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pmid:30148168
Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
Xiaojing Ren · Yuanyuan Ji · Xuhua Jiang · Xun Qi
BioMed research international · 2018 doi:10.1155/2018/5859415
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Complete file
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HCC patients with CYP2A6 and CYP2C8 low levels in tumor tissues suffered from poorer overall survival (OS) compared to those with high CYP2A6 and CYP2C8 in GSE14520 profile (log ranks P = 0.01 and P = 0.006, respectively). In addition, HCC patients with lower CYP2A6 and CYP2C8 in tumors had worse recurrence-free survival (RFS) than those with higher CYP2A6 and CYP2C8 (log ranks P = 0.02 and P = 0.012, respectively). In GSE36376 validation dataset, HCC patients with lower CYP2A6 and CYP2C8 had worse OS and RFS than those with higher CYP2A6 and CYP2C8 (all P < 0.05), in line with results in GSE14520 dataset. Additionally, lower CYP2A6 and CYP2C8 are associated with advanced clinicopathological features including tumor staging, vascular invasion, intrahepatic metastasis, and high alpha fetoprotein (all P < 0.05).\nCONCLUSION: Downregulation of CYP2A6 and CYP2C8 in tumor tissues links to poorer OS and RFS in HCC patients.", "claims": [{"id": "claim-method", "statement": "Student's t-test was used to compare means for normally distributed continuous data, and the Mann–Whitney U test was used for nonnormally distributed continuous data and the Chi-squared test was used for categorical variables. The Kaplan–Meier method was used to compare survivals between different groups, and the log-rank test was used to estimate the difference in survival.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30148168", "locator": "sections[7] \"2.5. 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