Identification of SERPINE1, PLAU and ACTA1 as biomarkers of head and neck squamous cell carcinoma based on integrated bioinformatics analysis.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:30937621", "kind": "science-record", "revision": 8, "content_hash": "sha256:803d0a073141b824214fcad0d454912442d0b66e5aaa844441977c2f5a501517", "created_at": "2026-11-01T15:40:43Z", "updated_at": "2026-11-01T22:00:28Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Identification of SERPINE1, PLAU and ACTA1 as biomarkers of head and neck squamous cell carcinoma based on integrated bioinformatics analysis.", "doi": "10.1007/s10147-019-01435-9", "pmid": "30937621", "authors": ["Ke Yang", "Shizhou Zhang", "Dongsheng Zhang", "Qian Tao", "Tianqi Zhang", "Guijun Liu", "Xingguang Liu", "Tengda Zhao"], "journal": "International journal of clinical oncology", "year": 2019, "abstract": "BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is the six leading cancer by incidence worldwide. The 5-year survival rate of HNSCC patients remains less than 65% due to lack of symptoms in the early stage. Hence, biomarkers which can improve detection of HNSCC should improve clinical outcome.\nMETHODS: Gene expression profiles (GSE6631, GSE58911) and the Cancer Genome Atlas (TCGA) HNSCC data were used for integrated bioinformatics analysis; the differentially expressed genes (DEGs) were then subjected to functional and pathway enrichment analysis, protein-protein interaction (PPI) network construction. Subsequently, module analysis of the PPI network was performed and overall survival (OS) analysis of hub genes in subnetwork was studied. Finally, immunohistochemistry was used to verify the selected markers.\nRESULTS: A total of 52 up-regulated and 80 down-regulated DEGs were identified, which were mainly associated with ECM-receptor interaction and focal adhesion signaling pathways. Importantly, a set of prognostic signatures including SERPINE1, PLAU and ACTA1 were screened from DEGs, which could predict OS in HNSCC patients from TCGA cohort. Experiment of clinical samples further successfully validated that these three signature genes were aberrantly expressed in the oral epithelial dysplasia and HNSCC, and correlated with aggressiveness of HNSCC patients.\nCONCLUSIONS: SERPINE1, PLAU and ACTA1 played important roles in regulating the initiation and progression of HNSCC, and could be identified as key biomarkers for precise diagnosis and prognosis of HNSCC, which will provide potential targets for clinical therapies.", "claims": [{"id": "claim-data-access", "statement": "In the present study, the gene expression profiles (GSE6631, GSE58911) were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/). Totally 22 paired samples of HNSCC and normal tissues were consisted in GSE6631, which based on GPL8300 platform (Affymetrix Human Genome U95 chips).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:30937621", "locator": "sections[3] \"Microarray data\" paragraph 2", "quote": "In the present study, the gene expression profiles (GSE6631, GSE58911) were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/). Totally 22 paired samples of HNSCC and normal tissues were consisted in GSE6631, which based on GPL8300 platform (Affymetrix Human Genome U95 chips)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:30937621"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE58911"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE58911"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:30937621", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1007/s10147-019-01435-9", "sha256": "sha256:09ba3ebab943dbdd70213470ad5fe78d4622a8d05818794718197f2117d63f6a", "bytes": 31096, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1007/s10147-019-01435-9", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC6687676", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE58911", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE58911", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE58911", "version": null, "note": "In the present study, the gene expression profiles (GSE6631, GSE58911) were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/). Totally 22 paired samples of HNSCC and normal tissues were consisted in GSE6631, which based on GPL8300 platform (Affymetrix Human Genome U95 chips).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "In the present study, the gene expression profiles (GSE6631, GSE58911) were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/). Totally 22 paired samples of HNSCC and normal tissues were consisted in GSE6631, which based on GPL8300 platform (Affymetrix Human Genome U95 chips).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM1422185", "GSM1422186", "GSM1422187", "GSM1422188", "GSM1422189", "GSM1422190", "GSM1422191", "GSM1422192", "GSM1422193", "GSM1422194", "GSM1422195", "GSM1422196", "GSM1422197", "GSM1422198", "GSM1422199", "GSM1422200", "GSM1422201", "GSM1422202", "GSM1422203", "GSM1422204", "GSM1422205", "GSM1422206", "GSM1422207", "GSM1422208", "GSM1422209", "GSM1422210", "GSM1422211", "GSM1422212", "GSM1422213", "GSM1422214"], "sample_count": 30, "group_sizes": null, "group_sizes_basis": null, "platform": "6244", "taxon": "Homo sapiens", "title": "Gene expression in normal and tumor samples from patients with HNSCC", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE6631", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE6631", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE6631", "version": null, "note": "In the present study, the gene expression profiles (GSE6631, GSE58911) were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/). Totally 22 paired samples of HNSCC and normal tissues were consisted in GSE6631, which based on GPL8300 platform (Affymetrix Human Genome U95 chips).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "In the present study, the gene expression profiles (GSE6631, GSE58911) were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/). Totally 22 paired samples of HNSCC and normal tissues were consisted in GSE6631, which based on GPL8300 platform (Affymetrix Human Genome U95 chips).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM153813", "GSM153814", "GSM153815", "GSM153816", "GSM153817", "GSM153818", "GSM153819", "GSM153820", "GSM153821", "GSM153822", "GSM153823", "GSM153824", "GSM153825", "GSM153826", "GSM153827", "GSM153828", "GSM153829", "GSM153830", "GSM153831", "GSM153832", "GSM153833", "GSM153834", "GSM153835", "GSM153836", "GSM153837", "GSM153838", "GSM153839", "GSM153840", "GSM153841", "GSM153842", "GSM153843", "GSM153844", "GSM153845", "GSM153846", "GSM153847", "GSM153848", "GSM153849", "GSM153850", "GSM153851", "GSM153852", "GSM153853", "GSM153854", "GSM153855", "GSM153856"], "sample_count": 44, "group_sizes": null, "group_sizes_basis": null, "platform": "8300", "taxon": "Homo sapiens", "title": "Expression data from head and neck squamous cell carcinoma", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:30937621:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:94bd8aca76a2c5de2ab022e20b9ab9cd266fdbdab9bd76948d2fc757efd5e16e", "bytes": 1274, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[12]/table-wrap[1]#Tab1", "version": null, "note": "132 DEGs were identified from three profile datasets, including 52 up-regulated genes and 80 down-regulated genes in the HNSCC tissues, compared to normal tissue", "structure": {"pmcid": "PMC6687676", "section_index": 12, "section_title": "Identification of aberrantly DEGs in HNSCC", "row_count": 3, "column_count": 2}, "table": {"label": "Table 1.", "caption": "132 DEGs were identified from three profile datasets, including 52 up-regulated genes and 80 down-regulated genes in the HNSCC tissues, compared to normal tissue", "rows": [["DEGs", "Gene names"], ["Up-regulated", "PXDN, KIF14, CDH11, NELL2, MMP1, FCGR2A, MMP3, FAT1, NREP, LAPTM4B, MMP13, PTHLH, MYO10, DFNA5, COL3A1, BST2, COL6A3, SPARC, PRAME, RBP1, IGF2BP3, LTBP1, FN1, LAMB3, COL5A2, SPP1, ITGA6, PLOD2, MMP12, MMP11, COL4A2, LUM, POSTN, MFAP2, COL4A1, LOX, LAMC2, MMP10, SLC16A1, PLAU, CXCL8, PFN2, TNC, FAP, LAMB1, LOXL2, DLX5, SERPINE1, COL10A1, TGFBI, SEMA3C, MMP9"], ["Down-regulated", "CEACAM6, ENDOU, TF, MYH2, FHL1, CSRP3, SORBS2, SPINK5, CSTA, PPL, PITX1, CLDN10, MALL, GPD1L, PDK4, BLNK, ALOX12, SASH1, KRT4, AQP3, FUT3, APOD, DIO2, IL1RN, SLURP1, ACTA1, CEACAM1, CKMT2, LPIN1, PSCA, SULT2B1, KAT2B, ABLIM1, HOPX, PTN, AADAC, KRT13, CRYAB, MAL, ECM1, ANXA9, EMP1, ATP2A1, ABCA8, SERPINB2, ADH7, FCER1A, TGM3, MYL1, ACPP, HPGD, SCEL, MYLPF, CRISP3, NEB, TGM1, CD24, NUCB2, KLK13, MB, EXPH5, SERPINB1, ALDH3A1, CXCL12, MYH7, FMO2, ZNF185, TTN, FLG, ADH1B, COX6A2, PDLIM3, PPP1R3C, RRAGD, LCN2, CASQ2, KLK11, TTC9, PGD, ATP10B"]], "row_count": 3, "column_count": 2, "numeric_cells": 2, "header_rows": 1, "locator": "section[12]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:30937621:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:015df5dd2a51b502d0bb72d9175c54d1e834f4efc1485f746536029e63842f41", "bytes": 2301, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#Tab2", "version": null, "note": "Go analysis of DEGs associated with HNSCC", "structure": {"pmcid": "PMC6687676", "section_index": 13, "section_title": "DEGs functional and pathway enrichment analysis", "row_count": 25, "column_count": 6}, "table": {"label": "Table 2", "caption": "Go analysis of DEGs associated with HNSCC", "rows": [["Category", "Term", "Count", "%", "p value", "FDR"], ["Up-regulated DEGs"], ["GOTERM_BP", "GO:0030198 ~ extracellular matrix organization", "21", "40.38", "4.57E−26", "6.38E−23"], ["GOTERM_BP", "GO:0030574 ~ collagen catabolic process", "13", "25", "4.42E−19", "6.17E−16"], ["GOTERM_BP", "GO:0022617 ~ extracellular matrix disassembly", "11", "21.15", "2.15E−14", "3.01E−11"], ["GOTERM_BP", "GO:0007155 ~ cell adhesion", "14", "26.92", "7.43E−10", "1.04E−06"], ["GOTERM_BP", "GO:0030199 ~ collagen fibril organization", "6", "11.54", "1.13E−07", "1.57E−04"], ["GOTERM_CC", "GO:0031012 ~ extracellular matrix", "19", "36.54", "6.18E−20", "6.78E−17"], ["GOTERM_CC", "GO:0005578 ~ proteinaceous extracellular matrix", "18", "34.62", "3.89E−19", "4.27E−16"], ["GOTERM_CC", "GO:0005576 ~ extracellular region", "30", "57.69", "4.60E−18", "5.05E−15"], ["GOTERM_CC", "GO:0005615 ~ extracellular space", "24", "46.15", "2.09E−13", "2.30E−10"], ["GOTERM_CC", "GO:0005604 ~ basement membrane", "7", "13.46", "8.44E−08", "9.25E−05"], ["GOTERM_MF", "GO:0004222 ~ metalloendopeptidase activity", "8", "15.38", "3.40E−08", "3.80E−05"], ["GOTERM_MF", "GO:0005201 ~ extracellular matrix structural constituent", "7", "13.46", "8.80E−08", "4.25E−05"], ["GOTERM_MF", "GO:0004252 ~ serine-type endopeptidase activity", "9", "17.31", "6.41E−07", "7.17E−04"], ["GOTERM_MF", "GO:0005518 ~ collagen binding", "6", "11.54", "8.09E−07", "9.05E−04"], ["GOTERM_MF", "GO:0004175 ~ endopeptidase activity", "5", "9.62", "1.78E−05", "1.99E−03"], ["Down-regulated DEGs"], ["GOTERM_BP", "GO:0006936 ~ muscle contraction", "8", "10", "5.33E−07", "7.80E−04"], ["GOTERM_BP", "GO:0030049 ~ muscle filament sliding", "6", "7.5", "7.42E−07", "1.09E−03"], ["GOTERM_CC", "GO:0070062 ~ extracellular exosome", "34", "42.5", "1.66E−08", "1.95E−05"], ["GOTERM_CC", "GO:0005859 ~ muscle myosin complex", "5", "6.25", "5.72E−07", "6.73E−04"], ["GOTERM_CC", "GO:0030018 ~ Z disk", "8", "10", "7.87E−07", "9.26E−04"], ["GOTERM_CC", "GO:0005615 ~ extracellular space", "20", "25", "3.46E−06", "4.07E−03"], ["GOTERM_MF", "GO:0008307 ~ structural constituent of muscle", "7", "8.75", "3.40E−08", "4.25E−05"]], "row_count": 25, "column_count": 6, "numeric_cells": 110, "header_rows": 1, "locator": "section[13]/table-wrap[1]#Tab2"}}, {"id": "asset:table:pmid:30937621:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:7dd1862535d374e38f1f61554cdf7b7d8055418d727f3367d799eab1269cf7f8", "bytes": 2091, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#Tab3", "version": null, "note": "KEGG pathway enrichment analysis of up-regulated and down-regulated DEGs", "structure": {"pmcid": "PMC6687676", "section_index": 13, "section_title": "DEGs functional and pathway enrichment analysis", "row_count": 20, "column_count": 6}, "table": {"label": "Table 3", "caption": "KEGG pathway enrichment analysis of up-regulated and down-regulated DEGs", "rows": [["Pathways", "Name", "Count", "%", "p value", "Genes"], ["Up-regulated DEGs"], ["hsa04512", "ECM–receptor interaction", "12", "23.08", "7.28E−15", "COL4A2, LAMB3, COL4A1, ITGA6, TNC, COL3A1, COL6A3, LAMC2, LAMB1, COL5A2, SPP1, FN1"], ["hsa04510", "Focal adhesion", "12", "23.08", "1.09E−10", "COL4A2, LAMB3, COL4A1, ITGA6, TNC, COL3A1, COL6A3, LAMC2, LAMB1, COL5A2, SPP1, FN1"], ["hsa05146", "Amoebiasis", "9", "17.31", "4.10E−09", "COL4A2, LAMB3, COL4A1, COL3A1, CXCL8, LAMC2, LAMB1, COL5A2, FN1"], ["hsa04151", "PI3K–Akt signaling pathway", "12", "23.08", "2.60E−08", "COL4A2, LAMB3, COL4A1, ITGA6, TNC, COL3A1, COL6A3, LAMC2, LAMB1, COL5A2, SPP1, FN1"], ["hsa05222", "Small cell lung cancer", "7", "13.46", "6.98E−07", "COL4A2, LAMB3, COL4A1, ITGA6, LAMC2, LAMB1, FN1"], ["hsa05200", "Pathways in cancer", "10", "19.23", "1.06E−05", "COL4A2, LAMB3, COL4A1, ITGA6, MMP9, CXCL8, LAMC2, LAMB1, MMP1, FN1"], ["hsa04974", "Protein digestion and absorption", "6", "11.54", "1.93E−05", "COL4A2, COL4A1, COL3A1, COL6A3, COL5A2, COL10A1"], ["hsa05145", "Toxoplasmosis", "4", "7.69", "0.0105", "LAMB3, ITGA6, LAMC2, LAMB1"], ["hsa05219", "Bladder cancer", "3", "5.77", "0.0110", "MMP9, CXCL8, MMP1"], ["hsa05202", "Transcriptional misregulation in cancer", "4", "7.69", "0.0269", "MMP9, CXCL8, MMP3, PLAU"], ["hsa05205", "Proteoglycans in cancer", "4", "7.69", "0.0419", "LUM, MMP9, PLAU, FN1"], ["hsa05323", "Rheumatoid arthritis", "3", "5.77", "0.0458", "CXCL8, MMP3, MMP1"], ["Down-regulated DEGs"], ["hsa00982", "Drug metabolism-cytochrome P450", "4", "5", "0.0040", "FMO2, ADH1B, ADH7, ALDH3A1"], ["hsa00350", "Tyrosine metabolism", "3", "3.75", "0.0119", "ADH1B, ADH7, ALDH3A1"], ["hsa04530", "Tight junction", "4", "5", "0.0270", "MYH2, MYLPF, CLDN10, MYH7"], ["hsa00010", "Glycolysis/gluconeogenesis", "3", "3.75", "0.0403", "ADH1B, ADH7, ALDH3A1"], ["hsa00980", "Metabolism of xenobiotics by cytochrome P450", "3", "3.75", "0.0483", "ADH1B, ADH7, ALDH3A1"]], "row_count": 20, "column_count": 6, "numeric_cells": 72, "header_rows": 1, "locator": "section[13]/table-wrap[2]#Tab3"}}, {"id": "asset:table:pmid:30937621:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:043890e38806b2818303cf6c214ca4edbf72ec777eef36a48fa1c39ce56dc2e6", "bytes": 479, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[16]/table-wrap[1]#Tab4", "version": null, "note": "The mean LS of SERPINE1, PLAU and ACTA1 in NOM, OED and HNSCC tissues", "structure": {"pmcid": "PMC6687676", "section_index": 16, "section_title": "SERPINE1, PLAU and ACTA1 are aberrantly expressed in the carcinogenesis of HNSCC.", "row_count": 5, "column_count": 4}, "table": {"label": "Table 4", "caption": "The mean LS of SERPINE1, PLAU and ACTA1 in NOM, OED and HNSCC tissues", "rows": [["Group", "Mean LS ± SD (100%)"], ["SERPINE1", "PLAU", "ACTA1"], ["NOM", "58.50 ± 15.072", "51.80 ± 10.727", "136.10 ± 49.249"], ["OED", "230.38 ± 53.046*", "194.54 ± 46.321*", "81.77 ± 5.403*"], ["HNSCC", "205.85 ± 51.427*", "199.61 ± 47.895*", "60.66 ± 9.089*,#"]], "row_count": 5, "column_count": 4, "numeric_cells": 10, "header_rows": 2, "locator": "section[16]/table-wrap[1]#Tab4"}}, {"id": "asset:table:pmid:30937621:5", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:c379e843c3d4cb3c83ec665248d2dd49942c1397d1b5f80e892b38cf4b03c660", "bytes": 508, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[17]/table-wrap[1]#Tab5", "version": null, "note": "The mean LS of SERPINE1, PLAU and ACTA1 in well, moderately and poorly differentiation of HNSCC tissues", "structure": {"pmcid": "PMC6687676", "section_index": 17, "section_title": "SERPINE1, PLAU and ACTA1 are correlated with clinical aggressiveness of HNSCC patients", "row_count": 5, "column_count": 4}, "table": {"label": "Table 5", "caption": "The mean LS of SERPINE1, PLAU and ACTA1 in well, moderately and poorly differentiation of HNSCC tissues", "rows": [["Histology", "Mean LS ± SD (100%)"], ["SERPINE1", "PLAU", "ACTA1"], ["Well", "166.78 ± 13.426", "106.78 ± 37.323", "64.78 ± 9.400"], ["Moderately", "234.60 ± 36.439*", "182.40 ± 6.450*", "0.000*"], ["Poorly", "282.00 ± 7.589*,#", "272.50 ± 36.812*,#", "0.000*"]], "row_count": 5, "column_count": 4, "numeric_cells": 10, "header_rows": 2, "locator": "section[17]/table-wrap[1]#Tab5"}}], "gaps": ["asset:data:geo:GSE58911 not downloaded", "asset:data:geo:GSE58911 licence not read", "asset:data:geo:GSE6631 not downloaded", "asset:data:geo:GSE6631 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "group_comparison", "specific": "anova", "label": "Group comparison", "dsl_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "missing_operations": [], 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The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE6631", "GSE58911"], "resolved_accessions": ["GSE6631", "GSE58911"], "statements": ["In the present study, the gene expression profiles (GSE6631, GSE58911) were obtained from Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/). Totally 22 paired samples of HNSCC and normal tissues were consisted in GSE6631, which based on GPL8300 platform (Affymetrix Human Genome U95 chips)."], "basis": "The paper names GSE6631, GSE58911 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. 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