RNA-sequencing data highlighting the time-of-day-dependent transcriptome of the central circadian pacemaker in Sox2-deficient mice.

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Here we present the RNA-sequencing based transcriptome profiles of control (Sox2 fl/fl ) and SOX2 conditional knock-out (Vgat-cre;Sox2 fl/fl ) mice at four time points in one 24-h circadian cycle. The raw sequencing data were deposited to ArrayExpress database at EMBL-EBI (https://www.ebi.ac.uk/arrayexpress) under the accession number E-MTAB-7496. Results of rhythmicity analysis, differential expression analysis, network prediction, and potential target identification stemming from the RNA-sequencing dataset are also given in this article. The interpretation and discussion of these data can be found in the related research article entitled \"SOX2-dependent transcription in clock neurons promotes the robustness of the central circadian pacemaker.\" Cheng et al. 2019.", "claims": [{"id": "claim-method", "statement": "Data were analyzed using two-way ANOVA, Mann-Whitney U test, and Kolmogorov-Smirnov test with R version 3.5.0. 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