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pmid:31431912

Data from quantitative serum proteomic analysis after laparoscopic gastric plication.

Parisa Savedoroudi · Tue Bjerg Bennike · Kenneth Kastaniegaard · Mohammad Talebpour · Alireza Ghassempour · Allan Stensballe

Data in brief · 2019 doi:10.1016/j.dib.2019.104077

Paper

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Experiment

complete

Data

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Analysis

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Execution

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title
Data from quantitative serum proteomic analysis after laparoscopic gastric plication.
doi
10.1016/j.dib.2019.104077
pmid
31431912
authors array · 6 items
[0]
Parisa Savedoroudi
[1]
Tue Bjerg Bennike
[2]
Kenneth Kastaniegaard
[3]
Mohammad Talebpour
[4]
Alireza Ghassempour
[5]
Allan Stensballe
journal
Data in brief
year
2019
abstract
Bariatric surgery is an effective treatment for morbid obesity with a sustained weight loss and improvements in metabolic syndrome. We present a label free quantitative shotgun proteomics approach to analyze the serum proteome of obese people who underwent Laparoscopic Gastric Plication (LGP) as a new bariatric surgery. Pre-surgery serum samples of obese individuals were compared with the serum of the same subjects 1-2 months post-surgery (T1) and 4-5 months post-surgery (T2). The data provide a list of 224 quantifiable proteins with at least two unique peptides that were quantifiable in at least 70% of samples. Gene ontology biological processes and molecular functions of differentially regulated proteins between pre- and post-surgery samples were investigated using WebGestalt online tool. In addition, molecular networks of differentially abundant proteins were determined through Ingenuity Pathway Analysis (IPA) software. This report is related to the research article entitled "Serum proteome changes and accelerated reduction of fat mass after Laparoscopic Gastric Plication in morbidly obese patients" (Savedoroudi et al. [1]). Proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository through the identifier PXD010528.
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Data are available within this article and from ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD010528.
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Data are available within this article and from ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD010528.
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Data in support of serum proteomics of Laparoscopic Gastric Plication
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Description of file-names and MaxQuant output in the ProteomeXchange repository PXD010528. MS files were analyzed in MaxQuant. All samples were analyzed in triplicates. Timepoint 1: 1–2 months post-surgery; Timepoint 2: 4–5 months post-surgery.
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Data
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Table 1
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Description of file-names and MaxQuant output in the ProteomeXchange repository PXD010528. MS files were analyzed in MaxQuant. All samples were analyzed in triplicates. Timepoint 1: 1–2 months post-surgery; Timepoint 2: 4–5 months post-surgery.
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21aft1-2
[1]
21/After surgery at timepoint 1
[2]
Q Exactive HF
[123] array · 3 items
[0]
21aft1-3
[1]
21/After surgery at timepoint 1
[2]
Q Exactive HF
[124] array · 1 item
[0]
The MaxQuant output in folder "txt" contains a range of files containing important search information. Below file was used for further processing in Perseus post-analysis program and quantitative analysis.
[125] array · 2 items
[0]
proteinGroups.txt
[1]
File containing all proteins with corresponding label free quantitative information
row_count
126
locator
section[3]/table-wrap[1]#tbl1
[3] object · 16 fields
id
asset:table:pmid:31431912:2
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:d8490fb03b1668a851826d070c308f322546c3b730843e812dcab39f68c92914
bytes
2441
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[3]/table-wrap[2]#tbl2
version
null
note
Enrichment analysis of Gene ontology biological process and molecular function for differentially abundant proteins at T1, using WebGestalt online tool.
structure object · 5 fields
pmcid
PMC6580113
section_index
3
section_title
Data
row_count
23
column_count
4
table object · 8 fields
label
Table 2
caption
Enrichment analysis of Gene ontology biological process and molecular function for differentially abundant proteins at T1, using WebGestalt online tool.
rows array · 23 items
[0] array · 4 items
[0]
Gen set
[1]
Description
[2]
P-value
[3]
Overlap Gen-ID
[1] array · 1 item
[0]
Biological Process
[2] array · 4 items
[0]
GO:0051223
[1]
regulation of protein transport
[2]
4.87E-05
[3]
CRP, GPLD1, APOA1, APOA2, APOD, IL1RAP, LCP1, SRGN, RBP4, SAA1, CD14, ADIPOQ
[3] array · 4 items
[0]
GO:0070201
[1]
regulation of establishment of protein localization
[2]
8.84E-05
[3]
CRP, GPLD1, APOA1, APOA2, APOD, IL1RAP, LCP1, SRGN, RBP4, SAA1, CD14, ADIPOQ
[4] array · 4 items
[0]
GO:0034284
[1]
response to monosaccharide
[2]
0.000109
[3]
GPLD1, APOA2, SERPINF1, APOM, SPARC, THBS1, ADIPOQ
[5] array · 4 items
[0]
GO:0032880
[1]
regulation of protein localization
[2]
0.000256
[3]
CRP, GPLD1, APOA1, APOA2, APOD, IL1RAP, LCP1, SRGN, RBP4, SAA1, CD14, ADIPOQ
[6] array · 4 items
[0]
GO:0009743
[1]
response to carbohydrate
[2]
0.000315
[3]
GPLD1, APOA2, SERPINF1, APOM, SPARC, THBS1, ADIPOQ
[7] array · 4 items
[0]
GO:0009746
[1]
response to hexose
[2]
0.000532
[3]
GPLD1, APOA2, SERPINF1, APOM, THBS1, ADIPOQ
[8] array · 4 items
[0]
GO:0009749
[1]
response to glucose
[2]
0.000532
[3]
GPLD1, APOA2, SERPINF1, APOM, THBS1, ADIPOQ
[9] array · 4 items
[0]
GO:0050707
[1]
regulation of cytokine secretion
[2]
0.000746
[3]
CRP, APOA1, APOA2, IL1RAP, SRGN, SAA1, CD14
[10] array · 4 items
[0]
GO:0051224
[1]
negative regulation of protein transport
[2]
0.00081
[3]
APOA1, APOA2, APOD, SRGN, ADIPOQ
[11] array · 4 items
[0]
GO:1904950
[1]
negative regulation of establishment of protein localization
[2]
0.00081
[3]
APOA1, APOA2, APOD, SRGN, ADIPOQ
[12] array · 1 item
[0]
Molecular Function
[13] array · 4 items
[0]
GO:0005319
[1]
lipid transporter activity
[2]
0.00279
[3]
APOF, APOA1, APOA2, APOD, APOM, RBP4
[14] array · 4 items
[0]
GO:0005496
[1]
steroid binding
[2]
0.00279
[3]
GC, APOF, APOA1, APOA2, APOD, SHBG
[15] array · 4 items
[0]
GO:0071813
[1]
lipoprotein particle binding
[2]
0.0101
[3]
CRP, APOA1, APOA2, THBS1
[16] array · 4 items
[0]
GO:0071814
[1]
protein-lipid complex binding
[2]
0.0101
[3]
CRP, APOA1, APOA2, THBS1
[17] array · 4 items
[0]
GO:0043178
[1]
alcohol binding
[2]
0.0105
[3]
APOF, APOA1, APOA2, APOD, RBP4
[18] array · 4 items
[0]
GO:0008289
[1]
lipid binding
[2]
0.0122
[3]
F10, GC, APOF, APOA1, APOA2, APOD, APOM, RBP4, SHBG, THBS1, CD14
[19] array · 4 items
[0]
GO:0005215
[1]
transporter activity
[2]
0.0128
[3]
GC, HBB, APOF, APOA1, APOA2, APOD, APOM, RBP4
[20] array · 4 items
[0]
GO:0022892
[1]
substrate-specific transporter activity
[2]
0.0170
[3]
HBB, APOF, APOA1, APOA2, APOD, APOM, RBP4
[21] array · 4 items
[0]
GO:0015485
[1]
cholesterol binding
[2]
0.0206
[3]
APOF, APOA1, APOA2, APOD
[22] array · 4 items
[0]
GO:0032934
[1]
sterol binding
[2]
0.0206
[3]
APOF, APOA1, APOA2, APOD
locator
section[3]/table-wrap[2]#tbl2
[4] object · 16 fields
id
asset:table:pmid:31431912:3
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:f679aea00896d9748fe3ef4d83f743bf616d0abfc754d1b4bf99808be0eb0f06
bytes
2035
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[3]/table-wrap[3]#tbl3
version
null
note
Enrichment analysis of Gene ontology biological process and molecular function for differentially abundant proteins at T2, using WebGestalt online tool.
structure object · 5 fields
pmcid
PMC6580113
section_index
3
section_title
Data
row_count
23
column_count
4
table object · 8 fields
label
Table 3
caption
Enrichment analysis of Gene ontology biological process and molecular function for differentially abundant proteins at T2, using WebGestalt online tool.
rows array · 23 items
[0] array · 4 items
[0]
Gen set
[1]
Description
[2]
P-value
[3]
Overlap Gen-ID
[1] array · 1 item
[0]
Biological Process
[2] array · 4 items
[0]
GO:0010976
[1]
positive regulation of neuron projection development
[2]
0.000151
[3]
FN1, IL1RAP, NRP1
[3] array · 4 items
[0]
GO:0045666
[1]
positive regulation of neuron differentiation
[2]
0.000151
[3]
FN1, IL1RAP, NRP1
[4] array · 4 items
[0]
GO:0050769
[1]
positive regulation of neurogenesis
[2]
0.000151
[3]
FN1, IL1RAP, NRP1
[5] array · 4 items
[0]
GO:0051962
[1]
positive regulation of nervous system development
[2]
0.000151
[3]
FN1, IL1RAP, NRP1
[6] array · 4 items
[0]
GO:0010975
[1]
regulation of neuron projection development
[2]
0.000262
[3]
FN1, IL1RAP, NRP1
[7] array · 4 items
[0]
GO:0031346
[1]
positive regulation of cell projection organization
[2]
0.000416
[3]
FN1, IL1RAP, NRP1
[8] array · 4 items
[0]
GO:0045664
[1]
regulation of neuron differentiation
[2]
0.000416
[3]
FN1, IL1RAP, NRP1
[9] array · 4 items
[0]
GO:0050767
[1]
regulation of neurogenesis
[2]
0.000618
[3]
FN1, IL1RAP, NRP1
[10] array · 4 items
[0]
GO:0051960
[1]
regulation of nervous system development
[2]
0.000618
[3]
FN1, IL1RAP, NRP1
[11] array · 4 items
[0]
GO:0031344
[1]
regulation of cell projection organization
[2]
0.00119
[3]
FN1, IL1RAP, NRP1
[12] array · 1 item
[0]
Molecular Function
[13] array · 4 items
[0]
GO:0004888
[1]
transmembrane signaling receptor activity
[2]
0.0226
[3]
IL1RAP, NRP1
[14] array · 4 items
[0]
GO:0099600
[1]
transmembrane receptor activity
[2]
0.0226
[3]
IL1RAP, NRP1
[15] array · 4 items
[0]
GO:0004872
[1]
receptor activity
[2]
0.0304
[3]
PRG4, IL1RAP, NRP1
[16] array · 4 items
[0]
GO:0060089
[1]
molecular transducer activity
[2]
0.0304
[3]
PRG4, IL1RAP, NRP1
[17] array · 4 items
[0]
GO:0038023
[1]
signaling receptor activity
[2]
0.0336
[3]
IL1RAP, NRP1
[18] array · 4 items
[0]
GO:0004871
[1]
signal transducer activity
[2]
0.0533
[3]
IL1RAP, NRP1
[19] array · 4 items
[0]
GO:0016301
[1]
kinase activity
[2]
0.135
[3]
NRP1
[20] array · 4 items
[0]
GO:0016504
[1]
peptidase activator activity
[2]
0.135
[3]
FN1
[21] array · 4 items
[0]
GO:0016772
[1]
transferase activity, transferring phosphorus-containing groups
[2]
0.135
[3]
NRP1
[22] array · 4 items
[0]
GO:0016773
[1]
phosphotransferase activity, alcohol group as acceptor
[2]
0.135
[3]
NRP1
locator
section[3]/table-wrap[3]#tbl3
[5] object · 16 fields
id
asset:table:pmid:31431912:4
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:5de4dcff6f96ebd5170db54c3c23b862f322f16286c4eb8264abfda57ce3d8e2
bytes
2768
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[3]/table-wrap[4]#tbl4
version
null
note
Networks identified using IPA.
structure object · 5 fields
pmcid
PMC6580113
section_index
3
section_title
Data
row_count
9
column_count
4
table object · 8 fields
label
Table 4
caption
Networks identified using IPA.
rows array · 9 items
[0] array · 4 items
[0]
Top Diseases and Functions
[1]
Score
[2]
Focus Molecules
[3]
Molecules in Network
[1] array · 1 item
[0]
T1
[2] array · 4 items
[0]
Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry
[1]
45
[2]
19
[3]
Adipokine, ADIPOQ, APCS, APOA1, APOA2, APOA4, APOD, APOF, APOM, C1q, C4BP, C4BPA, Collagen type II, CRP, ERK1/2, F10, Fibrinogen, GC, GPLD1, Growth hormone, HDL, HDL-cholesterol, Histone h4, IL12 (complex), LDL, NADPH oxidase, Pro-inflammatory Cytokine, RARRES2, Rbp, RBP4, SAA1, SERPINF1, SERPINF2, Sod, TTR
[3] array · 4 items
[0]
Cardiovascular System Development and Function, Cellular Movement, Cell-To-Cell Signaling and Interaction
[1]
28
[2]
13
[3]
Akt, Ap1, collagen, Collagen Alpha1, Collagen type I, Collagen type IV, Collagen type VI, Collagen(s), DBH, DSG2, elastase, Fc gamma receptor, GP1BA, Gp2b3a Receptor, IL1, IL-1R, IL1RAP, Integrin, Iti, ITIH2, ITIH3, Laminin (complex), LCP1, Mek, Mmp, MMP9, p85 (pik3r), Pdgf (complex), PDGF BB, PEPD, SPARC, SRGN, Tgf beta, THBS1, VWF
[4] array · 4 items
[0]
Cellular Assembly and Organization, Nervous System Development and Function, Cell-To-Cell Signaling and Interaction
[1]
18
[2]
9
[3]
CD14, CFP, Cg, Creb, CRTAC1, ERK, estrogen receptor, F7, FAH, GOT, HBB, HISTONE, Histone h3, Ifn, IFN Beta, Ige, IgG, IgG1, IL12 (family), Immunoglobulin, Insulin, Mapk, NFkB (complex), NRP1, P38 MAPK, PI3K (complex), Pka, PRG4, Rac, RNA polymerase II, SHBG, SRC (family), TCF, Tnf (family), Vegf
[5] array · 4 items
[0]
Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking
[1]
15
[2]
8
[3]
ACTG2, Actin, APCS, APP, C7, CASP8, caspase, CCL17, CD3, CFI, CLEC10A, CNDP1, CTF1, CYTIP, Ddx3x, DEFA6, Dstn/Dstnl1, FETUB, Granzyme, HBG1, IL13, IL10RB, Jnk, LIPA, LRP1, MMRN1, MT1G, PZP, Ras, S100A12, SCAVENGER receptor CLASS A, Sos, SRGN, TCR, ZFP36L1
[6] array · 4 items
[0]
Inflammatory Response, Infectious Diseases, Inflammatory Disease
[1]
5
[2]
3
[3]
ADIPOR2, APCS, BBS12, CD163, CD276, CLEC10A, CMKLR1, coagulation factor, CYP19, CYTIP, estrone, FBXO42, Fcgr2, FSH, glycosylphosphatidylinositol, GPER1, GPR119, HFE, IL6, IL17B, IL1RL2, LPAR2, N-cor, NfkB1 RelA, PAX8, Proinsulin, RARRES2, S100A12, SCAVENGER receptor CLASS A, SCN9A, SELENOS, SHBG, SMPDL3A, Timp, TNF
[7] array · 1 item
[0]
T2
[8] array · 4 items
[0]
Cell-To-Cell Signaling and Interaction, Cell Death and Survival, Inflammatory Response
[1]
21
[2]
7
[3]
Akt, ANGPTL1, B4GALT5, C4BPB, CHST3, CLEC10A, Collagen type VI, CRP, Enolase, ERK, ERK1/2, EXT1, Fc gamma receptor, Fc receptor, FCER1A, FCN1, FN1, GFRA2, HS6ST1, IL1, IL6, IL1RAP, ITIH3, miR-191-5p (and other miRNAs w/seed AACGGAA), NFkB (complex), NfkB1-RelA, NRP1, PRG4, PRSS38, pyridoxamine, S100A12, SEMA3D, SHBG, Stat3-Stat3, TGFB1
locator
section[3]/table-wrap[4]#tbl4
gaps array · 2 items
[0]
asset:data:geo:PXD010528 not downloaded
[1]
asset:data:geo:PXD010528 licence not read
analysis object · 4 fields
state
absent
methods array · 0 items
targets array · 0 items
gaps array · 2 items
[0]
method
[1]
operations
capability object · 3 fields
state
complete
requirements array · 1 item
[0] object · 6 fields
capability_id
capability:computational_analysis
label
Computational analysis platform
assay_families array · 9 items
[0]
meta_analysis
[1]
machine_learning
[2]
survival_analysis
[3]
statistical_regression
[4]
pca
[5]
molecular_docking
[6]
network_analysis
[7]
differential_expression
[8]
gwas
candidate
Automated Assays Laravel application and simulated adapters
gaps array · 0 items
readiness object · 8 fields
state
blocked
tier
R4
blocking_axis
method
blocked_on
method:not_determinable
axes object · 3 fields
method object · 5 fields
tier
R4
expressible
false
required_operations array · 0 items
missing_operations array · 0 items
basis
The reader quoted the method the paper names (not named), but the corpus's method extractor could not map it onto a DSL operation, so the method is published but not expressible.
capability object · 4 fields
tier
R1
capability_id
capability:computational_analysis
availability_state
owned
basis
The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here.
data object · 6 fields
tier
R1
reachable
true
accessions array · 1 item
[0]
PXD010528
resolved_accessions array · 1 item
[0]
PXD010528
statements array · 1 item
[0]
Data are available within this article and from ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD010528.
basis
The paper names PXD010528 in ProteomeXchange Consortium via the PRIDE partner repository and the accession resolves in the repository. No dataset was downloaded and no licence was read.
can_run object · 3 fields
dsl_operations array · 0 items
assets array · 6 items
[0]
source:pmid:31431912
[1]
data:geo:PXD010528
[2]
asset:table:pmid:31431912:1
[3]
asset:table:pmid:31431912:2
[4]
asset:table:pmid:31431912:3
[5]
asset:table:pmid:31431912:4
steps array · 1 item
[0]
run_analysis
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 0 items
capabilities array · 0 items
data_gaps array · 1 item
[0]
data:geo:PXD010528
gaps array · 1 item
[0]
method:not_determinable
review object · 5 fields
state
partial
machine_critique object · 5 fields
kind
extraction_review
reader object · 5 fields
model
MiniMax-M3.1-Flash
provider
minimax
provider_family
minimax
read_at
2026-10-31T18:15:51Z
independence
single_reader
evidence_check object · 2 fields
method
null
availability
verbatim
calls
3
usage object · 3 fields
prompt_tokens
11620
completion_tokens
1100
cached_tokens
784
stages array · 1 item
[0] object · 4 fields
id
extraction
state
complete
reader
MiniMax-M3.1-Flash
provider
minimax
gaps array · 3 items
[0]
review.independent_reader
[1]
review.machine_critique
[2]
review.human_critique
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
entities array · 3 items
[0] object · 3 fields
id
pmid:31431912
type
paper
label
pmid:31431912
[1] object · 3 fields
id
source:pmid:31431912
type
manuscript
label
PMID 31431912 full text
[2] object · 3 fields
id
data:geo:PXD010528
type
dataset
label
GEO PXD010528
activities array · 3 items
[0] object · 4 fields
id
activity-reading-sci-2026-11-01
type
classification
used array · 3 items
[0] object · 3 fields
id
pmid:31431912
type
paper
label
pmid:31431912
[1] object · 3 fields
id
source:pmid:31431912
type
manuscript
label
PMID 31431912 full text
[2] object · 3 fields
id
data:geo:PXD010528
type
dataset
label
GEO PXD010528
agent
agent:corpus-assay-engine
[1] object · 4 fields
id
activity-read-31431912
type
extraction
used array · 1 item
[0]
source:pmid:31431912
agent
agent:minimax-reader
[2] object · 4 fields
id
activity-resolve-PXD010528
type
accession_resolution
used array · 1 item
[0]
data:geo:PXD010528
agent
agent:corpus-assay-engine
agents array · 2 items
[0] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
[1] object · 3 fields
id
agent:minimax-reader
type
software
label
MiniMax literature reader
source_run_id
reading-sci-2026-11-01
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:31431912
parent_hash
sha256:57f4e7f92be686343dcc431f60ed8707ba216a5bdcc4958785794e5469bab31f
fork_of
null
gaps array · 8 items
[0]
asset:data:geo:PXD010528 licence not read
[1]
asset:data:geo:PXD010528 not downloaded
[2]
execution.not_run
[3]
method
[4]
operations
[5]
review.human_critique
[6]
review.independent_reader
[7]
review.machine_critique
Complete file
{"sci_version": "1.0", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:31431912", "kind": "science-record", "revision": 3, "content_hash": "sha256:8304e3c5d5941bfa5200f409379f87c35fa5c1b23e2716961d9e383a37d028ab", "created_at": "2026-11-01T15:40:48Z", "updated_at": "2026-11-01T18:51:11Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Data from quantitative serum proteomic analysis after laparoscopic gastric plication.", "doi": "10.1016/j.dib.2019.104077", "pmid": "31431912", "authors": ["Parisa Savedoroudi", "Tue Bjerg Bennike", "Kenneth Kastaniegaard", "Mohammad Talebpour", "Alireza Ghassempour", "Allan Stensballe"], "journal": "Data in brief", "year": 2019, "abstract": "Bariatric surgery is an effective treatment for morbid obesity with a sustained weight loss and improvements in metabolic syndrome. We present a label free quantitative shotgun proteomics approach to analyze the serum proteome of obese people who underwent Laparoscopic Gastric Plication (LGP) as a new bariatric surgery. Pre-surgery serum samples of obese individuals were compared with the serum of the same subjects 1-2 months post-surgery (T1) and 4-5 months post-surgery (T2). The data provide a list of 224 quantifiable proteins with at least two unique peptides that were quantifiable in at least 70% of samples. Gene ontology biological processes and molecular functions of differentially regulated proteins between pre- and post-surgery samples were investigated using WebGestalt online tool. In addition, molecular networks of differentially abundant proteins were determined through Ingenuity Pathway Analysis (IPA) software. This report is related to the research article entitled \"Serum proteome changes and accelerated reduction of fat mass after Laparoscopic Gastric Plication in morbidly obese patients\" (Savedoroudi et al. [1]). Proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository through the identifier PXD010528.", "claims": [{"id": "claim-data-access", "statement": "Data are available within this article and from ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD010528.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31431912", "locator": "sections[1] \"table-wrap\" paragraph 1", "quote": "Data are available within this article and from ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD010528."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31431912"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:PXD010528"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:PXD010528"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:31431912", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1016/j.dib.2019.104077", "sha256": "sha256:2f8713020c35098c59e01c0cf78308714dafaa8e839a31e88bc81d8d07cf41c8", "bytes": 13203, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1016/j.dib.2019.104077", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC6580113", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:PXD010528", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=PXD010528", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "PXD010528", "version": null, "note": "Data are available within this article and from ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD010528.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Data are available within this article and from ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD010528.", "access_statement_kind": "data_availability_statement", "sample_accessions": [], "sample_count": null, "group_sizes": null, "group_sizes_basis": null, "platform": null, "taxon": null, "title": "Data in support of serum proteomics of Laparoscopic Gastric Plication", "resolution_checked_at": "2026-10-31T18:35:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:31431912:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:cc241d935767e5a5145305e27a7b674aa5a2f7dd110eea5ed74c77d1f756df4c", "bytes": 7683, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[3]/table-wrap[1]#tbl1", "version": null, "note": "Description of file-names and MaxQuant output in the ProteomeXchange repository PXD010528. MS files were analyzed in MaxQuant. All samples were analyzed in triplicates. Timepoint 1: 1–2 months post-surgery; Timepoint 2: 4–5 months post-surgery.", "structure": {"pmcid": "PMC6580113", "section_index": 3, "section_title": "Data", "row_count": 126, "column_count": 3}, "table": {"label": "Table 1", "caption": "Description of file-names and MaxQuant output in the ProteomeXchange repository PXD010528. MS files were analyzed in MaxQuant. All samples were analyzed in triplicates. Timepoint 1: 1–2 months post-surgery; Timepoint 2: 4–5 months post-surgery.", "rows": [["Raw file", "Sample", "MS system"], ["2bef-1", "2/Before surgery", "Q Exactive HF"], ["2bef-2", "2/Before surgery", "Q Exactive HF"], ["2bef-3", "2/Before surgery", "Q Exactive HF"], ["2aft1-1", "2/After surgery at timepoint 1", "Q Exactive HF"], ["2aft1-2", "2/After surgery at timepoint 1", "Q Exactive HF"], ["2aft1-3", "2/After surgery at timepoint 1", "Q Exactive HF"], ["3bef-1", "3/Before surgery", "Q Exactive HF"], ["3bef-2", "3/Before surgery", "Q Exactive HF"], ["3bef-3", "3/Before surgery", "Q Exactive HF"], ["3aft1-1", "3/After surgery at timepoint 1", "Q Exactive HF"], ["3aft1-2", "3/After surgery at timepoint 1", "Q Exactive HF"], ["3aft1-3_170725101835", "3/After surgery at timepoint 1", "Q Exactive HF"], ["3aft2-1", "3/After surgery at timepoint 2", "Q Exactive HF"], ["3aft2-2", "3/After surgery at timepoint 2", "Q Exactive HF"], ["3aft2-3", "3/After surgery at timepoint 2", "Q Exactive HF"], ["4bef-1", "4/Before surgery", "Q Exactive HF"], ["4bef-2", "4/Before surgery", "Q Exactive HF"], ["4bef-3", "4/Before surgery", "Q Exactive HF"], ["4aft1-1", "4/After surgery at timepoint 1", "Q Exactive HF"], ["4aft1-2", "4/After surgery at timepoint 1", "Q Exactive HF"], ["4aft1-3", "4/After surgery at timepoint 1", "Q Exactive HF"], ["5bef-1", "5/Before surgery", "Q Exactive HF"], ["5bef-2", "5/Before surgery", "Q Exactive HF"], ["5bef-3", "5/Before surgery", "Q Exactive HF"], ["5aft1-1", "5/After surgery at timepoint 1", "Q Exactive HF"], ["5aft1-2", "5/After surgery at timepoint 1", "Q Exactive HF"], ["5aft1-3", "5/After surgery at timepoint 1", "Q Exactive HF"], ["5aft2-1", "5/After surgery at timepoint 2", "Q Exactive HF"], ["5aft2-2", "5/After surgery at timepoint 2", "Q Exactive HF"], ["5aft2-3", "5/After surgery at timepoint 2", "Q Exactive HF"], ["6bef-1", "6/Before surgery", "Q Exactive HF"], ["6bef-2", "6/Before surgery", "Q Exactive HF"], ["6bef-3", "6/Before surgery", "Q Exactive HF"], ["6aft1-1", "6/After surgery at timepoint 1", "Q Exactive HF"], ["6aft1-2", "6/After surgery at timepoint 1", "Q Exactive HF"], ["6aft1-3", "6/After surgery at timepoint 1", "Q Exactive HF"], ["6aft2-1", "6/After surgery at timepoint 2", "Q Exactive HF"], ["6aft2-2", "6/After surgery at timepoint 2", "Q Exactive HF"], ["6aft2-3", "6/After surgery at timepoint 2", "Q Exactive HF"], ["7bef-1", "7/Before surgery", "Q Exactive HF"], ["7bef-2", "7/Before surgery", "Q Exactive HF"], ["7bef-3", "7/Before surgery", "Q Exactive HF"], ["7aft1-1", "7/After surgery at timepoint 1", "Q Exactive HF"], ["7aft1-2", "7/After surgery at timepoint 1", "Q Exactive HF"], ["7aft1-3", "7/After surgery at timepoint 1", "Q Exactive HF"], ["7aft2-1", "7/After surgery at timepoint 2", "Q Exactive HF"], ["7aft2-2", "7/After surgery at timepoint 2", "Q Exactive HF"], ["7aft2-3", "7/After surgery at timepoint 2", "Q Exactive HF"], ["8bef-1", "8/Before surgery", "Q Exactive HF"], ["8bef-2", "8/Before surgery", "Q Exactive HF"], ["8bef-3", "8/Before surgery", "Q Exactive HF"], ["8aft1-1", "8/After surgery at timepoint 1", "Q Exactive HF"], ["8aft1-2", "8/After surgery at timepoint 1", "Q Exactive HF"], ["8aft1-3_170725085836", "8/After surgery at timepoint 1", "Q Exactive HF"], ["8aft2-1", "8/After surgery at timepoint 2", "Q Exactive HF"], ["8aft2-2", "8/After surgery at timepoint 2", "Q Exactive HF"], ["8aft2-3", "8/After surgery at timepoint 2", "Q Exactive HF"], ["9bef-1", "9/Before surgery", "Q Exactive HF"], ["9bef-2", "9/Before surgery", "Q Exactive HF"], ["9bef-3", "9/Before surgery", "Q Exactive HF"], ["9aft1-1", "9/After surgery at timepoint 1", "Q Exactive HF"], ["9aft1-2", "9/After surgery at timepoint 1", "Q Exactive HF"], ["9aft1-3", "9/After surgery at timepoint 1", "Q Exactive HF"], ["10bef-1", "10/Before surgery", "Q Exactive HF"], ["10bef-2", "10/Before surgery", "Q Exactive HF"], ["10bef-3", "10/Before surgery", "Q Exactive HF"], ["10aft1-1", "10/After surgery at timepoint 1", "Q Exactive HF"], ["10aft1-2", "10/After surgery at timepoint 1", "Q Exactive HF"], ["10aft1-3", "10/After surgery at timepoint 1", "Q Exactive HF"], ["10aft2-1", "10/After surgery at timepoint 2", "Q Exactive HF"], ["10aft2-2", "10/After surgery at timepoint 2", "Q Exactive HF"], ["10aft2-3", "10/After surgery at timepoint 2", "Q Exactive HF"], ["11bef-1", "11/Before surgery", "Q Exactive HF"], ["11bef-2", "11/Before surgery", "Q Exactive HF"], ["11bef-3", "11/Before surgery", "Q Exactive HF"], ["11aft1-1", "11/After surgery at timepoint 1", "Q Exactive HF"], ["11aft1-2", "11/After surgery at timepoint 1", "Q Exactive HF"], ["11aft1-3", "11/After surgery at timepoint 1", "Q Exactive HF"], ["11aft2-1", "11/After surgery at timepoint 2", "Q Exactive HF"], ["11aft2-2", "11/After surgery at timepoint 2", "Q Exactive HF"], ["11aft2-3", "11/After surgery at timepoint 2", "Q Exactive HF"], ["12bef-1", "12/Before surgery", "Q Exactive HF"], ["12bef-2", "12/Before surgery", "Q Exactive HF"], ["12bef-3", "12/Before surgery", "Q Exactive HF"], ["12aft1-1", "12/After surgery at timepoint 1", "Q Exactive HF"], ["12aft1-2", "12/After surgery at timepoint 1", "Q Exactive HF"], ["12aft1-3", "12/After surgery at timepoint 1", "Q Exactive HF"], ["14bef-1", "14/Before surgery", "Q Exactive HF"], ["14bef-2", "14/Before surgery", "Q Exactive HF"], ["14bef-3", "14/Before surgery", "Q Exactive HF"], ["14aft1-1", "14/After surgery at timepoint 1", "Q Exactive HF"], ["14aft1-2", "14/After surgery at timepoint 1", "Q Exactive HF"], ["14aft1-3", "14/After surgery at timepoint 1", "Q Exactive HF"], ["14aft2-1", "14/After surgery at timepoint 2", "Q Exactive HF"], ["14aft2-2", "14/After surgery at timepoint 2", "Q Exactive HF"], ["14aft2-3", "14/After surgery at timepoint 2", "Q Exactive HF"], ["15bef-1", "15/Before surgery", "Q Exactive HF"], ["15bef-2", "15/Before surgery", "Q Exactive HF"], ["15bef-3", "15/Before surgery", "Q Exactive HF"], ["15aft1-1", "15/After surgery at timepoint 1", "Q Exactive HF"], ["15aft1-2", "15/After surgery at timepoint 1", "Q Exactive HF"], ["15aft1-3", "15/After surgery at timepoint 1", "Q Exactive HF"], ["17bef-1", "17/Before surgery", "Q Exactive HF"], ["17bef-2", "17/Before surgery", "Q Exactive HF"], ["17bef-3", "17/Before surgery", "Q Exactive HF"], ["17aft1-1", "17/After surgery at timepoint 1", "Q Exactive HF"], ["17aft1-2", "17/After surgery at timepoint 1", "Q Exactive HF"], ["17aft1-3", "17/After surgery at timepoint 1", "Q Exactive HF"], ["17aft2-1", "17/After surgery at timepoint 2", "Q Exactive HF"], ["17aft2-2", "17/After surgery at timepoint 2", "Q Exactive HF"], ["17aft2-3", "17/After surgery at timepoint 2", "Q Exactive HF"], ["18bef-1", "18/Before surgery", "Q Exactive HF"], ["18bef-2", "18/Before surgery", "Q Exactive HF"], ["18bef-3", "18/Before surgery", "Q Exactive HF"], ["18aft1-1", "18/After surgery at timepoint 1", "Q Exactive HF"], ["18aft1-2", "18/After surgery at timepoint 1", "Q Exactive HF"], ["18aft1-3", "18/After surgery at timepoint 1", "Q Exactive HF"], ["21bef-1", "21/Before surgery", "Q Exactive HF"], ["21bef-2", "21/Before surgery", "Q Exactive HF"], ["21bef-3", "21/Before surgery", "Q Exactive HF"], ["21aft1-1", "21/After surgery at timepoint 1", "Q Exactive HF"], ["21aft1-2", "21/After surgery at timepoint 1", "Q Exactive HF"], ["21aft1-3", "21/After surgery at timepoint 1", "Q Exactive HF"], ["The MaxQuant output in folder \"txt\" contains a range of files containing important search information. Below file was used for further processing in Perseus post-analysis program and quantitative analysis."], ["proteinGroups.txt", "File containing all proteins with corresponding label free quantitative information"]], "row_count": 126, "column_count": 3, "numeric_cells": 246, "header_rows": 1, "locator": "section[3]/table-wrap[1]#tbl1"}}, {"id": "asset:table:pmid:31431912:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:d8490fb03b1668a851826d070c308f322546c3b730843e812dcab39f68c92914", "bytes": 2441, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[3]/table-wrap[2]#tbl2", "version": null, "note": "Enrichment analysis of Gene ontology biological process and molecular function for differentially abundant proteins at T1, using WebGestalt online tool.", "structure": {"pmcid": "PMC6580113", "section_index": 3, "section_title": "Data", "row_count": 23, "column_count": 4}, "table": {"label": "Table 2", "caption": "Enrichment analysis of Gene ontology biological process and molecular function for differentially abundant proteins at T1, using WebGestalt online tool.", "rows": [["Gen set", "Description", "P-value", "Overlap Gen-ID"], ["Biological Process"], ["GO:0051223", "regulation of protein transport", "4.87E-05", "CRP, GPLD1, APOA1, APOA2, APOD, IL1RAP, LCP1, SRGN, RBP4, SAA1, CD14, ADIPOQ"], ["GO:0070201", "regulation of establishment of protein localization", "8.84E-05", "CRP, GPLD1, APOA1, APOA2, APOD, IL1RAP, LCP1, SRGN, RBP4, SAA1, CD14, ADIPOQ"], ["GO:0034284", "response to monosaccharide", "0.000109", "GPLD1, APOA2, SERPINF1, APOM, SPARC, THBS1, ADIPOQ"], ["GO:0032880", "regulation of protein localization", "0.000256", "CRP, GPLD1, APOA1, APOA2, APOD, IL1RAP, LCP1, SRGN, RBP4, SAA1, CD14, ADIPOQ"], ["GO:0009743", "response to carbohydrate", "0.000315", "GPLD1, APOA2, SERPINF1, APOM, SPARC, THBS1, ADIPOQ"], ["GO:0009746", "response to hexose", "0.000532", "GPLD1, APOA2, SERPINF1, APOM, THBS1, ADIPOQ"], ["GO:0009749", "response to glucose", "0.000532", "GPLD1, APOA2, SERPINF1, APOM, THBS1, ADIPOQ"], ["GO:0050707", "regulation of cytokine secretion", "0.000746", "CRP, APOA1, APOA2, IL1RAP, SRGN, SAA1, CD14"], ["GO:0051224", "negative regulation of protein transport", "0.00081", "APOA1, APOA2, APOD, SRGN, ADIPOQ"], ["GO:1904950", "negative regulation of establishment of protein localization", "0.00081", "APOA1, APOA2, APOD, SRGN, ADIPOQ"], ["Molecular Function"], ["GO:0005319", "lipid transporter activity", "0.00279", "APOF, APOA1, APOA2, APOD, APOM, RBP4"], ["GO:0005496", "steroid binding", "0.00279", "GC, APOF, APOA1, APOA2, APOD, SHBG"], ["GO:0071813", "lipoprotein particle binding", "0.0101", "CRP, APOA1, APOA2, THBS1"], ["GO:0071814", "protein-lipid complex binding", "0.0101", "CRP, APOA1, APOA2, THBS1"], ["GO:0043178", "alcohol binding", "0.0105", "APOF, APOA1, APOA2, APOD, RBP4"], ["GO:0008289", "lipid binding", "0.0122", "F10, GC, APOF, APOA1, APOA2, APOD, APOM, RBP4, SHBG, THBS1, CD14"], ["GO:0005215", "transporter activity", "0.0128", "GC, HBB, APOF, APOA1, APOA2, APOD, APOM, RBP4"], ["GO:0022892", "substrate-specific transporter activity", "0.0170", "HBB, APOF, APOA1, APOA2, APOD, APOM, RBP4"], ["GO:0015485", "cholesterol binding", "0.0206", "APOF, APOA1, APOA2, APOD"], ["GO:0032934", "sterol binding", "0.0206", "APOF, APOA1, APOA2, APOD"]], "row_count": 23, "column_count": 4, "numeric_cells": 45, "header_rows": 1, "locator": "section[3]/table-wrap[2]#tbl2"}}, {"id": "asset:table:pmid:31431912:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:f679aea00896d9748fe3ef4d83f743bf616d0abfc754d1b4bf99808be0eb0f06", "bytes": 2035, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[3]/table-wrap[3]#tbl3", "version": null, "note": "Enrichment analysis of Gene ontology biological process and molecular function for differentially abundant proteins at T2, using WebGestalt online tool.", "structure": {"pmcid": "PMC6580113", "section_index": 3, "section_title": "Data", "row_count": 23, "column_count": 4}, "table": {"label": "Table 3", "caption": "Enrichment analysis of Gene ontology biological process and molecular function for differentially abundant proteins at T2, using WebGestalt online tool.", "rows": [["Gen set", "Description", "P-value", "Overlap Gen-ID"], ["Biological Process"], ["GO:0010976", "positive regulation of neuron projection development", "0.000151", "FN1, IL1RAP, NRP1"], ["GO:0045666", "positive regulation of neuron differentiation", "0.000151", "FN1, IL1RAP, NRP1"], ["GO:0050769", "positive regulation of neurogenesis", "0.000151", "FN1, IL1RAP, NRP1"], ["GO:0051962", "positive regulation of nervous system development", "0.000151", "FN1, IL1RAP, NRP1"], ["GO:0010975", "regulation of neuron projection development", "0.000262", "FN1, IL1RAP, NRP1"], ["GO:0031346", "positive regulation of cell projection organization", "0.000416", "FN1, IL1RAP, NRP1"], ["GO:0045664", "regulation of neuron differentiation", "0.000416", "FN1, IL1RAP, NRP1"], ["GO:0050767", "regulation of neurogenesis", "0.000618", "FN1, IL1RAP, NRP1"], ["GO:0051960", "regulation of nervous system development", "0.000618", "FN1, IL1RAP, NRP1"], ["GO:0031344", "regulation of cell projection organization", "0.00119", "FN1, IL1RAP, NRP1"], ["Molecular Function"], ["GO:0004888", "transmembrane signaling receptor activity", "0.0226", "IL1RAP, NRP1"], ["GO:0099600", "transmembrane receptor activity", "0.0226", "IL1RAP, NRP1"], ["GO:0004872", "receptor activity", "0.0304", "PRG4, IL1RAP, NRP1"], ["GO:0060089", "molecular transducer activity", "0.0304", "PRG4, IL1RAP, NRP1"], ["GO:0038023", "signaling receptor activity", "0.0336", "IL1RAP, NRP1"], ["GO:0004871", "signal transducer activity", "0.0533", "IL1RAP, NRP1"], ["GO:0016301", "kinase activity", "0.135", "NRP1"], ["GO:0016504", "peptidase activator activity", "0.135", "FN1"], ["GO:0016772", "transferase activity, transferring phosphorus-containing groups", "0.135", "NRP1"], ["GO:0016773", "phosphotransferase activity, alcohol group as acceptor", "0.135", "NRP1"]], "row_count": 23, "column_count": 4, "numeric_cells": 40, "header_rows": 1, "locator": "section[3]/table-wrap[3]#tbl3"}}, {"id": "asset:table:pmid:31431912:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:5de4dcff6f96ebd5170db54c3c23b862f322f16286c4eb8264abfda57ce3d8e2", "bytes": 2768, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[3]/table-wrap[4]#tbl4", "version": null, "note": "Networks identified using IPA.", "structure": {"pmcid": "PMC6580113", "section_index": 3, "section_title": "Data", "row_count": 9, "column_count": 4}, "table": {"label": "Table 4", "caption": "Networks identified using IPA.", "rows": [["Top Diseases and Functions", "Score", "Focus Molecules", "Molecules in Network"], ["T1"], ["Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry", "45", "19", "Adipokine, ADIPOQ, APCS, APOA1, APOA2, APOA4, APOD, APOF, APOM, C1q, C4BP, C4BPA, Collagen type II, CRP, ERK1/2, F10, Fibrinogen, GC, GPLD1, Growth hormone, HDL, HDL-cholesterol, Histone h4, IL12 (complex), LDL, NADPH oxidase, Pro-inflammatory Cytokine, RARRES2, Rbp, RBP4, SAA1, SERPINF1, SERPINF2, Sod, TTR"], ["Cardiovascular System Development and Function, Cellular Movement, Cell-To-Cell Signaling and Interaction", "28", "13", "Akt, Ap1, collagen, Collagen Alpha1, Collagen type I, Collagen type IV, Collagen type VI, Collagen(s), DBH, DSG2, elastase, Fc gamma receptor, GP1BA, Gp2b3a Receptor, IL1, IL-1R, IL1RAP, Integrin, Iti, ITIH2, ITIH3, Laminin (complex), LCP1, Mek, Mmp, MMP9, p85 (pik3r), Pdgf (complex), PDGF BB, PEPD, SPARC, SRGN, Tgf beta, THBS1, VWF"], ["Cellular Assembly and Organization, Nervous System Development and Function, Cell-To-Cell Signaling and Interaction", "18", "9", "CD14, CFP, Cg, Creb, CRTAC1, ERK, estrogen receptor, F7, FAH, GOT, HBB, HISTONE, Histone h3, Ifn, IFN Beta, Ige, IgG, IgG1, IL12 (family), Immunoglobulin, Insulin, Mapk, NFkB (complex), NRP1, P38 MAPK, PI3K (complex), Pka, PRG4, Rac, RNA polymerase II, SHBG, SRC (family), TCF, Tnf (family), Vegf"], ["Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking", "15", "8", "ACTG2, Actin, APCS, APP, C7, CASP8, caspase, CCL17, CD3, CFI, CLEC10A, CNDP1, CTF1, CYTIP, Ddx3x, DEFA6, Dstn/Dstnl1, FETUB, Granzyme, HBG1, IL13, IL10RB, Jnk, LIPA, LRP1, MMRN1, MT1G, PZP, Ras, S100A12, SCAVENGER receptor CLASS A, Sos, SRGN, TCR, ZFP36L1"], ["Inflammatory Response, Infectious Diseases, Inflammatory Disease", "5", "3", "ADIPOR2, APCS, BBS12, CD163, CD276, CLEC10A, CMKLR1, coagulation factor, CYP19, CYTIP, estrone, FBXO42, Fcgr2, FSH, glycosylphosphatidylinositol, GPER1, GPR119, HFE, IL6, IL17B, IL1RL2, LPAR2, N-cor, NfkB1 RelA, PAX8, Proinsulin, RARRES2, S100A12, SCAVENGER receptor CLASS A, SCN9A, SELENOS, SHBG, SMPDL3A, Timp, TNF"], ["T2"], ["Cell-To-Cell Signaling and Interaction, Cell Death and Survival, Inflammatory Response", "21", "7", "Akt, ANGPTL1, B4GALT5, C4BPB, CHST3, CLEC10A, Collagen type VI, CRP, Enolase, ERK, ERK1/2, EXT1, Fc gamma receptor, Fc receptor, FCER1A, FCN1, FN1, GFRA2, HS6ST1, IL1, IL6, IL1RAP, ITIH3, miR-191-5p (and other miRNAs w/seed AACGGAA), NFkB (complex), NfkB1-RelA, NRP1, PRG4, PRSS38, pyridoxamine, S100A12, SEMA3D, SHBG, Stat3-Stat3, TGFB1"]], "row_count": 9, "column_count": 4, "numeric_cells": 18, "header_rows": 1, "locator": "section[3]/table-wrap[4]#tbl4"}}], "gaps": ["asset:data:geo:PXD010528 not downloaded", "asset:data:geo:PXD010528 licence not read"]}, "analysis": {"state": "absent", "methods": [], "targets": [], "gaps": ["method", "operations"]}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "blocked", "tier": "R4", "blocking_axis": "method", "blocked_on": "method:not_determinable", "axes": {"method": {"tier": "R4", "expressible": false, "required_operations": [], "missing_operations": [], "basis": "The reader quoted the method the paper names (not named), but the corpus's method extractor could not map it onto a DSL operation, so the method is published but not expressible."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["PXD010528"], "resolved_accessions": ["PXD010528"], "statements": ["Data are available within this article and from ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD010528."], "basis": "The paper names PXD010528 in ProteomeXchange Consortium via the PRIDE partner repository and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": [], "assets": ["source:pmid:31431912", "data:geo:PXD010528", "asset:table:pmid:31431912:1", "asset:table:pmid:31431912:2", "asset:table:pmid:31431912:3", "asset:table:pmid:31431912:4"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:PXD010528"]}, "gaps": ["method:not_determinable"]}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:15:51Z", "independence": "single_reader"}, "evidence_check": {"method": null, "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 11620, "completion_tokens": 1100, "cached_tokens": 784}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:31431912", "type": "paper", "label": "pmid:31431912"}, {"id": "source:pmid:31431912", "type": "manuscript", "label": "PMID 31431912 full text"}, {"id": "data:geo:PXD010528", "type": "dataset", "label": "GEO PXD010528"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:31431912", "type": "paper", "label": "pmid:31431912"}, {"id": "source:pmid:31431912", "type": "manuscript", "label": "PMID 31431912 full text"}, {"id": "data:geo:PXD010528", "type": "dataset", "label": "GEO PXD010528"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-31431912", "type": "extraction", "used": ["source:pmid:31431912"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-PXD010528", "type": "accession_resolution", "used": ["data:geo:PXD010528"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:31431912", "parent_hash": "sha256:57f4e7f92be686343dcc431f60ed8707ba216a5bdcc4958785794e5469bab31f", "fork_of": null, "generation": 2}, "gaps": ["asset:data:geo:PXD010528 licence not read", "asset:data:geo:PXD010528 not downloaded", "execution.not_run", "method", "operations", "review.human_critique", "review.independent_reader", "review.machine_critique"]}