pmid:30643084
Investigation of the Underlying Genes and Mechanism of Macrophage-Enriched Ruptured Atherosclerotic Plaques Using Bioinformatics Method.
Hao Wang · Dongyuan Liu · Hongbing Zhang
Journal of atherosclerosis and thrombosis · 2019 doi:10.5551/jat.45963
Abstract
AIM: The study aimed to identify the underlying differentially expressed genes (DEGs) and mechanism of macrophage-enriched rupture atherosclerotic plaque using bioinformatics methods. METHODS: GSE41571, which includes six stable samples and five ruptured atherosclerotic samples, was downloaded from the GEO database. After preprocessing, DEGs between ruptured and stable atherosclerotic samples were identified using LIMMA. Gene Ontology biological process (GO_BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of DEGs were performed using the Database for Annotation, Visualization, and Integration Discovery (DAVID) online tool. Based on the STRING database, protein-protein interactions (PPIs) network among DEGs were constructed. Regulatory relationships between miRNAs/transcriptional factors (TFs) and target genes were predicted using Enrichr, and regulatory networks were visualized using Cytoscape. RESULTS: A total of 268 DEGs (64 up-regulated and 204 down-regulated DEGs) were identified between ruptured and stable samples. In the PPI network, collagen type III alpha 1 chain (COL3A1), collagen type I alpha 2 chain (COL1A2), and asporin (ASPN) were more than 15 interaction degrees. In the miRNA-target network, miR21 was highlighted with highest degrees and ASPN could be targeted by miR21. Functional enrichment analysis showed that COL3A1 and COL1A2 were significantly enriched in extracellular matrix organization and cell adhesion GO_BP terms. Pre-platelet basic protein (PPBP) was the most significantly up-regulated gene in ruptured atherosclerotic samples and enriched in immune response and inflammatory response GO_BP terms. CONCLUSIONS: Down-regulated COL3A1, COL1A2 and ASPN, and up-regulated PPBP might perform critical promotional roles in atherosclerotic plaque rupture. Furthermore, miR21 might be potential target to prevent atherosclerotic rupture.
The publication
- PubMed · PMID 30643084 The record in the National Library of Medicine.
- The publisher's article · doi:10.5551/jat.45963 Journal of atherosclerosis and thrombosis · 2019
- Hao Wang · Dongyuan Liu · Hongbing Zhang
Source data and code
- 10.5551/jat.45963 manuscript · resolved
- GSE41571 raw · resolved
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Five-stage experiment
- 1 normalise counts Definition differential_expression · supported
The order is the order the experiment runs them in. The full definitions, contracts and evidence are in the file below.
Paper
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Experiment
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Data
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Analysis
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Execution
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Complete file
{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:30643084", "kind": "science-record", "revision": 8, "content_hash": "sha256:098d63faed7c642fd21a6bd02d434835f05ad3e9e198952b75a51d84bfe5ee06", "created_at": "2026-11-01T15:40:40Z", "updated_at": "2026-11-01T22:43:42Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Investigation of the Underlying Genes and Mechanism of Macrophage-Enriched Ruptured Atherosclerotic Plaques Using Bioinformatics Method.", "doi": "10.5551/jat.45963", "pmid": "30643084", "authors": ["Hao Wang", "Dongyuan Liu", "Hongbing Zhang"], "journal": "Journal of atherosclerosis and thrombosis", "year": 2019, "abstract": "AIM: The study aimed to identify the underlying differentially expressed genes (DEGs) and mechanism of macrophage-enriched rupture atherosclerotic plaque using bioinformatics methods.\nMETHODS: GSE41571, which includes six stable samples and five ruptured atherosclerotic samples, was downloaded from the GEO database. After preprocessing, DEGs between ruptured and stable atherosclerotic samples were identified using LIMMA. Gene Ontology biological process (GO_BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of DEGs were performed using the Database for Annotation, Visualization, and Integration Discovery (DAVID) online tool. Based on the STRING database, protein-protein interactions (PPIs) network among DEGs were constructed. Regulatory relationships between miRNAs/transcriptional factors (TFs) and target genes were predicted using Enrichr, and regulatory networks were visualized using Cytoscape.\nRESULTS: A total of 268 DEGs (64 up-regulated and 204 down-regulated DEGs) were identified between ruptured and stable samples. In the PPI network, collagen type III alpha 1 chain (COL3A1), collagen type I alpha 2 chain (COL1A2), and asporin (ASPN) were more than 15 interaction degrees. In the miRNA-target network, miR21 was highlighted with highest degrees and ASPN could be targeted by miR21. Functional enrichment analysis showed that COL3A1 and COL1A2 were significantly enriched in extracellular matrix organization and cell adhesion GO_BP terms. Pre-platelet basic protein (PPBP) was the most significantly up-regulated gene in ruptured atherosclerotic samples and enriched in immune response and inflammatory response GO_BP terms.\nCONCLUSIONS: Down-regulated COL3A1, COL1A2 and ASPN, and up-regulated PPBP might perform critical promotional roles in atherosclerotic plaque rupture. Furthermore, miR21 might be potential target to prevent atherosclerotic rupture.", "claims": [{"id": "claim-method", "statement": "After processed, DEGs between groups were screened out using the Linear Models for Microarray (LIMMA; Version: 3.30.3) affy in R package12). q-value between gene expressions was determined using the T test and adjusted using Benjamin Hochberg (BH) method.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30643084", "locator": "sections[5] \"Identification of DEGs\" paragraph 2", "quote": "After processed, DEGs between groups were screened out using the Linear Models for Microarray (LIMMA; Version: 3.30.3) affy in R package12). q-value between gene expressions was determined using the T test and adjusted using Benjamin Hochberg (BH) method."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30643084", "locator": "sections[23] \"Availability of Data and Materials\" paragraph 2", "quote": "The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:30643084"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE41571"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE41571"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:30643084", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.5551/jat.45963", "sha256": "sha256:c5d266d8a99641dc41f63281563fb55e0c8a74813883ce139351435d1731bac3", "bytes": 22723, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.5551/jat.45963", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC6629752", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE41571", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE41571", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE41571", "version": null, "note": "The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1019539", "GSM1019540", "GSM1019541", "GSM1019542", "GSM1019543", "GSM1019544", "GSM1019545", "GSM1019546", "GSM1019547", "GSM1019548", "GSM1019549"], "sample_count": 11, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Genome-wide expression profiling of laser micro-dissected macrophages from ruptured and stable atherosclerotic human plaques", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:30643084:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:995851ea7a32b50e4a74e5ce78c9c3a90286da6efcbd1051c0d18e2f095860db", "bytes": 50593, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[1]#T3", "version": null, "note": "The list of all differentially expressed genes", "structure": {"pmcid": "PMC6629752", "section_index": 5, "section_title": "Identification of DEGs", "row_count": 574, "column_count": 7}, "table": {"label": "Supplementary Table 1.", "caption": "The list of all differentially expressed genes", "rows": [["", "logFC", "AveExpr", "t", "P.Value", "adj.P.Val", "B"], ["PIK3R6", "1.2", "6.319", "8.201", "3.85E-06", "0.011196886", "4.626"], ["CEMIP", "−1.25669178", "7.687", "−8.95594463", "1.59E-06", "0.011196886", "5.387"], ["CTNNAL1", "−1.50635456", "7.069", "−8.76434724", "1.98E-06", "0.011196886", "5.2"], ["ROBO1", "−2.70565648", "8.496", "−8.84771249", "1.79E-06", "0.011196886", 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"0.00061014", "0.035032694", "−0.040144013"], ["ATP6V0B", "1.249", "10.161", "4.67", "0.000605709", "0.035032694", "−0.033189336"], ["FERMT2", "−1.32252556", "6.945", "−4.66808806", "0.000607445", "0.035032694", "−0.035920518"], ["YAP1", "−1.72909066", "6.431", "−4.66877616", "0.000606747", "0.035032694", "−0.034822218"], ["EML1", "−1.99655211", "5.432", "−4.66075832", "0.000614941", "0.035032694", "−0.047624057"], ["CFH", "−2.1218776", "10.83", "−4.67777279", "0.000597689", "0.035032694", "−0.020468742"], ["2018/3/2", "−1.049441", "6.229", "−4.64018199", "0.000636504", "0.035582405", "−0.080520385"], ["IGFBP7", "−1.17251974", "8.893", "−4.61773173", "0.000660938", "0.036207263", "−0.116482484"], ["DZIP1", "−1.21446462", "5.069", "−4.61329159", "0.000665885", "0.036207263", "−0.123603551"], ["IQCJ-SCHIP1", "−1.89678603", "7.193", "−4.59387208", "0.000687985", "0.036631536", "−0.154781644"], ["TAF1A", "−1.29817562", "5.537", "−4.57505232", "0.000710136", "0.037323023", "−0.185048194"], ["MXRA5", "−2.08246518", "9.942", "−4.5760163", "0.000708983", "0.037323023", "−0.183496667"], ["MYO1B", "−1.06000364", "5.771", "−4.56172834", "0.000726268", "0.037659193", "−0.206506663"], ["SLCO2B1", "1.319", "8.457", "4.533", "0.000762207", "0.038274727", "−0.252652647"], ["GSTT2", "−1.10875678", "6.235", "−4.53840847", "0.000755434", "0.038274727", "−0.244123997"], ["AEBP1", "−2.35590453", "10.096", "−4.52961448", "0.000766748", "0.038274727", "−0.25832946"], ["FCGRT", "1.177", "10.833", "4.52", "0.000778957", "0.038504641", "−0.273426586"], ["FAT4", "−2.56303105", "6.048", "−4.51762232", "0.000782464", "0.038596008", "−0.27771853"], ["INHBA", "−1.86991676", "6.789", "−4.51503663", "0.000785896", "0.038683361", "−0.281901738"], ["IGKV1-17", "2.579", "7.067", "4.507", "0.00079641", "0.038894789", "−0.294602761"], ["CYP27A1", "1.326", "11.108", "4.498", "0.000808921", "0.039131153", "−0.30950161"], ["LOC100506119", "1.01", "7.294", "4.488", "0.000822133", "0.039303695", "−0.324987906"], ["VEGFC", "−1.83703081", "7.396", "−4.48856265", "0.000821959", "0.039303695", "−0.324785545"], ["GAA", "1.167", "9.206", "4.473", "0.000843911", "0.039994585", "−0.349981918"], ["NFIB", "−1.32832364", "5.712", "−4.45439285", "0.00087108", "0.040260819", "−0.38027823"], ["SERTAD4", "−1.21609373", "4.817", "−4.44402046", "0.00088659", "0.040401598", "−0.397154852"], ["PLTP", "1.311", "10.929", "4.432", "0.000904488", "0.040436634", "−0.416267419"], ["CTSA", "1.163", "10.809", "4.441", "0.000890772", "0.040436634", "−0.401654419"], ["SLC16A4", "−1.39699797", "4.694", "−4.42089439", "0.00092222", "0.040517383", "−0.434835104"], ["FOXC1", "−2.12951548", "8.291", "−4.42836534", "0.000910549", "0.040517383", "−0.422654485"], ["IGKV1OR2-108", "1.868", "7.811", "4.397", "0.000960932", "0.040756283", "−0.47416657"], ["TJP1", "−1.08938082", "6.622", "−4.40604957", "0.000945876", "0.040756283", "−0.459060347"], ["ZNRF3", "−1.12957808", "5.084", "−4.39928713", "0.000956861", "0.040756283", "−0.470105748"], ["MPDZ", "−1.54103226", "6.522", "−4.40894973", "0.000941205", "0.040756283", "−0.45432526"], ["NET1", "−1.60153131", "7.662", "−4.39586793", "0.000962467", "0.040756283", "−0.475692803"], ["SNAI2", "−2.33153198", "6.709", "−4.39421282", "0.000965192", "0.040756283", "−0.478397851"], ["TANC1", "−1.04522496", "5.558", "−4.38674571", "0.000977589", "0.040935653", "−0.490606346"], ["IGKC", "1.285", "6.009", "4.382", "0.000985827", "0.040965943", "−0.498633937"], ["ACOT13", "1.03", "7.829", "4.375", "0.000997539", "0.040965943", "−0.509933389"], ["SPARC", "−1.20354323", "11.219", "−4.3753052", "0.000996905", "0.040965943", "−0.509325556"], ["GSTA4", "−1.29851562", "6.86", "−4.36613168", "0.001012682", "0.040965943", "−0.524347965"], ["ZBTB8A", "−1.37631649", "7.052", "−4.37997542", "0.000988972", "0.040965943", "−0.50168195"], ["FST", "−1.76779273", "6.563", "−4.36991914", "0.001006137", "0.040965943", "−0.51814434"], ["TWIST1", "−2.11250906", "7.358", "−4.36900418", "0.001007714", "0.040965943", "−0.519642824"], ["AOC3", "−2.28787858", "7.915", "−4.3647634", "0.001015057", "0.040965943", "−0.52658959"], ["ATL1", "−1.00687259", "6.814", "−4.3604407", "0.0010226", "0.041059108", "−0.533672997"], ["CRISPLD1", "−3.53397277", "5.399", "−4.35427774", "0.001033455", "0.041200168", "−0.543776176"], ["SSPN", "−1.17667481", "5.806", "−4.35112305", "0.001039058", "0.041292889", "−0.548949711"], ["PPP1R15A", "1.035", "7.244", "4.335", "0.001068043", "0.041862246", "−0.575277661"], ["MGLL", "1.074", "10.068", "4.323", "0.001090989", "0.042231298", "−0.595619862"], ["CFHR2", "−1.05882399", "6.425", "−4.3235495", "0.001089399", "0.042231298", "−0.594224097"], ["AMOTL2", "−2.27119759", "7.063", "−4.3168058", "0.001102093", "0.04241147", "−0.605311898"], ["TNFRSF17", "2.009", "4.822", "4.298", "0.001138401", "0.043046977", "−0.636334631"], ["SLC24A3", "−1.37012793", "6.638", "−4.29952451", "0.001135333", "0.043046977", "−0.633751967"], ["NDC80", "−1.4974775", "7.142", "−4.30164087", "0.001131207", "0.043046977", "−0.630266987"], ["AP1B1", "1.11", "8.429", "4.28", "0.001174262", "0.043593147", "−0.666022436"], ["H2BFS", "1.222", "5.121", "4.271", "0.001191769", "0.04384424", "−0.68018847"], ["MAP4K4", "−1.04172561", "7.215", "−4.27171029", "0.001191044", "0.04384424", "−0.679606089"], ["PLD3", "1.916", "10.825", "4.264", "0.001208022", "0.043913909", "−0.693155632"], ["ENPP1", "−1.14642047", "4.826", "−4.26575893", "0.00120333", "0.043913909", "−0.689430104"], ["ITGA10", "−1.85620797", "7.214", "−4.26030907", "0.001214696", "0.043913909", "−0.69843019"], ["IGKV1-37", "1.831", "7.021", "4.236", "0.001267234", "0.044290054", "−0.738968381"], ["GPC6", "−1.1298533", "6.394", "−4.23566454", "0.001267508", "0.044290054", "−0.739175243"], ["C9orf3", "−1.47756582", "6.871", "−4.24153164", "0.001254722", "0.044290054", "−0.729468257"], ["GXYLT2", "−1.69386575", "5.555", "−4.24355961", "0.001250334", "0.044290054", "−0.726114027"], ["VMO1", "1.666", "7.962", "4.229", "0.001281973", "0.044349043", "−0.750040061"], ["MGARP", "−1.55504243", "5.353", "−4.19551", "0.001358735", "0.045692391", "−0.805723339"], ["GLUL", "1.145", "11.202", "4.182", "0.001390136", "0.046038611", "−0.827601836"], ["CD27", "1.21", "7.39", "4.179", "0.001399117", "0.046139169", "−0.833769133"], ["MYLK", "−1.14019221", "6.013", "−4.17280728", "0.001413311", "0.046410017", "−0.843434981"], ["LOC728061", "−2.05163732", "5.984", "−4.16582764", "0.001430544", "0.04677797", "−0.855041301"], ["COL3A1", "−2.07311618", "10.754", "−4.16094377", "0.001442732", "0.046974735", "−0.86316603"], ["SYNM", "−2.20201792", "7.297", "−4.13903732", "0.001498743", "0.047474464", "−0.899643872"], ["IL4I1", "1.077", "7.981", "4.13", "0.001523648", "0.047937254", "−0.915428286"], ["POR", "1.289", "7.363", "4.114", "0.001564286", "0.048233071", "−0.940638903"], ["LURAP1L", "−1.87326982", "5.808", "−4.11317906", "0.001567777", "0.048233071", "−0.942774118"], ["PEPD", "1.135", "8.808", "4.105", "0.00159094", "0.048355035", "−0.956822001"], ["SYNC", "−1.48850046", "5.161", "−4.10469247", "0.001591146", "0.048355035", "−0.956946087"], ["OMD", "−2.78152739", "5.449", "−4.10474212", "0.001591009", "0.048355035", "−0.956863151"], ["PROCR", "−1.00314734", "7.544", "−4.09518", "0.001617771", "0.048689939", "−0.972840972"], ["CD180", "1.345", "7.32", "4.083", "0.001653047", "0.048855534", "−0.993502199"], ["PPFIBP1", "−1.13010206", "5.456", "−4.07920891", "0.001663519", "0.048855534", "−0.999550951"], ["PRRX1", "−1.6549019", "6.099", "−4.07511267", "0.001675467", "0.048855534", "−1.0064061"], ["CFH", "−2.33548068", "9.12", "−4.07508164", "0.001675558", "0.048855534", "−1.00645803"], ["BGN", "−1.62394918", "8.095", "−4.06341277", "0.001710086", "0.04915337", "−1.02599645"], ["COL15A1", "−1.89798428", "9.581", "−4.06441292", "0.001707098", "0.04915337", "−1.02432119"], ["IGLL3P", "2.172", "9.334", "4.06", "0.001721112", "0.049322321", "−1.03215249"], ["CYAT1", "1.22", "7.027", "4.059", "0.001723207", "0.049322321", "−1.03331779"], ["ZNF404", "−1.06352944", "4.472", "−4.05407513", "0.001738248", "0.049353524", "−1.04164231"], ["SFRP4", "−2.93801794", "6.929", "−4.05424937", "0.001737718", "0.049353524", "−1.04135026"], ["IGLC1", "1.596", "7.517", "4.046", "0.001763359", "0.049473158", "−1.05538118"], ["HLA-DMA", "1.306", "11.378", "4.045", "0.001765836", "0.049473158", "−1.05672574"], ["CEP290", "−1.0804849", "6.391", "−4.04268175", "0.001773262", "0.049621504", "−1.0607457"], ["CXCL3", "1.317", "7.891", "4.039", "0.001784045", "0.049684365", "−1.06655264"], ["MS4A6E", "1.668", "4.81", "4.037", "0.001791087", "0.049820889", "−1.07032628"], ["ACKR4", "−1.52268155", "4.42", "−4.02988751", "0.001813455", "0.050044606", "−1.0822148"], ["EFEMP1", "−1.54844572", "8.354", "−4.02769537", "0.001820435", "0.050157839", "−1.08589504"], ["LHFP", "−1.81885212", "6.486", "−4.02237604", "0.00183749", "0.050516661", "−1.09482749"], ["ADM", "1.107", "11.237", "4.02", "0.001845287", "0.050543483", "−1.09888318"], ["SEMA5A", "−1.41324129", "6.863", "−4.01790982", "0.001851938", "0.050606592", "−1.10232973"], ["C3orf80", "−1.72303094", "4.81", "−4.01381707", "0.001865281", "0.050838319", "−1.10920649"], ["ZNF667-AS1", "−1.74621215", "6.251", "−3.99983639", "0.001911615", "0.051114758", "−1.13271066"], ["PCDH10", "−2.08087587", "5.158", "−4.00221063", "0.001903663", "0.051114758", "−1.12871765"], ["CD52", "1.832", "10.092", "3.997", "0.001922413", "0.051145657", "−1.13810607"], ["TCN2", "1.51", "9.023", "3.996", "0.001924853", "0.051145657", "−1.13932131"], ["PILRA", "1.096", "8.679", "3.99", "0.001943711", "0.051191763", "−1.14866009"], ["RP11-182L21", "−1.17416448", "6.41", "−3.98819442", "0.001951108", "0.051191763", "−1.15229877"], ["METTL7B", "2.348", "7.441", "3.974", "0.00199995", "0.05152927", "−1.17598256"], ["HIST1H2BK", "1.241", "8.407", "3.972", "0.002006245", "0.051555629", "−1.17899306"], ["CALD1", "−1.15502391", "6.474", "−3.97143398", "0.002009454", "0.051581145", "−1.18052373"], ["MIR143HG", "−1.7863461", "6.767", "−3.96581334", "0.002029422", "0.051859691", "−1.18999551"], ["PTN", "−1.23570748", "5.634", "−3.93877431", "0.002128393", "0.052998117", "−1.23560607"], ["GJA1", "−1.84211055", "9.798", "−3.93940584", "0.002126025", "0.052998117", "−1.23453994"], ["SLITRK4", "−1.09949375", "4.732", "−3.92826729", "0.002168187", "0.053248877", "−1.25334957"], ["ZNF680", "−1.15108211", "6.536", "−3.92920137", "0.002164618", "0.053248877", "−1.25177171"], ["RP11-305O6", "−1.5668101", "5.155", "−3.92047009", "0.002198215", "0.053590398", "−1.26652398"], ["PEAR1", "−1.45350304", "6.879", "−3.91007867", "0.002238903", "0.053945632", "−1.28409097"], ["PCOLCE", "−1.46136398", "8.89", "−3.90848164", "0.002245225", "0.053945632", "−1.28679173"], ["SLIT2", "−1.73248051", "7.539", "−3.91111181", "0.002234823", "0.053945632", "−1.28234394"], ["MID1", "−1.21316819", "6.613", "−3.90211625", "0.002270606", "0.054219745", "−1.29755876"], ["OGN", "−3.53385479", "5.648", "−3.90268222", "0.002268337", "0.054219745", "−1.29660127"], ["NKG7", "1.198", "5.988", "3.9", "0.002277495", "0.054328521", "−1.30046024"], ["PHOSPHO2", "−1.27042123", "5.769", "−3.89654933", "0.002293047", "0.054587647", "−1.30697841"], ["CD72", "1.917", "7.487", "3.881", "0.002356347", "0.055377521", "−1.33305954"], ["TMEM133", "−1.46004818", "4.868", "−3.88095243", "0.002357148", "0.055377521", "−1.3333853"], ["SYTL2", "−1.07422641", "5.833", "−3.87363677", "0.00238785", "0.055649564", "−1.34577929"], ["FAIM3", "1.669", "7.098", "3.868", "0.002412198", "0.055904268", "−1.35549554"], ["IGLC1", "1.244", "5.63", "3.865", "0.002424514", "0.055963427", "−1.36037311"], ["COL16A1", "−1.47126191", "7.34", "−3.85744434", "0.002457281", "0.056102143", "−1.37322983"], ["PRORSD1P", "−1.25635926", "5.119", "−3.8419094", "0.002525854", "0.056873241", "−1.39958844"], ["CSPG4", "−1.70433251", "6.435", "−3.83657651", "0.002549847", "0.05703302", "−1.40864197"], ["C1QA", "1.726", "10.971", "3.824", "0.002607739", "0.057988982", "−1.43014086"], ["PCDH18", "−1.20010692", "5.687", "−3.82245976", "0.0026145", "0.057988982", "−1.43262"], ["SLC2A10", "−1.82473554", "6.629", "−3.81256837", "0.002660806", "0.058145044", "−1.44943155"], ["LOC101929787", "−1.52065348", "6.235", "−3.79932411", "0.002724138", "0.058493484", "−1.47195507"], ["ACP2", "1.293", "9.064", "3.798", "0.002728784", "0.058500499", "−1.47358656"], ["AC128677", "1.314", "7.689", "3.796", "0.002740529", "0.058599953", "−1.47769888"], ["CDH13", "−1.59536168", "7.516", "−3.7881186", "0.002778933", "0.058710644", "−1.49102324"], ["TM4SF1", "−1.13482268", "6.372", "−3.78568638", "0.002790976", "0.05882372", "−1.49516351"], ["SETBP1", "−2.04001615", "5.492", "−3.78550728", "0.002791865", "0.05882372", "−1.49546841"], ["AKR1B1", "1.001", "11.004", "3.773", "0.002855397", "0.059250757", "−1.51701084"], ["CD14", "1.06", "12.276", "3.77", "0.002869783", "0.059352832", "−1.52182209"], ["GM2A", "1.026", "8.328", "3.763", "0.00290519", "0.059646061", "−1.53356152"], ["CHN1", "−1.43327294", "7.218", "−3.75742871", "0.002934899", "0.060044226", "−1.54330163"], ["TGFBR3", "−1.94883598", "7.354", "−3.75376994", "0.002954086", "0.060277845", "−1.54953931"], ["PKIG", "−1.33129041", "7.111", "−3.75201347", "0.002963342", "0.060360921", "−1.55253423"], ["P2RX4", "1.357", "8.316", "3.749", "0.002977745", "0.060495517", "−1.55717564"], ["LY86", "1.05", "10.429", "3.741", "0.003019884", "0.060768315", "−1.57062683"], ["IGKC", "1.131", "6.415", "3.737", "0.003044466", "0.060946901", "−1.57838682"], ["LINC00702", "−1.44549954", "5.255", "−3.71950703", "0.003140146", "0.061821447", "−1.60800455"], ["FCER1G", "1.055", "10.016", "3.71", "0.003193331", "0.061904366", "−1.62407893"], ["PLA2G7", "1.197", "11.348", "3.709", "0.003202244", "0.061936817", "−1.62674627"], ["LINC00657", "−1.36968121", "8.481", "−3.69566712", "0.003276684", "0.062315323", "−1.64873798"], ["COL5A1", "−1.56308726", "8.873", "−3.69034404", "0.003307996", "0.062351143", "−1.65783893"], ["SDS", "1.479", "7.287", "3.683", "0.003350515", "0.062655973", "−1.67005981"], ["TREM2", "1.627", "9.53", "3.681", "0.003364255", "0.062761682", "−1.67397568"], ["RRN3P2", "1.172", "5.753", "3.668", "0.003442043", "0.063601298", "−1.69584691"], ["COL6A3", "−1.78321343", "11.797", "−3.6438087", "0.003595174", "0.064386793", "−1.73748812"], ["HBA1", "2.739", "8.398", "3.641", "0.003611872", "0.064536915", "−1.74192076"], ["PTPN13", "−1.03095065", "4.503", "−3.64078073", "0.003614725", "0.064538358", "−1.74267599"], ["HAMP", "1.271", "7.182", "3.626", "0.003709523", "0.065529521", "−1.76743745"], ["AHNAK2", "−1.16667494", "7.662", "−3.60878191", "0.003828129", "0.066019364", "−1.79753723"], ["CHSY3", "−1.22204212", "6.676", "−3.60638586", "0.00384462", "0.066019364", "−1.80164787"], ["NR2F2", "−1.52328366", "5.648", "−3.60405828", "0.003860709", "0.066019364", "−1.80564141"], ["NOV", "−1.91939829", "7.518", "−3.61275996", "0.00380091", "0.066019364", "−1.79071333"], ["ADH1B", "−2.23275369", "5.263", "−3.60611297", "0.003846503", "0.066019364", "−1.80211607"], ["KIAA1462", "−1.23390712", "5.005", "−3.59957708", "0.00389188", "0.066123504", "−1.81333093"], ["CD200", "−1.23990656", "6.373", "−3.59120956", "0.003950777", "0.066308294", "−1.82769256"], ["C11orf96", "−1.8970491", "9.023", "−3.59326057", "0.003936256", "0.066308294", "−1.82417191"], ["NDP", "−1.52712861", "4.978", "−3.58699312", "0.0039808", "0.066576401", "−1.8349311"], ["CCL23", "1.185", "4.999", "3.578", "0.004043445", "0.066907955", "−1.84985935"], ["LOC100506585", "1", "6.671", "3.573", "0.00408413", "0.067199089", "−1.8594304"], ["LOC100506558", "−1.09670933", "5.314", "−3.57323447", "0.004080407", "0.067199089", "−1.85855858"], ["FMOD", "−1.50776967", "8.355", "−3.57284018", "0.004083299", "0.067199089", "−1.85923586"], ["PCSK5", "−1.28009798", "6.504", "−3.56713186", "0.004125401", "0.067544018", "−1.86904207"], ["UACA", "−1.05013878", "6.654", "−3.55904856", "0.004185783", "0.068006558", "−1.88293145"], ["IGLV1-44", "1.525", "6.707", "3.553", "0.004232359", "0.068367945", "−1.89350824"], ["IGK", "2.096", "8.425", "3.548", "0.004269896", "0.068623023", "−1.90194756"], ["USP1", "−1.14547526", "7.686", "−3.53669661", "0.004357506", "0.068950885", "−1.92135753"], ["AK025288", "−1.98571356", "8.033", "−3.5350646", "0.004370323", "0.068982952", "−1.92416424"], ["GZMB", "1.385", "6.613", "3.498", "0.004675599", "0.070549122", "−1.9886731"], ["CTSD", "1.568", "11.244", "3.494", "0.004708177", "0.070735539", "−1.99530536"], ["LRRC15", "−1.12921205", "5.814", "−3.48577685", "0.004776139", "0.071144001", "−2.00899357"], ["SLC9B2", "−1.35623012", "5.458", "−3.48354936", "0.004795364", "0.071167995", "−2.01283012"], ["ADAM1A", "−1.43593993", "6.533", "−3.47742566", "0.004848625", "0.071537196", "−2.02337853"], ["SLC22A18", "1.314", "8.866", "3.476", "0.00485765", "0.071624955", "−2.02515427"], ["TPRA1", "1.382", "7.212", "3.467", "0.004939522", "0.071966184", "−2.04111418"], ["PFN2", "−1.92215403", "7.835", "−3.45452005", "0.005053263", "0.073210991", "−2.06284955"], ["MT1M", "−1.20995452", "5.25", "−3.45398354", "0.00505816", "0.073236371", "−2.06377435"], ["PLAGL1", "−1.17697226", "8.294", "−3.4374629", "0.005211362", "0.074103921", "−2.09225691"], ["VGLL3", "−1.86051455", "5.492", "−3.43570056", "0.005227981", "0.074103921", "−2.09529592"], ["TGFB1I1", "−1.91203016", "6.9", "−3.43770237", "0.005209107", "0.074103921", "−2.09184396"], ["PBX1", "−1.01705906", "5.355", "−3.43106813", "0.005271926", "0.074208576", "−2.1032848"], ["FPR1", "1.084", "6.106", "3.429", "0.005290933", "0.074385801", "−2.10671942"], ["DDIT4", "1.49", "9.718", "3.425", "0.005334084", "0.074579661", "−2.1144709"], ["VCAN", "−1.5582745", "9.014", "−3.42256774", "0.005353546", "0.074582358", "−2.11794629"], ["TLCD2", "−1.01274834", "5.575", "−3.41837151", "0.005394312", "0.074845274", "−2.12518497"], ["COL24A1", "−1.20468207", "5.625", "−3.41642392", "0.00541334", "0.074938028", "−2.12854486"], ["FAM171A1", "−1.23232038", "6.785", "−3.40813696", "0.005495071", "0.075042307", "−2.14284264"], ["PDGFD", "−1.65623364", "5.872", "−3.40000426", "0.005576505", "0.075615545", "−2.15687664"], ["LOC101928916", "−1.24868866", "9.412", "−3.38908463", "0.005687782", "0.075974146", "−2.17572328"], ["abParts", "1.055", "6.89", "3.378", "0.005800963", "0.076912316", "−2.19451488"], ["TNFRSF11B", "−2.32614996", "8.959", "−3.37306976", "0.005855088", "0.077249334", "−2.20337088"], ["CCRL2", "1.069", "9.279", "3.365", "0.005937457", "0.077894866", "−2.21669122"], ["CCDC113", "−1.17122181", "4.579", "−3.36082978", "0.005986329", "0.07824588", "−2.22450672"], ["OLFML1", "−1.85943197", "6.329", "−3.35750026", "0.006022545", "0.078508896", "−2.23025681"], ["ZNF302", "−1.01985971", "7.658", "−3.35151039", "0.00608826", "0.078859711", "−2.24060208"], ["RUNDC3B", "−1.47075415", "4.742", "−3.34993023", "0.006105717", "0.078867572", "−2.24333138"], ["IGLL5", "2.546", "6.618", "3.341", "0.006207258", "0.079187602", "−2.25905202"], ["SAMSN1", "1.212", "6.716", "3.3", "0.006686271", "0.082084201", "−2.32987484"], ["RGS5", "−1.47176028", "5.433", "−3.29976294", "0.006687231", "0.082084201", "−2.33001146"], ["CCL18", "1.7", "12.378", "3.297", "0.006715839", "0.082111048", "−2.33407705"], ["PXDN", "−1.61084531", "8.374", "−3.29718734", "0.006718561", "0.082111048", "−2.334463"], ["PLK2", "−1.72107139", "6.446", "−3.29524778", "0.006742253", "0.082290914", "−2.3378153"], ["FCRL5", "1.034", "4.663", "3.289", "0.00681584", "0.08239289", "−2.34815202"], ["C12orf75", "−1.56631522", "6.387", "−3.29035853", "0.006802353", "0.08239289", "−2.34626606"], ["DHRS3", "1.17", "8.695", "3.287", "0.006843462", "0.082497646", "−2.35200311"], ["BACE2", "−1.13729452", "8.3", "−3.2866389", "0.00684844", "0.082497646", "−2.35269546"], ["DCN", "−1.27797183", "6.941", "−3.27884117", "0.006946086", "0.082871272", "−2.36617454"], ["PCDHB16", "−2.0403688", "4.744", "−3.28141758", "0.006913668", "0.082871272", "−2.36172088"], ["FPR3", "1.108", "8.998", "3.275", "0.006992625", "0.082958974", "−2.37253155"], ["FDX1", "1.044", "9.311", "3.276", "0.006982964", "0.082958974", "−2.37121541"], ["FBXL7", "−1.10298254", "6.347", "−3.27704144", "0.006968823", "0.082958974", "−2.36928565"], ["RP11-379H18", "−1.26161514", "5.742", "−3.27700657", "0.006969264", "0.082958974", "−2.36934592"], ["SDSL", "1.193", "7.509", "3.272", "0.007038201", "0.083119231", "−2.37871581"], ["HACE1", "−1.01249208", "7.259", "−3.2716711", "0.007037119", "0.083119231", "−2.37856938"], ["HLA-DMB", "1", "11.958", "3.26", "0.007185634", "0.083941761", "−2.39844726"], ["EPHX1", "1.281", "6.325", "3.242", "0.007430938", "0.084942411", "−2.43038762"], ["FNBP1L", "−1.17944856", "7.479", "−3.2415762", "0.007432599", "0.084942411", "−2.43060032"], ["TNC", "−1.37578741", "7.69", "−3.23325442", "0.007545881", "0.085104671", "−2.44498911"], ["AQP1", "−1.49341568", "7.025", "−3.22534816", "0.007655127", "0.085609579", "−2.45865982"], ["RP11-124L9", "−1.12643933", "5.719", "−3.22277474", "0.007691029", "0.085757925", "−2.46310956"], ["CXCL1", "1.137", "6.775", "3.22", "0.007727722", "0.085890838", "−2.46763557"], ["SLC15A3", "1.214", "9.406", "3.212", "0.007839458", "0.086081652", "−2.48128533"], ["HS3ST2", "1.206", "11.404", "3.213", "0.007834345", "0.086081652", "−2.480665"], ["ANGPT1", "−1.16253508", "4.798", "−3.19883173", "0.008033349", "0.08653032", "−2.5045106"], ["HBB", "2.301", "8.438", "3.188", "0.008200276", "0.087217375", "−2.52405622"], ["LOC101928620", "1.214", "4.851", "3.184", "0.008254768", "0.08769952", "−2.53034954"], ["LRRC49", "−1.14867086", "5.705", "−3.17829006", "0.008339302", "0.088217178", "−2.54002987"], ["LAMA2", "−1.0481289", "5.445", "−3.1670848", "0.008511135", "0.088660508", "−2.55940451"], ["ZNF423", "−1.04457418", "4.446", "−3.16092116", "0.008607175", "0.089221833", "−2.57006149"], ["ZNF23", "−1.11669749", "7.011", "−3.14224086", "0.008904983", "0.090230763", "−2.60235781"], ["LINC01279", "−2.02681924", "8.138", "−3.14175538", "0.00891286", "0.090230763", "−2.6031971"], ["CTB-167B5", "−2.31293162", "5.307", "−3.14420574", "0.008873174", "0.090230763", "−2.5989609"], ["FOLR2", "1.192", "7.817", "3.138", "0.008980412", "0.090353121", "−2.61036421"], ["RAPGEF4", "−1.03668555", "4.378", "−3.13513916", "0.009020911", "0.090543007", "−2.6146349"], ["LOC100127972", "−1.01216172", "5.313", "−3.10834255", "0.009472216", "0.092466307", "−2.66095306"], ["COMP", "−2.66774652", "7.887", "−3.10283885", "0.009567691", "0.092947345", "−2.67046473"], ["RP11-690I21", "−1.02869854", "6.001", "−3.10092157", "0.009601178", "0.09298905", "−2.67377809"], ["SBDS", "−1.11130408", "6.895", "−3.09837781", "0.009645789", "0.093140037", "−2.678174"], ["IL13RA2", "−1.84607884", "5.783", "−3.08858504", "0.009819488", "0.093888012", "−2.69509576"], ["PLA2G15", "1.04", "9.387", "3.086", "0.009873995", "0.094254348", "−2.70034338"], ["COL4A1", "−1.59461938", "9.74", "−3.08497929", "0.009884235", "0.094301373", "−2.70132592"], ["MICU3", "−1.65121416", "4.776", "−3.07900138", "0.009992527", "0.094778654", "−2.71165409"], ["MRGPRF", "−1.32811473", "6.587", "−3.07627303", "0.010042348", "0.09500344", "−2.71636764"], ["SHISA3", "−2.89115811", "7.35", "−3.07619179", "0.010043835", "0.09500344", "−2.71650798"], ["SCG5", "−1.79294998", "6.654", "−3.07435902", "0.010077448", "0.095134323", "−2.71967421"], ["ESF1", "−1.01991963", "7.362", "−3.07194815", "0.010121835", "0.09529178", "−2.723839"], ["C1QB", "1.594", "11.646", "3.061", "0.010327621", "0.096081559", "−2.74290853"], ["PPAP2A", "−1.18883309", "8.397", "−3.0473476", "0.010586162", "0.09748556", "−2.76632741"], ["LOXL1", "−1.45575401", "7.401", "−3.04001176", "0.010728726", "0.09786511", "−2.77899386"], ["EFNB2", "−1.7614713", "6.572", "−3.03366254", "0.010853673", "0.098363256", "−2.78995536"], ["MFAP5", "−1.99102483", "7.296", "−3.01954597", "0.011136735", "0.099381171", "−2.81432163"], ["PRPF39", "−1.08112002", "7.339", "−3.01372934", "0.011255515", "0.099836985", "−2.82435944"], ["HLA-DRA", "1.05", "12.472", "3.008", "0.011374911", "0.100236116", "−2.83434154"], ["PALD1", "−1.13409746", "6.356", "−3.00434742", "0.011449785", "0.100236116", "−2.84054718"], ["LIMS3-LOC440895", "−1.00361209", "4.943", "−3.00361724", "0.011465045", "0.100236269", "−2.8418069"], ["SRGAP2C", "−1.12202496", "8.51", "−2.99612123", "0.01162289", "0.100589895", "−2.85473787"], ["LILRB5", "1.058", "7.406", "2.992", "0.011711091", "0.100834918", "−2.861886"], ["GUCY1B3", "−1.09481873", "6.043", "−2.98824718", "0.011791042", "0.101074761", "−2.86831842"], ["MAP1B", "−1.26295569", "7.014", "−2.98678584", "0.011822517", "0.10115834", "−2.87083853"], ["SLC14A1", "−2.08714663", "5.023", "−2.97554416", "0.012067475", "0.102481695", "−2.8902218"], ["CAV1", "−1.54266666", "9.273", "−2.97162638", "0.012154033", "0.102795272", "−2.89697559"], ["CAP2", "−1.3285113", "6.031", "−2.97096325", "0.012168746", "0.10280373", "−2.89811867"], ["MCOLN1", "1.463", "8.13", "2.969", "0.01221883", "0.102923357", "−2.90199944"], ["LUC7L3", "−1.05672069", "8.768", "−2.96672843", "0.012263123", "0.103136633", "−2.90541804"], ["ZNF185", "1.021", "8.026", "2.962", "0.012375046", "0.103527067", "−2.91400079"], ["GEM", "−1.31254579", "9.126", "−2.94762008", "0.012698168", "0.104648883", "−2.9383431"], ["G6PD", "1.013", "7.245", "2.944", "0.01278875", "0.104955796", "−2.94505403"], ["SMOC2", "−1.32742429", "6.086", "−2.9416023", "0.012838349", "0.105122304", "−2.94870821"], ["UHRF1", "−1.19022326", "6.062", "−2.93775939", "0.012928677", "0.105337267", "−2.95532626"], ["SMC3", "−1.25436837", "6.196", "−2.93208304", "0.013063263", "0.105677166", "−2.96510026"], ["ABHD17A", "1.049", "8.667", "2.93", "0.013104232", "0.105861458", "−2.96805519"], ["ANKRD36BP2", "1.259", "4.886", "2.911", "0.01358772", "0.107455605", "−3.00223375"], ["GOLGA8A", "−1.33502678", "7.411", "−2.90660944", "0.013684694", "0.107892663", "−3.00893968"], ["CCDC80", "−1.47135906", "7.984", "−2.9019688", "0.013801041", "0.10811435", "−3.01692182"], ["GPR124", "−1.04704431", "6.619", "−2.90075678", "0.013831591", "0.108178391", "−3.01900633"], ["GPRASP1", "−1.21408354", "6.161", "−2.90013968", "0.013847171", "0.10821844", "−3.02006763"], ["CSRP2", "−1.0528362", "7.237", "−2.88943576", "0.014120222", "0.108979328", "−3.03847238"], ["EDNRA", "−1.11557607", "5.042", "−2.87552836", "0.01448303", "0.110117829", "−3.06237382"], ["AJ420595", "−1.93827636", "6.9", "−2.87065154", "0.014612442", "0.110360104", "−3.07075202"], ["PCED1B", "1.082", "7.195", "2.87", "0.014631696", "0.110385766", "−3.07199205"], ["FLJ45482", "−1.15599542", "5.962", "−2.86957912", "0.014641055", "0.110385766", "−3.07259417"], ["TRIB2", "−1.33020834", "6.242", "−2.86777486", "0.014689318", "0.110606956", "−3.07569325"], ["SUSD5", 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"6.383", "−2.83821982", "0.015502856", "0.113203814", "−3.1264239"], ["PSENEN", "1.4", "7.63", "2.835", "0.015600401", "0.113510457", "−3.13232348"], ["ADORA3", "1.506", "8.249", "2.807", "0.01639745", "0.115441619", "−3.17916393"], ["FHOD3", "−1.36684403", "4.999", "−2.80469636", "0.016480005", "0.115626385", "−3.18388196"], ["SYNPO2", "−1.04598587", "5.51", "−2.80004775", "0.01662025", "0.116096583", "−3.19184194"], ["IGLJ3", "2.196", "7.381", "2.789", "0.016943387", "0.116649653", "−3.2099243"], ["INTU", "−1.06120671", "5.354", "−2.78933493", "0.016947975", "0.116649653", "−3.21017851"], ["TTC14", "−1.02237882", "7.064", "−2.78734066", "0.017009688", "0.116668823", "−3.21359085"], ["SGCE", "−1.54727914", "5.697", "−2.78702188", "0.017019573", "0.116668823", "−3.21413627"], ["ALDH1A1", "1.366", "9.167", "2.775", "0.01740769", "0.11764985", "−3.23529852"], ["CWC27", "−1.03998318", "7.371", "−2.77446547", "0.017413512", "0.11764985", "−3.23561225"], ["PCDHB10", "−1.2483677", "4.317", "−2.77218427", "0.017486046", "0.11771822", "−3.23951233"], ["COL4A2", "−1.23543218", "8.964", "−2.75287084", "0.018112264", "0.1194927", "−3.2725113"], ["JAM2", "−1.57791951", "5.778", "−2.75027808", "0.018198006", "0.119618316", "−3.27693846"], ["MS4A4A", "1.212", "10.225", "2.74", "0.018540224", "0.120631263", "−3.29439839"], ["TNFSF4", "−1.3513573", "5.39", "−2.73276259", "0.018787856", "0.121184544", "−3.30682809"], ["GHR", "−1.27758998", "4.535", "−2.71595095", "0.019371777", "0.122391782", "−3.33548585"], ["GRAMD3", "−1.12266645", "5.579", "−2.70354869", "0.019814009", "0.123078962", "−3.35660713"], ["TMEM178A", "−1.10816793", "4.327", "−2.68917108", "0.020339164", "0.124880621", "−3.38107034"], ["LRRC32", "−1.29488862", "7.886", "−2.68879414", "0.020353115", "0.124930459", "−3.38171138"], ["BRE-AS1", "1.21", "5.413", "2.68", "0.020664605", "0.125584268", "−3.39590751"], ["CRYL1", "1.018", "9.3", "2.673", "0.020957562", "0.126506082", "−3.40906024"], ["LOC101930415", "−1.13138302", "7.538", "−2.6697484", "0.021070457", "0.126805168", "−3.41407856"], ["ITGA1", "−1.43419542", "5.197", "−2.66572768", "0.021225051", "0.127197331", "−3.42090588"], ["FHL2", "−1.36563838", "8.325", "−2.65435513", "0.021668391", "0.128432655", "−3.44020578"], ["LOC100134445", "−1.11977348", "8.329", "−2.64334506", "0.022106281", "0.129903695", "−3.45887473"], ["CYB561A3", "1.151", "9.832", "2.642", "0.02215034", "0.129947681", "−3.46073208"], ["SNORD50A", "−1.04346702", "6.105", "−2.63943635", "0.022263823", "0.13022485", "−3.46549862"], ["ZNF367", "−1.03406552", "5.621", "−2.63477152", "0.022453286", "0.130646243", "−3.4734012"], ["SCG2", "−2.46514311", "5.894", "−2.62786288", "0.022736797", "0.131191602", "−3.48509962"], ["PLN", "−1.77310428", "4.955", "−2.62374641", "0.022907396", "0.131588944", "−3.49206697"], ["LINC00622", "−1.29760971", "4.816", "−2.62204858", "0.022978124", "0.131800122", "−3.49493996"], ["CCDC3", "−1.14629604", "8.171", "−2.61901746", "0.02310493", "0.131984439", "−3.50006811"], ["BDP1", "−1.02156787", "6.396", "−2.60396943", "0.023744702", "0.133564668", "−3.52550781"], ["ATP6V0D2", "1.299", "7.947", "2.603", "0.023769522", "0.133639702", "−3.52648047"], ["CDC7", "−1.2299785", "5.748", "−2.59773007", "0.024015042", "0.134500408", "−3.53604642"], ["LOC100507311", "−1.1014119", "4.723", "−2.59494021", "0.024136896", "0.134638546", "−3.54075683"], ["C2orf40", "−2.00780375", "5.604", "−2.58958986", "0.024372284", "0.134949872", "−3.54978718"], ["EFEMP2", "−1.01495407", "8.312", "−2.57717436", "0.024927207", "0.13607391", "−3.57072584"], ["SGCG", "−1.23332282", "5.997", "−2.57103843", "0.02520601", "0.136733928", "−3.58106551"], ["EFHD1", "−1.39488703", "6.468", "−2.57032983", "0.025238403", "0.136745109", "−3.58225919"], ["KMO", "1.092", "8.409", "2.57", "0.02527123", "0.136797207", "−3.58346726"], ["IGFBP6", "−1.09339489", "8.386", "−2.563997", "0.025529721", "0.137399954", "−3.59292392"], ["HSPA2", "−1.16363559", "6.492", "−2.5622374", "0.025611248", "0.137645677", "−3.59588606"], ["INHBB", "1.075", "5.453", "2.559", "0.025760526", "0.137945413", "−3.60128476"], ["GYPC", "1.031", "8.17", "2.558", "0.025791692", "0.13801015", "−3.60240783"], ["RGS4", "−1.0175785", "6.26", "−2.55787658", "0.025814394", "0.138036455", "−3.60322504"], ["CADPS2", "−1.19152589", "6.48", "−2.55757742", "0.025828388", "0.13807957", "−3.6037284"], ["RARRES1", "1.253", "9.202", "2.55", "0.026188027", "0.139012687", "−3.61656913"], ["AQP9", "1.41", "9.605", "2.545", "0.026432749", "0.139674824", "−3.62520339"], ["LOC389834", "−1.2184531", "7.174", "−2.54446388", "0.026449147", "0.139698017", "−3.62577899"], ["TMEM45A", "−1.20152293", "8.765", "−2.53745321", "0.026786972", "0.14073182", "−3.63755621"], ["GPR183", "1.037", "9.969", "2.533", "0.026986459", "0.141112074", "−3.64443905"], ["LINC00619", "−1.0745705", "3.743", "−2.52008766", "0.027642021", "0.14272822", "−3.6666939"], ["SPRY4", "−1.15340389", "7.363", "−2.51484388", "0.027905412", "0.143207217", "−3.67548254"], ["FAM20A", "1.074", "7.481", "2.514", "0.027932064", "0.143209492", "−3.67636706"], ["PKIB", "−1.69038403", "6.538", "−2.50121819", "0.028601315", "0.145050097", "−3.69829742"], ["PPP1R14A", "−1.94935478", "6.21", "−2.49821224", "0.028757099", "0.145327282", "−3.70332625"], ["DNASE2B", "1.139", "6.444", "2.486", "0.029411775", "0.146772313", "−3.72415661"], ["VMP1", "1.562", "9.523", "2.483", "0.029580001", "0.147133627", "−3.7294319"], ["IGJ", "3.104", "8.864", "2.482", "0.029625818", "0.147193406", "−3.73086328"], ["PLOD2", "−1.16827633", "8.908", "−2.47499807", "0.029988334", "0.14802969", "−3.74210872"], ["LOC101927069", "−1.60316052", "5.125", "−2.47180935", "0.030161414", "0.148104476", "−3.74742831"], ["SPARCL1", "−1.88778385", "9.426", "−2.47061628", "0.030226422", "0.148241776", "−3.74941817"], ["GPX3", "1.22", "10.365", "2.463", "0.030651314", "0.149356193", "−3.76231603"], ["PRICKLE2", "−1.08501938", "4.945", "−2.45977406", "0.030823469", "0.149757159", "−3.76748936"], ["THBS1", "−1.00450902", "6.406", "−2.45649882", "0.031006068", "0.150173348", "−3.77294402"], ["PPP1R3C", "−1.10842436", "5.881", "−2.45049465", "0.031343543", "0.15083513", "−3.78293825"], ["CTGF", "−1.68043237", "10.245", "−2.44316364", "0.031760431", "0.151849734", "−3.79513177"], ["PLGLB1", "−1.04046038", "5.02", "−2.44033293", "0.031922839", "0.152238333", "−3.79983726"], ["ZNF521", "−1.25923381", "4.897", "−2.43804712", "0.032054572", "0.152398313", "−3.80363583"], ["PTPRZ1", "−1.04325", "4.2", "−2.42396632", "0.032877759", "0.154295501", "−3.82701284"], ["GPM6B", "−1.15925929", "4.968", "−2.41770644", "0.033250266", "0.155136811", "−3.8373929"], ["AK021977", "−1.05674346", "5.415", "−2.40910828", "0.033768584", "0.156085006", "−3.85163739"], ["OLFML2A", "−1.13887278", "6.219", "−2.39552362", "0.034603473", "0.157597428", "−3.87411218"], ["MANSC1", "−1.20061235", "5.162", "−2.37742265", "0.035746982", "0.159649267", "−3.90399891"], ["CX3CL1", "−1.20643257", "6.702", "−2.37411628", "0.035959764", "0.160110005", "−3.90945057"], ["MEOX1", "−1.3648004", "5.619", "−2.37259553", "0.036058041", "0.160155144", "−3.91195724"], ["FIGN", "−1.16179673", "4.34", "−2.37020584", "0.036212997", "0.160409247", "−3.91589518"], ["F3", "−1.2706323", "7.831", "−2.36731755", "0.036401141", "0.160690719", "−3.9206531"], ["AC012065", "−1.36960739", "7.269", "−2.36455566", "0.036581934", "0.161096543", "−3.92520112"], ["HSP90B1", "−1.0931333", "6.992", "−2.35529786", "0.037194283", "0.162507108", "−3.94043371"], ["FAM46C", "1.128", "6.681", "2.331", "0.038840666", "0.164775579", "−3.98013075"], ["DYSF", "1.147", "8.407", "2.325", "0.039302486", "0.16534884", "−3.99095213"], ["AKR1C3", "−1.37012153", "8.401", "−2.3184279", "0.039732384", "0.166435652", "−4.00090724"], ["LOC100506076", "−1.03285843", "6.345", "−2.30883743", "0.040419389", "0.167696452", "−4.01658575"], ["AK5", "−1.13886628", "5.649", "−2.30470529", "0.040718893", "0.167998808", "−4.02333424"], ["BC017398", "−1.18816092", "4.847", "−2.29570776", "0.041378431", "0.169190839", "−4.03801454"], ["SRGAP2B", "−1.49183273", "7.338", "−2.28478755", "0.042192668", "0.170586274", "−4.05580544"], ["LOC100130872", "1.199", "7.965", "2.283", "0.042330561", "0.170715418", "−4.0587829"], ["PDGFRB", "−1.21137854", "7.133", "−2.26745861", "0.043516326", "0.172980554", "−4.08397666"], ["CRYAB", "−1.00937569", "7.311", "−2.26452563", "0.043744255", "0.173371994", "−4.08873726"], ["IBSP", "−1.27075954", "8.743", "−2.23484703", "0.046115718", "0.176965926", "−4.13678496"], ["JPX", "−1.01960017", "4.715", "−2.22531267", "0.04690324", "0.178402425", "−4.15217142"], ["IFIT2", "−1.27238246", "7.817", "−2.19997112", "0.04905913", "0.181687766", "−4.19294792"]], "row_count": 574, "column_count": 7, "numeric_cells": 3585, "header_rows": 1, "locator": "section[12]/table-wrap[1]#T3"}}, {"id": "asset:table:pmid:30643084:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:995851ea7a32b50e4a74e5ce78c9c3a90286da6efcbd1051c0d18e2f095860db", "bytes": 50593, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[1]#T3", "version": null, "note": "The list of all differentially expressed genes", "structure": {"pmcid": "PMC6629752", "section_index": 12, "section_title": "Identification of DEGs", "row_count": 574, "column_count": 7}, "table": {"label": "Supplementary Table 1.", "caption": "The list of all differentially expressed genes", "rows": [["", "logFC", "AveExpr", "t", "P.Value", "adj.P.Val", "B"], ["PIK3R6", "1.2", "6.319", "8.201", "3.85E-06", "0.011196886", "4.626"], ["CEMIP", "−1.25669178", "7.687", "−8.95594463", "1.59E-06", "0.011196886", "5.387"], ["CTNNAL1", "−1.50635456", "7.069", "−8.76434724", "1.98E-06", "0.011196886", "5.2"], ["ROBO1", "−2.70565648", "8.496", "−8.84771249", "1.79E-06", "0.011196886", "5.282"], ["ITGBL1", "−3.36215802", "7.681", "−8.27010501", "3.54E-06", "0.011196886", "4.699"], ["METRNL", "1.002", "9.818", "8.071", "4.51E-06", "0.011665271", "4.487"], ["CD38", "1.565", "6.27", "7.222", "1.33E-05", "0.014239233", "3.526"], ["MPP1", "1.133", "10.398", "7.139", "1.49E-05", "0.014239233", "3.426"], ["TMA16", "−1.37306826", "6.025", "−7.14752281", "1.47E-05", "0.014239233", "3.436"], ["LNX1", "−1.43840671", "5.596", "−7.69369652", "7.22E-06", "0.014239233", "4.073"], ["NT5E", "−1.45802181", "6.667", "−7.10333002", "1.56E-05", "0.014239233", "3.383"], ["PMEPA1", "−1.62651784", "7.781", "−6.9731982", "1.86E-05", "0.014239233", "3.224"], ["CRTAC1", "−1.76339168", "7.001", "−7.42291778", "1.02E-05", "0.014239233", "3.763"], ["SULF1", "−1.79939429", "10.654", "−7.25296984", "1.28E-05", "0.014239233", "3.563"], ["HECW2", "−1.89456819", "5.37", "−7.158743", "1.45E-05", "0.014239233", "3.45"], ["GLIS2", "−2.1429111", "7.666", "−7.34832308", "1.13E-05", 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["ISLR", "−2.49728223", "7.143", "−5.8014734", "9.98E-05", "0.020557983", "1.674"], ["FRY", "−1.05072072", "5.327", "−5.74316552", "0.000109014", "0.02098725", "1.591"], ["ACTA2", "−2.91276358", "5.63", "−5.74280218", "0.000109074", "0.02098725", "1.59"], ["STON1", "−1.1288534", "5.259", "−5.70844297", "0.00011494", "0.021749286", "1.541"], ["RBMS3", "−1.20418414", "4.754", "−5.70335452", "0.000115837", "0.021749286", "1.534"], ["SNX7", "−1.01351647", "8.664", "−5.66744557", "0.00012238", "0.021750042", "1.482"], ["TRPC1", "−1.48467559", "5.479", "−5.68361084", "0.000119387", "0.021750042", "1.505"], ["LOC102725271", "−2.08021698", "6.195", "−5.6792456", "0.000120188", "0.021750042", "1.499"], ["FZD6", "−2.52508467", "6.587", "−5.66876178", "0.000122134", "0.021750042", "1.484"], ["TMEM200A", "−2.65799647", "7.649", "−5.68436322", "0.00011925", "0.021750042", "1.506"], ["LTBP1", "−2.66774268", "9.446", "−5.63414494", "0.000128799", "0.021887182", "1.434"], ["HCK", "1.027", "10.062", "5.586", "0.00013864", "0.022335508", "1.365"], ["WISP1", "−1.09763938", "5.262", "−5.58419252", "0.000139105", "0.022335508", "1.362"], ["GPX8", "−2.09217016", "7.453", "−5.58734641", "0.000138429", "0.022335508", "1.366"], ["ECM2", "−2.26273265", "6.217", "−5.56641706", "0.00014298", "0.022645381", "1.336"], ["ZNF532", "−1.17796726", "7.645", "−5.54560073", "0.000147664", "0.022803536", "1.306"], ["KCNT2", "−3.25602404", "6.031", "−5.54458613", "0.000147897", "0.022803536", "1.304"], ["FSTL1", "−1.2961765", "8.781", "−5.53364296", "0.000150428", "0.02299253", "1.288"], ["POSTN", "−2.00535336", "7.828", "−5.5290006", "0.000151516", "0.02299253", "1.281"], ["LCP1", "1.126", "9.603", "5.458", "0.000169281", "0.023576697", "1.177"], ["ASAP2", "−1.0195605", "8.974", "−5.42846544", "0.000177234", "0.023576697", "1.134"], ["LOC100996668", "−1.03219502", "5.509", "−5.43837456", "0.000174505", "0.023576697", "1.148"], ["LOXL1-AS1", "−1.29412144", "4.801", "−5.46806046", "0.000166593", 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["GRN", "1.017", "12.203", "4.901", "0.000412639", "0.031191784", "0.332599348"], ["TNFAIP6", "−2.22807951", "7.13", "−4.86846811", "0.000435649", "0.031943596", "0.280950449"], ["ZBTB20", "−1.00515779", "6.98", "−4.84421694", "0.000453401", "0.03248024", "0.242921225"], ["SUGCT", "−1.88509353", "7.086", "−4.84428645", "0.000453349", "0.03248024", "0.243030364"], ["CDH11", "−1.95194678", "7.012", "−4.84519063", "0.000452674", "0.03248024", "0.244449829"], ["KIAA1377", "−1.11080072", "4.659", "−4.82196057", "0.000470362", "0.032662868", "0.20794168"], ["CCND1", "−1.15263195", "8.102", "−4.8216234", "0.000470624", "0.032662868", "0.207411186"], ["CDH2", "−1.2169333", "7.663", "−4.8223331", "0.000470072", "0.032662868", "0.208527793"], ["NOX4", "−1.82320944", "4.658", "−4.82715307", "0.000466346", "0.032662868", "0.216109247"], ["HMOX1", "2.226", "11.122", "4.813", "0.000477479", "0.032773348", "0.193633653"], ["IL10RA", "1.003", "10.987", "4.812", "0.000478063", "0.032773348", "0.192469301"], ["BICC1", "−1.10999716", "4.796", "−4.79730384", "0.000489933", "0.032967077", "0.169102285"], ["AX747132", "−1.48765545", "5.276", "−4.78862768", "0.000497021", "0.03306183", "0.15541382"], ["SFRP2", "−3.62509444", "8.232", "−4.78137924", "0.000503025", "0.033365917", "0.143969241"], ["ARRB2", "1.21", "8.361", "4.759", "0.000521784", "0.033462477", "0.109069249"], ["SPATA18", "−1.01167048", "6.085", "−4.7517964", "0.000528332", "0.033462477", "0.097179376"], ["PRTFDC1", "−1.20002167", "5.839", "−4.75113323", "0.000528915", "0.033462477", "0.096128966"], ["HEG1", "−1.29863636", "9.213", "−4.75486385", "0.000525647", "0.033462477", "0.10203709"], ["PCDHGA4", "−1.61801494", "4.893", "−4.76503003", "0.00051685", "0.033462477", "0.11812655"], ["COL1A2", "−2.23065822", "10.887", "−4.75182652", "0.000528306", "0.033462477", "0.097227086"], ["MYH10", "−2.4727541", "7.291", "−4.75829436", "0.000522661", "0.033462477", "0.107468095"], ["SLC48A1", "1.098", "7.003", "4.744", "0.000535212", "0.033625891", "0.084843842"], ["PTPRG", "−1.06299347", "4.626", "−4.72336071", "0.00055392", "0.034040944", "0.052081228"], ["PDGFA", "−1.20814415", "7.245", "−4.7231203", "0.000554141", "0.034040944", "0.051699445"], ["STEAP1", "−1.59703261", "7.015", "−4.71504336", "0.000561647", "0.034411224", "0.03886755"], ["TPM1", "−1.28919304", "7.279", "−4.71171411", "0.000564772", "0.03441254", "0.033575558"], ["NEU1", "1.14", "8.864", "4.701", "0.000575252", "0.034515567", "0.016035637"], ["CX3CR1", "−1.15611971", "6.078", "−4.69985497", "0.000576051", "0.034515567", "0.014711631"], ["RP4-614O4", "−1.30864069", "5.283", "−4.69918825", "0.000576693", "0.034515567", "0.01365048"], ["GUCY1A3", "−2.45288651", "6.228", "−4.69733727", "0.000578476", "0.034533555", "0.010704154"], ["DPT", "−2.10253648", "6.383", "−4.68924907", "0.000586339", "0.034865462", "−0.002176312"], ["COL5A2", "−2.51114645", "9.242", "−4.68842114", "0.00058715", "0.034865462", "−0.003495332"], ["MZB1", "2.34", "6.786", "4.665", "0.00061014", "0.035032694", "−0.040144013"], ["ATP6V0B", "1.249", "10.161", "4.67", "0.000605709", "0.035032694", "−0.033189336"], ["FERMT2", "−1.32252556", "6.945", "−4.66808806", "0.000607445", "0.035032694", "−0.035920518"], ["YAP1", "−1.72909066", "6.431", "−4.66877616", "0.000606747", "0.035032694", "−0.034822218"], ["EML1", "−1.99655211", "5.432", "−4.66075832", "0.000614941", "0.035032694", "−0.047624057"], ["CFH", "−2.1218776", "10.83", "−4.67777279", "0.000597689", "0.035032694", "−0.020468742"], ["2018/3/2", "−1.049441", "6.229", "−4.64018199", "0.000636504", "0.035582405", "−0.080520385"], ["IGFBP7", "−1.17251974", "8.893", "−4.61773173", "0.000660938", "0.036207263", "−0.116482484"], ["DZIP1", "−1.21446462", "5.069", "−4.61329159", "0.000665885", "0.036207263", "−0.123603551"], ["IQCJ-SCHIP1", "−1.89678603", "7.193", "−4.59387208", "0.000687985", "0.036631536", "−0.154781644"], ["TAF1A", "−1.29817562", "5.537", "−4.57505232", "0.000710136", "0.037323023", "−0.185048194"], ["MXRA5", "−2.08246518", "9.942", "−4.5760163", "0.000708983", "0.037323023", "−0.183496667"], ["MYO1B", "−1.06000364", "5.771", "−4.56172834", "0.000726268", "0.037659193", "−0.206506663"], ["SLCO2B1", "1.319", "8.457", "4.533", "0.000762207", "0.038274727", "−0.252652647"], ["GSTT2", "−1.10875678", "6.235", "−4.53840847", "0.000755434", "0.038274727", "−0.244123997"], ["AEBP1", "−2.35590453", "10.096", "−4.52961448", "0.000766748", "0.038274727", "−0.25832946"], ["FCGRT", "1.177", "10.833", "4.52", "0.000778957", "0.038504641", "−0.273426586"], ["FAT4", "−2.56303105", "6.048", "−4.51762232", "0.000782464", "0.038596008", "−0.27771853"], ["INHBA", "−1.86991676", "6.789", "−4.51503663", "0.000785896", "0.038683361", "−0.281901738"], ["IGKV1-17", "2.579", "7.067", "4.507", "0.00079641", "0.038894789", "−0.294602761"], ["CYP27A1", "1.326", "11.108", "4.498", "0.000808921", "0.039131153", "−0.30950161"], ["LOC100506119", "1.01", "7.294", "4.488", "0.000822133", "0.039303695", "−0.324987906"], ["VEGFC", "−1.83703081", "7.396", "−4.48856265", "0.000821959", "0.039303695", "−0.324785545"], ["GAA", "1.167", "9.206", "4.473", "0.000843911", "0.039994585", "−0.349981918"], ["NFIB", "−1.32832364", "5.712", "−4.45439285", "0.00087108", "0.040260819", "−0.38027823"], ["SERTAD4", "−1.21609373", "4.817", "−4.44402046", "0.00088659", "0.040401598", "−0.397154852"], ["PLTP", "1.311", "10.929", "4.432", "0.000904488", "0.040436634", "−0.416267419"], ["CTSA", "1.163", "10.809", "4.441", "0.000890772", "0.040436634", "−0.401654419"], ["SLC16A4", "−1.39699797", "4.694", "−4.42089439", "0.00092222", "0.040517383", "−0.434835104"], ["FOXC1", "−2.12951548", "8.291", "−4.42836534", "0.000910549", "0.040517383", "−0.422654485"], ["IGKV1OR2-108", "1.868", "7.811", "4.397", "0.000960932", "0.040756283", "−0.47416657"], ["TJP1", "−1.08938082", "6.622", "−4.40604957", "0.000945876", "0.040756283", "−0.459060347"], ["ZNRF3", "−1.12957808", "5.084", "−4.39928713", "0.000956861", "0.040756283", "−0.470105748"], ["MPDZ", "−1.54103226", "6.522", "−4.40894973", "0.000941205", "0.040756283", "−0.45432526"], ["NET1", "−1.60153131", "7.662", "−4.39586793", "0.000962467", "0.040756283", "−0.475692803"], ["SNAI2", "−2.33153198", "6.709", "−4.39421282", "0.000965192", "0.040756283", "−0.478397851"], ["TANC1", "−1.04522496", "5.558", "−4.38674571", "0.000977589", "0.040935653", "−0.490606346"], ["IGKC", "1.285", "6.009", "4.382", "0.000985827", "0.040965943", "−0.498633937"], ["ACOT13", "1.03", "7.829", "4.375", "0.000997539", "0.040965943", "−0.509933389"], ["SPARC", "−1.20354323", "11.219", "−4.3753052", "0.000996905", "0.040965943", "−0.509325556"], ["GSTA4", "−1.29851562", "6.86", "−4.36613168", "0.001012682", "0.040965943", "−0.524347965"], ["ZBTB8A", "−1.37631649", "7.052", "−4.37997542", "0.000988972", "0.040965943", "−0.50168195"], ["FST", "−1.76779273", "6.563", "−4.36991914", "0.001006137", "0.040965943", "−0.51814434"], ["TWIST1", "−2.11250906", "7.358", "−4.36900418", "0.001007714", "0.040965943", "−0.519642824"], ["AOC3", "−2.28787858", "7.915", "−4.3647634", "0.001015057", "0.040965943", "−0.52658959"], ["ATL1", "−1.00687259", "6.814", "−4.3604407", "0.0010226", "0.041059108", "−0.533672997"], ["CRISPLD1", "−3.53397277", "5.399", "−4.35427774", "0.001033455", "0.041200168", "−0.543776176"], ["SSPN", "−1.17667481", "5.806", "−4.35112305", "0.001039058", "0.041292889", "−0.548949711"], ["PPP1R15A", "1.035", "7.244", "4.335", "0.001068043", "0.041862246", "−0.575277661"], ["MGLL", "1.074", "10.068", "4.323", "0.001090989", "0.042231298", "−0.595619862"], ["CFHR2", "−1.05882399", "6.425", "−4.3235495", "0.001089399", "0.042231298", "−0.594224097"], ["AMOTL2", "−2.27119759", "7.063", "−4.3168058", "0.001102093", "0.04241147", "−0.605311898"], ["TNFRSF17", "2.009", "4.822", "4.298", "0.001138401", "0.043046977", "−0.636334631"], ["SLC24A3", "−1.37012793", "6.638", "−4.29952451", "0.001135333", "0.043046977", "−0.633751967"], ["NDC80", "−1.4974775", "7.142", "−4.30164087", "0.001131207", "0.043046977", "−0.630266987"], ["AP1B1", "1.11", "8.429", "4.28", "0.001174262", "0.043593147", "−0.666022436"], ["H2BFS", "1.222", "5.121", "4.271", "0.001191769", "0.04384424", "−0.68018847"], ["MAP4K4", "−1.04172561", "7.215", "−4.27171029", "0.001191044", "0.04384424", "−0.679606089"], ["PLD3", "1.916", "10.825", "4.264", "0.001208022", "0.043913909", "−0.693155632"], ["ENPP1", "−1.14642047", "4.826", "−4.26575893", "0.00120333", "0.043913909", "−0.689430104"], ["ITGA10", "−1.85620797", "7.214", "−4.26030907", "0.001214696", "0.043913909", "−0.69843019"], ["IGKV1-37", "1.831", "7.021", "4.236", "0.001267234", "0.044290054", "−0.738968381"], ["GPC6", "−1.1298533", "6.394", "−4.23566454", "0.001267508", "0.044290054", "−0.739175243"], ["C9orf3", "−1.47756582", "6.871", "−4.24153164", "0.001254722", "0.044290054", "−0.729468257"], ["GXYLT2", "−1.69386575", "5.555", "−4.24355961", "0.001250334", "0.044290054", "−0.726114027"], ["VMO1", "1.666", "7.962", "4.229", "0.001281973", "0.044349043", "−0.750040061"], ["MGARP", "−1.55504243", "5.353", "−4.19551", "0.001358735", "0.045692391", "−0.805723339"], ["GLUL", "1.145", "11.202", "4.182", "0.001390136", "0.046038611", "−0.827601836"], ["CD27", "1.21", "7.39", "4.179", "0.001399117", "0.046139169", "−0.833769133"], ["MYLK", "−1.14019221", "6.013", "−4.17280728", "0.001413311", "0.046410017", "−0.843434981"], ["LOC728061", "−2.05163732", "5.984", "−4.16582764", "0.001430544", "0.04677797", "−0.855041301"], ["COL3A1", "−2.07311618", "10.754", "−4.16094377", "0.001442732", "0.046974735", "−0.86316603"], ["SYNM", "−2.20201792", "7.297", "−4.13903732", "0.001498743", "0.047474464", "−0.899643872"], ["IL4I1", "1.077", "7.981", "4.13", "0.001523648", "0.047937254", "−0.915428286"], ["POR", "1.289", "7.363", "4.114", "0.001564286", "0.048233071", "−0.940638903"], ["LURAP1L", "−1.87326982", "5.808", "−4.11317906", "0.001567777", "0.048233071", "−0.942774118"], ["PEPD", "1.135", "8.808", "4.105", "0.00159094", "0.048355035", "−0.956822001"], ["SYNC", "−1.48850046", "5.161", "−4.10469247", "0.001591146", "0.048355035", "−0.956946087"], ["OMD", "−2.78152739", "5.449", "−4.10474212", "0.001591009", "0.048355035", "−0.956863151"], ["PROCR", "−1.00314734", "7.544", "−4.09518", "0.001617771", "0.048689939", "−0.972840972"], ["CD180", "1.345", "7.32", "4.083", "0.001653047", "0.048855534", "−0.993502199"], ["PPFIBP1", "−1.13010206", "5.456", "−4.07920891", "0.001663519", "0.048855534", "−0.999550951"], ["PRRX1", "−1.6549019", "6.099", "−4.07511267", "0.001675467", "0.048855534", "−1.0064061"], ["CFH", "−2.33548068", "9.12", "−4.07508164", "0.001675558", "0.048855534", "−1.00645803"], ["BGN", "−1.62394918", "8.095", "−4.06341277", "0.001710086", "0.04915337", "−1.02599645"], ["COL15A1", "−1.89798428", "9.581", "−4.06441292", "0.001707098", "0.04915337", "−1.02432119"], ["IGLL3P", "2.172", "9.334", "4.06", "0.001721112", "0.049322321", "−1.03215249"], ["CYAT1", "1.22", "7.027", "4.059", "0.001723207", "0.049322321", "−1.03331779"], ["ZNF404", "−1.06352944", "4.472", "−4.05407513", "0.001738248", "0.049353524", "−1.04164231"], ["SFRP4", "−2.93801794", "6.929", "−4.05424937", "0.001737718", "0.049353524", "−1.04135026"], ["IGLC1", "1.596", "7.517", "4.046", "0.001763359", "0.049473158", "−1.05538118"], ["HLA-DMA", "1.306", "11.378", "4.045", "0.001765836", "0.049473158", "−1.05672574"], ["CEP290", "−1.0804849", "6.391", "−4.04268175", "0.001773262", "0.049621504", "−1.0607457"], ["CXCL3", "1.317", "7.891", "4.039", "0.001784045", "0.049684365", "−1.06655264"], ["MS4A6E", "1.668", "4.81", "4.037", "0.001791087", "0.049820889", "−1.07032628"], ["ACKR4", "−1.52268155", "4.42", "−4.02988751", "0.001813455", "0.050044606", "−1.0822148"], ["EFEMP1", "−1.54844572", "8.354", "−4.02769537", "0.001820435", "0.050157839", "−1.08589504"], ["LHFP", "−1.81885212", "6.486", "−4.02237604", "0.00183749", "0.050516661", "−1.09482749"], ["ADM", "1.107", "11.237", "4.02", "0.001845287", "0.050543483", "−1.09888318"], ["SEMA5A", "−1.41324129", "6.863", "−4.01790982", "0.001851938", "0.050606592", "−1.10232973"], ["C3orf80", "−1.72303094", "4.81", "−4.01381707", "0.001865281", "0.050838319", "−1.10920649"], ["ZNF667-AS1", "−1.74621215", "6.251", "−3.99983639", "0.001911615", "0.051114758", "−1.13271066"], ["PCDH10", "−2.08087587", "5.158", "−4.00221063", "0.001903663", "0.051114758", "−1.12871765"], ["CD52", "1.832", "10.092", "3.997", "0.001922413", "0.051145657", "−1.13810607"], ["TCN2", "1.51", "9.023", "3.996", "0.001924853", "0.051145657", "−1.13932131"], ["PILRA", "1.096", "8.679", "3.99", "0.001943711", "0.051191763", "−1.14866009"], ["RP11-182L21", "−1.17416448", "6.41", "−3.98819442", "0.001951108", "0.051191763", "−1.15229877"], ["METTL7B", "2.348", "7.441", "3.974", "0.00199995", "0.05152927", "−1.17598256"], ["HIST1H2BK", "1.241", "8.407", "3.972", "0.002006245", "0.051555629", "−1.17899306"], ["CALD1", "−1.15502391", "6.474", "−3.97143398", "0.002009454", "0.051581145", "−1.18052373"], ["MIR143HG", "−1.7863461", "6.767", "−3.96581334", "0.002029422", "0.051859691", "−1.18999551"], ["PTN", "−1.23570748", "5.634", "−3.93877431", "0.002128393", "0.052998117", "−1.23560607"], ["GJA1", "−1.84211055", "9.798", "−3.93940584", "0.002126025", "0.052998117", "−1.23453994"], ["SLITRK4", "−1.09949375", "4.732", "−3.92826729", "0.002168187", "0.053248877", "−1.25334957"], ["ZNF680", "−1.15108211", "6.536", "−3.92920137", "0.002164618", "0.053248877", "−1.25177171"], ["RP11-305O6", "−1.5668101", "5.155", "−3.92047009", "0.002198215", "0.053590398", "−1.26652398"], ["PEAR1", "−1.45350304", "6.879", "−3.91007867", "0.002238903", "0.053945632", "−1.28409097"], ["PCOLCE", "−1.46136398", "8.89", "−3.90848164", "0.002245225", "0.053945632", "−1.28679173"], ["SLIT2", "−1.73248051", "7.539", "−3.91111181", "0.002234823", "0.053945632", "−1.28234394"], ["MID1", "−1.21316819", "6.613", "−3.90211625", "0.002270606", "0.054219745", "−1.29755876"], ["OGN", "−3.53385479", "5.648", "−3.90268222", "0.002268337", "0.054219745", "−1.29660127"], ["NKG7", "1.198", "5.988", "3.9", "0.002277495", "0.054328521", "−1.30046024"], ["PHOSPHO2", "−1.27042123", "5.769", "−3.89654933", "0.002293047", "0.054587647", "−1.30697841"], ["CD72", "1.917", "7.487", "3.881", "0.002356347", "0.055377521", "−1.33305954"], ["TMEM133", "−1.46004818", "4.868", "−3.88095243", "0.002357148", "0.055377521", "−1.3333853"], ["SYTL2", "−1.07422641", "5.833", "−3.87363677", "0.00238785", "0.055649564", "−1.34577929"], ["FAIM3", "1.669", "7.098", "3.868", "0.002412198", "0.055904268", "−1.35549554"], ["IGLC1", "1.244", "5.63", "3.865", "0.002424514", "0.055963427", "−1.36037311"], ["COL16A1", "−1.47126191", "7.34", "−3.85744434", "0.002457281", "0.056102143", "−1.37322983"], ["PRORSD1P", "−1.25635926", "5.119", "−3.8419094", "0.002525854", "0.056873241", "−1.39958844"], ["CSPG4", "−1.70433251", "6.435", "−3.83657651", "0.002549847", "0.05703302", "−1.40864197"], ["C1QA", "1.726", "10.971", "3.824", "0.002607739", "0.057988982", "−1.43014086"], ["PCDH18", "−1.20010692", "5.687", "−3.82245976", "0.0026145", "0.057988982", "−1.43262"], ["SLC2A10", "−1.82473554", "6.629", "−3.81256837", "0.002660806", "0.058145044", "−1.44943155"], ["LOC101929787", "−1.52065348", "6.235", "−3.79932411", "0.002724138", "0.058493484", "−1.47195507"], ["ACP2", "1.293", "9.064", "3.798", "0.002728784", "0.058500499", "−1.47358656"], ["AC128677", "1.314", "7.689", "3.796", "0.002740529", "0.058599953", "−1.47769888"], ["CDH13", "−1.59536168", "7.516", "−3.7881186", "0.002778933", "0.058710644", "−1.49102324"], ["TM4SF1", "−1.13482268", "6.372", "−3.78568638", "0.002790976", "0.05882372", "−1.49516351"], ["SETBP1", "−2.04001615", "5.492", "−3.78550728", "0.002791865", "0.05882372", "−1.49546841"], ["AKR1B1", "1.001", "11.004", "3.773", "0.002855397", "0.059250757", "−1.51701084"], ["CD14", "1.06", "12.276", "3.77", "0.002869783", "0.059352832", "−1.52182209"], ["GM2A", "1.026", "8.328", "3.763", "0.00290519", "0.059646061", "−1.53356152"], ["CHN1", "−1.43327294", "7.218", "−3.75742871", "0.002934899", "0.060044226", "−1.54330163"], ["TGFBR3", "−1.94883598", "7.354", "−3.75376994", "0.002954086", "0.060277845", "−1.54953931"], ["PKIG", "−1.33129041", "7.111", "−3.75201347", "0.002963342", "0.060360921", "−1.55253423"], ["P2RX4", "1.357", "8.316", "3.749", "0.002977745", "0.060495517", "−1.55717564"], ["LY86", "1.05", "10.429", "3.741", "0.003019884", "0.060768315", "−1.57062683"], ["IGKC", "1.131", "6.415", "3.737", "0.003044466", "0.060946901", "−1.57838682"], ["LINC00702", "−1.44549954", "5.255", "−3.71950703", "0.003140146", "0.061821447", "−1.60800455"], ["FCER1G", "1.055", "10.016", "3.71", "0.003193331", "0.061904366", "−1.62407893"], ["PLA2G7", "1.197", "11.348", "3.709", "0.003202244", "0.061936817", "−1.62674627"], ["LINC00657", "−1.36968121", "8.481", "−3.69566712", "0.003276684", "0.062315323", "−1.64873798"], ["COL5A1", "−1.56308726", "8.873", "−3.69034404", "0.003307996", "0.062351143", "−1.65783893"], ["SDS", "1.479", "7.287", "3.683", "0.003350515", "0.062655973", "−1.67005981"], ["TREM2", "1.627", "9.53", "3.681", "0.003364255", "0.062761682", "−1.67397568"], ["RRN3P2", "1.172", "5.753", "3.668", "0.003442043", "0.063601298", "−1.69584691"], ["COL6A3", "−1.78321343", "11.797", "−3.6438087", "0.003595174", "0.064386793", "−1.73748812"], ["HBA1", "2.739", "8.398", "3.641", "0.003611872", "0.064536915", "−1.74192076"], ["PTPN13", "−1.03095065", "4.503", "−3.64078073", "0.003614725", "0.064538358", "−1.74267599"], ["HAMP", "1.271", "7.182", "3.626", "0.003709523", "0.065529521", "−1.76743745"], ["AHNAK2", "−1.16667494", "7.662", "−3.60878191", "0.003828129", "0.066019364", "−1.79753723"], ["CHSY3", "−1.22204212", "6.676", "−3.60638586", "0.00384462", "0.066019364", "−1.80164787"], ["NR2F2", "−1.52328366", "5.648", "−3.60405828", "0.003860709", "0.066019364", "−1.80564141"], ["NOV", "−1.91939829", "7.518", "−3.61275996", "0.00380091", "0.066019364", "−1.79071333"], ["ADH1B", "−2.23275369", "5.263", "−3.60611297", "0.003846503", "0.066019364", "−1.80211607"], ["KIAA1462", "−1.23390712", "5.005", "−3.59957708", "0.00389188", "0.066123504", "−1.81333093"], ["CD200", "−1.23990656", "6.373", "−3.59120956", "0.003950777", "0.066308294", "−1.82769256"], ["C11orf96", "−1.8970491", "9.023", "−3.59326057", "0.003936256", "0.066308294", "−1.82417191"], ["NDP", "−1.52712861", "4.978", "−3.58699312", "0.0039808", "0.066576401", "−1.8349311"], ["CCL23", "1.185", "4.999", "3.578", "0.004043445", "0.066907955", "−1.84985935"], ["LOC100506585", "1", "6.671", "3.573", "0.00408413", "0.067199089", "−1.8594304"], ["LOC100506558", "−1.09670933", "5.314", "−3.57323447", "0.004080407", "0.067199089", "−1.85855858"], ["FMOD", "−1.50776967", "8.355", "−3.57284018", "0.004083299", "0.067199089", "−1.85923586"], ["PCSK5", "−1.28009798", "6.504", "−3.56713186", "0.004125401", "0.067544018", "−1.86904207"], ["UACA", "−1.05013878", "6.654", "−3.55904856", "0.004185783", "0.068006558", "−1.88293145"], ["IGLV1-44", "1.525", "6.707", "3.553", "0.004232359", "0.068367945", "−1.89350824"], ["IGK", "2.096", "8.425", "3.548", "0.004269896", "0.068623023", "−1.90194756"], ["USP1", "−1.14547526", "7.686", "−3.53669661", "0.004357506", "0.068950885", "−1.92135753"], ["AK025288", "−1.98571356", "8.033", "−3.5350646", "0.004370323", "0.068982952", "−1.92416424"], ["GZMB", "1.385", "6.613", "3.498", "0.004675599", "0.070549122", "−1.9886731"], ["CTSD", "1.568", "11.244", "3.494", "0.004708177", "0.070735539", "−1.99530536"], ["LRRC15", "−1.12921205", "5.814", "−3.48577685", "0.004776139", "0.071144001", "−2.00899357"], ["SLC9B2", "−1.35623012", "5.458", "−3.48354936", "0.004795364", "0.071167995", "−2.01283012"], ["ADAM1A", "−1.43593993", "6.533", "−3.47742566", "0.004848625", "0.071537196", "−2.02337853"], ["SLC22A18", "1.314", "8.866", "3.476", "0.00485765", "0.071624955", "−2.02515427"], ["TPRA1", "1.382", "7.212", "3.467", "0.004939522", "0.071966184", "−2.04111418"], ["PFN2", "−1.92215403", "7.835", "−3.45452005", "0.005053263", "0.073210991", "−2.06284955"], ["MT1M", "−1.20995452", "5.25", "−3.45398354", "0.00505816", "0.073236371", "−2.06377435"], ["PLAGL1", "−1.17697226", "8.294", "−3.4374629", "0.005211362", "0.074103921", "−2.09225691"], ["VGLL3", "−1.86051455", "5.492", "−3.43570056", "0.005227981", "0.074103921", "−2.09529592"], ["TGFB1I1", "−1.91203016", "6.9", "−3.43770237", "0.005209107", "0.074103921", "−2.09184396"], ["PBX1", "−1.01705906", "5.355", "−3.43106813", "0.005271926", "0.074208576", "−2.1032848"], ["FPR1", "1.084", "6.106", "3.429", "0.005290933", "0.074385801", "−2.10671942"], ["DDIT4", "1.49", "9.718", "3.425", "0.005334084", "0.074579661", "−2.1144709"], ["VCAN", "−1.5582745", "9.014", "−3.42256774", "0.005353546", "0.074582358", "−2.11794629"], ["TLCD2", "−1.01274834", "5.575", "−3.41837151", "0.005394312", "0.074845274", "−2.12518497"], ["COL24A1", "−1.20468207", "5.625", "−3.41642392", "0.00541334", "0.074938028", "−2.12854486"], ["FAM171A1", "−1.23232038", "6.785", "−3.40813696", "0.005495071", "0.075042307", "−2.14284264"], ["PDGFD", "−1.65623364", "5.872", "−3.40000426", "0.005576505", "0.075615545", "−2.15687664"], ["LOC101928916", "−1.24868866", "9.412", "−3.38908463", "0.005687782", "0.075974146", "−2.17572328"], ["abParts", "1.055", "6.89", "3.378", "0.005800963", "0.076912316", "−2.19451488"], ["TNFRSF11B", "−2.32614996", "8.959", "−3.37306976", "0.005855088", "0.077249334", "−2.20337088"], ["CCRL2", "1.069", "9.279", "3.365", "0.005937457", "0.077894866", "−2.21669122"], ["CCDC113", "−1.17122181", "4.579", "−3.36082978", "0.005986329", "0.07824588", "−2.22450672"], ["OLFML1", "−1.85943197", "6.329", "−3.35750026", "0.006022545", "0.078508896", "−2.23025681"], ["ZNF302", "−1.01985971", "7.658", "−3.35151039", "0.00608826", "0.078859711", "−2.24060208"], ["RUNDC3B", "−1.47075415", "4.742", "−3.34993023", "0.006105717", "0.078867572", "−2.24333138"], ["IGLL5", "2.546", "6.618", "3.341", "0.006207258", "0.079187602", "−2.25905202"], ["SAMSN1", "1.212", "6.716", "3.3", "0.006686271", "0.082084201", "−2.32987484"], ["RGS5", "−1.47176028", "5.433", "−3.29976294", "0.006687231", "0.082084201", "−2.33001146"], ["CCL18", "1.7", "12.378", "3.297", "0.006715839", "0.082111048", "−2.33407705"], ["PXDN", "−1.61084531", "8.374", "−3.29718734", "0.006718561", "0.082111048", "−2.334463"], ["PLK2", "−1.72107139", "6.446", "−3.29524778", "0.006742253", "0.082290914", "−2.3378153"], ["FCRL5", "1.034", "4.663", "3.289", "0.00681584", "0.08239289", "−2.34815202"], ["C12orf75", "−1.56631522", "6.387", "−3.29035853", "0.006802353", "0.08239289", "−2.34626606"], ["DHRS3", "1.17", "8.695", "3.287", "0.006843462", "0.082497646", "−2.35200311"], ["BACE2", "−1.13729452", "8.3", "−3.2866389", "0.00684844", "0.082497646", "−2.35269546"], ["DCN", "−1.27797183", "6.941", "−3.27884117", "0.006946086", "0.082871272", "−2.36617454"], ["PCDHB16", "−2.0403688", "4.744", "−3.28141758", "0.006913668", "0.082871272", "−2.36172088"], ["FPR3", "1.108", "8.998", "3.275", "0.006992625", "0.082958974", "−2.37253155"], ["FDX1", "1.044", "9.311", "3.276", "0.006982964", "0.082958974", "−2.37121541"], ["FBXL7", "−1.10298254", "6.347", "−3.27704144", "0.006968823", "0.082958974", "−2.36928565"], ["RP11-379H18", "−1.26161514", "5.742", "−3.27700657", "0.006969264", "0.082958974", "−2.36934592"], ["SDSL", "1.193", "7.509", "3.272", "0.007038201", "0.083119231", "−2.37871581"], ["HACE1", "−1.01249208", "7.259", "−3.2716711", "0.007037119", "0.083119231", "−2.37856938"], ["HLA-DMB", "1", "11.958", "3.26", "0.007185634", "0.083941761", "−2.39844726"], ["EPHX1", "1.281", "6.325", "3.242", "0.007430938", "0.084942411", "−2.43038762"], ["FNBP1L", "−1.17944856", "7.479", "−3.2415762", "0.007432599", "0.084942411", "−2.43060032"], ["TNC", "−1.37578741", "7.69", "−3.23325442", "0.007545881", "0.085104671", "−2.44498911"], ["AQP1", "−1.49341568", "7.025", "−3.22534816", "0.007655127", "0.085609579", "−2.45865982"], ["RP11-124L9", "−1.12643933", "5.719", "−3.22277474", "0.007691029", "0.085757925", "−2.46310956"], ["CXCL1", "1.137", "6.775", "3.22", "0.007727722", "0.085890838", "−2.46763557"], ["SLC15A3", "1.214", "9.406", "3.212", "0.007839458", "0.086081652", "−2.48128533"], ["HS3ST2", "1.206", "11.404", "3.213", "0.007834345", "0.086081652", "−2.480665"], ["ANGPT1", "−1.16253508", "4.798", "−3.19883173", "0.008033349", "0.08653032", "−2.5045106"], ["HBB", "2.301", "8.438", "3.188", "0.008200276", "0.087217375", "−2.52405622"], ["LOC101928620", "1.214", "4.851", "3.184", "0.008254768", "0.08769952", "−2.53034954"], ["LRRC49", "−1.14867086", "5.705", "−3.17829006", "0.008339302", "0.088217178", "−2.54002987"], ["LAMA2", "−1.0481289", "5.445", "−3.1670848", "0.008511135", "0.088660508", "−2.55940451"], ["ZNF423", "−1.04457418", "4.446", "−3.16092116", "0.008607175", "0.089221833", "−2.57006149"], ["ZNF23", "−1.11669749", "7.011", "−3.14224086", "0.008904983", "0.090230763", "−2.60235781"], ["LINC01279", "−2.02681924", "8.138", "−3.14175538", "0.00891286", "0.090230763", "−2.6031971"], ["CTB-167B5", "−2.31293162", "5.307", "−3.14420574", "0.008873174", "0.090230763", "−2.5989609"], ["FOLR2", "1.192", "7.817", "3.138", "0.008980412", "0.090353121", "−2.61036421"], ["RAPGEF4", "−1.03668555", "4.378", "−3.13513916", "0.009020911", "0.090543007", "−2.6146349"], ["LOC100127972", "−1.01216172", "5.313", "−3.10834255", "0.009472216", "0.092466307", "−2.66095306"], ["COMP", "−2.66774652", "7.887", "−3.10283885", "0.009567691", "0.092947345", "−2.67046473"], ["RP11-690I21", "−1.02869854", "6.001", "−3.10092157", "0.009601178", "0.09298905", "−2.67377809"], ["SBDS", "−1.11130408", "6.895", "−3.09837781", "0.009645789", "0.093140037", "−2.678174"], ["IL13RA2", "−1.84607884", "5.783", "−3.08858504", "0.009819488", "0.093888012", "−2.69509576"], ["PLA2G15", "1.04", "9.387", "3.086", "0.009873995", "0.094254348", "−2.70034338"], ["COL4A1", "−1.59461938", "9.74", "−3.08497929", "0.009884235", "0.094301373", "−2.70132592"], ["MICU3", "−1.65121416", "4.776", "−3.07900138", "0.009992527", "0.094778654", "−2.71165409"], ["MRGPRF", "−1.32811473", "6.587", "−3.07627303", "0.010042348", "0.09500344", "−2.71636764"], ["SHISA3", "−2.89115811", "7.35", "−3.07619179", "0.010043835", "0.09500344", "−2.71650798"], ["SCG5", "−1.79294998", "6.654", "−3.07435902", "0.010077448", "0.095134323", "−2.71967421"], ["ESF1", "−1.01991963", "7.362", "−3.07194815", "0.010121835", "0.09529178", "−2.723839"], ["C1QB", "1.594", "11.646", "3.061", "0.010327621", "0.096081559", "−2.74290853"], ["PPAP2A", "−1.18883309", "8.397", "−3.0473476", "0.010586162", "0.09748556", "−2.76632741"], ["LOXL1", "−1.45575401", "7.401", "−3.04001176", "0.010728726", "0.09786511", "−2.77899386"], ["EFNB2", "−1.7614713", "6.572", "−3.03366254", "0.010853673", "0.098363256", "−2.78995536"], ["MFAP5", "−1.99102483", "7.296", "−3.01954597", "0.011136735", "0.099381171", "−2.81432163"], ["PRPF39", "−1.08112002", "7.339", "−3.01372934", "0.011255515", "0.099836985", "−2.82435944"], ["HLA-DRA", "1.05", "12.472", "3.008", "0.011374911", "0.100236116", "−2.83434154"], ["PALD1", "−1.13409746", "6.356", "−3.00434742", "0.011449785", "0.100236116", "−2.84054718"], ["LIMS3-LOC440895", "−1.00361209", "4.943", "−3.00361724", "0.011465045", "0.100236269", "−2.8418069"], ["SRGAP2C", "−1.12202496", "8.51", "−2.99612123", "0.01162289", "0.100589895", "−2.85473787"], ["LILRB5", "1.058", "7.406", "2.992", "0.011711091", "0.100834918", "−2.861886"], ["GUCY1B3", "−1.09481873", "6.043", "−2.98824718", "0.011791042", "0.101074761", "−2.86831842"], ["MAP1B", "−1.26295569", "7.014", "−2.98678584", "0.011822517", "0.10115834", "−2.87083853"], ["SLC14A1", "−2.08714663", "5.023", "−2.97554416", "0.012067475", "0.102481695", "−2.8902218"], ["CAV1", "−1.54266666", 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"4.945", "−2.45977406", "0.030823469", "0.149757159", "−3.76748936"], ["THBS1", "−1.00450902", "6.406", "−2.45649882", "0.031006068", "0.150173348", "−3.77294402"], ["PPP1R3C", "−1.10842436", "5.881", "−2.45049465", "0.031343543", "0.15083513", "−3.78293825"], ["CTGF", "−1.68043237", "10.245", "−2.44316364", "0.031760431", "0.151849734", "−3.79513177"], ["PLGLB1", "−1.04046038", "5.02", "−2.44033293", "0.031922839", "0.152238333", "−3.79983726"], ["ZNF521", "−1.25923381", "4.897", "−2.43804712", "0.032054572", "0.152398313", "−3.80363583"], ["PTPRZ1", "−1.04325", "4.2", "−2.42396632", "0.032877759", "0.154295501", "−3.82701284"], ["GPM6B", "−1.15925929", "4.968", "−2.41770644", "0.033250266", "0.155136811", "−3.8373929"], ["AK021977", "−1.05674346", "5.415", "−2.40910828", "0.033768584", "0.156085006", "−3.85163739"], ["OLFML2A", "−1.13887278", "6.219", "−2.39552362", "0.034603473", "0.157597428", "−3.87411218"], ["MANSC1", "−1.20061235", "5.162", "−2.37742265", "0.035746982", "0.159649267", "−3.90399891"], ["CX3CL1", "−1.20643257", "6.702", "−2.37411628", "0.035959764", "0.160110005", "−3.90945057"], ["MEOX1", "−1.3648004", "5.619", "−2.37259553", "0.036058041", "0.160155144", "−3.91195724"], ["FIGN", "−1.16179673", "4.34", "−2.37020584", "0.036212997", "0.160409247", "−3.91589518"], ["F3", "−1.2706323", "7.831", "−2.36731755", "0.036401141", "0.160690719", "−3.9206531"], ["AC012065", "−1.36960739", "7.269", "−2.36455566", "0.036581934", "0.161096543", "−3.92520112"], ["HSP90B1", "−1.0931333", "6.992", "−2.35529786", "0.037194283", "0.162507108", "−3.94043371"], ["FAM46C", "1.128", "6.681", "2.331", "0.038840666", "0.164775579", "−3.98013075"], ["DYSF", "1.147", "8.407", "2.325", "0.039302486", "0.16534884", "−3.99095213"], ["AKR1C3", "−1.37012153", "8.401", "−2.3184279", "0.039732384", "0.166435652", "−4.00090724"], ["LOC100506076", "−1.03285843", "6.345", "−2.30883743", "0.040419389", "0.167696452", "−4.01658575"], ["AK5", "−1.13886628", "5.649", 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"format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:7dd503517d90e9bef42208d8c189ef8f3fb9ec95e8cc0ef6d08cc24829b4b023", "bytes": 1250, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#T1", "version": null, "note": "The top five results of functional enrichment analyses of up-regulated DEGs ranked by P-value", "structure": {"pmcid": "PMC6629752", "section_index": 13, "section_title": "Functional Enrichment Analysis", "row_count": 13, "column_count": 4}, "table": {"label": "Table 1.", "caption": "The top five results of functional enrichment analyses of up-regulated DEGs ranked by P-value", "rows": [["Term", "Count", "Gene", "P-value"], ["GO-BPs", "", "", ""], ["GO:0006955∼immune response", "9", "PPBP, IGKV1-17, CXCL3, NCF4, FCGR3A, IGKC, HLA-DMA, IGLC1, CD27", "4.82E-05"], ["GO:0050853∼B cell receptor signaling pathway", "4", "CD38, IGKC, IGHM, IGLC1", "6.57E-04"], ["GO:0038096∼Fc-gamma receptor signaling pathway involved in phagocytosis", "5", "IGKV1-17, HCK, FCGR3A, IGKC, IGLC1", "6.86E-04"], ["GO:0006954∼inflammatory response", "7", "PPBP, CXCL3, HCK, S100A9, MGLL, CD27, CD180", "0.001192"], ["GO:0050776∼regulation of immune response", "5", "LAIR1, IGKV1-17, FCGR3A, IGKC, IGLC1", "0.002385"], ["KEGG pathways", "", "", ""], ["hsa04142:Lysosome", "6", "AP1B1, GLA, GAA, NEU1, CTSA, ATP6V0B", "1.08E-04"], ["hsa04060:Cytokine-cytokine receptor interaction", "5", "LEP, PPBP, IL10RA, TNFRSF17, CD27", "0.013065"], ["hsa04145:Phagosome", "4", "NCF4, FCGR3A, HLA-DMA, ATP6V0B", "0.023255"], ["hsa03320:PPAR signaling pathway", "3", "CYP27A1, FABP4, PLTP", "0.02977"], ["hsa05140:Leishmaniasis", "3", "NCF4, FCGR3A, HLA-DMA", "0.033129"]], "row_count": 13, "column_count": 4, "numeric_cells": 37, "header_rows": 1, "locator": "section[13]/table-wrap[1]#T1"}}, {"id": "asset:table:pmid:30643084:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:effe73212cc0d96cb4545cc21a31e0d550ff8c1d775ada29a8fdd9853edbf582", "bytes": 1659, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#T2", "version": null, "note": "The top five results of functional enrichment analyses of down-regulated DEGs ranked by P-value", "structure": {"pmcid": "PMC6629752", "section_index": 13, "section_title": "Functional Enrichment Analysis", "row_count": 13, "column_count": 4}, "table": {"label": "Table 2.", "caption": "The top five results of functional enrichment analyses of down-regulated DEGs ranked by P-value", "rows": [["Term", "Count", "Gene", "P-value"], ["GO-BPs", "", "", ""], ["GO:0007155∼cell adhesion", "30", "CTNNAL1, IGFBP7, ITGA10, SPOCK1, POSTN, CDH2, ITGBL1, ISLR, VCAM1, WISP1, ROBO1, FAT1, FAP, COL8A1, LAMB1, THBS2, DPT, PTPRK, MPDZ, PODXL, COL15A1, PPFIBP1, SSPN, TPBG, TNFAIP6, OMD, CX3CR1, MYH10, CDH11, AOC3", "3.32E-15"], ["GO:0030198∼extracellular matrix organization", "15", "PDGFA, LUM, COL3A1, FBN1, ITGA10, POSTN, SPARC, ECM2, COL5A2, VCAM1, EGFLAM, BGN, COL1A2, LAMB1, COL8A1", "1.44E-08"], ["GO:0030199∼collagen fibril organization", "7", "SFRP2, LUM, COL3A1, COL1A2, FOXC1, COL5A2, DPT", "2.61E-06"], ["GO:0001501∼skeletal system development", "10", "AEBP1, COL3A1, FBN1, COL1A2, POSTN, FOXC1, EXT1, COL5A2, PRELP, CDH11", "1.17E-05"], ["GO:0001503∼ossification", "8", "MGP, LRRC17, FOXC1, SPARC, EXT1, COL5A2, CDH11, TWIST1", "1.77E-05"], ["KEGG pathways", "", "", ""], ["hsa04510:Focal adhesion", "11", "VEGFC, CAV2, CCND1, PDGFA, COL3A1, COL1A2, ITGA10, LAMB1, THBS2, COL5A2, MYLK", "7.82E-06"], ["hsa04611:Platelet activation", "7", "GNAI1, COL3A1, COL1A2, GUCY1A3, COL5A2, MYLK, F2R", "7.86E-04"], ["hsa04512:ECM-receptor interaction", "6", "COL3A1, COL1A2, ITGA10, LAMB1, THBS2, COL5A2", "8.27E-04"], ["hsa04151:PI3K-Akt signaling pathway", "10", "VEGFC, CCND1, PDGFA, COL3A1, COL1A2, ITGA10, LAMB1, THBS2, COL5A2, F2R", "0.002384"], ["hsa04974:Protein digestion and absorption", "5", "COL21A1, COL3A1, COL1A2, COL15A1, COL5A2", "0.00656"]], "row_count": 13, "column_count": 4, "numeric_cells": 38, "header_rows": 1, "locator": "section[13]/table-wrap[2]#T2"}}], "gaps": ["asset:data:geo:GSE41571 not downloaded", "asset:data:geo:GSE41571 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "differential_expression", "specific": "limma_voom", "label": "Differential expression analysis", "dsl_operations": ["normalise_counts", "differential_expression_fit", "fdr_bh"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["count_matrix_with_condition"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "After processed, DEGs between groups were screened out using the Linear Models for Microarray (LIMMA; Version: 3.30.3) affy in R package12). q-value between gene expressions was 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