Proteomic data on the nuclear interactome of human MCM9.

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MCM9 has been shown to bind MCM8, and has been implicated in DNA replication and homologous recombination. However, the mechanistic basis of MCM9's role in DNA repair is poorly understood, and proteins with which it interacts were hitherto unknown. We performed tandem affinity purification of MCM9 and its interacting proteins from nuclear extracts of human cells, followed by proteomic analysis, thereby generating a set of mass spectrometry data corresponding to the MCM9 interactome [1]. The proteomic data set comprises 29 mass spectrometry RAW files, deposited to the ProteomeXchange Consortium, and freely available from the PRIDE partner repository with the data set identifier PXD000212. A set of 22 interacting proteins identified from the proteomic data was used to create an MCM9-centered interactive network diagram, using the Cytoscape program. These data allow the scientific community to access, mine and explore the human nuclear MCM9 interactome.", "claims": [{"id": "claim-data-access", "statement": "The data are provided in the public PRIDE repository with the dataset identifier PXD000212. The direct URL to access the data ishttp://www.ebi.ac.uk/pride/archive/projects/PXD000212", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:26870752", "locator": "sections[2] \"table-wrap\" paragraph 1", "quote": "The data are provided in the public PRIDE repository with the dataset identifier PXD000212. 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The proteomic data set comprises 29 mass spectrometry RAW", "teomic analysis, thereby generating a set of mass spectrometry data corresponding to the MCM9 interactome ["], "order_basis": "paper_text_order:0", "id": "assay:1"}]}