Genome-scale analysis identifies GJB2 and ERO1LB as prognosis markers in patients with pancreatic cancer.

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The deadly nature of pancreatic cancer, with an extremely low 5-year survival rate, renders urgent a better understanding of the molecular events underlying it. The aim of this study is to investigate the gene expression module of pancreatic adenocarcinoma and to identify differentially expressed genes (DEGs) with prognostic potentials. Transcriptome microarray data of five GEO datasets (GSE15471, GSE16515, GSE18670, GSE32676, GSE71989), including 117 primary tumor samples and 73 normal pancreatic tissue samples, were utilized to identify DEGs. The five sets of DEGs had an overlapping subset consisting of 98 genes (90 up-regulated and 8 down-regulated), which were probably common to pancreatic cancer. Gene ontology (GO) analysis of the 98 DEGs showed that cell cycle and cell adhesion were the major enriched processes, and extracellular matrix (ECM)-receptor interaction and p53 signaling pathway were the most enriched pathways according to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Elevated expression of gap junction protein beta 2 (GJB2) and reduced endoplasmic reticulum oxidoreductase 1-like beta (ERO1LB) expression were validated in an independent cohort. Kaplan-Meier survival analysis revealed that GJB2 and ERO1LB levels were significantly associated with the overall survival of pancreatic cancer patients. GJB2 and ERO1LB are implicated in pancreatic cancer progression and can be used to predict patient survival. Therapeutic strategies targeting GJB2 and facilitating ERO1LB expression may deserve evaluation to improve prognosis of pancreatic cancer patients.", "claims": [{"id": "claim-method", "statement": "Survival analysis was performed through the Kaplan-Meier method and the log-rank test was used to evaluate the statistical significance of the differences.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:28177904", "locator": "sections[13] \"Statistical analysis\" paragraph 2", "quote": "Survival analysis was performed through the Kaplan-Meier method and the log-rank test was used to evaluate the statistical significance of the differences."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The DEGs were identified using five independent pancreatic adenocarcinoma microarray datasets including GSE15471, GSE16515, GSE18670, GSE32676 and GSE71989, with 190 samples in total (117 primary tumor samples and 73 normal control samples).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:28177904", "locator": "sections[9] \"Pancreatic adenocarcinoma datasets\" paragraph 2", "quote": "The DEGs were identified using five independent pancreatic adenocarcinoma microarray datasets including GSE15471, GSE16515, GSE18670, GSE32676 and GSE71989, with 190 samples in total (117 primary tumor samples and 73 normal control samples)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:28177904"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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OSBPL3, C1orf106, ANLN, KLF5, PI3, MGLL, HN1, CDH3, MLPH, LOC102724257///TMC5, MALL, RACGAP1, MBOAT2, ITGA3, WNT5A, SDC1, FAM83D, AHNAK2, RTP4, MELK, PKM, CDC20, ARNTL2, S100A16, ECM1, CENPK, MTMR11, FAT1, ZWINT, IFI6, SERPINB5, ZG16B, KCNN4, CEACAM5, CEP55, MPZL2, RHPN2, CDC42EP5, PRC1, SPAG1, CCNB1, ABHD17C, AOC1, DLGAP5"], ["Down-regulated", "PAIP2B, ERO1LB, IAPP, AF070581, FAM46C, CA4, FAM150B, AOX1"]], "row_count": 3, "column_count": 2, "numeric_cells": 2, "header_rows": 1, "locator": "section[3]/table-wrap[1]#T1"}}, {"id": "asset:table:pmid:28177904:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:a006244af668db9b29d434eb311655fc1a47ff01133ec0dfbed91789fc63612f", "bytes": 1076, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[6]/table-wrap[1]#T2", "version": null, "note": "Correlation between GJB2, ERO1LB expression and clinicopathologic 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