Time-course proteomics dataset monitoring HeLa cells subjected to DTT induced endoplasmic reticulum stress.

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During ER stress, accumulation of misfolded and unfolded proteins in the lumen of the ER initiates the Unfolded Protein Response (UPR), resulting in a large-scale redistribution of proteins. We used label-free mass spectrometry to monitor the proteomic changes of HeLa cells during a 30-h time course, monitoring eight time points (0, 0.5, 1, 2, 8, 16, 24, and 30 h). The data are associated with the research article \"Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress\" [1], which discusses a core dataset of 1237 proteins. Here, we present the extended dataset of 2131 proteins. 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