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pmid:28932774
Transcriptomic and bioinformatics analysis of the early time-course of the response to prostaglandin F2 alpha in the bovine corpus luteum.
Heather Talbott · Xiaoying Hou · Fang Qiu · Pan Zhang · Chittibabu Guda · Fang Yu · Robert A Cushman · Jennifer R Wood · Cheng Wang · Andrea S Cupp · John S Davis
Data in brief · 2017 doi:10.1016/j.dib.2017.08.026
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Complete file
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The normalized linear microarray data was uploaded to the NCBI GEO repository (GSE94069). Subsequent statistical analysis determined differentially expressed transcripts ± 1.5-fold change from saline control with P ≤ 0.05. Gene ontology of differentially expressed transcripts was annotated by DAVID and Panther. Physiological characteristics of the study animals are presented in a figure. Bioinformatic analysis by Ingenuity Pathway Analysis was curated, compiled, and presented in tables. A dataset comparison with similar microarray analyses was performed and bioinformatics analysis by Ingenuity Pathway Analysis, DAVID, Panther, and String of differentially expressed genes from each dataset as well as the differentially expressed genes common to all three datasets were curated, compiled, and presented in tables. Finally, a table comparing four bioinformatics tools' predictions of functions associated with genes common to all three datasets is presented. 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Data", "row_count": 37, "column_count": 10}, "table": {"label": "Table 1", "caption": "Canonical pathways of PGF2α time course ⁎.", "rows": [["", "0.5 h", "1 h", "2 h", "4 h", ""], ["Ingenuity Canonical Pathways", "z-score", "P-value (B-H)", "z-score", "P-value (B-H)", "z-score", "P-value (B-H)", "z-score", "P-value (B-H)", "|Avg.| z-score"], ["Death Receptor Signaling", "", "", "", "", "", "", "−2.71", "3.23E-01", "0.90"], ["Integrin Signaling", "", "", "", "", "", "", "−2.68", "4.69E-01", "0.89"], ["UVA-Induced MAPK Signaling", "", "2.51E-02", "", "2.65E-01", "", "7.96E-01", "−2.50", "1.64E-01", "0.83"], ["MIF Regulation of Innate Immunity", "", "1.58E-02", "", "8.71E-02", "", "6.44E-01", "2.45", "3.44E-01", "0.82"], ["Retinoic acid Mediated Apoptosis Signaling", "", "", "", "", "", "4.81E-01", "−2.45", "1.78E-01", "0.82"], ["Melanocyte Development and Pigmentation Signaling", "", "", "", "", "", "", "−2.32", "1.64E-01", "0.77"], ["TREM1 Signaling", "", "", "", "", "", "7.89E-01", "2.31", "1.10E-01", "0.77"], ["CREB Signaling in Neurons", "", "", "", "", "", "", "−2.18", "4.61E-01", "0.73"], ["Aldosterone Signaling in Epithelial Cells", "", "4.37E-02", "", "7.76E-02", "", "4.89E-01", "−2.14", "9.55E-02", "0.71"], ["NGF Signaling", "", "", "", "", "", "8.39E-01", "−2.13", "4.79E-02", "0.71"], ["Calcium Signaling", "", "", "", "", "", "", "−2.11", "2.64E-01", "0.53"], ["Toll-like Receptor Signaling", "", "2.24E-02", "", "6.61E-02", "2.00", "2.99E-01", "2.14", "2.69E-02", "1.03"], ["ILK Signaling", "", "5.25E-02", "2.45", "2.34E-02", "1.63", "7.31E-01", "", "1.60E-01", "1.36"], ["Inflammasome pathway", "", "", "", "", "", "7.55E-01", "2.00", "2.98E-01", "0.50"], ["MIF-mediated Glucocorticoid Regulation", "", "", "", "", "", "", "2.00", "5.16E-01", "0.50"], ["JAK/Stat Signaling", "", "2.24E-02", "", "2.45E-02", "", "3.49E-01", "−2.00", "8.32E-02", "0.50"], ["Granzyme B Signaling", "", "", "", "", "", "7.43E-01", "−2.00", "2.30E-01", "0.50"], ["Dopamine-DARPP32 Feedback in cAMP Signaling", "", "", "", "6.15E-01", "", "", "−2.00", "4.50E-01", "0.50"], ["Signaling by Rho Family GTPases", "", "7.59E-02", "2.00", "1.61E-01", "", "", "", "", "0.67"], ["LPS/IL-1 Mediated Inhibition of RXR Function", "", "2.57E-01", "", "", "2.00", "7.43E-01", "1.90", "5.79E-01", "0.97"], ["LXR/RXR Activation", "", "", "", "", "−1.34", "4.99E-01", "−2.32", "1.61E-01", "0.92"], ["Cholecystokinin/Gastrin-mediated Signaling", "", "2.45E-02", "2.00", "3.89E-02", "2.65", "2.99E-01", "0.69", "6.76E-02", "1.33"], ["TGF-β Signaling", "", "2.24E-02", "", "7.76E-02", "2.00", "5.45E-01", "1.16", "1.66E-01", "0.79"], ["Acute Phase Response Signaling", "", "4.37E-02", "1.00", "7.76E-02", "2.12", "4.81E-01", "1.53", "1.23E-01", "1.16"], ["HMGB1 Signaling", "", "3.09E-02", "2.00", "2.45E-02", "1.89", "3.44E-01", "0.69", "1.34E-01", "1.14"], ["Gαq Signaling", "", "", "", "6.41E-01", "−0.45", "7.46E-01", "−2.07", "3.13E-01", "0.63"], ["Colorectal Cancer Metastasis Signaling", "", "7.41E-02", "2.00", "1.61E-01", "1.13", "7.52E-01", "−0.38", "2.59E-01", "0.69"], ["Endothelin-1 Signaling", "", "4.90E-02", "2.00", "8.71E-02", "", "", "−0.66", "3.94E-01", "0.34"], ["PI3K Signaling in B Lymphocytes", "", "1.41E-02", "", "1.22E-01", "1.34", "4.81E-01", "−0.21", "2.69E-02", "0.28"], ["Corticotropin Releasing Hormone Signaling", "", "1.41E-02", "", "3.89E-02", "", "6.43E-01", "−0.54", "2.00E-01", "0.18"], ["IL-8 Signaling", "", "5.62E-02", "2.00", "1.08E-01", "0.45", "8.39E-01", "−1.09", "4.00E-01", "0.34"], ["NRF2-mediated Oxidative Stress Response", "", "1.41E-02", "0.45", "1.00E-02", "0.38", "1.75E-01", "0.24", "1.11E-01", "0.27"], ["Cardiac Hypertrophy Signaling", "", "2.86E-01", "", "2.88E-01", "1.63", "7.99E-01", "−2.04", "1.71E-01", "0.10"], ["IGF-1 Signaling", "", "1.41E-02", "1.00", "1.91E-02", "0.82", "2.41E-01", "−1.29", "8.51E-02", "0.13"], ["IL-17A Signaling in Gastric Cells", "", "1.41E-02", "", "6.61E-02", "", "4.99E-01", "", "6.10E-01", ""]], "row_count": 37, "column_count": 10, "numeric_cells": 204, "header_rows": 2, "locator": "section[4]/table-wrap[1]#t0005"}}, {"id": "asset:table:pmid:28932774:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:6a3d6dca90c092ec36f794bf0abd371b5bf319c87694958c561ec04d7092fab4", "bytes": 5881, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[4]/table-wrap[2]#t0010", "version": null, "note": "Canonical pathways of dataset comparison ⁎.", "structure": {"pmcid": "PMC5596332", "section_index": 4, "section_title": "1. Data", "row_count": 62, "column_count": 8}, "table": {"label": "Table 2", "caption": "Canonical pathways of dataset comparison ⁎.", "rows": [["", "GSE94069", "GSE23348", "GSE27961", ""], ["Ingenuity Canonical Pathways", "z-score", "P-value (B-H)", "z-score", "P-value (B-H)", "z-score", "P-value (B-H)", "|Avg.| z-score"], ["TREM1 Signaling", "2.31", "1.90E-01", "4.24", "3.55E-01", "2.24", "4.34E-01", "2.93"], ["p38 MAPK Signaling", "1.34", "7.94E-01", "3.36", "1.66E-01", "2.53", "1.75E-01", "2.41"], ["Acute Phase Response Signaling", "1.53", "1.19E-01", "3.58", "2.19E-01", "2.12", "6.24E-01", "2.41"], ["Dendritic Cell Maturation", "", "1.13E-01", "3.27", "2.90E-01", "1.41", "5.18E-01", "2.34"], ["Inflammasome pathway", "2.00", "3.20E-01", "2.65", "5.13E-01", "", "5.10E-01", "2.33"], ["MIF Regulation of Innate Immunity", "2.45", "3.52E-01", "2.00", "2.67E-01", "", "", "2.23"], ["CREB Signaling in Neurons", "−2.18", "4.67E-01", "", "", "", "", "2.18"], ["LPS/IL-1 Mediated Inhibition of RXR Function", "1.90", "5.85E-01", "2.45", "1.80E-01", "", "2.26E-01", "2.18"], ["Role of IL-17F in Allergic Inflammatory Airway Diseases", "1.27", "4.68E-01", "3.00", "1.20E-01", "2.24", "1.35E-01", "2.17"], ["LXR/RXR Activation", "−2.32", "1.17E-01", "−2.83", "1.35E-01", "−1.34", "4.28E-01", "2.16"], ["Aldosterone Signaling in Epithelial Cells", "−2.14", "9.12E-01", "", "1.75E-01", "", "4.99E-01", "2.14"], ["Type I Diabetes Mellitus Signaling", "", "6.11E-01", "2.11", "4.70E-01", "", "", "2.11"], ["IL-6 Signaling", "1.23", "2.57E-01", "3.41", "2.75E-01", "1.67", "3.27E-01", "2.10"], ["MIF-mediated Glucocorticoid Regulation", "2.00", "5.18E-01", "2.00", "1.61E-01", "", "", "2.00"], ["Granzyme B Signaling", "−2.00", "2.32E-01", "", "6.98E-01", "", "7.60E-01", "2.00"], ["Dopamine-DARPP32 Feedback in cAMP Signaling", "−2.00", "4.62E-01", "", "", "", "", "2.00"], ["Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza", "", "", "", "", "2.00", "5.10E-01", "2.00"], ["Toll-like Receptor Signaling", "2.14", "2.57E-01", "2.71", "5.62E-01", "1.00", "6.24E-01", "1.95"], ["PI3K/AKT Signaling", "2.13", "2.57E-01", "1.90", "6.92E-01", "1.67", "3.83E-01", "1.90"], ["Actin Nucleation by ARP-WASP Complex", "", "", "1.63", "1.58E-01", "2.00", "5.10E-01", "1.82"], ["ILK Signaling", "", "1.53E-01", "2.32", "5.25E-01", "1.29", "1.59E-01", "1.81"], ["Retinoic acid Mediated Apoptosis Signaling", "−2.45", "1.74E-01", "-1.00", "1.61E-01", "", "7.26E-01", "1.73"], ["HMGB1 Signaling", "0.45", "1.90E-01", "2.99", "2.82E-01", "1.67", "3.45E-01", "1.70"], ["Regulation of Actin-based Motility by Rho", "", "", "1.34", "5.77E-01", "2.00", "7.60E-01", "1.67"], ["Rac Signaling", "", "4.67E-01", "2.14", "1.70E-01", "1.13", "5.31E-01", "1.64"], ["Cholecystokinin/Gastrin-mediated Signaling", "0.69", "7.80E-01", "2.31", "2.57E-01", "1.89", "4.75E-01", "1.63"], ["VDR/RXR Activation", "0.82", "1.19E-01", "1.67", "2.34E-01", "2.24", "2.82E-01", "1.58"], ["NF-κB Signaling", "0.54", "2.57E-01", "3.27", "2.75E-01", "0.91", "4.34E-01", "1.57"], ["iNOS Signaling", "1.00", "1.14E-01", "2.00", "3.21E-01", "", "", "1.50"], ["Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses", "−0.28", "1.66E-01", "3.21", "4.37E-01", "", "4.84E-01", "1.47"], ["Ephrin Receptor Signaling", "", "", "0.82", "3.93E-01", "2.00", "5.85E-01", "1.41"], ["Agrin Interactions at Neuromuscular Junction", "0.38", "5.27E-01", "2.00", "5.86E-01", "1.63", "1.59E-01", "1.34"], ["Tec Kinase Signaling", "−1.21", "5.31E-01", "3.50", "7.80E-01", "1.41", "6.59E-01", "1.23"], ["ERK5 Signaling", "0.28", "8.32E-01", "1.41", "5.75E-01", "2.00", "5.51E-01", "1.23"], ["Production of Nitric Oxide and Reactive Oxygen Species in Macrophages", "−0.76", "1.90E-01", "3.15", "3.39E-01", "", "", "1.20"], ["UVA-Induced MAPK Signaling", "−2.67", "1.19E-01", "", "1.90E-01", "0.45", "5.51E-01", "1.11"], ["PI3K Signaling in B Lymphocytes", "−0.21", "2.57E-01", "2.36", "5.13E-01", "", "", "1.08"], ["Colorectal Cancer Metastasis Signaling", "−0.56", "2.18E-01", "2.70", "7.80E-01", "1.00", "3.70E-01", "1.05"], ["Basal Cell Carcinoma Signaling", "−0.45", "6.34E-01", "", "", "2.45", "3.70E-01", "1.00"], ["B Cell Receptor Signaling", "−0.58", "9.77E-01", "2.83", "8.71E-01", "0.71", "6.50E-01", "0.99"], ["Phospholipase C Signaling", "−1.41", "4.62E-01", "3.32", "5.32E-01", "1.00", "5.10E-01", "0.97"], ["Glioma Invasiveness Signaling", "−0.30", "2.69E-01", "2.11", "8.32E-01", "1.00", "1.38E-01", "0.94"], ["Oncostatin M Signaling", "−0.45", "4.23E-01", "2.24", "9.12E-01", "", "4.95E-01", "0.90"], ["Neuregulin Signaling", "−0.30", "3.13E-01", "2.00", "5.81E-01", "", "7.60E-01", "0.85"], ["JAK/Stat Signaling", "−2.00", "7.94E-01", "0.33", "8.32E-01", "", "", "0.84"], ["Calcium Signaling", "−2.11", "2.77E-01", "", "", "0.45", "1.38E-01", "0.83"], ["Role of RIG1-like Receptors in Antiviral Innate Immunity", "−0.45", "1.90E-01", "2.00", "5.75E-01", "", "", "0.78"], ["Type II Diabetes Mellitus Signaling", "−0.58", "3.36E-01", "2.12", "2.23E-01", "", "", "0.77"], ["PKCθ Signaling in T Lymphocytes", "−1.41", "1.66E-01", "2.50", "3.72E-01", "", "", "0.55"], ["NGF Signaling", "−2.13", "5.10E-01", "2.33", "2.85E-01", "1.34", "6.32E-01", "0.51"], ["Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes", "−1.73", "3.97E-01", "2.12", "2.31E-01", "1.13", "4.28E-01", "0.51"], ["Role of NFAT in Regulation of the Immune Response", "−1.50", "3.75E-01", "2.50", "6.92E-01", "", "", "0.50"], ["Cardiac Hypertrophy Signaling", "−2.40", "1.69E-01", "1.70", "4.00E-01", "2.14", "4.34E-01", "0.48"], ["Death Receptor Signaling", "−2.71", "3.36E-01", "0.28", "3.89E-01", "1.00", "7.24E-01", "0.48"], ["Wnt/Ca+ pathway", "−1.13", "4.67E-01", "0.45", "2.92E-01", "2.00", "5.10E-01", "0.44"], ["Gαq Signaling", "−2.36", "4.40E-01", "1.51", "2.39E-01", "", "", "0.43"], ["CNTF Signaling", "−2.11", "1.33E-01", "1.34", "3.51E-01", "", "5.26E-01", "0.39"], ["IL-8 Signaling", "−1.90", "4.19E-01", "2.00", "5.10E-01", "0.58", "4.70E-01", "0.23"], ["Integrin Signaling", "−2.68", "4.88E-01", "1.51", "4.99E-01", "1.39", "4.34E-01", "0.07"], ["Melanocyte Development and Pigmentation Signaling", "−2.32", "1.56E-01", "1.34", "4.90E-01", "0.82", "4.34E-01", "0.05"]], "row_count": 62, "column_count": 8, "numeric_cells": 368, "header_rows": 2, "locator": "section[4]/table-wrap[2]#t0010"}}, {"id": "asset:table:pmid:28932774:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:d775ce8ed5e2d05d6532c98101b8ea08d518c0dd20c250031bf502911fac9413", "bytes": 2503, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[4]/table-wrap[3]#t0015", "version": null, "note": "Canonical pathways of common genes ⁎.", "structure": {"pmcid": "PMC5596332", "section_index": 4, "section_title": "1. Data", "row_count": 30, "column_count": 4}, "table": {"label": "Table 3", "caption": "Canonical pathways of common genes ⁎.", "rows": [["Ingenuity Canonical Pathways", "z-score", "P-value", "Molecules"], ["Glioma Invasiveness Signaling", "2.00", "1.74E-03", "PIK3CA, ITGAV, PLAUR, CD44"], ["IL-6 Signaling", "2.00", "2.00E-03", "IL18, PIK3CA, SRF, CD14, IL33"], ["Acute Phase Response Signaling", "2.00", "2.57E-02", "IL18, PIK3CA, SERPINE1, IL33"], ["NF-κB Signaling", "2.00", "3.16E-02", "IL18, PIK3CA, BMP2, IL33"], ["PDGF Signaling", "1.00", "3.63E-03", "PIK3CA, SRF, SPHK1, PDGFC"], ["LXR/RXR Activation", "−1.00", "7.41E-03", "IL18, CD14, ARG2, IL33"], ["Atherosclerosis Signaling", "", "1.05E-03", "IL18, TNFRSF12A, MMP1, IL33, PDGFC"], ["HIF1α Signaling", "", "1.07E-03", "PIK3CA, LDHA, SLC2A1, MMP1, PDGFC"], ["GDP-glucose Biosynthesis", "", "1.10E-03", "HK2, PGM5"], ["IL-10 Signaling", "", "1.23E-03", "IL18, CD14, ARG2, IL33"], ["Hepatic Fibrosis / Hepatic Stellate Cell Activation", "", "1.29E-03", "BAMBI, CD14, SERPINE1, AGTR1, MMP1, PDGFC"], ["Glucose and Glucose-1-phosphate Degradation", "", "1.45E-03", "HK2, PGM5"], ["Bladder Cancer Signaling", "", "2.34E-03", "CDKN1A, THBS1, MMP1, PDGFC"], ["Human Embryonic Stem Cell Pluripotency", "", "2.57E-03", "INHBA, PIK3CA, SPHK1, BMP2, PDGFC"], ["TGF-β Signaling", "", "3.24E-03", "INHBA, TGIF1, SERPINE1, BMP2"], ["Granulocyte Adhesion and Diapedesis", "", "3.80E-03", "IL18, SDC4, CLDN1, MMP1, IL33"], ["Agranulocyte Adhesion and Diapedesis", "", "4.79E-03", "IL18, SDC4, CLDN1, MMP1, IL33"], ["Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis", "", "4.79E-03", "IL18, PIK3CA, BMP2, SPP1, MMP1, IL33"], ["Role of Tissue Factor in Cancer", "", "1.07E-02", "PIK3CA, ITGAV, PLAUR, MMP1"], ["LPS/IL-1 Mediated Inhibition of RXR Function", "", "1.12E-02", "IL18, CD14, HS3ST5, NR5A2, IL33"], ["VDR/RXR Activation", "", "1.41E-02", "CD14, CDKN1A, SPP1"], ["Altered T Cell and B Cell Signaling in Rheumatoid Arthritis", "", "1.41E-02", "IL18, SPP1, IL33"], ["Palmitate Biosynthesis I (Animals)", "", "1.45E-02", "OXSM"], ["Fatty Acid Biosynthesis Initiation II", "", "1.45E-02", "OXSM"], ["Toll-like Receptor Signaling", "", "1.48E-02", "IL18, CD14, IL33"], ["Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza", "", "1.78E-02", "IL18, IL33"], ["Graft-versus-Host Disease Signaling", "", "1.91E-02", "IL18, IL33"], ["Macropinocytosis Signaling", "", "1.95E-02", "PIK3CA, CD14, PDGFC"], ["Hepatic Cholestasis", "", "2.00E-02", "IL18, CD14, NR5A2, IL33"]], "row_count": 30, "column_count": 4, "numeric_cells": 58, "header_rows": 1, "locator": "section[4]/table-wrap[3]#t0015"}}, {"id": "asset:table:pmid:28932774:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:3fa5bfce73ac93ebd46c9e7585fa3c3696371c3be26ddd3a2f87bac9067bfcee", "bytes": 3474, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[4]/table-wrap[4]#t0020", "version": null, "note": "Comparison of bioinformatic tools ⁎.", "structure": {"pmcid": "PMC5596332", "section_index": 4, "section_title": "1. Data", "row_count": 56, "column_count": 5}, "table": {"label": "Table 4", "caption": "Comparison of bioinformatic tools ⁎.", "rows": [["", "DAVID (124/124)", "IPA (116/124)", "Panther (94/124)", "String (93/124)"], ["Canonical Pathways", "P-value", "P-value", "P-value", "False Discovery Rate"], ["TGF-beta signaling pathway", "5.20E-03", "3.24E-03", "2.21E-02", "2.94E-02"], ["p53 signaling pathway", "2.20E-02", "3.89E-02", "", "2.26E-02"], ["Proteoglycans in cancer", "1.50E-03", "", "", "8.24E-03"], ["HIF-1 signaling pathway", "9.50E-03", "1.07E-03", "", ""], ["ECM-receptor interaction", "6.10E-03", "", "", "8.24E-03"], ["Bladder cancer", "4.50E-02", "2.34E-03", "", ""], ["Atherosclerosis Signaling", "", "1.05E-03", "", ""], ["GDP-glucose Biosynthesis", "", "1.10E-03", "", ""], ["IL-10 Signaling", "", "1.23E-03", "", ""], ["Hepatic Fibrosis/Hepatic Stellate Cell Activation", "", "1.29E-03", "", ""], ["Glucose and Glucose-1-phosphate Degradation", "", "1.45E-03", "", ""], ["Glioma Invasiveness Signaling", "", "1.74E-03", "", ""], ["Human Embryonic Stem Cell Pluripotency", "", "2.57E-03", "", ""], ["PDGF Signaling", "", "3.63E-03", "", ""], ["Granulocyte Adhesion and Diapedesis", "", "3.80E-03", "", ""], ["Agranulocyte Adhesion and Diapedesis", "", "4.79E-03", "", ""], ["Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis", "", "4.79E-03", "", ""], ["Plasminogen activating cascade", "", "", "7.05E-03", ""], ["LXR/RXR Activation", "", "7.41E-03", "", ""], ["Role of Tissue Factor in Cancer", "", "1.07E-02", "", ""], ["LPS/IL-1 Mediated Inhibition of RXR Function", "", "1.12E-02", "", ""], ["VDR/RXR Activation", "", "1.41E-02", "", ""], ["Altered T Cell and B Cell Signaling in Rheumatoid Arthritis", "", "1.41E-02", "", ""], ["Palmitate Biosynthesis I (Animals)", "", "1.45E-02", "", ""], ["Fatty Acid Biosynthesis Initiation II", "", "1.45E-02", "", ""], ["Toll-like Receptor Signaling", "", "1.48E-02", "", ""], ["Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza", "", "1.78E-02", "", ""], ["Graft-versus-Host Disease Signaling", "", "1.91E-02", "", ""], ["Macropinocytosis Signaling", "", "1.95E-02", "", ""], ["Hepatic Cholestasis", "", "2.00E-02", "", ""], ["Coagulation System", "", "2.40E-02", "", ""], ["LPS-stimulated MAPK Signaling", "", "2.45E-02", "", ""], ["PPAR Signaling", "", "2.45E-02", "", ""], ["Acute Phase Response Signaling", "", "2.57E-02", "", ""], ["HER-2 Signaling in Breast Cancer", "", "2.57E-02", "", ""], ["RNA degradation", "2.60E-02", "", "", ""], ["Role of Cytokines in Mediating Communication between Immune Cells", "", "2.69E-02", "", ""], ["Prostate Cancer Signaling", "", "2.75E-02", "", ""], ["Aldosterone Signaling in Epithelial Cells", "", "2.75E-02", "", ""], ["Trehalose Degradation II (Trehalase)", "", "2.88E-02", "", ""], ["Pyruvate Fermentation to Lactate", "", "2.88E-02", "", ""], ["Arginine Degradation I (Arginase Pathway)", "", "2.88E-02", "", ""], ["NF-κB Signaling", "", "3.16E-02", "", ""], ["tRNA Splicing", "", "3.16E-02", "", ""], ["Cholecystokinin/Gastrin-mediated Signaling", "", "3.31E-02", "", ""], ["Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency", "", "3.80E-02", "", ""], ["Glucocorticoid Receptor Signaling", "", "3.98E-02", "", ""], ["Nitric Oxide Signaling in the Cardiovascular System", "", "3.98E-02", "", ""], ["Glioma Signaling", "", "4.27E-02", "", ""], ["Urea Cycle", "", "4.27E-02", "", ""], ["Arginine Degradation VI (Arginase 2 Pathway)", "", "4.27E-02", "", ""], ["Pentose Phosphate Pathway (Non-oxidative Branch)", "", "4.27E-02", "", ""], ["p38 MAPK Signaling", "", "4.47E-02", "", ""], ["FXR/RXR Activation", "", "4.68E-02", "", ""]], "row_count": 56, "column_count": 5, "numeric_cells": 75, "header_rows": 2, "locator": "section[4]/table-wrap[4]#t0020"}}], "gaps": ["asset:data:geo:GSE23348 not downloaded", "asset:data:geo:GSE23348 licence not read", "asset:data:geo:GSE27961 not downloaded", 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