 8
[2]
Q28810
[3]
37
[4]
4
[5]
KRT8
[6]
structural
[7]
cell structure
[59] array · 8 items
[0]
59
[1]
Keratin, type I cytoskeletal 9
[2]
P35527
[3]
115
[4]
17
[5]
KRT9
[6]
structural
[7]
cell structure
[60] array · 8 items
[0]
60
[1]
Myosin-binding protein C cardiac-type
[2]
O70468
[3]
43
[4]
13
[5]
Mybpc3
[6]
structural
[7]
cell structure
[61] array · 8 items
[0]
61
[1]
Collagen alpha-2(IV) chain
[2]
P08122
[3]
39
[4]
6
[5]
Col4a2
[6]
matrix protein
[7]
angiogenesis
[62] array · 8 items
[0]
62
[1]
Arylsulfatase K
[2]
Q32KH0
[3]
35
[4]
5
[5]
ARSK
[6]
hydrolase
[7]
unclassified
[63] array · 8 items
[0]
63
[1]
Glycogen debranching enzyme
[2]
Q2PQH8
[3]
25
[4]
9
[5]
AGL
[6]
hydrolase
[7]
glycogen biosynthesis
[64] array · 8 items
[0]
64
[1]
Cystic fibrosis transmembrane conductance regulator
[2]
Q5U820
[3]
29
[4]
7
[5]
CFTR
[6]
hydrolase
[7]
ion transport
[65] array · 8 items
[0]
65
[1]
Lysozyme C, spleen isozyme
[2]
P81709
[3]
32
[4]
3
[5]
N/A
[6]
hydrolase
[7]
antimicrobial
[66] array · 8 items
[0]
66
[1]
Coagulation factor IX
[2]
P19540
[3]
33
[4]
5
[5]
F9
[6]
hydrolase
[7]
haemostasis
[67] array · 8 items
[0]
67
[1]
Proteasome subunit beta type-3
[2]
P33672
[3]
54
[4]
6
[5]
PSMB3
[6]
hydrolase
[7]
unclassified
[68] array · 8 items
[0]
68
[1]
Endonuclease 8-like 3
[2]
Q6IE77
[3]
57
[4]
10
[5]
NEIL2
[6]
hydrolase
[7]
DNA repair
[69] array · 8 items
[0]
69
[1]
Gamma-glutamyl hydrolase
[2]
A7YWG4
[3]
30
[4]
6
[5]
GGH
[6]
hydrolase
[7]
unclassified
[70] array · 8 items
[0]
70
[1]
Multidrug resistance-associated protein 1
[2]
Q6UR05
[3]
31
[4]
11
[5]
ABCC1
[6]
hydrolase
[7]
transport
[71] array · 8 items
[0]
71
[1]
Ubiquitin carboxyl-terminal hydrolase 15
[2]
Q9Y4E8
[3]
32
[4]
6
[5]
USP15
[6]
hydrolase
[7]
transcription
[72] array · 8 items
[0]
72
[1]
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
[2]
O60825
[3]
45
[4]
5
[5]
PFKFB12
[6]
hydrolase
[7]
unclassified
[73] array · 8 items
[0]
73
[1]
Probable ATP-dependent RNA helicase DDX58
[2]
Q9GLV6
[3]
43
[4]
10
[5]
DDX58
[6]
hydrolase
[7]
immune response
[74] array · 8 items
[0]
74
[1]
ATP-dependent RNA helicase DDX3X
[2]
O00571
[3]
40
[4]
10
[5]
DDX3X
[6]
hydrolase
[7]
unclassified
[75] array · 8 items
[0]
75
[1]
Endonuclease 8-like 3
[2]
Q3MHN7
[3]
57
[4]
10
[5]
NEIL3
[6]
hydrolase
[7]
DNA repair
[76] array · 8 items
[0]
76
[1]
Werner syndrome ATP-dependent helicase
[2]
Q14191
[3]
68
[4]
17
[5]
WRN
[6]
hydrolase
[7]
DNA repair
[77] array · 8 items
[0]
77
[1]
6-Phosphofructokinase, muscle type
[2]
P52784
[3]
21
[4]
2
[5]
PFKM
[6]
kinase, transferase
[7]
glycolysis
[78] array · 8 items
[0]
78
[1]
Tyrosine-protein kinase Fer
[2]
Q9TTY2
[3]
36
[4]
6
[5]
FER
[6]
kinase, transferase
[7]
unclassified
[79] array · 8 items
[0]
79
[1]
Kalirin
[2]
O60229
[3]
40
[4]
14
[5]
KALRN
[6]
kinase
[7]
unclassified
[80] array · 8 items
[0]
80
[1]
Cell division protein kinase 3//Cyclin-dependent kinase 3
[2]
Q80YP0
[3]
43
[4]
4
[5]
Cdk3
[6]
kinase
[7]
cell cycle
[81] array · 8 items
[0]
81
[1]
Ribosomal protein S6 kinase delta-1
[2]
Q8BLK9
[3]
14 MS/MS
[4]
1
[5]
Rps6kc1
[6]
kinase
[7]
unclassified
[82] array · 8 items
[0]
82
[1]
Dual specificity protein kinase CLK3
[2]
P49761
[3]
23 MS/MS
[4]
5
[5]
CLK3
[6]
kinase
[7]
unclassified
[83] array · 8 items
[0]
83
[1]
Amine oxidase (flavin-containing)
[2]
Q7YRB7
[3]
16
[4]
4
[5]
MAOB
[6]
oxidoreductase
[7]
unclassified
[84] array · 8 items
[0]
84
[1]
Peroxiredoxin-5, mitochondrial
[2]
Q9BGI1
[3]
57
[4]
4
[5]
PRDX5
[6]
oxidoreductase
[7]
unclassified
[85] array · 8 items
[0]
85
[1]
Cytochrome P450 1A2
[2]
P56592
[3]
40
[4]
5
[5]
CYP1A2
[6]
oxidoreductase
[7]
unclassified
[86] array · 8 items
[0]
86
[1]
Lysine-specific demethylase 5C
[2]
Q38JA7
[3]
37
[4]
12
[5]
KDM5C
[6]
oxidoreductase
[7]
transcription
[87] array · 8 items
[0]
87
[1]
Lysine-specific demethylase 2B
[2]
Q8NHM5
[3]
46, 38 MS/MS
[4]
12
[5]
KDM2B
[6]
oxidoreductase
[7]
transcription
[88] array · 8 items
[0]
88
[1]
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
[2]
O00469
[3]
40
[4]
5
[5]
PLOD2
[6]
oxidoreductase
[7]
unclassified
[89] array · 8 items
[0]
89
[1]
Hydroxysteroid dehydrogenase-like protein 2
[2]
Q2TPA8
[3]
42
[4]
7
[5]
Hsdl2
[6]
oxidoreductase
[7]
unclassified
[90] array · 8 items
[0]
90
[1]
Adenine phosphoribosyltransferase
[2]
P08030
[3]
37
[4]
4
[5]
Aprt
[6]
transferase
[7]
purine salvage
[91] array · 8 items
[0]
91
[1]
F-box only protein 4
[2]
Q9UKT5
[3]
58
[4]
7
[5]
FBXO4
[6]
transferase
[7]
cell cycle
[92] array · 8 items
[0]
92
[1]
Fukutin
[2]
O75072
[3]
41
[4]
5
[5]
FKTN
[6]
transferase
[7]
unclassified
[93] array · 8 items
[0]
93
[1]
Chondroitin sulphate synthase 3
[2]
Q70JA7
[3]
36
[4]
5
[5]
CHSY3
[6]
transferase
[7]
unclassified
[94] array · 8 items
[0]
94
[1]
Poly[ADP-ribose] polymerase 12
[2]
Q9H0J9
[3]
33
[4]
7
[5]
PARP12
[6]
transferase
[7]
unclassified
[95] array · 8 items
[0]
95
[1]
Alkyldihydroxyacetonephosphate synthase, peroxisomal
[2]
O00116
[3]
31
[4]
5
[5]
AGPS
[6]
transferase
[7]
lipid metabolism
[96] array · 8 items
[0]
96
[1]
Heparan sulphate glucosamine 3-O-sulfotransferase 6
[2]
Q5GFD5
[3]
55
[4]
6
[5]
Hs3st6
[6]
transferase
[7]
unclassified
[97] array · 8 items
[0]
97
[1]
Rhophilin-2
[2]
Q8HXG3
[3]
22
[4]
3
[5]
RHPN2
[6]
signal transduction
[7]
unclassified
[98] array · 8 items
[0]
98
[1]
F-actin capping protein subunit alpha-2
[2]
Q09YN4
[3]
56
[4]
5
[5]
CAPZA2
[6]
actin capping
[7]
unclassified
[99] array · 8 items
[0]
99
[1]
Adenylate cyclase type 5
[2]
P30803
[3]
32
[4]
7
[5]
ADCY5
[6]
cyclase
[7]
cAMP biosynthesis
[100] array · 8 items
[0]
100
[1]
Calnexin
[2]
P24643
[3]
28
[4]
5
[5]
CANX
[6]
chaperone
[7]
protein folding
[101] array · 8 items
[0]
101
[1]
Rho GTPase-activating protein 7
[2]
B9VTT2
[3]
46
[4]
10
[5]
DLC1
[6]
GTPase
[7]
signal transduction
[102] array · 8 items
[0]
102
[1]
Signal recognition particle 68 kDa protein
[2]
Q00004
[3]
27
[4]
6
[5]
SRP68
[6]
ribonucleoprotein
[7]
unclassified
[103] array · 8 items
[0]
103
[1]
Endothelin-1
[2]
P13206
[3]
34
[4]
5
[5]
EDN1
[6]
vasoactive
[7]
unclassified
[104] array · 8 items
[0]
104
[1]
Signal recognition particle 54kDa protein
[2]
P61010
[3]
26
[4]
7
[5]
SRP54
[6]
ribonucleoprotein
[7]
unclassified
[105] array · 8 items
[0]
105
[1]
Oxygen-regulated protein 1
[2]
Q8MJ04
[3]
27
[4]
13
[5]
RP1
[6]
microtubule binding
[7]
sensory transduction
[106] array · 8 items
[0]
106
[1]
Arf-GAP with SH3 domain ANK repeat and PH domain-containing protein 1
[2]
O97902
[3]
42
[4]
7
[5]
ASAP1
[6]
GTPase activation
[7]
cilium biogenesis/degradation
[107] array · 8 items
[0]
107
[1]
E3 ubiquitin-protein ligase RNF115
[2]
Q9Y4L5
[3]
43
[4]
4
[5]
RNF115
[6]
ligase
[7]
unclassified
[108] array · 8 items
[0]
108
[1]
Collectrin
[2]
Q0VCT4
[3]
34
[4]
4
[5]
TMEM27
[6]
metalopeptidase
[7]
unclassified
[109] array · 8 items
[0]
109
[1]
EGF-like module-containing mucin like hormone receptor-like 2
[2]
Q2Q421
[3]
25
[4]
4
[5]
2EMR2
[6]
unclassified
[7]
inflammatory response
[110] array · 8 items
[0]
110
[1]
Gastrin-releasing peptide
[2]
P47851
[3]
55
[4]
5
[5]
GRP
[6]
unclassified
[7]
neuropeptide signalling
[111] array · 8 items
[0]
111
[1]
Protein SDA1 homolog
[2]
Q9NVU7
[3]
34
[4]
5
[5]
SDAD1
[6]
unclassified
[7]
transport
[112] array · 8 items
[0]
112
[1]
Sorcin
[2]
P30626
[3]
28
[4]
3
[5]
SRI
[6]
unclassified
[7]
unclassified
[113] array · 8 items
[0]
113
[1]
Bcl-2-like protein
[2]
Q9HB09
[3]
31
[4]
4
[5]
BCL2L12
[6]
unclassified
[7]
apoptosis
[114] array · 8 items
[0]
114
[1]
Girdin
[2]
Q3V6T2
[3]
40, 34 MS/MS
[4]
6
[5]
CCDC88A
[6]
unclassified
[7]
DNA replication
[115] array · 8 items
[0]
115
[1]
Leucine-rich repeat-containing protein 16C
[2]
Q6F5E8
[3]
31
[4]
6
[5]
RLTPR
[6]
unclassified
[7]
immune response
[116] array · 8 items
[0]
116
[1]
Coiled-coil domain-containing protein 148
[2]
Q8HZY8
[3]
58
[4]
9
[5]
CCDC148
[6]
unclassified
[7]
unclassified
[117] array · 8 items
[0]
117
[1]
COMM domain-containing protein 6
[2]
Q3V4B5
[3]
34
[4]
4
[5]
Commd6
[6]
unclassified
[7]
unclassified
[118] array · 8 items
[0]
118
[1]
Breast cancer anti-oestrogen resistance protein 3
[2]
Q9QZK2
[3]
40
[4]
5
[5]
Bcar3
[6]
unclassified
[7]
unclassified
[119] array · 8 items
[0]
119
[1]
SH2 domain-containing protein 3C
[2]
Q9QZS8
[3]
48
[4]
12
[5]
Sh2d3c
[6]
unclassified
[7]
unclassified
[120] array · 8 items
[0]
120
[1]
Keratin, type II cytoskeletal 1
[2]
P04264
[3]
112
[4]
15
[5]
KRT1
[6]
unclassified
[7]
unclassified
[121] array · 8 items
[0]
121
[1]
Sestrin-1
[2]
Q4R6P7
[3]
55
[4]
9
[5]
SESN1
[6]
unclassified
[7]
unclassified
[122] array · 8 items
[0]
122
[1]
Myelin transcription factor 1-like protein
[2]
P70475
[3]
45
[4]
6
[5]
Myt1l
[6]
unclassified
[7]
transcription
[123] array · 8 items
[0]
123
[1]
Coiled-coil domain-containing protein 125
[2]
Q5U465
[3]
54
[4]
6
[5]
Ccdc125
[6]
unclassified
[7]
unclassified
[124] array · 8 items
[0]
124
[1]
Phosducin
[2]
O77560
[3]
37
[4]
5
[5]
PDC
[6]
unclassified
[7]
sensory transduction
[125] array · 8 items
[0]
125
[1]
Growth arrest-specific protein 6
[2]
Q14393
[3]
8 MS/MS
[4]
1
[5]
GAS6
[6]
unclassified
[7]
growth regulation
row_count
126
column_count
8
numeric_cells
556
header_rows
1
locator
section[5]/table-wrap[1]#pone.0144242.t001
[3] object · 16 fields
id
asset:table:pmid:26701646:2
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:bd0d59ec3c55e6d79f491c6021a8cf030f1be2c227b9fb4cdad9ed63cc97c5a1
bytes
6865
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[5]/table-wrap[2]#pone.0144242.t002
version
null
note
Proteins found in each band of electrophoretic pattern.
structure object · 5 fields
pmcid
PMC4689550
section_index
5
section_title
Results and Discussion
row_count
138
column_count
4
table object · 8 fields
label
Table 2
caption
Proteins found in each band of electrophoretic pattern.
rows array · 138 items
[0] array · 4 items
[0]
Band
[1]
Protein
[2]
Mass (kDa)
[3]
Score
[1] array · 4 items
[0]
1
[1]
Collectrin
[2]
25
[3]
34
[2] array · 4 items
[0]
[1]
Major alergen Can 1
[2]
19
[3]
90
[3] array · 4 items
[0]
[1]
Sorcin
[2]
22
[3]
28
[4] array · 4 items
[0]
[1]
Bcl-2-like protein
[2]
22
[3]
31
[5] array · 4 items
[0]
[1]
E3 ubiquitin-protein ligase RNF115
[2]
34
[3]
43
[6] array · 4 items
[0]
[1]
Ig heavy chain V-II region COR
[2]
13
[3]
37
[7] array · 4 items
[0]
2
[1]
COMM domain-containing protein 6
[2]
10
[3]
34
[8] array · 4 items
[0]
[1]
Zinc finger UFM1-specific peptidase domain protein
[2]
67
[3]
50
[9] array · 4 items
[0]
[1]
Hepatoma-derived growth factor
[2]
27
[3]
37
[10] array · 4 items
[0]
[1]
Major allergen Can f 1
[2]
19
[3]
95 MS/MS
[11] array · 4 items
[0]
[1]
Phosducin
[2]
29
[3]
37
[12] array · 4 items
[0]
[1]
C-C motif chemokine 25
[2]
17
[3]
47
[13] array · 4 items
[0]
[1]
Cysteine and glycine-rich protein 2
[2]
22
[3]
35
[14] array · 4 items
[0]
[1]
Adenine phosphoribosyltransferase
[2]
20
[3]
37
[15] array · 4 items
[0]
[1]
Signal recognition particle 68 kDa protein
[2]
70
[3]
26
[16] array · 4 items
[0]
[1]
Endothelin-1
[2]
23
[3]
34
[17] array · 4 items
[0]
[1]
Adipocyte plasma membrane-associated protein
[2]
46
[3]
55
[18] array · 4 items
[0]
[1]
DnaJ homolog subfamily C member 18
[2]
42
[3]
54
[19] array · 4 items
[0]
3
[1]
Ankyrin repeat domain-containing protein 5
[2]
87
[3]
42
[20] array · 4 items
[0]
4
[1]
Friend of PRMT1 protein
[2]
27
[3]
10 MS/MS
[21] array · 4 items
[0]
[1]
Heparan sulphate glucosamine 3-O-sulfotransferase 6
[2]
40
[3]
55
[22] array · 4 items
[0]
[1]
Keratin, type II cytoskeletal 8
[2]
35
[3]
37
[23] array · 4 items
[0]
[1]
Cell division protein kinase 3
[2]
34
[3]
43
[24] array · 4 items
[0]
[1]
Visual system homeobox 2
[2]
66
[3]
47
[25] array · 4 items
[0]
[1]
Transcription factor TFIIIB component B'' homolog
[2]
300
[3]
40
[26] array · 4 items
[0]
[1]
6-phosphofructo-2-kinase/fructose-2,6-biphosphatse 2
[2]
59
[3]
42
[27] array · 4 items
[0]
5
[1]
Ankyrin repeat domain-containing protein 5
[2]
87
[3]
42
[28] array · 4 items
[0]
[1]
Zinc finger protein 2
[2]
54
[3]
61
[29] array · 4 items
[0]
6
[1]
UPF0557 protein C10orf119 homolog
[2]
74
[3]
70
[30] array · 4 items
[0]
[1]
Calcium uptake protein 1, mitochondrial
[2]
55
[3]
48
[31] array · 4 items
[0]
7
[1]
Cysteine and glycine-rich protein 2
[2]
22
[3]
49
[32] array · 4 items
[0]
8
[1]
[2]
[3]
[33] array · 4 items
[0]
[1]
Coagulation factor IX
[2]
53
[3]
33
[34] array · 4 items
[0]
[1]
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
[2]
86
[3]
40
[35] array · 4 items
[0]
[1]
Ubiquitin carboxyl-terminal hydrolase 15
[2]
114
[3]
32
[36] array · 4 items
[0]
9
[1]
Dual specificity protein kinase CLK3
[2]
74
[3]
23 MS/MS
[37] array · 4 items
[0]
10
[1]
[2]
[3]
[38] array · 4 items
[0]
[1]
Parafibromin
[2]
61
[3]
44
[39] array · 4 items
[0]
[1]
ATP-dependent RNA helicase DDX3X
[2]
74
[3]
40
[40] array · 4 items
[0]
[1]
Haemoglobin subunit gamma
[2]
16
[3]
60
[41] array · 4 items
[0]
[1]
Myosin-Ic
[2]
120
[3]
56
[42] array · 4 items
[0]
[1]
Zinc finger protein 582
[2]
62
[3]
34
[43] array · 4 items
[0]
[1]
Nuclear protein 14
[2]
100
[3]
33
[44] array · 4 items
[0]
[1]
Hydroxysteroid dehydrogenase-like protein 2
[2]
55
[3]
42
[45] array · 4 items
[0]
[1]
Kinesin-like protein KIF11
[2]
120
[3]
55
[46] array · 4 items
[0]
[1]
Metastasis-associated protein MTA3
[2]
68
[3]
32
[47] array · 4 items
[0]
[1]
6-Phosphofructokinase, muscle type
[2]
86
[3]
21
[48] array · 4 items
[0]
[1]
Tyrosine-protein kinase Fer
[2]
95
[3]
22
[49] array · 4 items
[0]
[1]
Keratin, type I microfibrillar 48kDa, component 8C-1
[2]
48
[3]
52
[50] array · 4 items
[0]
[1]
Gamma-glutamyl hydrolase
[2]
36
[3]
30
[51] array · 4 items
[0]
[1]
Arf-GAP with SH3 domain ANK repeat and PH domain-containing protein 1
[2]
126
[3]
42
[52] array · 4 items
[0]
[1]
Ig heavy chain V region GOM
[2]
13
[3]
23 MS/MS
[53] array · 4 items
[0]
11
[1]
Ribosomal protein S6 kinase delta-1
[2]
117
[3]
14 MS/MS
[54] array · 4 items
[0]
[1]
Sestrin-1
[2]
57
[3]
55
[55] array · 4 items
[0]
[1]
Myelin transcription factor 1-like protein
[2]
135
[3]
45
[56] array · 4 items
[0]
[1]
Serum albumin
[2]
70
[3]
60
[57] array · 4 items
[0]
[1]
Beta-crystallin B2
[2]
23
[3]
76
[58] array · 4 items
[0]
[1]
Tyrosine-protein kinase Fer
[2]
95
[3]
23
[59] array · 4 items
[0]
[1]
Calnexin
[2]
68
[3]
28
[60] array · 4 items
[0]
[1]
Rhophilin-2
[2]
78
[3]
22
[61] array · 4 items
[0]
[1]
Collagen alpha-2(I) chain
[2]
130
[3]
58
[62] array · 4 items
[0]
[1]
Arylsulfatase K
[2]
61
[3]
28
[63] array · 4 items
[0]
[1]
Adenylate cyclase type 5
[2]
142
[3]
24
[64] array · 4 items
[0]
[1]
Peroxiredoxin-5, mitochondrial
[2]
23
[3]
57
[65] array · 4 items
[0]
[1]
Lysozyme C, spleen isozyme
[2]
15
[3]
32
[66] array · 4 items
[0]
[1]
Interleukin-18
[2]
22
[3]
27
[67] array · 4 items
[0]
[1]
Guanine nucleotide-binding protein G(t) subunit alpha-2
[2]
41
[3]
30
[68] array · 4 items
[0]
[1]
Gastrin/cholecystokinin type B receptor
[2]
50
[3]
40
[69] array · 4 items
[0]
12
[1]
Growth hormone receptor
[2]
72
[3]
25
[70] array · 4 items
[0]
[1]
Coiled-coil domain-containing protein 125
[2]
57
[3]
54
[71] array · 4 items
[0]
[1]
Werner syndrome ATP-dependent helicase
[2]
164
[3]
68
[72] array · 4 items
[0]
[1]
Eukaryotic translation initiation factor 3 subunit H
[2]
40
[3]
54
[73] array · 4 items
[0]
[1]
Pinin
[2]
88
[3]
30
[74] array · 4 items
[0]
[1]
G2/mitotic-specific cyclin-B3
[2]
153
[3]
19
[75] array · 4 items
[0]
[1]
Collagen alpha-2(I) chain
[2]
130
[3]
44
[76] array · 4 items
[0]
[1]
Scavenger receptor cysteine-rich type 1 protein M130
[2]
127
[3]
23
[77] array · 4 items
[0]
[1]
Gastrin-releasing peptide
[2]
15
[3]
55
[78] array · 4 items
[0]
[1]
F-actin capping protein subunit alpha-2
[2]
33
[3]
56
[79] array · 4 items
[0]
[1]
Desmoglein-1
[2]
115
[3]
31
[80] array · 4 items
[0]
[1]
Cytochrome P450 1A2
[2]
58
[3]
40
[81] array · 4 items
[0]
[1]
Endonuclease 8-like 3
[2]
62
[3]
57
[82] array · 4 items
[0]
[1]
Interleukin-6
[2]
24
[3]
79
[83] array · 4 items
[0]
13
[1]
Interleukin-1 family member 8
[2]
49
[3]
48
[84] array · 4 items
[0]
[1]
Amine oxidase (flavin-containing) B
[2]
59
[3]
16
[85] array · 4 items
[0]
[1]
Transcription factor 4
[2]
69
[3]
18
[86] array · 4 items
[0]
[1]
Fukutin
[2]
54
[3]
41
[87] array · 4 items
[0]
[1]
Growth arrest-specific protein 6
[2]
82
[3]
8 MS/MS
[88] array · 4 items
[0]
[1]
Interleukin-1 family member 8
[2]
19
[3]
46
[89] array · 4 items
[0]
[1]
Amine oxidase (flavin-containing) B
[2]
59
[3]
16
[90] array · 4 items
[0]
[1]
Selenocysteine insertion sequence-binding protein 2-like
[2]
123
[3]
34
[91] array · 4 items
[0]
[1]
Splicing factor, proline- and glutamine-rich
[2]
76
[3]
37
[92] array · 4 items
[0]
[1]
Putative fidgetin-like protein 2
[2]
67
[3]
40
[93] array · 4 items
[0]
[1]
Protein SDA1 homolog
[2]
80
[3]
34
[94] array · 4 items
[0]
[1]
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
[2]
142
[3]
30
[95] array · 4 items
[0]
[1]
Zinc finger protein 780A
[2]
77
[3]
34
[96] array · 4 items
[0]
14
[1]
Putative homeodomain transcription factor 1
[2]
88
[3]
32
[97] array · 4 items
[0]
[1]
Rho GTPase-activating protein 7
[2]
126
[3]
46
[98] array · 4 items
[0]
[1]
Signal recognition particle 54kDa protein
[2]
56
[3]
26
[99] array · 4 items
[0]
[1]
Alpha-fetoprotein
[2]
70
[3]
25
[100] array · 4 items
[0]
[1]
Interleukin-12 subunit alpha
[2]
25
[3]
41
[101] array · 4 items
[0]
[1]
Lysine-specific demethylase 5C
[2]
177
[3]
37
[102] array · 4 items
[0]
[1]
Pleckstrin
[2]
40
[3]
32
[103] array · 4 items
[0]
[1]
Tuftelin-interacting protein 11
[2]
96
[3]
35
[104] array · 4 items
[0]
[1]
Transferrin receptor protein 1
[2]
87
[3]
36
[105] array · 4 items
[0]
[1]
Protein Spindly
[2]
70
[3]
54
[106] array · 4 items
[0]
[1]
SH2 domain-containing protein 3C
[2]
95
[3]
48
[107] array · 4 items
[0]
[1]
Keratin, type II cytoskeletal 1
[2]
66
[3]
112
[108] array · 4 items
[0]
[1]
Myosin-binding protein C cardiac-type
[2]
142
[3]
43
[109] array · 4 items
[0]
[1]
Gastrin-releasing peptide receptor
[2]
[3]
15 MS/MS
[110] array · 4 items
[0]
15
[1]
Desmin
[2]
53
[3]
87
[111] array · 4 items
[0]
[1]
78 kDa glucose-regulated protein
[2]
73
[3]
62
[112] array · 4 items
[0]
[1]
Desmin
[2]
53
[3]
20
[113] array · 4 items
[0]
[1]
Multidrug resistance-associated protein 1
[2]
173
[3]
31
[114] array · 4 items
[0]
[1]
F-box only protein 4
[2]
46
[3]
58
[115] array · 4 items
[0]
[1]
Lysine-specific demethylase 2B
[2]
155
[3]
46, 38 MS/MS
[116] array · 4 items
[0]
[1]
Kalirin
[2]
343
[3]
40
[117] array · 4 items
[0]
[1]
Girdin
[2]
217
[3]
40, 34 MS/MS
[118] array · 4 items
[0]
[1]
Tensin-1
[2]
187
[3]
61
[119] array · 4 items
[0]
[1]
Chondroitin sulphate synthase 3
[2]
101
[3]
36
[120] array · 4 items
[0]
[1]
Leucine-rich repeat-containing protein 16C
[2]
156
[3]
31
[121] array · 4 items
[0]
[1]
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
[2]
65
[3]
43
[122] array · 4 items
[0]
[1]
Coiled-coil domain-containing protein 148
[2]
73
[3]
58
[123] array · 4 items
[0]
[1]
Probable ATP-dependent RNA helicase DDX58
[2]
109
[3]
43
[124] array · 4 items
[0]
[1]
Cysteinyl-tRNA synthetase, cytoplasmic //Cysteine—tRNA ligase, cytoplasmic
[2]
95
[3]
38 MS/MS
[125] array · 4 items
[0]
[1]
Collagen alpha-2(IV) chain
[2]
108
[3]
39
[126] array · 4 items
[0]
[1]
Breast cancer anti-oestrogen resistance protein 3
[2]
93
[3]
40
[127] array · 4 items
[0]
16
[1]
Oxygen-regulated protein 1
[2]
243
[3]
27
[128] array · 4 items
[0]
[1]
EGF-like module-containing mucin like hormone receptor-like 2
[2]
94
[3]
25
[129] array · 4 items
[0]
[1]
Desmin
[2]
53
[3]
36
[130] array · 4 items
[0]
[1]
Zinc finger BED domain-containing protein 5
[2]
80
[3]
28
[131] array · 4 items
[0]
[1]
Tyrosine-protein kinase Fer
[2]
95
[3]
36
[132] array · 4 items
[0]
[1]
Arylsulfatase K
[2]
61
[3]
35
[133] array · 4 items
[0]
[1]
Transcription factor 4
[2]
69
[3]
28
[134] array · 4 items
[0]
[1]
Adenylate cyclase type 5
[2]
142
[3]
32
[135] array · 4 items
[0]
[1]
Glycogen debranching enzyme
[2]
177
[3]
25
[136] array · 4 items
[0]
[1]
Cystic fibrosis transmembrane conductance regulator
[2]
169
[3]
29
[137] array · 4 items
[0]
17
[1]
Proteasome subunit beta type-3
[2]
23
[3]
54
row_count
138
column_count
4
numeric_cells
369
header_rows
1
locator
section[5]/table-wrap[2]#pone.0144242.t002
[4] object · 16 fields
id
asset:table:pmid:26701646:3
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:05533357b9244f4878213499ffbca49fa58871ec06599a5c27706784d553c87a
bytes
1430
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[5]/table-wrap[3]#pone.0144242.t003
version
null
note
Proteins common for human and dog.
structure object · 5 fields
pmcid
PMC4689550
section_index
5
section_title
Results and Discussion
row_count
25
column_count
3
table object · 8 fields
label
Table 3
caption
Proteins common for human and dog.
rows array · 25 items
[0] array · 3 items
[0]
No
[1]
Protein
[2]
Gene
[1] array · 3 items
[0]
1
[1]
Hepatoma-derived growth factor
[2]
Hdgf
[2] array · 3 items
[0]
2
[1]
78 kDa glucose-regulated protein//Heat shock 70 kDa protein 5
[2]
HSPA5
[3] array · 3 items
[0]
3
[1]
Splicing factor, proline- and glutamine-rich
[2]
SFPQ
[4] array · 3 items
[0]
4
[1]
Guanine nucleotide-binding protein G(t) subunit alpha-2
[2]
GNAI2
[5] array · 3 items
[0]
5
[1]
Cysteinyl-tRNA synthetase, cytoplasmic//Cysteine—tRNA ligase, cytoplasmic
[2]
Cars
[6] array · 3 items
[0]
6
[1]
Interleukin-18
[2]
IL18
[7] array · 3 items
[0]
7
[1]
Ig heavy chain V-II region COR
[2]
N/A
[8] array · 3 items
[0]
8
[1]
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
[2]
HBA
[9] array · 3 items
[0]
9
[1]
Drebrin-like protein
[2]
DBNL
[10] array · 3 items
[0]
10
[1]
Serum albumin
[2]
ALB
[11] array · 3 items
[0]
11
[1]
Keratin, type I microfibrillar 48kDa, component 8C-1
[2]
N/A
[12] array · 3 items
[0]
12
[1]
Keratin, type II cytoskeletal 8
[2]
KRT8
[13] array · 3 items
[0]
13
[1]
Keratin, type I cytoskeletal 9
[2]
KRT9
[14] array · 3 items
[0]
14
[1]
Keratin, type II cytoskeletal 1
[2]
KRT1
[15] array · 3 items
[0]
15
[1]
Glycogen debranching enzyme
[2]
AGL
[16] array · 3 items
[0]
16
[1]
Lysozyme C, spleen isozyme
[2]
N/A
[17] array · 3 items
[0]
17
[1]
Proteasome subunit beta type-3
[2]
PSMB3
[18] array · 3 items
[0]
18
[1]
6-Phosphofructokinase, muscle type
[2]
PKFM
[19] array · 3 items
[0]
19
[1]
Peroxiredoxin-5, mitochondrial
[2]
PRDX5
[20] array · 3 items
[0]
20
[1]
Adenine phosphoribosyltransferase
[2]
Aprt
[21] array · 3 items
[0]
21
[1]
F-actin capping protein subunit alpha-2
[2]
CAPZA2
[22] array · 3 items
[0]
22
[1]
Calnexin
[2]
CANX
[23] array · 3 items
[0]
23
[1]
Sorcin
[2]
SRI
[24] array · 3 items
[0]
24
[1]
Growth arrest-specific protein 6
[2]
GAS6
row_count
25
column_count
3
numeric_cells
38
header_rows
1
locator
section[5]/table-wrap[3]#pone.0144242.t003
gaps array · 2 items
[0]
asset:data:geo:PXD003124 not downloaded
[1]
asset:data:geo:PXD003124 licence not read
analysis object · 4 fields
state
absent
methods array · 0 items
targets array · 0 items
gaps array · 2 items
[0]
method
[1]
operations
capability object · 3 fields
state
complete
requirements array · 1 item
[0] object · 6 fields
capability_id
capability:computational_analysis
label
Computational analysis platform
assay_families array · 9 items
[0]
meta_analysis
[1]
machine_learning
[2]
survival_analysis
[3]
statistical_regression
[4]
pca
[5]
molecular_docking
[6]
network_analysis
[7]
differential_expression
[8]
gwas
availability_state
owned
tier_unlocked
R1
candidate
Automated Assays Laravel application and simulated adapters
gaps array · 0 items
readiness object · 8 fields
state
blocked
tier
R4
blocking_axis
method
blocked_on
method:not_determinable
axes object · 3 fields
method object · 5 fields
tier
R4
expressible
false
required_operations array · 0 items
missing_operations array · 0 items
basis
The reader quoted the method the paper names (not named), but the corpus's method extractor could not map it onto a DSL operation, so the method is published but not expressible.
capability object · 4 fields
tier
R1
capability_id
capability:computational_analysis
availability_state
owned
basis
The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here.
data object · 6 fields
tier
R1
reachable
true
accessions array · 1 item
[0]
PXD003124
resolved_accessions array · 1 item
[0]
PXD003124
statements array · 1 item
[0]
All relevant data are within the paper, and the mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003124.
basis
The paper names PXD003124 in ProteomeXchange Consortium and the accession resolves in the repository. No dataset was downloaded and no licence was read.
can_run object · 3 fields
dsl_operations array · 0 items
assets array · 5 items
[0]
source:pmid:26701646
[1]
data:geo:PXD003124
[2]
asset:table:pmid:26701646:1
[3]
asset:table:pmid:26701646:2
[4]
asset:table:pmid:26701646:3
steps array · 1 item
[0]
run_analysis
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 0 items
capabilities array · 0 items
data_gaps array · 1 item
[0]
data:geo:PXD003124
gaps array · 1 item
[0]
method:not_determinable
review object · 5 fields
state
partial
machine_critique object · 5 fields
kind
extraction_review
reader object · 5 fields
model
MiniMax-M3.1-Flash
provider
minimax
provider_family
minimax
read_at
2026-10-31T18:27:05Z
independence
same_provider
evidence_check object · 2 fields
method
null
availability
verbatim
calls
8
usage object · 3 fields
prompt_tokens
50219
completion_tokens
3091
cached_tokens
1840
human_critique
null
stages array · 1 item
[0] object · 4 fields
id
extraction
state
complete
reader
MiniMax-M3.1-Flash
provider
minimax
gaps array · 3 items
[0]
review.independent_reader
[1]
review.machine_critique
[2]
review.human_critique
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
entities array · 3 items
[0] object · 3 fields
id
pmid:26701646
type
paper
label
pmid:26701646
[1] object · 3 fields
id
source:pmid:26701646
type
manuscript
label
PMID 26701646 full text
[2] object · 3 fields
id
data:geo:PXD003124
type
dataset
label
GEO PXD003124
activities array · 3 items
[0] object · 4 fields
id
activity-reading-sci-2026-11-01
type
classification
used array · 3 items
[0] object · 3 fields
id
pmid:26701646
type
paper
label
pmid:26701646
[1] object · 3 fields
id
source:pmid:26701646
type
manuscript
label
PMID 26701646 full text
[2] object · 3 fields
id
data:geo:PXD003124
type
dataset
label
GEO PXD003124
agent
agent:corpus-assay-engine
[1] object · 4 fields
id
activity-read-26701646
type
extraction
used array · 1 item
[0]
source:pmid:26701646
agent
agent:minimax-reader
[2] object · 4 fields
id
activity-resolve-PXD003124
type
accession_resolution
used array · 1 item
[0]
data:geo:PXD003124
agent
agent:corpus-assay-engine
agents array · 2 items
[0] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
[1] object · 3 fields
id
agent:minimax-reader
type
software
label
MiniMax literature reader
source_run_id
reading-sci-2026-11-01
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:26701646
parent_hash
sha256:de90483dd7eb5de33fbe88f2a5f30416c6bd37580484cc255182035c844589be
fork_of
null
generation
2
gaps array · 8 items
[0]
asset:data:geo:PXD003124 licence not read
[1]
asset:data:geo:PXD003124 not downloaded
[2]
execution.not_run
[3]
method
[4]
operations
[5]
review.human_critique
[6]
review.independent_reader
[7]
review.machine_critique
assays array · 1 item
[0] object · 11 fields
role
data_generation
definition_id
mass_spectrometry
definition_version
99e1195c7d6f
definition_digest
null
required_operations array · 0 items
support_state
partial
source_hashes object · 1 field
assay_lexicon
99e1195c7d6f
confidence
0.99
evidence array · 3 items
[0]
In this study, mass spectrometry was used to explore the canine tear proteome
[1]
desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF-MS/MS) to characterize the protei
[2]
highest scores. The results showed that the proteomic strategy used in this study was successful i
order_basis
paper_text_order:42
id
assay:1
Complete file 
{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:26701646", "kind": "science-record", "revision": 3, "content_hash": "sha256:9f9224655a216ff522ef59dc5f0cae1d5236e73fb3402136c1d47d5be458ac0a", "created_at": "2026-11-01T15:40:15Z", "updated_at": "2026-11-01T18:47:55Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Dog Tear Film Proteome In-Depth Analysis.", "doi": "10.1371/journal.pone.0144242", "pmid": "26701646", "authors": ["Mateusz Winiarczyk", "Dagmara Winiarczyk", "Tomasz Banach", "Lukasz Adaszek", "Jacek Madany", "Jerzy Mackiewicz", "Dorota Pietras-Ozga", "Stanislaw Winiarczyk"], "journal": "PloS one", "year": 2015, "abstract": "In this study, mass spectrometry was used to explore the canine tear proteome. Tear samples were obtained from six healthy dogs, and one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis (1D SDS-PAGE) was used as a first step to separate intact proteins into 17 bands. Each fraction was then trypsin digested and analysed by matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry (MALDI-TOF-MS/MS) to characterize the protein components in each fraction. In total, 125 tear proteins were identified, with MCA (Major Canine Allergen), Serum albumin, UPF0557 protein C10orf119 homolog, Collagen alpha-2(I) chain, Tyrosine -protein kinase Fer, Keratine type II cytoskeletal, Beta-crystallin B2, Interleukin-6 and Desmin occurring as the most confident ones with the highest scores. The results showed that the proteomic strategy used in this study was successful in the analysis of the dog tear proteome. To the best of our knowledge, this study is the first to report the comprehensive proteome profile of tears from healthy dogs by 1D SDS PAGE and MALDI-TOF. Data are available via ProteomeXchange with identifier PXD003124.", "claims": [{"id": "claim-data-access", "statement": "All relevant data are within the paper, and the mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003124.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:26701646", "locator": "sections[7] \"Data Availability\" paragraph 2", "quote": "All relevant data are within the paper, and the mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003124."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Using 1D SDS-PAGE followed by MALDI-TOF-MS/MS, the study identified 125 tear proteins in healthy dogs; the mass-spectrometry proteomics data were deposited in ProteomeXchange under identifier PXD003124.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:26701646", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "In total, 125 tear proteins were identified, with MCA (Major Canine Allergen), Serum albumin, UPF0557 protein C10orf119 homolog, Collagen alpha-2(I) chain, Tyrosine -protein kinase Fer, Keratine type II cytoskeletal, Beta-crystallin B2, Interleukin-6 and Desmin occuring as the most confident ones with the highest scores."}, {"asset": "source:pmid:26701646", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Data are available via ProteomeXchange with identifier PXD003124."}, {"asset": "source:pmid:26701646", "locator": "sections[5] \"Results and Discussion\" paragraph 3", "quote": "From the 17 bands, a total of 125 distinct/unique proteins were identified (Tables 1 and 2)."}, {"asset": "source:pmid:26701646", "locator": "sections[5] \"Results and Discussion\" paragraph 13", "quote": "The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium [26] via the PRIDE partner repository [27] with the dataset identifier PXD003124."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Using 1D SDS-PAGE followed by MALDI-TOF-MS/MS, the study identified 125 tear proteins in healthy dogs; the mass-spectrometry proteomics data were deposited in ProteomeXchange under identifier PXD003124.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:26701646"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:PXD003124"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:PXD003124"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:26701646", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1371/journal.pone.0144242", "sha256": 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Consortium via the PRIDE partner repository with the dataset identifier PXD003124.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "All relevant data are within the paper, and the mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD003124.", "access_statement_kind": "data_availability_statement", "sample_accessions": [], "sample_count": null, "group_sizes": null, "group_sizes_basis": null, "platform": null, "taxon": null, "title": "Dog tear film proteome in-depth analysis", "resolution_checked_at": "2026-10-31T18:35:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:26701646:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:b4119f4366a0dcc44e341750179726d6636912ab1c827660a8dca364af91e664", "bytes": 12735, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[5]/table-wrap[1]#pone.0144242.t001", "version": null, "note": "Summary of protein identification.", "structure": {"pmcid": "PMC4689550", "section_index": 5, "section_title": "Results and Discussion", "row_count": 126, "column_count": 8}, "table": {"label": "Table 1", "caption": "Summary of protein identification.", "rows": [["No.", "Protein", "Accession no.", "Score", "Matches", "Gene name", "Molecular function", "Biological process"], ["1", "Tuftelin-interacting protein 11", "Q29RR5", "35", "12", "TFIP11", "DNA binding", "mRNA processing"], ["2", "Selenocysteine insertion sequence-binding protein 2-like", "Q93073", "34", "4", "SECISBP2L", "RNA binding", "unclassified"], ["3", "Visual system homeobox 2", "P58304", "51", "6", "VSX2", "DNA binding", "transcription"], ["4", "Tensin-1", "Q9HBL0", "61", "11", "TNS1", "RNA binding", "unclassified"], ["5", "Zinc finger protein 780A", "O75290", "34", "4", "ZNF780A", "DNA binding", "transcription"], ["6", "Putative homeodomain transcription factor 1", "Q9UMS5", "32", "5", "PHTF1", "DNA binding", "transcription"], ["7", "Transcription factor TFIIIB component B'' homologue", "A6H8Y1", "40", "14", "BDP1", "DNA binding", "transcription"], ["8", "Hepatoma-derived growth factor", "Q8VHK7", "37", "5", "Hdgf", "DNA binding", "transcription"], ["9", "Metastasis-associated protein MTA3", "Q924K8", "32", "9", "Mta3", "DNA binding", "cell cycle"], ["10", "Nuclear protein 14", "Q8R3N1", "33", "13", "Nop14", "RNA binding", "rRNA processing"], ["11", "Zinc finger protein 582", "Q96NG8", "34", "9", "ZNF582", "DNA binding", "transcription"], ["12", "Zinc finger protein 2", "P08043", "61", "6", "Zfp2", "DNA binding", "transcription"], ["13", "Eukaryotic translation initiation factor 3 subunit H", "Q91WK2", "54", "7", "Eif3h", "RNA binding", "protein biosynthesis"], ["14", "78 kDa glucose-regulated protein//Heat shock 70 kDa protein 5", "Q0VCX2", "62", "10", "HSPA5", "nucleotide binding", "unclassified"], ["15", "Splicing factor, proline- and glutamine-rich", "P23246", "37", "4", "SFPQ", "nucleotide binding", "unclassified"], ["16", "Putative fidgetin-like protein 2", "A6NMB9", "41", "4", "FIGNL2", "nucleotide binding", "unclassified"], ["17", "UPF0557 protein C10orf119 homolog", "A5PJM5", "51", "10", "MCMBP", "chromatin binding", "cell cycle"], ["18", "Guanine nucleotide-binding protein G(t) subunit alpha-2", "P38400", "30", "5", "GNAI2", "transducer", "cell cycle"], ["19", "Protein Spindly", "Q08DR9", "54", "13", "SPDL1", "kinetochore binding", "cell cycle"], ["20", "Cell division cycle protein 27 homolog", "P30260", "41", "7", "CDC27", "phosphatase binding", "cell cycle"], ["21", "Kinesin-like protein KIF11", "P52732", "55", "9", "KIF11", "motor protein", "cell cycle"], ["22", "Parafibromin", "Q6P1J9", "44", "5", "CDC73", "RNA polymerase binding", "cell cycle"], ["23", "G2/mitotic-specific cyclin-B3", "Q659K0", "19", "5", "CCNB3", "cycline", "cell cycle"], ["24", "Transcription factor 4", "P15881", "28", "4", "TCF4", "activator", "transcription"], ["25", "Cysteinyl-tRNA synthetase, cytoplasmic//Cysteine—tRNA ligase, cytoplasmic", "Q9ER72", "38 MS/MS", "10", "Cars", "ligase", "protein biosynthesis"], ["26", "Pinin", "P79149", "30", "4", "PNN", "activator", "transcription"], ["27", "C-C motif chemokine 25", "Q68A93", "47", "4", "CCL25", "cytokine", "inflammatory response"], ["28", "Interleukin-18", "Q9XSR0", "27", "3", "IL18", "cytokine", "immune response"], ["29", "Interleukin-12 subunit alpha", "Q28267", "41", "4", "IL12A", "cytokine", "immune response"], ["30", "Interleukin-1 family member 8//Interleukin-36 beta", "Q9NZH7", "46", "4", "IL36B", "cytokine", "immune response"], ["31", "Interleukin-6", "P79341", "79", "7", "IL6", "cytokine", "immune response"], ["32", "Ig heavy chain V-II region COR", "P01815", "37", "3", "N/A", "antigen binding", "immune response"], ["33", "Scavenger receptor cysteine-rich type 1 protein M130", "Q2VLG6", "23", "5", "CD163", "scavenger receptor", "inflammatory response"], ["34", "Ig heavy chain V region GOM", "P01784", "23 MS/MS", "1", "N/A", "antigen binding", "unclassified"], ["35", "Zinc finger BED domain-containing protein 5", "A4Z944", "33", "6", "ZBED5", "DNA and metal ion binding", "unclassified"], ["36", "Desmoglein-1", "Q9GKQ8", "31", "5", "DSG1", "ion binding", "cell adhesion"], ["37", "Calcium uptake protein 1, mitochondrial", "Q8VCX5", "48", "7", "Micu1", "ion binding", "calcium transport"], ["38", "Cysteine and glycine-rich protein 2", "Q32LE9", "49", "5", "CSRP2", "ion binding", "differentiation"], ["39", "Alpha-fetoprotein", "Q8MJU5", "25", "3", "AFP", "ion binding", "transport"], ["40", "Ankyrin repeat domain-containing protein 5//Ankyrin repeat and EF-hand domain-containing protein 1", "Q9NU02", "42", "5", "ANKEF1", "ion binding", "unclassified"], ["41", "Zinc finger UFM1-specific peptidase domain protein", "Q3T9Z9", "50", "7", "Zufsp", "ion binding", "unclassified"], ["42", "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "P60529", "Protein autopho", "4", "HBA", "oxygen binding", "oxygen transport"], ["43", "Haemoglobin subunit gamma", "P02099", "60", "6", "HBG", "oxygen binding", "transport"], ["44", "Myosin-Ic", "Q63355", "56", "6", "Myo1c", "motor activity", "transport"], ["45", "Drebrin-like protein", "Q9UJU6", "48", "6", "DBNL", "actin binding", "transport"], ["46", "Serum albumin", "P49822", "60", "9", "ALB", "transport/carrier protein", "unclassified"], ["47", "Major allergen Can f 1", "O18873", "95, 200 MS/MS", "8", "N/A", "transport protein", "unclassified"], ["48", "Gastrin/cholecystokinin type B receptor", "F1Q0L4", "40", "3", "CCKBR", "gastrin receptor", "unclassified"], ["49", "Growth hormone receptor", "Q9TU69", "25", "4", "GHR", "receptor", "endocytosis"], ["50", "Transferrin receptor protein", "Q9GLD3", "36", "8", "TFRC", "receptor", "endocytosis"], ["51", "Gastrin-releasing peptide receptor", "P30550", "15 MS/MS", "1", "GRPR", "receptor", "cell proliferation"], ["52", "Desmin", "Q5XFN2", "87", "4", "DES", "muscle protein", "cell structure"], ["53", "Beta-crystallin B2", "P02522", "76", "6", "CRYBB2", "eye lens protein", "cell structure"], ["54", "Keratin, type I microfibrillar 48kDa, component 8C-1", "P02534", "52", "8", "N/A", "structural", "cell structure"], ["55", "Collagen alpha-2(I) chain", "O46392", "58", "10", "COL1A2", "matrix protein", "cell structure"], ["56", "Adipocytes plasma membrane-associated protein", "Q3T0E5", "55", "5", "APMAP", "structural", "membrane protein"], ["57", "DnaJ homologue subfamily member 18", "Q5EA26", "54", "7", "DNAJC18", "structural", "membrane protein"], ["58", "Keratin, type II cytoskeletal 8", "Q28810", "37", "4", "KRT8", "structural", "cell structure"], ["59", "Keratin, type I cytoskeletal 9", "P35527", "115", "17", "KRT9", "structural", "cell structure"], ["60", "Myosin-binding protein C cardiac-type", "O70468", "43", "13", "Mybpc3", "structural", "cell structure"], ["61", "Collagen alpha-2(IV) chain", "P08122", "39", "6", "Col4a2", "matrix protein", "angiogenesis"], ["62", "Arylsulfatase K", "Q32KH0", "35", "5", "ARSK", "hydrolase", "unclassified"], ["63", "Glycogen debranching enzyme", "Q2PQH8", "25", "9", "AGL", "hydrolase", "glycogen biosynthesis"], ["64", "Cystic fibrosis transmembrane conductance regulator", "Q5U820", "29", "7", "CFTR", "hydrolase", "ion transport"], ["65", "Lysozyme C, spleen isozyme", "P81709", "32", "3", "N/A", "hydrolase", "antimicrobial"], ["66", "Coagulation factor IX", "P19540", "33", "5", "F9", "hydrolase", "haemostasis"], ["67", "Proteasome subunit beta type-3", "P33672", "54", "6", "PSMB3", "hydrolase", "unclassified"], ["68", "Endonuclease 8-like 3", "Q6IE77", "57", "10", "NEIL2", "hydrolase", "DNA repair"], ["69", "Gamma-glutamyl hydrolase", "A7YWG4", "30", "6", "GGH", "hydrolase", "unclassified"], ["70", "Multidrug resistance-associated protein 1", "Q6UR05", "31", "11", "ABCC1", "hydrolase", "transport"], ["71", "Ubiquitin carboxyl-terminal hydrolase 15", "Q9Y4E8", "32", "6", "USP15", "hydrolase", "transcription"], ["72", "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2", "O60825", "45", "5", "PFKFB12", "hydrolase", "unclassified"], ["73", "Probable ATP-dependent RNA helicase DDX58", "Q9GLV6", "43", "10", "DDX58", "hydrolase", "immune response"], ["74", "ATP-dependent RNA helicase DDX3X", "O00571", "40", "10", "DDX3X", "hydrolase", "unclassified"], ["75", "Endonuclease 8-like 3", "Q3MHN7", "57", "10", "NEIL3", "hydrolase", "DNA repair"], ["76", "Werner syndrome ATP-dependent helicase", "Q14191", "68", "17", "WRN", "hydrolase", "DNA repair"], ["77", "6-Phosphofructokinase, muscle type", "P52784", "21", "2", "PFKM", "kinase, transferase", "glycolysis"], ["78", "Tyrosine-protein kinase Fer", "Q9TTY2", "36", "6", "FER", "kinase, transferase", "unclassified"], ["79", "Kalirin", "O60229", "40", "14", "KALRN", "kinase", "unclassified"], ["80", "Cell division protein kinase 3//Cyclin-dependent kinase 3", "Q80YP0", "43", "4", "Cdk3", "kinase", "cell cycle"], ["81", "Ribosomal protein S6 kinase delta-1", "Q8BLK9", "14 MS/MS", "1", "Rps6kc1", "kinase", "unclassified"], ["82", "Dual specificity protein kinase CLK3", "P49761", "23 MS/MS", "5", "CLK3", "kinase", "unclassified"], ["83", "Amine oxidase (flavin-containing)", "Q7YRB7", "16", "4", "MAOB", "oxidoreductase", "unclassified"], ["84", "Peroxiredoxin-5, mitochondrial", "Q9BGI1", "57", "4", "PRDX5", "oxidoreductase", "unclassified"], ["85", "Cytochrome P450 1A2", "P56592", "40", "5", "CYP1A2", "oxidoreductase", "unclassified"], ["86", "Lysine-specific demethylase 5C", "Q38JA7", "37", "12", "KDM5C", "oxidoreductase", "transcription"], ["87", "Lysine-specific demethylase 2B", "Q8NHM5", "46, 38 MS/MS", "12", "KDM2B", "oxidoreductase", "transcription"], ["88", "Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2", "O00469", "40", "5", "PLOD2", "oxidoreductase", "unclassified"], ["89", "Hydroxysteroid dehydrogenase-like protein 2", "Q2TPA8", "42", "7", "Hsdl2", "oxidoreductase", "unclassified"], ["90", "Adenine phosphoribosyltransferase", "P08030", "37", "4", "Aprt", "transferase", "purine salvage"], ["91", "F-box only protein 4", "Q9UKT5", "58", "7", "FBXO4", "transferase", "cell cycle"], ["92", "Fukutin", "O75072", "41", "5", "FKTN", "transferase", "unclassified"], ["93", "Chondroitin sulphate synthase 3", "Q70JA7", "36", "5", "CHSY3", "transferase", "unclassified"], ["94", "Poly[ADP-ribose] polymerase 12", "Q9H0J9", "33", "7", "PARP12", "transferase", "unclassified"], ["95", "Alkyldihydroxyacetonephosphate synthase, peroxisomal", "O00116", "31", "5", "AGPS", "transferase", "lipid metabolism"], ["96", "Heparan sulphate glucosamine 3-O-sulfotransferase 6", "Q5GFD5", "55", "6", "Hs3st6", "transferase", "unclassified"], ["97", "Rhophilin-2", "Q8HXG3", "22", "3", "RHPN2", "signal transduction", "unclassified"], ["98", "F-actin capping protein subunit alpha-2", "Q09YN4", "56", "5", "CAPZA2", "actin capping", "unclassified"], ["99", "Adenylate cyclase type 5", "P30803", "32", "7", "ADCY5", "cyclase", "cAMP biosynthesis"], ["100", "Calnexin", "P24643", "28", "5", "CANX", "chaperone", "protein folding"], ["101", "Rho GTPase-activating protein 7", "B9VTT2", "46", "10", "DLC1", "GTPase", "signal transduction"], ["102", "Signal recognition particle 68 kDa protein", "Q00004", "27", "6", "SRP68", "ribonucleoprotein", "unclassified"], ["103", "Endothelin-1", "P13206", "34", "5", "EDN1", "vasoactive", "unclassified"], ["104", "Signal recognition particle 54kDa protein", "P61010", "26", "7", "SRP54", "ribonucleoprotein", "unclassified"], ["105", "Oxygen-regulated protein 1", "Q8MJ04", "27", "13", "RP1", "microtubule binding", "sensory transduction"], ["106", "Arf-GAP with SH3 domain ANK repeat and PH domain-containing protein 1", "O97902", "42", "7", "ASAP1", "GTPase activation", "cilium biogenesis/degradation"], ["107", "E3 ubiquitin-protein ligase RNF115", "Q9Y4L5", "43", "4", "RNF115", "ligase", "unclassified"], ["108", "Collectrin", "Q0VCT4", "34", "4", "TMEM27", "metalopeptidase", "unclassified"], ["109", "EGF-like module-containing mucin like hormone receptor-like 2", "Q2Q421", "25", "4", "2EMR2", "unclassified", "inflammatory response"], ["110", "Gastrin-releasing peptide", "P47851", "55", "5", "GRP", "unclassified", "neuropeptide signalling"], ["111", "Protein SDA1 homolog", "Q9NVU7", "34", "5", "SDAD1", "unclassified", "transport"], ["112", "Sorcin", "P30626", "28", "3", "SRI", "unclassified", "unclassified"], ["113", "Bcl-2-like protein", "Q9HB09", "31", "4", "BCL2L12", "unclassified", "apoptosis"], ["114", "Girdin", "Q3V6T2", "40, 34 MS/MS", "6", "CCDC88A", "unclassified", "DNA replication"], ["115", "Leucine-rich repeat-containing protein 16C", "Q6F5E8", "31", "6", "RLTPR", "unclassified", "immune response"], ["116", "Coiled-coil domain-containing protein 148", "Q8HZY8", "58", "9", "CCDC148", "unclassified", "unclassified"], ["117", "COMM domain-containing protein 6", "Q3V4B5", "34", "4", "Commd6", "unclassified", "unclassified"], ["118", "Breast cancer anti-oestrogen resistance protein 3", "Q9QZK2", "40", "5", "Bcar3", "unclassified", "unclassified"], ["119", "SH2 domain-containing protein 3C", "Q9QZS8", "48", "12", "Sh2d3c", "unclassified", "unclassified"], ["120", "Keratin, type II cytoskeletal 1", "P04264", "112", "15", "KRT1", "unclassified", "unclassified"], ["121", "Sestrin-1", "Q4R6P7", "55", "9", "SESN1", "unclassified", "unclassified"], ["122", "Myelin transcription factor 1-like protein", "P70475", "45", "6", "Myt1l", "unclassified", "transcription"], ["123", "Coiled-coil domain-containing protein 125", "Q5U465", "54", "6", "Ccdc125", "unclassified", "unclassified"], ["124", "Phosducin", "O77560", "37", "5", "PDC", "unclassified", "sensory transduction"], ["125", "Growth arrest-specific protein 6", "Q14393", "8 MS/MS", "1", "GAS6", "unclassified", "growth regulation"]], "row_count": 126, "column_count": 8, "numeric_cells": 556, "header_rows": 1, "locator": "section[5]/table-wrap[1]#pone.0144242.t001"}}, {"id": "asset:table:pmid:26701646:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:bd0d59ec3c55e6d79f491c6021a8cf030f1be2c227b9fb4cdad9ed63cc97c5a1", "bytes": 6865, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[5]/table-wrap[2]#pone.0144242.t002", "version": null, "note": "Proteins found in each band of electrophoretic pattern.", "structure": {"pmcid": "PMC4689550", "section_index": 5, "section_title": "Results and Discussion", "row_count": 138, "column_count": 4}, "table": {"label": "Table 2", "caption": "Proteins found in each band of electrophoretic pattern.", "rows": [["Band", "Protein", "Mass (kDa)", "Score"], ["1", "Collectrin", "25", "34"], ["", "Major alergen Can 1", "19", "90"], ["", "Sorcin", "22", "28"], ["", "Bcl-2-like protein", "22", "31"], ["", "E3 ubiquitin-protein ligase RNF115", "34", "43"], ["", "Ig heavy chain V-II region COR", "13", "37"], ["2", "COMM domain-containing protein 6", "10", "34"], ["", "Zinc finger UFM1-specific peptidase domain protein", "67", "50"], ["", "Hepatoma-derived growth factor", "27", "37"], ["", "Major allergen Can f 1", "19", "95 MS/MS"], ["", "Phosducin", "29", "37"], ["", "C-C motif chemokine 25", "17", "47"], ["", "Cysteine and glycine-rich protein 2", "22", "35"], ["", "Adenine phosphoribosyltransferase", "20", "37"], ["", "Signal recognition particle 68 kDa protein", "70", "26"], ["", "Endothelin-1", "23", "34"], ["", "Adipocyte plasma membrane-associated protein", "46", "55"], ["", "DnaJ homolog subfamily C member 18", "42", "54"], ["3", "Ankyrin repeat domain-containing protein 5", "87", "42"], ["4", "Friend of PRMT1 protein", "27", "10 MS/MS"], ["", "Heparan sulphate glucosamine 3-O-sulfotransferase 6", "40", "55"], ["", "Keratin, type II cytoskeletal 8", "35", "37"], ["", "Cell division protein kinase 3", "34", "43"], ["", "Visual system homeobox 2", "66", "47"], ["", "Transcription factor TFIIIB component B'' homolog", "300", "40"], ["", "6-phosphofructo-2-kinase/fructose-2,6-biphosphatse 2", "59", "42"], ["5", "Ankyrin repeat domain-containing protein 5", "87", "42"], ["", "Zinc finger protein 2", "54", "61"], ["6", "UPF0557 protein C10orf119 homolog", "74", "70"], ["", "Calcium uptake protein 1, mitochondrial", "55", "48"], ["7", "Cysteine and glycine-rich protein 2", "22", "49"], ["8", "", "", ""], ["", "Coagulation factor IX", "53", "33"], ["", "Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2", "86", "40"], ["", "Ubiquitin carboxyl-terminal hydrolase 15", "114", "32"], ["9", "Dual specificity protein kinase CLK3", "74", "23 MS/MS"], ["10", "", "", ""], ["", "Parafibromin", "61", "44"], ["", "ATP-dependent RNA helicase DDX3X", "74", "40"], ["", "Haemoglobin subunit gamma", "16", "60"], ["", "Myosin-Ic", "120", "56"], ["", "Zinc finger protein 582", "62", "34"], ["", "Nuclear protein 14", "100", "33"], ["", "Hydroxysteroid dehydrogenase-like protein 2", "55", "42"], ["", "Kinesin-like protein KIF11", "120", "55"], ["", "Metastasis-associated protein MTA3", "68", "32"], ["", "6-Phosphofructokinase, muscle type", "86", "21"], ["", "Tyrosine-protein kinase Fer", "95", "22"], ["", "Keratin, type I microfibrillar 48kDa, component 8C-1", "48", "52"], ["", "Gamma-glutamyl hydrolase", "36", "30"], ["", "Arf-GAP with SH3 domain ANK repeat and PH domain-containing protein 1", "126", "42"], ["", "Ig heavy chain V region GOM", "13", "23 MS/MS"], ["11", "Ribosomal protein S6 kinase delta-1", "117", "14 MS/MS"], ["", "Sestrin-1", "57", "55"], ["", "Myelin transcription factor 1-like protein", "135", "45"], ["", "Serum albumin", "70", "60"], ["", "Beta-crystallin B2", "23", "76"], ["", "Tyrosine-protein kinase Fer", "95", "23"], ["", "Calnexin", "68", "28"], ["", "Rhophilin-2", "78", "22"], ["", "Collagen alpha-2(I) chain", "130", "58"], ["", "Arylsulfatase K", "61", "28"], ["", "Adenylate cyclase type 5", "142", "24"], ["", "Peroxiredoxin-5, mitochondrial", "23", "57"], ["", "Lysozyme C, spleen isozyme", "15", "32"], ["", "Interleukin-18", "22", "27"], ["", "Guanine nucleotide-binding protein G(t) subunit alpha-2", "41", "30"], ["", "Gastrin/cholecystokinin type B receptor", "50", "40"], ["12", "Growth hormone receptor", "72", "25"], ["", "Coiled-coil domain-containing protein 125", "57", "54"], ["", "Werner syndrome ATP-dependent helicase", "164", "68"], ["", "Eukaryotic translation initiation factor 3 subunit H", "40", "54"], ["", "Pinin", "88", "30"], ["", "G2/mitotic-specific cyclin-B3", "153", "19"], ["", "Collagen alpha-2(I) chain", "130", "44"], ["", "Scavenger receptor cysteine-rich type 1 protein M130", "127", "23"], ["", "Gastrin-releasing peptide", "15", "55"], ["", "F-actin capping protein subunit alpha-2", "33", "56"], ["", "Desmoglein-1", "115", "31"], ["", "Cytochrome P450 1A2", "58", "40"], ["", "Endonuclease 8-like 3", "62", "57"], ["", "Interleukin-6", "24", "79"], ["13", "Interleukin-1 family member 8", "49", "48"], ["", "Amine oxidase (flavin-containing) B", "59", "16"], ["", "Transcription factor 4", "69", "18"], ["", "Fukutin", "54", "41"], ["", "Growth arrest-specific protein 6", "82", "8 MS/MS"], ["", "Interleukin-1 family member 8", "19", "46"], ["", "Amine oxidase (flavin-containing) B", "59", "16"], ["", "Selenocysteine insertion sequence-binding protein 2-like", "123", "34"], ["", "Splicing factor, proline- and glutamine-rich", "76", "37"], ["", "Putative fidgetin-like protein 2", "67", "40"], ["", "Protein SDA1 homolog", "80", "34"], ["", "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "142", "30"], ["", "Zinc finger protein 780A", "77", "34"], ["14", "Putative homeodomain transcription factor 1", "88", "32"], ["", "Rho GTPase-activating protein 7", "126", "46"], ["", "Signal recognition particle 54kDa protein", "56", "26"], ["", "Alpha-fetoprotein", "70", "25"], ["", "Interleukin-12 subunit alpha", "25", "41"], ["", "Lysine-specific demethylase 5C", "177", "37"], ["", "Pleckstrin", "40", "32"], ["", "Tuftelin-interacting protein 11", "96", "35"], ["", "Transferrin receptor protein 1", "87", "36"], ["", "Protein Spindly", "70", "54"], ["", "SH2 domain-containing protein 3C", "95", "48"], ["", "Keratin, type II cytoskeletal 1", "66", "112"], ["", "Myosin-binding protein C cardiac-type", "142", "43"], ["", "Gastrin-releasing peptide receptor", "", "15 MS/MS"], ["15", "Desmin", "53", "87"], ["", "78 kDa glucose-regulated protein", "73", "62"], ["", "Desmin", "53", "20"], ["", "Multidrug resistance-associated protein 1", "173", "31"], ["", "F-box only protein 4", "46", "58"], ["", "Lysine-specific demethylase 2B", "155", "46, 38 MS/MS"], ["", "Kalirin", "343", "40"], ["", "Girdin", "217", "40, 34 MS/MS"], ["", "Tensin-1", "187", "61"], ["", "Chondroitin sulphate synthase 3", "101", "36"], ["", "Leucine-rich repeat-containing protein 16C", "156", "31"], ["", "6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 2", "65", "43"], ["", "Coiled-coil domain-containing protein 148", "73", "58"], ["", "Probable ATP-dependent RNA helicase DDX58", "109", "43"], ["", "Cysteinyl-tRNA synthetase, cytoplasmic //Cysteine—tRNA ligase, cytoplasmic", "95", "38 MS/MS"], ["", "Collagen alpha-2(IV) chain", "108", "39"], ["", "Breast cancer anti-oestrogen resistance protein 3", "93", "40"], ["16", "Oxygen-regulated protein 1", "243", "27"], ["", "EGF-like module-containing mucin like hormone receptor-like 2", "94", "25"], ["", "Desmin", "53", "36"], ["", "Zinc finger BED domain-containing protein 5", "80", "28"], ["", "Tyrosine-protein kinase Fer", "95", "36"], ["", "Arylsulfatase K", "61", "35"], ["", "Transcription factor 4", "69", "28"], ["", "Adenylate cyclase type 5", "142", "32"], ["", "Glycogen debranching enzyme", "177", "25"], ["", "Cystic fibrosis transmembrane conductance regulator", "169", "29"], ["17", "Proteasome subunit beta type-3", "23", "54"]], "row_count": 138, "column_count": 4, "numeric_cells": 369, "header_rows": 1, "locator": "section[5]/table-wrap[2]#pone.0144242.t002"}}, {"id": "asset:table:pmid:26701646:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:05533357b9244f4878213499ffbca49fa58871ec06599a5c27706784d553c87a", "bytes": 1430, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[5]/table-wrap[3]#pone.0144242.t003", "version": null, "note": "Proteins common for human and dog.", "structure": {"pmcid": "PMC4689550", "section_index": 5, "section_title": "Results and Discussion", "row_count": 25, "column_count": 3}, "table": {"label": "Table 3", "caption": "Proteins common for human and dog.", "rows": [["No", "Protein", "Gene"], ["1", "Hepatoma-derived growth factor", "Hdgf"], ["2", "78 kDa glucose-regulated protein//Heat shock 70 kDa protein 5", "HSPA5"], ["3", "Splicing factor, proline- and glutamine-rich", "SFPQ"], ["4", "Guanine nucleotide-binding protein G(t) subunit alpha-2", "GNAI2"], ["5", "Cysteinyl-tRNA synthetase, cytoplasmic//Cysteine—tRNA ligase, cytoplasmic", "Cars"], ["6", "Interleukin-18", "IL18"], ["7", "Ig heavy chain V-II region COR", "N/A"], ["8", "N-acetylglucosamine-1-phosphotransferase subunits alpha/beta", "HBA"], ["9", "Drebrin-like protein", "DBNL"], ["10", "Serum albumin", "ALB"], ["11", "Keratin, type I microfibrillar 48kDa, component 8C-1", "N/A"], ["12", "Keratin, type II cytoskeletal 8", "KRT8"], ["13", "Keratin, type I cytoskeletal 9", "KRT9"], ["14", "Keratin, type II cytoskeletal 1", "KRT1"], ["15", "Glycogen debranching enzyme", "AGL"], ["16", "Lysozyme C, spleen isozyme", "N/A"], ["17", "Proteasome 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