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pmid:30158148

Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis.

BMJ (Clinical research ed.) · 2018 doi:10.1136/bmj.k3310

Paper

partial

Experiment

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Data

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Analysis

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Execution

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Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis.
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10.1136/bmj.k3310
pmid
30158148
authors
null
journal
BMJ (Clinical research ed.)
year
2018
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null
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the pooled relative risk of cardiovascular disease for lead comparing top versus bottom thirds of baseline levels
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Comparing top versus bottom thirds of baseline levels, pooled relative risks for arsenic and lead were 1.30 (95% confidence interval 1.04 to 1.63) and 1.43 (1.16 to 1.76) for cardiovascular disease
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the pooled relative risk of cardiovascular disease for lead comparing top versus bottom thirds of baseline levels
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Study level characteristics
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Summary of the studies included in the systematic review
rows array · 54 items
[0] array · 11 items
[0]
Study or lead author (Publication year)
[1]
Country
[2]
Population source
[3]
Study design
[4]
Baseline survey
[5]
Mean age
[6]
Male (%)
[7]
Total follow-up (Years)
[8]
No of participants
[9]
[10]
No of cases
[1] array · 3 items
[0]
CVD
[1]
CHD
[2]
Stroke
[2] array · 1 item
[0]
Arsenic
[3] array · 13 items
[0]
Afridi (2011)31
[1]
Pakistan
[2]
Hospital records
[3]
Case-control
[4]
2007-2008
[5]
45-60 *
[6]
52
[7]
NA
[8]
119
[9]
[10]
0
[11]
58
[12]
0
[4] array · 13 items
[0]
Chen (1996)† 2 32
[1]
Taiwan
[2]
General
[3]
Prospective cohort
[4]
1988-1989
[5]
NR
[6]
46
[7]
7
[8]
1760
[9]
[10]
0
[11]
39
[12]
0
[5] array · 13 items
[0]
DCH (2017)33
[1]
Denmark
[2]
Cancer register
[3]
Prospectivecohort
[4]
1993-1997
[5]
50-64*
[6]
46.9
[7]
14.8
[8]
53 856
[9]
[10]
0
[11]
2707
[12]
0
[6] array · 13 items
[0]
HEALS34
[1]
Bangladesh
[2]
General
[3]
Prospective cohort
[4]
2000-2002
[5]
18-75*
[6]
43
[7]
9
[8]
11 109
[9]
[10]
192
[11]
101
[12]
82
[7] array · 13 items
[0]
Liao (2012)† 2 35
[1]
Taiwan
[2]
General
[3]
Case-control
[4]
2002
[5]
61
[6]
43
[7]
7
[8]
676
[9]
[10]
10
[11]
0
[12]
0
[8] array · 13 items
[0]
NHSCS36
[1]
USA
[2]
Cancer register
[3]
Prospective Cohort
[4]
1993-1995
[5]
59
[6]
56
[7]
20
[8]
3939
[9]
[10]
312
[11]
154
[12]
43
[9] array · 13 items
[0]
Ruiz-Navarro (1998)37
[1]
Spain
[2]
Hospital records
[3]
Case-control
[4]
NR
[5]
NR
[6]
39
[7]
NA
[8]
78
[9]
[10]
0
[11]
29
[12]
0
[10] array · 13 items
[0]
SHS38
[1]
USA
[2]
Health survey
[3]
Prospective Cohort
[4]
1989-1991
[5]
45-74*
[6]
40
[7]
19
[8]
3575
[9]
[10]
1184
[11]
846
[12]
264
[11] array · 13 items
[0]
SLVDS39
[1]
USA
[2]
Hospital based
[3]
Case-cohort
[4]
1984-1998
[5]
57‡
[6]
48
[7]
14
[8]
555
[9]
[10]
0
[11]
96
[12]
0
[12] array · 13 items
[0]
Sohel (2009)40
[1]
Bangladesh
[2]
Health survey
[3]
Prospective cohort
[4]
1991-2000
[5]
>15
[6]
50
[7]
9
[8]
115 903
[9]
[10]
1211
[11]
639
[12]
572
[13] array · 13 items
[0]
Wade (2015)41
[1]
China
[2]
Hospital records
[3]
Case-control
[4]
NR
[5]
21-70*
[6]
69
[7]
NA
[8]
533
[9]
[10]
277
[11]
0
[12]
0
[14] array · 13 items
[0]
Wu (2010)†1 42
[1]
Taiwan
[2]
Household records
[3]
Prospective cohort
[4]
1991-1994
[5]
>40
[6]
47
[7]
11
[8]
504
[9]
[10]
22
[11]
0
[12]
0
[15] array · 1 item
[0]
Lead
[16] array · 13 items
[0]
ABLES43
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1987-2005
[5]
39
[6]
100
[7]
17
[8]
58 368
[9]
[10]
692
[11]
569
[12]
123
[17] array · 13 items
[0]
BRHS44
[1]
UK
[2]
Registers
[3]
Prospective cohort
[4]
1978-1980
[5]
40-59
[6]
100
[7]
7
[8]
7379
[9]
[10]
382
[11]
316
[12]
66
[18] array · 13 items
[0]
McElvenny (2015)45
[1]
UK
[2]
Health survey
[3]
Prospective cohort
[4]
1975-1979
[5]
35
[6]
85
[7]
36
[8]
9122
[9]
[10]
941
[11]
792
[12]
149
[19] array · 13 items
[0]
Moller (1992)46
[1]
Denmark
[2]
Hospital records
[3]
Prospective cohort
[4]
1976
[5]
40
[6]
48
[7]
14
[8]
1045
[9]
[10]
54
[11]
40
[12]
0
[20] array · 13 items
[0]
NHANES II47
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1976-1980
[5]
54
[6]
47
[7]
16
[8]
4190
[9]
[10]
424
[11]
0
[12]
0
[21] array · 13 items
[0]
NHANES III†4 48
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1988-1994
[5]
58
[6]
48
[7]
12
[8]
9757
[9]
[10]
1189
[11]
0
[12]
0
[22] array · 13 items
[0]
NHANES III†4 49
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1988-1994
[5]
44
[6]
47
[7]
12
[8]
13 946
[9]
[10]
0
[11]
367
[12]
141
[23] array · 13 items
[0]
NHANES III†4 50
[1]
USA
[2]
Health Survey
[3]
Prospective cohort
[4]
1999-2010
[5]
58
[6]
47.6
[7]
12
[8]
18602
[9]
[10]
985
[11]
0
[12]
0
[24] array · 13 items
[0]
SOF51
[1]
USA
[2]
General
[3]
Prospective cohort
[4]
1990-1991
[5]
70
[6]
0
[7]
13
[8]
533
[9]
[10]
54
[11]
23
[12]
21
[25] array · 13 items
[0]
VA-NAS52
[1]
USA
[2]
Health screening
[3]
Prospective cohort
[4]
1991-1999
[5]
67
[6]
100
[7]
16
[8]
1235
[9]
[10]
185
[11]
82
[12]
0
[26] array · 13 items
[0]
Earlier randomised26
[1]
Netherlands
[2]
Health survey
[3]
Prospective cohort
[4]
1977-1978
[5]
57-76*
[6]
100
[7]
8
[8]
146
[9]
[10]
64
[11]
39
[12]
18
[27] array · 1 item
[0]
Cadmium
[28] array · 13 items
[0]
CadmiBel53
[1]
Belgium
[2]
Population registers
[3]
Prospective cohort
[4]
1985-1989
[5]
47
[6]
45
[7]
22
[8]
956
[9]
[10]
88
[11]
56
[12]
21
[29] array · 13 items
[0]
HPFS54
[1]
USA
[2]
Health professionals
[3]
Nested case-control
[4]
1987
[5]
62‡
[6]
100
[7]
5
[8]
884
[9]
[10]
0
[11]
442
[12]
0
[30] array · 13 items
[0]
Li (2011)55
[1]
Japan
[2]
Health survey
[3]
Prospective cohort
[4]
1981-1982
[5]
>50
[6]
45
[7]
22
[8]
3119
[9]
[10]
267
[11]
0
[12]
217
[31] array · 13 items
[0]
MDCS56
[1]
Sweden
[2]
Health study
[3]
Prospective cohort
[4]
1991-1994
[5]
46-67*
[6]
41
[7]
17
[8]
4819
[9]
[10]
713
[11]
377
[12]
336
[32] array · 13 items
[0]
NHANES (1999-2004)† 3 57
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1999-2004
[5]
>20
[6]
48
[7]
7
[8]
8989
[9]
[10]
191
[11]
88
[12]
0
[33] array · 13 items
[0]
NHANES III58
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1988-1994
[5]
>20
[6]
47
[7]
12
[8]
13 958
[9]
[10]
769
[11]
367
[12]
0
[34] array · 13 items
[0]
NHANES III50
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1999-2010
[5]
58
[6]
48
[7]
12
[8]
18602
[9]
[10]
985
[11]
0
[12]
0
[35] array · 13 items
[0]
SHS59
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1989-1991
[5]
56
[6]
40
[7]
19
[8]
3348
[9]
[10]
1010
[11]
766
[12]
244
[36] array · 1 item
[0]
Mercury
[37] array · 13 items
[0]
EURAMIC60
[1]
Multinational
[2]
Population registers and hospital records
[3]
Case-control
[4]
1991-1992
[5]
≤70
[6]
100
[7]
NA
[8]
1408
[9]
[10]
0
[11]
684
[12]
0
[38] array · 13 items
[0]
Gothenburg61
[1]
Sweden
[2]
Health study
[3]
Prospective cohort
[4]
1968-1969
[5]
38-60*
[6]
0
[7]
32
[8]
1391
[9]
[10]
301
[11]
128
[12]
173
[39] array · 13 items
[0]
Hallgren (2001)†5 62
[1]
Sweden
[2]
Health survey
[3]
Nested case-control
[4]
1985-1994
[5]
55
[6]
79
[7]
9
[8]
234
[9]
[10]
0
[11]
78
[12]
0
[40] array · 13 items
[0]
HPFS and NHS63
[1]
USA
[2]
Health professionals
[3]
Nested case-control
[4]
1976 and 1986
[5]
56
[6]
35
[7]
15.3
[8]
6854
[9]
[10]
3427
[11]
2363
[12]
1064
[41] array · 13 items
[0]
KIHD†6 64
[1]
Finland
[2]
General
[3]
Prospective cohort
[4]
1984-1989
[5]
52
[6]
100
[7]
17.8
[8]
1871
[9]
[10]
414
[11]
282
[12]
0
[42] array · 13 items
[0]
KIHD (2016)† § 6 65
[1]
Finland
[2]
General
[3]
Prospective cohort
[4]
1984-1989
[5]
42-60*
[6]
100
[7]
21.2
[8]
2682
[9]
[10]
0
[11]
0
[12]
202
[43] array · 13 items
[0]
NSHDS†§ 5 66
[1]
Sweden
[2]
Health surveys
[3]
Nested case-control
[4]
1994-1999
[5]
NR
[6]
75
[7]
5
[8]
930
[9]
[10]
0
[11]
431
[12]
0
[44] array · 13 items
[0]
NSHDS†§ 5 67
[1]
Sweden
[2]
Health surveys
[3]
Nested case-control
[4]
1985-2000
[5]
55
[6]
60
[7]
15
[8]
2271
[9]
[10]
878
[11]
0
[12]
369
[45] array · 13 items
[0]
PREDIMED68
[1]
Spain
[2]
Primary care centres
[3]
Nested case-control
[4]
2003-2009
[5]
55-80*
[6]
59
[7]
4.8
[8]
414
[9]
[10]
147
[11]
0
[12]
0
[46] array · 1 item
[0]
Copper
[47] array · 13 items
[0]
EPOZ69
[1]
Netherlands
[2]
Health survey
[3]
Nested case-control
[4]
1975-1978
[5]
68
[6]
53
[7]
9
[8]
186
[9]
[10]
62
[11]
0
[12]
0
[48] array · 13 items
[0]
KIHD70
[1]
Finland
[2]
General
[3]
Prospective cohort
[4]
1984-1988
[5]
52
[6]
100
[7]
5.75
[8]
1666
[9]
[10]
0
[11]
51
[12]
0
[49] array · 13 items
[0]
Marniemi (2005)71
[1]
Finland
[2]
Health survey
[3]
Prospective cohort
[4]
1986-1987
[5]
65-99*
[6]
48
[7]
10
[8]
660
[9]
[10]
200
[11]
130
[12]
70
[50] array · 13 items
[0]
NHANES II72
[1]
USA
[2]
Health survey
[3]
Prospective cohort
[4]
1976-1980
[5]
48
[6]
46
[7]
12
[8]
4574
[9]
[10]
0
[11]
151
[12]
0
[51] array · 13 items
[0]
PPS II73
[1]
France
[2]
Public employees
[3]
Prospective cohort
[4]
1980-1985
[5]
43
[6]
100
[7]
21
[8]
4035
[9]
[10]
56
[11]
0
[12]
0
[52] array · 13 items
[0]
Reunanen (1996)74
[1]
Finland
[2]
Screening programme
[3]
Nested case-control
[4]
1981
[5]
15-69*
[6]
100
[7]
10
[8]
504
[9]
[10]
220
[11]
160
[12]
30
[53] array · 13 items
[0]
Overall total¶
[1]
[2]
[3]
[4]
[5]
[6]
[7]
[8]
348 259
[9]
[10]
15 274
[11]
13 033
[12]
4205
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54
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13
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409
header_rows
2
locator
section[9]/table-wrap[1]#tbl1
[4] object · 16 fields
id
asset:table:pmid:30158148:2
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table
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jats-table
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application/vnd.jats.table+json
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null
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sha256:52b3e54f8821696b55c96d07dbe5887d71ccc146767d5549706b6fe8a8ceadd8
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verified
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read_table
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available
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section[9]/table-wrap[2]#tbl2
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null
note
Newcastle-Ottawa scale for assessing cohort study quality
structure object · 5 fields
pmcid
PMC6113772
section_index
9
section_title
Study level characteristics
row_count
33
column_count
5
table object · 8 fields
label
Table 2
caption
Newcastle-Ottawa scale for assessing cohort study quality
rows array · 33 items
[0] array · 5 items
[0]
Author, year (Pubmed ID)
[1]
Selection(Max=4)
[2]
Comparability(Max=2)
[3]
Outcome(Max=3)
[4]
Overall quality score (Max=9)
[1] array · 5 items
[0]
Aoki, 2016 (26735529)
[1]
3
[2]
2
[3]
3
[4]
8
[2] array · 5 items
[0]
Barregard, 2015 (26517380)
[1]
3
[2]
2
[3]
3
[4]
8
[3] array · 5 items
[0]
Bergdahl, 2013 (22350276)*
[1]
2
[2]
2
[3]
3
[4]
7
[4] array · 5 items
[0]
Chen, 2011 (21546419)
[1]
3
[2]
2
[3]
3
[4]
8
[5] array · 5 items
[0]
Chen, 1996 (8624771)
[1]
1
[2]
2
[3]
3
[4]
6
[6] array · 5 items
[0]
Chowdhury, 2014 (24769120)
[1]
1
[2]
1
[3]
3
[4]
5
[7] array · 5 items
[0]
Daneshmand. 2016 (26991769)*
[1]
3
[2]
2
[3]
3
[4]
8
[8] array · 5 items
[0]
Farzan, 2015 (26048586)
[1]
2
[2]
2
[3]
3
[4]
7
[9] array · 5 items
[0]
Ford, 2000 (10905530)
[1]
4
[2]
2
[3]
3
[4]
9
[10] array · 5 items
[0]
Khalil, 2009 (19344498)
[1]
2
[2]
2
[3]
3
[4]
7
[11] array · 5 items
[0]
Kromhout 1988, (3203644)
[1]
3
[2]
2
[3]
1
[4]
7
[12] array · 5 items
[0]
Leone, 2006 (16570028)
[1]
2
[2]
2
[3]
2
[4]
6
[13] array · 5 items
[0]
Li, 2011 (22340168)*
[1]
3
[2]
1
[3]
3
[4]
7
[14] array · 5 items
[0]
Liao, 2012 (22569360)
[1]
1
[2]
2
[3]
2
[4]
5
[15] array · 5 items
[0]
Lustberg, 2002 (12437403)
[1]
3
[2]
2
[3]
3
[4]
8
[16] array · 5 items
[0]
Marniemi, 2005 (15955467)
[1]
3
[2]
2
[3]
2
[4]
7
[17] array · 5 items
[0]
McElvenny, 2015 (25872777)
[1]
2
[2]
1
[3]
2
[4]
5
[18] array · 5 items
[0]
Menke 2006, (16982939)
[1]
3
[2]
2
[3]
3
[4]
8
[19] array · 5 items
[0]
Menke, 2009 (19270787)
[1]
4
[2]
2
[3]
3
[4]
9
[20] array · 5 items
[0]
Moller, 1992 (1462969)
[1]
4
[2]
2
[3]
1
[4]
7
[21] array · 5 items
[0]
Monrad, 2017 (28157645)
[1]
2
[2]
2
[3]
2
[4]
6
[22] array · 5 items
[0]
Moon, 2013 (24061511)
[1]
3
[2]
2
[3]
3
[4]
8
[23] array · 5 items
[0]
Nawrot, 2008 (19079711)
[1]
3
[2]
2
[3]
3
[4]
8
[24] array · 5 items
[0]
Pocock, 1988 (3203640)
[1]
3
[2]
1
[3]
3
[4]
7
[25] array · 5 items
[0]
Salonen, 1991 (1877585)
[1]
3
[2]
2
[3]
2
[4]
7
[26] array · 5 items
[0]
Schober, 2006 (17035139)
[1]
3
[2]
2
[3]
2
[4]
7
[27] array · 5 items
[0]
Sohel, 2009 (19797964)
[1]
2
[2]
1
[3]
1
[4]
4
[28] array · 5 items
[0]
Tellez-Plaza, 2013 (23514838)
[1]
3
[2]
2
[3]
3
[4]
8
[29] array · 5 items
[0]
Tellez-Plaza, 2012 (22472185)
[1]
3
[2]
2
[3]
1
[4]
6
[30] array · 5 items
[0]
Virtanen, 2005 (15539625)
[1]
4
[2]
2
[3]
3
[4]
9
[31] array · 5 items
[0]
Weisskopf, 2009 (19738141)
[1]
2
[2]
2
[3]
2
[4]
6
[32] array · 5 items
[0]
Wu, 2010 (20708634)
[1]
1
[2]
2
[3]
3
[4]
6
row_count
33
column_count
5
numeric_cells
164
header_rows
1
locator
section[9]/table-wrap[2]#tbl2
[5] object · 16 fields
id
asset:table:pmid:30158148:3
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table
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jats-table
media_type
application/vnd.jats.table+json
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null
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sha256:2cbd2bda1e22752290f9288e45aa21d3a2eb085d6d7d540e77baf6fee939cbb1
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verified
reader
read_table
reader_status
available
identifier
section[9]/table-wrap[3]#tbl3
version
null
note
Newcastle-Ottawa scale for assessing case-control study quality
structure object · 5 fields
pmcid
PMC6113772
section_index
9
section_title
Study level characteristics
row_count
14
column_count
5
table object · 8 fields
label
Table 3
caption
Newcastle-Ottawa scale for assessing case-control study quality
rows array · 14 items
[0] array · 5 items
[0]
Author, year (Pubmed ID)
[1]
Selection(Max=4)
[2]
Comparability(Max=2)
[3]
Exposure(Max=3)
[4]
Overall quality score (Max=9)
[1] array · 5 items
[0]
Afridi, 2011 (20480400)
[1]
4
[2]
1
[3]
2
[4]
7
[2] array · 5 items
[0]
Downer, 2016 (28056794)
[1]
4
[2]
2
[3]
3
[4]
9
[3] array · 5 items
[0]
Guallar, 2005 (11570992)
[1]
2
[2]
2
[3]
2
[4]
6
[4] array · 5 items
[0]
Hallgren, 2001 (11572934)
[1]
3
[2]
2
[3]
3
[4]
8
[5] array · 5 items
[0]
James, 2015 (25350952)
[1]
4
[2]
2
[3]
2
[4]
8
[6] array · 5 items
[0]
Kok, 1988 (3394701)
[1]
3
[2]
2
[3]
3
[4]
8
[7] array · 5 items
[0]
Mozaffarian, 2011 (21428767)
[1]
3
[2]
2
[3]
3
[4]
8
[8] array · 5 items
[0]
Reunanen, 1996 (8862478)
[1]
2
[2]
2
[3]
3
[4]
7
[9] array · 5 items
[0]
Ruiz-Navarro, 1998 (9618928)*
[1]
1
[2]
1
[3]
2
[4]
4
[10] array · 5 items
[0]
Wade, 2015 (25889926)
[1]
2
[2]
2
[3]
2
[4]
7
[11] array · 5 items
[0]
Wennberg, 2007 (17537290)*
[1]
4
[2]
2
[3]
3
[4]
9
[12] array · 5 items
[0]
Wennberg, 2011 (21048056)
[1]
4
[2]
2
[3]
3
[4]
9
[13] array · 5 items
[0]
Yoshizawa, 2002 (12456851)*
[1]
4
[2]
2
[3]
3
[4]
9
row_count
14
column_count
5
numeric_cells
69
header_rows
1
locator
section[9]/table-wrap[3]#tbl3
gaps array · 3 items
[0]
asset:materials:the analysis programme that recomputes the published estimate not verified
[1]
asset:materials:the study data pooled behind the published estimate in pmid:30158148 not verified
[2]
asset:source:pmid:30158148 not verified
analysis object · 4 fields
state
partial
methods array · 1 item
[0] object · 10 fields
id
method-1
family
meta_analysis
specific
random_effects
label
Meta-analysis / evidence synthesis
dsl_operations array · 1 item
[0]
random_effects_pool
missing_operations array · 0 items
expressible
true
parameters object · 0 fields
data_shapes array · 1 item
[0]
study_level_effect_estimates
evidence object · 3 fields
score
0.7
band
medium
quote
random effects
targets array · 1 item
[0] object · 7 fields
id
target-1
claim_id
claim-1
operation
null
expected_value
1.43
unit
relative risk
tolerance
null
state
complete
gaps array · 0 items
capability object · 3 fields
state
complete
requirements array · 1 item
[0] object · 6 fields
capability_id
capability:computational_analysis
label
Computational analysis platform
assay_families array · 9 items
[0]
differential_expression
[1]
gwas
[2]
machine_learning
[3]
meta_analysis
[4]
molecular_docking
[5]
network_analysis
[6]
pca
[7]
statistical_regression
[8]
survival_analysis
availability_state
owned
tier_unlocked
R1
candidate
Automated Assays Laravel application and simulated adapters
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readiness object · 8 fields
state
blocked
tier
R4
blocking_axis
data
blocked_on
data:accession_absent
axes object · 3 fields
method object · 4 fields
axis
method
tier
R1
blocker
null
detail object · 5 fields
outcome
determined
family
meta_analysis
specific_method
random_effects
required_operations array · 1 item
[0]
random_effects_pool
basis
Every DSL operation this method needs already exists.
capability object · 4 fields
axis
capability
tier
R1
blocker
null
detail object · 3 fields
families array · 0 items
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false
basis
This paper needs no bench capability: it computes on data it already has.
data object · 4 fields
axis
data
tier
R4
blocker
data:accession_absent
detail object · 3 fields
applies
true
reachable
false
basis
The record names no repository accession and no data-availability statement, so the source data has to be requested from the authors.
can_run object · 3 fields
dsl_operations array · 1 item
[0]
random_effects_pool
assets array · 3 items
[0]
asset:table:pmid:30158148:1
[1]
asset:table:pmid:30158148:2
[2]
asset:table:pmid:30158148:3
steps array · 1 item
[0]
read_published_estimate
must_build object · 5 fields
dsl_operations array · 0 items
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readers array · 2 items
[0]
txt
[1]
unknown
capabilities array · 0 items
data_gaps array · 3 items
[0]
source:pmid:30158148
[1]
materials:the study data pooled behind the published estimate in pmid:30158148
[2]
materials:the analysis programme that recomputes the published estimate
gaps array · 1 item
[0]
data:accession_absent
review object · 5 fields
state
partial
machine_critique object · 7 fields
status
blocked
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provider
minimax-m3-1-flash
model
MiniMax-M3.1-Flash
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peer-review-reading-v1
prompt_hash
ff94837e99f0214d447b7d69f0e90c8a723400925103320500cfc3a449b47cc9
source_hash
9a0e95b40d40b800a3e0cebc2f1c9b42e8aa9be9f09a2f65bfaf0d0124045044
raw_response_sha256
sha256:6065345760f884d4b0bb529f96b2f7208f7fe59d840ddc5d0f0de89decbc32cc
raw_response_chars
1050
[1] object · 7 fields
provider
minimax-m3
model
MiniMax-M3
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raw_response_sha256
sha256:ca903b6591a56793cb25e0efbca19f5c8c796e56ad4829368c273e8dd267e6f9
raw_response_chars
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target_providers array · 2 items
[0] object · 8 fields
provider
minimax-m3-1-flash
model
MiniMax-M3.1-Flash
prompt_version
replication-target-v2
prompt_hash
9241c18f88bec221537ac006f71aad7c81480b945b866c3bacdc1328c19c4873
source_hash
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raw_response
{"parent_value":1.43,"unit":"relative risk","evidence":"Comparing top versus bottom thirds of baseline levels, pooled relative risks for arsenic and lead were 1.30 (95% confidence interval 1.04 to 1.63) and 1.43 (1.16 to 1.76) for cardiovascular disease","target_result":"The pooled relative risk of cardiovascular disease for lead comparing top versus bottom thirds of baseline levels was 1.43 (1.16 to 1.76).","number_stated":true}
reading object · 6 fields
parent_value
1.43
unit
relative risk
evidence
Comparing top versus bottom thirds of baseline levels, pooled relative risks for arsenic and lead were 1.30 (95% confidence interval 1.04 to 1.63) and 1.43 (1.16 to 1.76) for cardiovascular disease
target_result
The pooled relative risk of cardiovascular disease for lead comparing top versus bottom thirds of baseline levels was 1.43 (1.16 to 1.76).
number_stated
true
source_locator
chars 980-1177 of source sha256 9a0e95b40d40b800a3e0cebc2f1c9b42e8aa9be9f09a2f65bfaf0d0124045044
recorded_at
2026-10-31T13:25:07.232571+00:00
[1] object · 8 fields
provider
minimax-m3
model
MiniMax-M3
prompt_version
replication-target-v2
prompt_hash
1188aa3d8ecca090596475a05abf8f4604d13dbcfb61031df7c69447d7358c51
source_hash
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raw_response
{"parent_value":1.43,"unit":"relative risk","evidence":"Comparing top versus bottom thirds of baseline levels, pooled relative risks for arsenic and lead were 1.30 (95% confidence interval 1.04 to 1.63) and 1.43 (1.16 to 1.76) for cardiovascular disease","target_result":"1.43","number_stated":true}
reading object · 6 fields
parent_value
1.43
unit
relative risk
evidence
Comparing top versus bottom thirds of baseline levels, pooled relative risks for arsenic and lead were 1.30 (95% confidence interval 1.04 to 1.63) and 1.43 (1.16 to 1.76) for cardiovascular disease
target_result
1.43
number_stated
true
source_locator
chars 980-1177 of source sha256 9a0e95b40d40b800a3e0cebc2f1c9b42e8aa9be9f09a2f65bfaf0d0124045044
recorded_at
2026-10-31T13:25:11.182472+00:00
agreement
false
disagreements object · 4 fields
target_result object · 3 fields
minimax-m3-1-flash
Pooled relative risk 1.43 (95% confidence interval 1.16 to 1.76) for cardiovascular disease when comparing lead levels in the top versus bottom thirds at baseline.
minimax-m3
Pooled relative risk of cardiovascular disease for lead comparing top versus bottom thirds of baseline levels: 1.43 (95% confidence interval 1.16 to 1.76).
decisive
false
work_type object · 3 fields
minimax-m3-1-flash
analysis_only_for_target
minimax-m3
review_or_method_without_reexecutible_result
decisive
true
analysis_methods object · 3 fields
minimax-m3-1-flash array · 2 items
[0]
Random-effects meta-analysis
[1]
Standardisation of reported relative risks to a common scale
minimax-m3 array · 4 items
[0]
Systematic review and meta-analysis of epidemiological studies
[1]
Standardization of relative risks to a common scale
[2]
Random-effects meta-analysis pooled across studies for each marker
[3]
Comparison of top versus bottom thirds of baseline exposure levels
decisive
false
source_claims object · 3 fields
minimax-m3-1-flash array · 2 items
[0]
Comparing top versus bottom thirds of baseline levels, the pooled relative risk for lead was 1.43 (95% confidence interval 1.16 to 1.76) for cardiovascular disease.
[1]
Relative risks were standardised to a common scale and pooled across studies for each marker using random effects meta-analyses.
minimax-m3 array · 2 items
[0]
Comparing top versus bottom thirds of baseline levels, the pooled relative risk for lead was 1.43 (95% confidence interval 1.16 to 1.76) for cardiovascular disease.
[1]
Relative risks were standardized to a common scale and pooled across studies using random-effects meta-analyses.
decisive
false
agreement_basis object · 3 fields
policy
decisive_fields
decisive_fields array · 4 items
[0]
number_stated
[1]
parent_value
[2]
unit
[3]
work_type
advisory_fields array · 3 items
[0]
analysis_methods
[1]
source_claims
[2]
target_result
blinded
true
human_critique object · 5 fields
status
not_run
reviewer
null
signed_at
null
conflict_checked
false
commentary
null
stages array · 7 items
[0] object · 4 fields
key
target_materials
status
pending
reason
null
evidence
null
[1] object · 4 fields
key
independent_readings
status
blocked
reason
The independent readings are incomplete or disagree; the source evidence must resolve the difference.
evidence object · 1 field
provider_errors array · 0 items
[2] object · 4 fields
key
source_resolution
status
pending
reason
null
evidence
null
[3] object · 4 fields
key
protocol_reconstruction
status
pending
reason
null
evidence
null
[4] object · 4 fields
key
control_execution
status
pending
reason
null
evidence
null
[5] object · 4 fields
key
control_comparison
status
pending
reason
null
evidence
null
[6] object · 4 fields
key
publication
status
pending
reason
null
evidence
null
gaps array · 2 items
[0]
review.human_critique
[1]
review.machine_critique.blocked
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
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[0] object · 3 fields
id
package:6ea829fb81f595cea12e1eaaccfbaabe80d255be10cc34571a58cdc1955a50d1
type
sep_package
label
SEP v1 package for pmid:30158148
activities array · 1 item
[0] object · 4 fields
id
activity:conversion:pmid:30158148
type
conversion
used array · 1 item
[0]
package:6ea829fb81f595cea12e1eaaccfbaabe80d255be10cc34571a58cdc1955a50d1
agent
agent:corpus-assay-engine
agents array · 3 items
[0] object · 3 fields
id
agent:minimax-m3
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model
label
minimax-m3
[1] object · 3 fields
id
agent:minimax-m3-1-flash
type
model
label
minimax-m3-1-flash
[2] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
source_run_id
run-20261023T122449232913
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:30158148
parent_hash
sha256:c031daa10963d4dd9a069be9a2513004370e362335b23bc22eed8c9f91d6a109
fork_of
null
generation
2
gaps array · 11 items
[0]
abstract
[1]
asset:materials:the analysis programme that recomputes the published estimate not verified
[2]
asset:materials:the study data pooled behind the published estimate in pmid:30158148 not verified
[3]
asset:source:pmid:30158148 not verified
[4]
authors
[5]
data:accession_absent
[6]
execution.not_run
[7]
review.human_critique
[8]
review.machine_critique.blocked
[9]
step:obtain_source_data blocked on data:accession_absent
[10]
step:run_analysis blocked on data:accession_absent
Complete file 
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"4190", "", "424", "0", "0"], ["NHANES III†4 48", "USA", "Health survey", "Prospective cohort", "1988-1994", "58", "48", "12", "9757", "", "1189", "0", "0"], ["NHANES III†4 49", "USA", "Health survey", "Prospective cohort", "1988-1994", "44", "47", "12", "13 946", "", "0", "367", "141"], ["NHANES III†4 50", "USA", "Health Survey", "Prospective cohort", "1999-2010", "58", "47.6", "12", "18602", "", "985", "0", "0"], ["SOF51", "USA", "General", "Prospective cohort", "1990-1991", "70", "0", "13", "533", "", "54", "23", "21"], ["VA-NAS52", "USA", "Health screening", "Prospective cohort", "1991-1999", "67", "100", "16", "1235", "", "185", "82", "0"], ["Earlier randomised26", "Netherlands", "Health survey", "Prospective cohort", "1977-1978", "57-76*", "100", "8", "146", "", "64", "39", "18"], ["Cadmium"], ["CadmiBel53", "Belgium", "Population registers", "Prospective cohort", "1985-1989", "47", "45", "22", "956", "", "88", "56", "21"], ["HPFS54", "USA", "Health professionals", "Nested case-control", "1987", "62‡", "100", "5", "884", "", "0", "442", "0"], ["Li (2011)55", "Japan", "Health survey", "Prospective cohort", "1981-1982", ">50", "45", "22", "3119", "", "267", "0", "217"], ["MDCS56", "Sweden", "Health study", "Prospective cohort", "1991-1994", "46-67*", "41", "17", "4819", "", "713", "377", "336"], ["NHANES (1999-2004)† 3 57", "USA", "Health survey", "Prospective cohort", "1999-2004", ">20", "48", "7", "8989", "", "191", "88", "0"], ["NHANES III58", "USA", "Health survey", "Prospective cohort", "1988-1994", ">20", "47", "12", "13 958", "", "769", "367", "0"], ["NHANES III50", "USA", "Health survey", "Prospective cohort", "1999-2010", "58", "48", "12", "18602", "", "985", "0", "0"], ["SHS59", "USA", "Health survey", "Prospective cohort", "1989-1991", "56", "40", "19", "3348", "", "1010", "766", "244"], ["Mercury"], ["EURAMIC60", "Multinational", "Population registers and hospital records", "Case-control", "1991-1992", "≤70", "100", "NA", "1408", "", "0", "684", "0"], ["Gothenburg61", "Sweden", "Health study", "Prospective cohort", "1968-1969", "38-60*", "0", "32", "1391", "", "301", "128", "173"], ["Hallgren (2001)†5 62", "Sweden", "Health survey", "Nested case-control", "1985-1994", "55", "79", "9", "234", "", "0", "78", "0"], ["HPFS and NHS63", "USA", "Health professionals", "Nested case-control", "1976 and 1986", "56", "35", "15.3", "6854", "", "3427", "2363", "1064"], ["KIHD†6 64", "Finland", "General", "Prospective cohort", "1984-1989", "52", "100", "17.8", "1871", "", "414", "282", "0"], ["KIHD (2016)† § 6 65", "Finland", "General", "Prospective cohort", "1984-1989", "42-60*", "100", "21.2", "2682", "", "0", "0", "202"], ["NSHDS†§ 5 66", "Sweden", "Health surveys", "Nested case-control", "1994-1999", "NR", "75", "5", "930", "", "0", "431", "0"], ["NSHDS†§ 5 67", "Sweden", "Health surveys", "Nested case-control", "1985-2000", "55", "60", "15", "2271", "", "878", "0", "369"], ["PREDIMED68", "Spain", "Primary care centres", "Nested 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