Gene expression profiling of Ctr9-regulated transcriptome in ERα-positive breast cancer.

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Recently, our study found that loss of Ctr9 led to apparent morphological change, decrease of proliferation, and reduced colony formation in ERα(+) breast cancer cells. Moreover, Ctr9 and ERα show positive correlation at protein levels and the high levels of Ctr9 are associated with poor survival among all women with ERα(+) breast cancers, and specifically among those treated with tamoxifen. To gain a molecular understanding of the role of Ctr9 in promoting ERα(+) breast cancer, we performed a microarray gene expression profiling of Ctr9-regulated transcriptome. Here we provide the experimental details and analysis of the microarray data, which have been deposited into Gene Expression Omnibus (GEO): GSE73388.", "claims": [{"id": "claim-method", "statement": "Data analysis and visualization were performed using the Affymetrix Transcriptome Analysis Console (TAC) Software per the manufacturer's protocol. 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