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pmid:30854058
Identification of B-cell translocation gene 1-controlled gene networks in diffuse large B-cell lymphoma: A study based on bioinformatics analysis.
Wei Yan · Shawn Xiang Li · Hongyu Gao · Wei Yang
Oncology letters · 2019 doi:10.3892/ol.2019.9900
Paper
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Experiment
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Analysis
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Complete file
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The present study evaluated the impact of BTG1 gene expression on the clinical outcome of diffuse large B-cell lymphoma (DLBCL) and investigated potential mechanisms using the Gene Expression Omnibus (GEO) database. The gene expression profile datasets GSE31312, GSE10846, GSE65420 and GSE87371 were downloaded from the GEO database. BTG1 expression and clinicopathological data were obtained from the GSE31312 dataset. In 498 cases, the expression of BTG1 in DLBCL was associated with treatment response (χ2=19.020; P<0.001) and International Prognostic Index score (χ2=5.320; P=0.025). Using the Kaplan-Meier method, it was identified that the expression of BTG1 was associated with overall survival (OS) and progression-free survival (PFS) times. Univariate and multivariate Cox regression analysis demonstrated that BTG1 was an independent predictive factor for OS and PFS. From the overlapping analysis of 407 BTG1-associated genes and 22,187 DLBCL-associated genes, 401 genes were identified as BTG1-associated DLBCL genes. Pathway analysis revealed that BTG1-associated DLBCL genes were associated with cancer progression and DLBCL signaling pathways. Subsequently, a protein-protein interaction network was constructed of the BTG1-associated genes, which consisted of 235 genes and 601 interactions. Additionally, 24 genes with high degrees in the network were identified as hub genes, which included genes associated with 'ribosome' [ribosomal protein (RP) L11, RPL3, RPS29, RPL19, RPL15 and RPL12], 'cell cycle' (ubiquitin carboxyl extension protein 52, ATM and Ras homolog family member H), 'mitogen-activated protein kinase pathway' (mitogen-activated protein kinase 1), 'histone modification' (ASH1-like protein) and 'transcription/translation' (eukaryotic translation initiation factor 3 subunit E, eukaryotic translation elongation factor 1 δ, transcription termination factor 1, cAMP responsive element binding protein 1 and RNA polymerase II subunit F). In conclusion, BTG1 may serve as a predictive biomarker for DLBCL prognosis. 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(46.8)", "110", "110", "", ""], ["III/IV", "250 (53.2)", "125", "125", "", ""], ["ECOG score", "", "", "", "0.209", "0.732"], ["Low", "374 (79.6)", "185", "189", "", ""], ["High", "96 (20.4)", "50", "46", "", ""], ["Subtype", "", "", "", "0.034", "0.926"], ["Non-GCB", "222 (47.2)", "112", "110", "", ""], ["GCB", "248 (52.8)", "123", "125", "", ""], ["IPI score", "", "", "", "5.320", "0.025"], ["Low", "274 (64.6)", "135", "139", "", ""], ["High", "150 (35.4)", "79", "71", "", ""], ["B symptom", "", "", "", "0.513", "0.526"], ["No", "276 (67.6)", "138", "138", "", ""], ["Yes", "132 (32.4)", "61", "71", "", ""], ["Bulky disease", "", "", "", "0.141", "0.724"], ["No", "268 (73.2)", "129", "139", "", ""], ["Yes", "98 (26.8)", "45", "53", "", ""], ["LDH level", "", "", "", "0.071", "0.839"], ["Normal", "148 (34.7)", "76", "72", "", ""], ["High", "278 (65.3)", "139", "139", "", ""], ["Treatment response", "", "", "", "19.020", "<0.001"], ["CR", "354 (75.3)", "157", "197", "", ""], ["PR", "72 (15.3)", "48", "24", "", ""], ["PD", "24 (5.1)", "15", "9", "", ""], ["SD", "20 (4.3)", "15", "5", "", ""]], "row_count": 33, "column_count": 6, "numeric_cells": 89, "header_rows": 1, "locator": "section[10]/table-wrap[1]#tI-ol-0-0-9900"}}, {"id": "asset:table:pmid:30854058:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:4b3bac3067196bc52a7f4f829afbb39204e6ff2651f44676e64f8963baade190", "bytes": 2386, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[1]#tII-ol-0-0-9900", "version": null, "note": "Univariate and multivariate Cox regression analysis for patients with diffuse large B-cell lymphoma.", "structure": {"pmcid": "PMC6365947", "section_index": 12, "section_title": "Prognostic performance of BTG1 for DLBCL", "row_count": 34, "column_count": 5}, "table": {"label": "Table II.", "caption": "Univariate and multivariate Cox regression analysis for patients with diffuse large B-cell lymphoma.", "rows": [["A, Overall survival"], [""], ["", "Univariate analysis", "Multivariate analysis"], ["", "", ""], ["Variable", "HR (95% CI)", "P-value", "HR (95% CI)", "P-value"], ["Sex (males vs. females)", "1.050 (0.775–1.423)", "0.752", "", ""], ["Age (≥63 vs. <63), years", "1.697 (1.246–2.312)", "0.752", "1.742 (1.244–2.441)", "0.001"], ["Stage (low vs. high)", "2.307 (1.668–3.189)", "<0.001", "1.594 (1.103–2.302)", "0.013"], ["ECOG score (low vs. high)", "2.021 (1.450–2.818)", "<0.001", "1.978 (1.376–2.844)", "<0.001"], ["Subtype (non-GCB vs. GCB)", "0.668 (0.494–0.904)", "0.009", "1.978 (1.376–2.844)", "<0.001"], ["IPI score (low vs. high)", "1.411 (1.026–1.940)", "0.034", "", ""], ["B symptom (no vs. yes)", "1.105 (1.787–1.551)", "0.565", "", ""], ["LDH (normal vs. high)", "1.120 (0.803–1.563)", "0.503", "", ""], ["Bulky disease (no vs. yes)", "1.051 (0.732–1.509)", "0.787", "", ""], ["Treatment response (CR+PR vs. PD+SD)", "2.605 (2.828–2.990)", "<0.001", "2.612 (2.214–3.081)", "<0.001"], ["BTG1 expression (low vs. high)", "2.066 (1.508–2.829)", "<0.001", "1.692 (1.193–2.401)", "0.003"], [""], ["B, Progression free survival"], [""], ["", "Univariate analysis", "Multivariate analysis"], ["", "", ""], ["Variable", "HR (95% CI)", "P-value", "HR (95% CI)", "P-value"], [""], ["Sex (males vs. females)", "0.864 (0.639–1.169)", "0.343", "", ""], ["Age (≥63 vs. <63), years", "1.156 (0.855–1.563)", "0.346", "", ""], ["Stage (low vs. high)", "2.469 (1.781–3.422)", "<0.001", "1.538 (1.063–2.226)", "0.022"], ["ECOG score (low vs. high)", "1.678 (1.191–2.366)", "0.003", "1.187 (0.815–1.729)", "0.371"], ["Subtype (non-GCB vs. GCB)", "0.624 (0.461–0.846)", "0.002", "0.563 (0.406–0.782)", "0.001"], ["IPI score (low vs. high)", "1.545 (1.124–2.124)", "0.007", "", ""], ["B symptom (no vs. yes)", "1.261 (0.902–1.763)", "0.125", "", ""], ["LDH (normal vs. high)", "1.078 (0.774–1.501)", "0.659", "", ""], ["Bulky 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