High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:31088409", "kind": "science-record", "revision": 6, "content_hash": "sha256:6bac94ebce185677678642cae0431f812e0966e009060c18c57b55e12a8f76fe", "created_at": "2026-11-01T15:40:45Z", "updated_at": "2026-11-01T21:22:11Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer.", "doi": "10.1186/s12885-019-5673-6", "pmid": "31088409", "authors": ["Zaiping Chen", "Guiyang Wu", "Fubo Ye", "Guoping Chen", "Qinghao Fan", "Hao Dong", "Xiongwen Zhu", "Chongshan Wu"], "journal": "BMC cancer", "year": 2019, "abstract": "BACKGROUND: Matrix metalloproteinase 19 (MMP19) is a member of zinc-dependent endopeptidases, which have been involved in various physiological and pathological processes. Its expression has been demonstrated in some types of cancers, but the clinical significance of MMP19 in colorectal cancer (CRC) has not been reported. Thus, we aimed to analyze the clinical significance of MMP19 in CRC in present study.\nMETHODS: The expression of MMP19 was first explored in The Cancer Genome Atlas (TCGA) cohort, and then validated in the GSE39582 cohort and our own database. Clinicopathological features and survival rate were also investigated.\nRESULTS: MMP19 was found to be a predictor for overall survival (OS) in both univariate (hazard ratio [HR]: 1.449, 95% confidence interval [CI]: 1.108-1.893, P = 0.007) and multivariate survival analyses (HR: 1.401, 95% CI: 1.036-1.894, P = 0.028) in the TCGA database. MMP19 was further validated as an independent factor for recurrence free survival in the GSE39582 database by both univariate analysis (HR: 2.061, 95%CI: 1.454-2.921, P < 0.001) and multivariate analysis (HR = 1.470, 95% CI: 1.025-2.215, P = 0.032). In an in-house cohort, MMP19 was significantly upregulated in CRC tissues when compared with their adjacent normal controls (P < 0.001). Ectopic MMP19 expression was positively associated with lymph node metastases (P = 0.029), intramural vascular invasion (P = 0.015) and serum carcinoembryonic antigen levels (P = 0.045). High MMP19 expression correlated with a shorter OS (HR = 5.595; 95% CI: 2.573-12.164; P < 0.001) and disease free survival (HR = 4.699; 95% CI: 2.461-8.974; P < 0.001) in multivariate cox regression analysis.\nCONCLUSIONS: Expression of MMP19 was upregulated in CRC. High expression of MMP19 was determined to be an independent and poor prognostic factor in CRC. These results suggest that MMP19 may be a good biomarker for CRC.", "claims": [{"id": "claim-method", "statement": "Survival analysis were compared using the univariate and multivariate Cox proportional hazard model among different MMP19 mRNA expression levels in the TCGA and GSE39582 database.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31088409", "locator": "sections[8] \"Statistical analysis\" paragraph 2", "quote": "Survival analysis were compared using the univariate and multivariate Cox proportional hazard model among different MMP19 mRNA expression levels in the TCGA and GSE39582 database."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The TCGA portal (http://tcga-data.nci.nih.gov/) and GSE39582 database (https://www.ncbi.nlm.nih.gov/geo/) are public available. The validation cohort cannot be made publicly available for ethical reasons since public availability would compromise patient confidentiality or participant privacy, but are available from the corresponding author upon reasonable request meeting the criteria for access to confidential data.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31088409", "locator": "sections[17] \"ack\" paragraph 1", "quote": "The TCGA portal (http://tcga-data.nci.nih.gov/) and GSE39582 database (https://www.ncbi.nlm.nih.gov/geo/) are public available. The validation cohort cannot be made publicly available for ethical reasons since public availability would compromise patient confidentiality or participant privacy, but are available from the corresponding author upon reasonable request meeting the criteria for access to confidential data."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31088409"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE39582"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE39582"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:31088409", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1186/s12885-019-5673-6", "sha256": "sha256:fde2b88da6dfe4dca7d6f1654beb0a6c7255bb434983125b01c44c2bc96751ea", "bytes": 24867, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1186/s12885-019-5673-6", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC6518766", "source": "europe_pmc_fulltext", "coverage": "whole_body_without_references", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE39582", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE39582", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE39582", "version": null, "note": "The TCGA portal (http://tcga-data.nci.nih.gov/) and GSE39582 database (https://www.ncbi.nlm.nih.gov/geo/) are public available. 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