Higher programmed cell death 1 ligand 1 (PD-L1) mRNA level in clear cell renal cell carcinomas is associated with a favorable outcome due to the active immune responses in tumor tissues.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:27926518", "kind": "science-record", "revision": 7, "content_hash": "sha256:9255429f24ea5e323ddd448107e2f1efaf0357ba0c38e41d062c2df8241b6c81", "created_at": "2026-11-01T15:40:21Z", "updated_at": "2026-11-01T22:42:50Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Higher programmed cell death 1 ligand 1 (PD-L1) mRNA level in clear cell renal cell carcinomas is associated with a favorable outcome due to the active immune responses in tumor tissues.", "doi": "10.18632/oncotarget.13765", "pmid": "27926518", "authors": ["Xiang-Hui Ning", "Yan-Qing Gong", "Shi-Ming He", "Teng Li", "Jiang-Yi Wang", "Shuang-He Peng", "Jin-Chao Chen", "Jia-Yuan Liu", "Nie-Nie Qi", "Ying-Lu Guo", "Kan Gong"], "journal": "Oncotarget", "year": 2017, "abstract": "Renal cell carcinoma is one of the most common urological tumors. The role of programmed cell death 1 ligand 1 (PD-L1) in renal cell carcinomas in predicting outcome of the patients is yet unclear. We analyzed the clinical and RNA-seq data of 522 kidney clear cell cancer, 259 kidney papillary cell carcinoma and 66 kidney chromophobe patients from The Cancer Genome Atlas (TCGA) database. In kidney clear cell cancer patients with high PD-L1 mRNA level and low PD-L1 mRNA level in tumors, the median overall survival periods were 45.0 and 37.1 months respectively (p=0.002). Multivariate Cox regression tests found that PD-L1 mRNA level in tumor was an independent predictor for overall survival status in kidney clear cell cancer patients (HR=0.7, 95% CI 0.5-0.9, p=0.007). However, no significant difference in overall survival status was found between high and low PD-L1 groups in kidney papillary cell carcinoma and kidney chromophobe cohorts. Gene-set enrichment analysis on the data from databases of TCGA and GSE53757 dataset in Gene Expression Omnibus databases showed that several pathways relating to immunological functions were activated in kidney clear cell cancers with high PD-L1 mRNA expression, and glycolysis and epithelial-mesenchymal transition pathways relating to tumor progression and metastasis were increased in kidney clear cell cancers with low PD-L1 mRNA level. In conclusion, higher PD-L1 mRNA level in kidney clear cell cancer tissues was associated with a favorable outcome due to the higher immunological responses in tumor tissues.", "claims": [{"id": "claim-method", "statement": "Overall survival was assessed using Kaplan-Meier method and log-rank test.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:27926518", "locator": "sections[11] \"Statistical methods\" paragraph 2", "quote": "Overall survival was assessed using Kaplan-Meier method and log-rank test."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The data used in this study are opened to public for access without limitation and restriction.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:27926518", "locator": "sections[9] \"Patients and data collection\" paragraph 2", "quote": "The data used in this study are opened to public for access without limitation and restriction."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Using TCGA clinical and RNA-seq data analyzed with multivariate Cox regression, higher tumor PD-L1 mRNA was an independent predictor of longer overall survival in kidney clear cell cancer (HR=0.7, 95% CI 0.5–0.9, p=0.007).", "kind": "quantitative", "target": {"value": 95.0, "unit": "per cent", "tolerance": null, "source": "Multivariate Cox regression tests found that PD-L1 mRNA level in tumor was an independent predictor for overall survival status in kidney clear cell cancer patients (HR=0.7, 95% CI 0.5-0.9, p=0.007)."}, "evidence": [{"asset": "source:pmid:27926518", "locator": "sections[1] \"INTRODUCTION\" paragraph 5", "quote": "we aimed to investigate the role of PD-L1 mRNA expression in tumors in predicting the outcome of RCC based on the analyses of the clinical and RNA-seq data presented in The Cancer Genome Atlas (TCGA) database."}, {"asset": "source:pmid:27926518", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Multivariate Cox regression tests found that PD-L1 mRNA level in tumor was an independent predictor for overall survival status in kidney clear cell cancer patients (HR=0.7, 95% CI 0.5-0.9, p=0.007)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Using TCGA clinical and RNA-seq data analyzed with multivariate Cox regression, higher tumor PD-L1 mRNA was an independent predictor of longer overall survival in kidney clear cell cancer (HR=0.7, 95% CI 0.5–0.9, p=0.007).", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:27926518"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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