[Expression of transcription factor SOX12 in lung adenocarcinoma and its clinical significance].

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:30890507", "kind": "science-record", "revision": 3, "content_hash": "sha256:7849209f0336f564135fa139e343730be8005504231fc7447bf1b5e9866d234f", "created_at": "2026-11-01T17:32:42Z", "updated_at": "2026-11-01T21:22:04Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "[Expression of transcription factor SOX12 in lung adenocarcinoma and its clinical significance].", "doi": "10.12122/j.issn.1673-4254.2019.09.10", "pmid": "30890507", "authors": ["Li Li", "Tingting Zhang", "Yuhua Chen", "Jia Song", "Yao Meng", "Shu Liu", "Jianming Xie"], "journal": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University", "year": 2019, "abstract": "OBJECTIVE: To explore the expression patterns of transcription factor SOX12 in lung adenocarcinoma and its significance in the diagnosis and prognosis of the malignancy.\nMETHODS: Large cancer genome databases were used to analyze SOX12 expression level in lung adenocarcinoma. Immunohistochemistry (IHC) and semiquantitative PCR were used to detect the expression of SOX12 in 36 specimens of lung adenocarcinoma tissues, 15 adjacent tissues and 21 normal lung tissues. The prognostic value of SOX12 in lung adenocarcinoma and lung squamous cell carcinoma were analyzed using Kaplan-Meier Plotter database, and the relationship between SOX12 expression and the overall survival (OS) and progression free survival (PPS) of the patients were analyzed.\nRESULTS: Analysis of TCGA database and GEO (GSE40419) database showed that SOX12 expression levels were significantly higher in in lung adenocarcinoma than in normal lung tissues (P &lt; 0.001). The results of IHC and semiquantitative PCR revealed that SOX12 was expressed at significantly higher levels in lung adenocarcinoma than in normal lung tissues (P &lt; 0.001). Kaplan-Meier survival analysis showed that patients with lung adenocarcinoma positive for SOX12 had a significantly shorter OS and PPS time than those negative for SOX12 (P &lt; 0.05), but SOX12 positivity did not significantly affect OS and PPS of patients with lung squamous cell carcinoma.\nCONCLUSIONS: High expression levels of SOX12 in lung adenocarcinoma are significantly associated with a poor OS of the patients, suggesting the value of SOX12 to assist in early diagnosis and prognostic evaluation of lung adenocarcinoma.", "claims": [{"id": "claim-data-access", "statement": "TCGA数据库和GEO (GSE40419)样本集提示SOX12的表达水平在肺腺癌组中显著高于癌旁组(P < 0.001)", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30890507", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "TCGA数据库和GEO (GSE40419)样本集提示SOX12的表达水平在肺腺癌组中显著高于癌旁组(P < 0.001)"}], "state": "complete"}, {"id": "claim-target-result", "statement": "SOX12在肺腺癌组织中呈明显高表达水平，且高表达患者的总生存期和进展后生存期较短，但其对肺鳞癌患者的总生存期和进展后生存期无明显影响。", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:30890507", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "TCGA数据库和GEO (GSE40419)样本集提示SOX12的表达水平在肺腺癌组中显著高于癌旁组(P < 0.001), 同时IHC和半定量PCR结果均显示SOX12在肺腺癌组织中的表达高于癌旁正常组织和正常肺组织, 差异具有统计学意义(P < 0.001);分析Kaplan-Meier Plotter数据库显示SOX12基因表达水平高的肺腺癌患者较表达水平低的患者OS和PPS短, 差异具有统计学意义(P < 0.05);而SOX12基因表达水平对肺鳞癌患者的OS和PPS均无明显影响。"}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "SOX12在肺腺癌组织中呈明显高表达水平，且高表达患者的总生存期和进展后生存期较短，但其对肺鳞癌患者的总生存期和进展后生存期无明显影响。", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:30890507"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE40419"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE40419"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:30890507", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.12122/j.issn.1673-4254.2019.09.10", "sha256": "sha256:38259ebe8ec58f3eb8419d8cdf648712a3cdc9b8df80f3acbd2ad23c2dfddb38", "bytes": 571, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.12122/j.issn.1673-4254.2019.09.10", "version": null, "note": "Full article fetched from PMC; 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