CBX8 and CD96 Are Important Prognostic Biomarkers of Colorectal Cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:30383736", "kind": "science-record", "revision": 8, "content_hash": "sha256:851d0a5a6fe40a4a6a87d32d81dd49bda49550c38978f84216f097ec2fc74848", "created_at": "2026-11-01T15:40:38Z", "updated_at": "2026-11-01T22:43:36Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "CBX8 and CD96 Are Important Prognostic Biomarkers of Colorectal Cancer.", "doi": "10.12659/MSM.908656", "pmid": "30383736", "authors": ["Xin Song", "Tao Tang", "Chaofeng Li", "Xin Liu", "Lei Zhou"], "journal": "Medical science monitor : international medical journal of experimental and clinical research", "year": 2018, "abstract": "BACKGROUND Colorectal cancer (CRC) is one of the most common malignancies worldwide, with high morbidity and mortality rates. The purpose of this study was to identify potential biomarkers in the progression of CRC. MATERIAL AND METHODS Gene and isoform expression datasets of CRC was downloaded from The Cancer Genome Atlas (TCGA). EBSeq of R was used for the normalization of gene and isoform expression, as well as the identification of differential expression genes (DEGs) and isoforms (DEIs) of CRC samples compared with normal samples. The enriched functions of DEGs and DEIs were obtained based on the Database for Annotation, Visualization and Integrated Discovery (DAVID). An independent dataset, GSE38832, was downloaded from the Gene Expression Omnibus (GEO) database for survival analysis of genes with sustained decreased/increased expression values at both gene and isoform levels with the development of CRC. RESULTS A total of 2301 genes and 4241 isoforms were found to be significantly differentially expressed in stage I-IV CRC samples. They are closely associated with muscle or cell system activity. Sixteen genes were screened out with sustained decreased/increased expression values at both gene and isoform levels with the development of CRC. Aberrant CBX8 and CD96 expressions were found to be significantly associated with CRC survival. CONCLUSIONS Through combined analysis of gene and isoform expression profiles, we identified several potential biomarkers that may play an important role in the development of CRC and could be helpful in its early diagnosis and treatment.", "claims": [{"id": "claim-method", "statement": "Kaplan-Meier (KM) analysis was performed for relations of specific gene expression with CRC overall survival (OS) and the log-rank test was used for estimation of significance.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30383736", "locator": "sections[6] \"Survival analysis\" paragraph 2", "quote": "Kaplan-Meier (KM) analysis was performed for relations of specific gene expression with CRC overall survival (OS) and the log-rank test was used for estimation of significance."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Gene and isoform expression datasets in this study were downloaded from TCGA on 12 June 2015. We used the CRC level 3 RNA-Seq V2 datasets, which includes gene- and isoform-level expression values based on Illumina HiSeq 2000. Clinical data from CRC samples was also obtained.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30383736", "locator": "sections[3] \"Gene and isoform expression datasets\" paragraph 2", "quote": "Gene and isoform expression datasets in this study were downloaded from TCGA on 12 June 2015. We used the CRC level 3 RNA-Seq V2 datasets, which includes gene- and isoform-level expression values based on Illumina HiSeq 2000. Clinical data from CRC samples was also obtained."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:30383736"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE38832"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE38832"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:30383736", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.12659/MSM.908656", "sha256": "sha256:e92dfd233a8f3525fa3ef4c004c1016f011ba5c55ae4a8972b2d3fd1d4c2f364", "bytes": 24318, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.12659/MSM.908656", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC6225733", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE38832", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38832", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE38832", "version": null, "note": "Gene and isoform expression datasets in this study were downloaded from TCGA on 12 June 2015. 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