Global expression profiling of metabolic pathway-related lncRNAs in human gastric cancer and the identification of RP11-555H23.1 as a new diagnostic biomarker.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:30320481", "kind": "science-record", "revision": 4, "content_hash": "sha256:e5d2dfc50576163f072c38b64766e15c2fb681ccc13e6f91e90b24f7b3936a66", "created_at": "2026-11-01T17:32:26Z", "updated_at": "2026-11-01T22:00:06Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Global expression profiling of metabolic pathway-related lncRNAs in human gastric cancer and the identification of RP11-555H23.1 as a new diagnostic biomarker.", "doi": "10.1002/jcla.22692", "pmid": "30320481", "authors": ["Xiaoyan Mo", "Yuanyuan Wu", "Li Chen", "Ming Zhai", "Zhengdong Gao", "Kainan Hu", "Junming Guo"], "journal": "Journal of clinical laboratory analysis", "year": 2019, "abstract": "BACKGROUND: Long noncoding RNAs (lncRNAs) have roles in regulating metabolism; however, the global expression profile of metabolic pathway-associated lncRNAs in gastric cancer is unknown. The purpose of our study was to examine metabolic pathway-related lncRNAs in gastric cancer and their possible diagnostic values.\nMETHODS: Differential expression patterns of metabolic pathway-related lncRNAs between gastric cancer and paired nontumor tissues were detected using metabolic pathway-associated lncRNA microarrays. The expression of RP11-555H23.1, one representative metabolic pathway-associated lncRNA, was validated using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). The associations between RP11-55H23.1 expression and the clinicopathological features of gastric cancer patients were analyzed. A receiver operating characteristic (ROC) curve was further established.\nRESULTS: A total of 114 differentially expressed metabolic pathway-associated lncRNAs (fold change >2, P < 0.05) between cancer and nontumor tissues were found (GEO No. GSE96856). Among them, TUG1, RP11-555H23.1, RP1-257I20.13, UGP2, GCSHP3, and XLOC_000889 lncRNAs were downregulated more than sixfold in gastric cancer tissues. In contrast, RP11-605F14.2, TBC1D3P5, BC130595, LINC00475, RP11-19P22.6, BC080653, XLOC_004923, AFAP1-AS1, EPB49, and RP11-296I10.3 lncRNAs were upregulated more than sixfold in gastric cancer tissues. We further demonstrated that RP11-555H23.1 expression was significantly correlated with TNM stage (P = 0.038). The area under the ROC curve (AUC) was 0.65, and the specificity and sensitivity were 62% and 81%, respectively.\nCONCLUSIONS: Metabolic pathway-associated lncRNAs play an important role in the occurrence of gastric cancer, and metabolic pathway-associated lncRNAs, such as RP11-555H23.1, may represent novel biomarkers of gastric cancer.", "claims": [{"id": "claim-method", "statement": "A receiver operating characteristic (ROC) curve was further established.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30320481", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "A receiver operating characteristic (ROC) curve was further established."}], "state": "complete"}, {"id": "claim-data-access", "statement": "A total of 114 differentially expressed metabolic pathway‐associated lncRNAs (fold change >2, P < 0.05) between cancer and nontumor tissues were found (GEO No. GSE96856).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30320481", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "A total of 114 differentially expressed metabolic pathway‐associated lncRNAs (fold change >2, P < 0.05) between cancer and nontumor tissues were found (GEO No. GSE96856)."}], "state": "complete"}, {"id": "claim-target-result", "statement": "Metabolic pathway‐associated lncRNAs play an important role in the occurrence of gastric cancer, and metabolic pathway‐associated lncRNAs, such as RP11‐555H23.1, may represent novel biomarkers of gastric cancer.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:30320481", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "Metabolic pathway‐associated lncRNAs play an important role in the occurrence of gastric cancer, and metabolic pathway‐associated lncRNAs, such as RP11‐555H23.1, may represent novel biomarkers of gastric cancer."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "Metabolic pathway‐associated lncRNAs play an important role in the occurrence of gastric cancer, and metabolic pathway‐associated lncRNAs, such as RP11‐555H23.1, may represent novel biomarkers of gastric cancer.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:30320481"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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