HOXC10 Promotes the Metastasis of Human Lung Adenocarcinoma and Indicates Poor Survival Outcome.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:28824453", "kind": "science-record", "revision": 9, "content_hash": "sha256:f7c2b83c0e29c5ec221152eb640bc54622d8717d7bc4cb9d385077320beaf367", "created_at": "2026-11-01T15:40:27Z", "updated_at": "2026-11-01T22:43:04Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "HOXC10 Promotes the Metastasis of Human Lung Adenocarcinoma and Indicates Poor Survival Outcome.", "doi": "10.3389/fphys.2017.00557", "pmid": "28824453", "authors": ["Xiao-Lei Tang", "Bang-Xian Ding", "Ying Hua", "Hao Chen", "Tao Wu", "Zhang-Quan Chen", "Chun-Hui Yuan"], "journal": "Frontiers in physiology", "year": 2017, "abstract": "Background: As master regulator of embryonic morphogenesis, homeodomain-containing gene 10 (HOXC10) has been found to promote progression of human cancers and indicates poor survival outcome. However, the role of HOXC10 in lung adenocarcinoma still unclear. Methods: HOXC10 expression was evaluated in 63 primary lung adenocarcinoma tissues from our local hospital, and further systematically confirmed in lung cancer tissues from six GEO datasets (GSE19188, GSE31210, GSE10072, GSE7670, GSE32863, GSE30219), and Kaplan-Meier plotter database. The role of HOXC10 in lung cancer metastasis was further validated by cellular and molecular studies. Results: The expression of HOXC10 was significantly increased in human lung adenocarcinoma samples from Wuhu No.2 People's Hospital, about 4.219 times compared with normal tissues, and significantly correlated with TNM stage, lymph node, and distal metastasis. Upregulation of HOXC10 indicated a poor overall/relapse free survival of lung cancer patients from Wuhu No.2 People's Hospital, GEO datasets, and Kaplan-Meier plotter database, especially in patients with lung adenocarcinoma. Knockdown or ectopic expression assays confirmed that HOXC10 enhanced the phosphorylation of PI3K, regulated the expression of epithelial-to-mesenchymal transition (EMT) markers: MMP2/9, VCAM-1, vimentin and E-cadherin. Cellular study further confirmed that HOXC10 was required for migration, invasion and adhesion of lung cancer cells. Conclusion: These findings suggest that HOXC10 plays a pivotal role in the metastasis of human lung cancer and highlight its usefulness as a potential prognostic marker or therapeutic target in human lung adenocarcinoma.", "claims": [{"id": "claim-method", "statement": "Survival analysis was carried out by the Kaplan-Meier method, and subjected to the log rank test.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:28824453", "locator": "sections[12] \"Statistical analysis\" paragraph 2", "quote": "Survival analysis was carried out by the Kaplan-Meier method, and subjected to the log rank test."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Next, to support our conclusion that HOXC10 is upregulated in lung cancer, we further examined the expression of HOXC10 mRNA in lung cancer patients included in six GEO datasets (GSE19188, GSE31210, GSE10072, GSE7670, GSE32863, GSE30219).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:28824453", "locator": "sections[18] \"Upregulated HOXC10 expression indicates poor prognosis of lung cancer\" paragraph 2", "quote": "Next, to support our conclusion that HOXC10 is upregulated in lung cancer, we further examined the expression of HOXC10 mRNA in lung cancer patients included in six GEO datasets (GSE19188, GSE31210, GSE10072, GSE7670, GSE32863, GSE30219)."}], "state": "complete"}, {"id": "claim-target-result", "statement": "HOXC10 was reported to promote lung-cancer metastasis and indicate poor lung-adenocarcinoma prognosis; survival was analyzed by the Kaplan–Meier method with log-rank testing using local-hospital samples, six GEO datasets, and the Kaplan–Meier Plotter database, with overall-survival HR = 1.4 (95% CI 1.11–1.77, p = 0.0043) and relapse-free-survival HR = 1.4 (95% CI 1.02–1.96, p = 0.0366).", "kind": "quantitative", "target": {"value": 95.0, "unit": "per cent", "tolerance": null, "source": "Similar with the results obtained from GSE30219, HOXC10 predicted a poor overall survival (Figure 6F, HR = 1.4, 95%CI:1.11–1.77, p = 0.0043) and relapse free survival (Figure 6G, HR = 1.4, 95%CI:1.02–1.96, p = 0.0366) of lung adenocarcinoma, but not obvious in lung squamous cell carcinoma (Figures 6H,I)."}, "evidence": [{"asset": "source:pmid:28824453", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "These findings suggest that HOXC10 plays a pivotal role in the metastasis of human lung cancer and highlight its usefulness as a potential prognostic marker or therapeutic target in human lung adenocarcinoma."}, {"asset": "source:pmid:28824453", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "HOXC10 expression was evaluated in 63 primary lung adenocarcinoma tissues from our local hospital, and further systematically confirmed in lung cancer tissues from six GEO datasets (GSE19188, GSE31210, GSE10072, GSE7670, GSE32863, GSE30219), and Kaplan-Meier plotter database."}, {"asset": "source:pmid:28824453", "locator": "sections[12] \"Statistical analysis\" paragraph 2", "quote": "Survival analysis was carried out by the Kaplan-Meier method, and subjected to the log rank test."}, {"asset": "source:pmid:28824453", "locator": "sections[18] \"Upregulated HOXC10 expression indicates poor prognosis of lung cancer\" paragraph 2", "quote": "Similar with the results obtained from GSE30219, HOXC10 predicted a poor overall survival (Figure 6F, HR = 1.4, 95%CI:1.11–1.77, p = 0.0043) and relapse free survival (Figure 6G, HR = 1.4, 95%CI:1.02–1.96, p = 0.0366) of lung adenocarcinoma, but not obvious in lung squamous cell carcinoma (Figures 6H,I)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "HOXC10 was reported to promote lung-cancer metastasis and indicate poor lung-adenocarcinoma prognosis; survival was analyzed by the Kaplan–Meier method with log-rank testing using local-hospital samples, six GEO datasets, and the Kaplan–Meier Plotter database, with overall-survival HR = 1.4 (95% CI 1.11–1.77, p = 0.0043) and relapse-free-survival HR = 1.4 (95% CI 1.02–1.96, p = 0.0366).", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:28824453"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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