Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:31113446", "kind": "science-record", "revision": 6, "content_hash": "sha256:47fef91e03c69b49ee063a58d82a552078139dc6558085472d1fc4f21a6fded8", "created_at": "2026-11-01T15:40:45Z", "updated_at": "2026-11-01T21:22:12Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer.", "doi": "10.1186/s13048-019-0524-2", "pmid": "31113446", "authors": ["Jun Li", "Huiran Yue", "Hailin Yu", "Xin Lu", "Xiaohong Xue"], "journal": "Journal of ovarian research", "year": 2019, "abstract": "OBJECTIVE: Our aim is to analyzed the expression pattern of sirtuin(SIRT) superfamily and evaluated their prognostic values in serous ovarian cancer patients.\nMETHODS: We first analyzed the differential expression of SIRT members among fallopian tube epithelium (FTE), primary serous ovarian cancers/tubal cancers (PSOCs/PSTCs), and omental metastases using GSE10971 and GSE30587 datasets. The prognostic values of SIRT members were evaluated using TCGA and GSE9891 dataset.\nRESULTS: SIRT3 and SIRT5 expression were significantly decreased and increased in PSOCs/PSTCs compared with that in normal counterparts, respectively. SIRT6 and SIRT7 were overexpressed in ometal metastases compared with corresponding primary counterparts. With respect to recurrence free survival, however, SIRT7 overexpression was correlated with better prognosis. A similar trend was observed by multivariable analysis. Regarding overall survival (OS), increased expression of SIRT3, SIRT5, and SIRT7 were associated with better survival by univariable analysis. Subsequent multivariable analysis showed that SIRT3 remained an independent favorable prognostic factor for OS. The SIRT3-related nomogram illustrated age at initial diagnosis as sharing the largest contribution to OS, followed by SIRT3 expression and FIGO stage. The C-index for OS prediction was 0.65 (95%CI, 0.61-0.69) in training cohort (TCGA dataset) and 0.65 (95%CI, 0.59-0.71) in validation cohort (GSE9891 dataset), respectively. The calibration plots showed optimal agreement between the prediction by SIRT3-related nomogram and actual observation for 1-, 3-, and 5-year OS probability.\nCONCLUSION: In conclusion, SIRT3 was an independent favorable prognostic factor for OS in serous ovarian cancer, and added prognostic value to the traditional clinicopathological factors used to evaluate patients' prognosis.", "claims": [{"id": "claim-method", "statement": "All factors reaching statistical significance in the univariable analysis were entered into the multivariable Cox regression analysis.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31113446", "locator": "sections[7] \"The prognostic value of SIRT members in serous ovarian cancer patients\" paragraph 2", "quote": "All factors reaching statistical significance in the univariable analysis were entered into the multivariable Cox regression analysis."}], "state": "complete"}, {"id": "claim-data-access", "statement": "All data used in present study are all available in TCGA and GEO databases.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31113446", "locator": "sections[10] \"ack\" paragraph 1", "quote": "All data used in present study are all available in TCGA and GEO databases."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31113446"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE10971"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE10971"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:31113446", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1186/s13048-019-0524-2", "sha256": 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"resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:31113446:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:eef7e001643c6ae045a019833273ffac6dcf52eb107f19811a0cc988e7ac34db", "bytes": 1973, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[7]/table-wrap[1]#Tab1", "version": null, "note": "The associations of each SIRT member’s expression with RFS and OS", "structure": {"pmcid": "PMC6530022", "section_index": 7, "section_title": "The prognostic value of SIRT members in serous ovarian cancer patients", "row_count": 20, "column_count": 10}, "table": {"label": "Table 1", "caption": "The associations of each SIRT member’s expression with RFS and OS", "rows": [["Variables", "Number of patients", "RFS", "OS"], ["Univariate analysis", "Multivariate analysis", "Univariate analysis", "Multivariate analysis"], ["HR (95%CI)", "P value", "HR (95%CI)", "P value", "HR (95%CI)", "P value", "HR (95%CI)", "P value"], ["Age", "462", "1.003 (0.991–1.014)", "0.661", "/", "/", "1.024 (1.013–1.036)", "< 0.001", "1.023 (1.011–1.034)", "< 0.001"], ["Stage", "", "", "0.015", "", "0.016", "", "0.001", "", "0.005"], ["Early", "33", "1", "", "1", "", "1", "", "1", ""], ["Late", "429", "2.003 (1.144–3.506)", "", "1.986 (1.134–3.477)", "", "3.478 (1.639–7.381)", "", "2.995 (1.392–6.446)", ""], ["Grade", "", "", "0.254", "", "/", "", "0.048", "", "0.196"], ["Low", "57", "1", "", "/", "", "1", "", "1", ""], ["High", "405", "1.227 (0.863–1.745)", "", "/", "", "1.438 (1.003–2.063)", "", "1.280 (0.881–1859)", ""], ["Debulking", "", "", "0.886", "", "/", "", "0.030", "", "0.540"], ["Optimal", "344", "1", "", "/", "", "1", "", "1", ""], ["Suboptimal", "118", "0.979 (0.734–1.306)", "", "/", "", "1.353 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