Correlations Between mRNA Levels of Centrosomal Protein 55 (CEP55) and Clinical Features of Patients with Lung Cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:29750778", "kind": "science-record", "revision": 7, "content_hash": "sha256:31b96081d3c3bbcafc167e93fb4cf031af37364e890700f748c23f122f9dd05f", "created_at": "2026-11-01T15:40:33Z", "updated_at": "2026-11-01T21:21:25Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Correlations Between mRNA Levels of Centrosomal Protein 55 (CEP55) and Clinical Features of Patients with Lung Cancer.", "doi": "10.12659/MSM.907266", "pmid": "29750778", "authors": ["Xue-Ping Ma", "Wenping Zhang", "Bu-Qiang Wu", "Jun Qin"], "journal": "Medical science monitor : international medical journal of experimental and clinical research", "year": 2018, "abstract": "BACKGROUND The aim of this study was to investigate the prognostic relevance of CEP55 in lung cancer (LC). MATERIAL AND METHODS LC microarray profile GSE30219 was obtained from the GEO database. The 2-sample t test was performed to clarify the difference in CEP55 expression between LC and normal lung tissue. The chi-square test and logistic regression analysis were preformed to investigate the relationship between CEP55 expression and the clinical features of LC patients. Log-rank test and Cox proportional hazards regression analysis were conducted to evaluate the disease-free survival (DFS) and overall survival (OS) of LC patients. Gene set enrichment analysis was conducted to investigate the related mechanisms. RESULTS CEP55 was significantly increased in LC cells relative to normal lung tissues (P<0.0001). Univariate and multivariate correlation analyses demonstrated that CEP55 expression was associated with advanced T and N staging of LC (P<0.0001). Survival analyses indicated that CEP55 expression was an independent risk factor for DFS (HR: 1.515, 95% CI: 1.277-1.797, P<0.0001) and OS (HR: 1.436, 95% CI: 1.278-1.615). CEP55 might affect the proliferation of LC cells through Myc signaling, DNA repair, and G2M checkpoint. CONCLUSIONS Our results indicated that CEP55 was increased in LC cells and was associated with poor clinical outcomes of LC patients, and could be a prognostic biomarker for LC.", "claims": [{"id": "claim-method", "statement": "We used the log-rank test to evaluate the disease-free survival (DFS) and overall survival (OS) in these 2 groups, and Kaplan-Meier plots of DFS and OS were generated for LC patients in the CEP55 low-expression group and CEP55 high-expression group.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:29750778", "locator": "sections[4] \"Statistical analysis\" paragraph 2", "quote": "We used the log-rank test to evaluate the disease-free survival (DFS) and overall survival (OS) in these 2 groups, and Kaplan-Meier plots of DFS and OS were generated for LC patients in the CEP55 low-expression group and CEP55 high-expression group."}], "state": "complete"}, {"id": "claim-data-access", "statement": "We selected the LC microarray GSE30219 [13], obtained from Gene Expression Omnibus (GEO) (https://www.ncbi.nlm.nih.gov/geo/) database, to conduct our analysis.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:29750778", "locator": "sections[3] \"LC microarray\" paragraph 2", "quote": "We selected the LC microarray GSE30219 [13], obtained from Gene Expression Omnibus (GEO) (https://www.ncbi.nlm.nih.gov/geo/) database, to conduct our analysis."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:29750778"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE30219"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE30219"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:29750778", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.12659/MSM.907266", "sha256": 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"note": "Gene sets enriched in CEP55 high expression group.", "structure": {"pmcid": "PMC5973496", "section_index": 9, "section_title": "Gene sets enriched in the CEP55 high-expression group", "row_count": 5, "column_count": 5}, "table": {"label": "Table 3", "caption": "Gene sets enriched in CEP55 high expression group.", "rows": [["Gene set", "ES", "NES", "NOM p-val", "FDR q-val"], ["Myc targets_v1", "−0.58652", "−1.73688", "0.019342", "0.152046"], ["Myc targets_v2", "−0.73024", "−1.68969", "0.009804", "0.1162"], ["DNA repair", "−0.4043", "−1.58924", "0.046875", "0.205288"], ["G2M checkpoint", "−0.72575", "−1.56384", "0.033531", "0.196249"]], "row_count": 5, "column_count": 5, "numeric_cells": 16, "header_rows": 1, "locator": "section[9]/table-wrap[1]#t3-medscimonit-24-3093"}}], "gaps": ["asset:data:geo:GSE30219 not downloaded", "asset:data:geo:GSE30219 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": 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The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE30219"], "resolved_accessions": ["GSE30219"], "statements": ["We selected the LC microarray GSE30219 [13], obtained from Gene Expression Omnibus (GEO) (https://www.ncbi.nlm.nih.gov/geo/) database, to conduct our analysis."], "basis": "The paper names GSE30219 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["survival_km"], "assets": ["source:pmid:29750778", "data:geo:GSE30219", "asset:table:pmid:29750778:1", "asset:table:pmid:29750778:2", "asset:table:pmid:29750778:3"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE30219"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": null, "independence": "same_provider"}, "evidence_check": {"method": "verbatim", "availability": null}, "calls": 0, "usage": {}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:29750778", "type": "paper", "label": "pmid:29750778"}, {"id": "source:pmid:29750778", "type": "manuscript", "label": "PMID 29750778 full text"}, {"id": "data:geo:GSE30219", "type": "dataset", "label": "GEO GSE30219"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:29750778", "type": "paper", "label": "pmid:29750778"}, {"id": "source:pmid:29750778", "type": "manuscript", "label": "PMID 29750778 full text"}, {"id": "data:geo:GSE30219", "type": "dataset", "label": "GEO GSE30219"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-29750778", "type": "extraction", "used": ["source:pmid:29750778"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE30219", "type": "accession_resolution", "used": ["data:geo:GSE30219"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:29750778", "parent_hash": "sha256:d5e9aedf476654918d87ab1cd36477dd4bb0807de744612826f66291160d59e0", "fork_of": null, "generation": 6}, "gaps": ["asset:data:geo:GSE30219 licence not read", "asset:data:geo:GSE30219 not downloaded", "execution.not_run", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "microarray", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.93, "evidence": ["in lung cancer (LC). MATERIAL AND METHODS LC microarray profile GSE30219 was obtained from the GEO d"], "order_basis": "paper_text_order:205", "id": "assay:1"}, {"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["survival_km"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["We used the log-rank test to evaluate the disease-free survival (DFS) and overall survival (OS) in these 2 groups, and Kaplan-Meier plots of DFS and OS were generated for LC patients in the CEP55 low-expression group and CEP55 high-expression group."], "order_basis": "consumes_earlier_output", "id": "assay:2"}]}