Identification of LINC01279 as a cell cycle‑associated long non‑coding RNA in endometriosis with GBA analysis.

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Elucidating the mechanisms is urgently required for improving the therapeutic efficiency of endometriosis treatment. Long non‑coding RNAs (lncRNAs) have recently acquired extensive attention as regulatory components in a variety of biological processes and diseases. However, the functions of many lncRNAs in endometriosis are poorly understood. Therefore, the exploration of the dysregulated genes in endometriosis, particularly lncRNAs, is of importance. In the present study, datasets for endometriosis, including GSE7305, GSE7846, GSE29981 and E‑MTAB‑694, were downloaded from Gene Expression Omnibus and ArrayExpress. Then, the limma and Affy packages were used to analyze the CEL file. The RankProd method was used to conduct meta‑analysis. Long intergenic non‑protein coding RNA 1279 (LINC01279) was significantly upregulated in the three datasets, and was the most upregulated lncRNA as determined by the RankProd method. Gene set enrichment and Gene Ontology analyses were conducted, which revealed that LINC01279 is likely to function as a cell cycle mediator in endometriosis. Finally, it was identified that LINC01279 is strongly associated with certain previously identified key factors in the development of endometriosis, including cyclin‑dependent kinase 14 and C‑X‑C motif chemokine ligand 12. Thus, it was demonstrated that LINC01279 may be associated with the pathogenesis of endometriosis. This may potentially represent a target in the therapy of endometriosis.", "claims": [{"id": "claim-method", "statement": "Meta-analysis was performed for the GSE7305, GSE7846 and E-MTAB-694 which contain normal samples and endometriosis using the RankProd package (22) to identify the upregulated and downregulated genes between normal endometrial tissue and endometriosis.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30106115", "locator": "sections[6] \"Meta-analysis of multiple microarray datasets\" paragraph 2", "quote": "Meta-analysis was performed for the GSE7305, GSE7846 and E-MTAB-694 which contain normal samples and endometriosis using the RankProd package (22) to identify the upregulated and downregulated genes between normal endometrial tissue and endometriosis."}], "state": "complete"}, {"id": "claim-data-access", "statement": "All data generated or analyzed during this study are included in this published article.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30106115", "locator": "sections[17] \"Availability of data and materials\" paragraph 2", "quote": "All data generated or analyzed during this study are included in this published article."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The study used the RankProd meta-analysis method on microarray datasets downloaded from Gene Expression Omnibus and ArrayExpress, identifying LINC01279 as significantly upregulated and the most upregulated lncRNA in endometriosis.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:30106115", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Then, the limma and Affy packages were used to analyze the CEL file. The RankProd method was used to conduct meta-analysis."}, {"asset": "source:pmid:30106115", "locator": "sections[0] \"Abstract\" paragraph 1", "quote": "Long intergenic non-protein coding RNA 1279 (LINC01279) was significantly upregulated in the three datasets, and was the most upregulated lncRNA as determined by the RankProd method."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "The study used the RankProd meta-analysis method on microarray datasets downloaded from Gene Expression Omnibus and ArrayExpress, identifying LINC01279 as significantly upregulated and the most upregulated lncRNA in endometriosis.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:30106115"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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