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pmid:31545503
Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer.
Guo-Tian Ruan · Yi-Zhen Gong · Xi-Wen Liao · Shuai Wang · Wei Huang · Xiang-Kun Wang · Guang-Zhi Zhu · Cun Liao · Feng Gao
Oncology reports · 2019 doi:10.3892/or.2019.7326
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Complete file
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Therefore, the objective of the present study was to use cohorts of patients from Guangxi Medical University and the Gene Expression Omnibus (GEO) database to investigate and validate CXCL3 for the diagnosis and prognosis of CC, and to explore its prospective molecular mechanism. Reverse transcription‑quantitative PCR (RT‑qPCR) analysis of 38 paired tumor and non‑tumor tissues, and immunohistochemistry (IHC) of 212 tumor and 46 non‑tumor tissues was conducted to explore the expression of CXCL3 and its diagnostic and prognostic significance in the Guangxi Medical University CC cohort. A GEO dataset, GSE40967, was used to validate the prognostic significance of CXCL3. Gene set enrichment analysis (GSEA) was also conducted to explore the potential molecular mechanisms underlying the effects of CXCL3 in CC. The RT‑qPCR results indicated that CXCL3 expression was significantly higher in cancer tissues compared with adjacent normal tissues, suggesting that it may have high diagnostic value for CC. Multivariate Cox analysis based on the IHC results suggested that there was no appreciable association between CXCL3 positivity and the overall survival (OS) time of CC. However, a stratified analysis revealed that high expression of CXCL3 was associated with considerably increased mortality in the subgroup of CC patients with tumor size <5 cm (adjusted P=0.042, adjusted HR=2.298, 95% CI=1.030‑5.126) and with tumor thrombus (adjusted P=0.019, adjusted HR=5.096, 95% CI=1.306‑19.886). In the GSE40967 dataset, high expression of CXCL3 was closely associated with poor OS in CC (adjusted P=0.049, adjusted HR=1.416, 95% CI=1.002‑2.003). Furthermore, GSEA indicated that the high expression of CXCL3 was closely associated with DNA repair, cell cycle process, cell apoptosis process and the P53 regulation pathway. In summary, these result suggest that CXCL3 might serve as a novel biomarker in the diagnosis and prognosis of CC.", "claims": [{"id": "claim-method", "statement": "Cox proportional hazards regression analysis was applied to calculate the crude and adjusted hazard ratio (HR) and 95% confidence interval (CI) in uni- and multivariate analyses.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31545503", "locator": "sections[12] \"Statistical analysis\" paragraph 2", "quote": "Cox proportional hazards regression analysis was applied to calculate the crude and adjusted hazard ratio (HR) and 95% confidence interval (CI) in uni- and multivariate analyses."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The analyzed datasets generated during the study are available from Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/), and the datasets for the colon cancer cohort from the First Affiliated Hospital of Guangxi Medical University used and/or analyzed during the current study are available from the corresponding author on reasonable request.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31545503", "locator": "sections[24] \"Availability of data and materials\" paragraph 2", "quote": "The analyzed datasets generated during the study are available from Gene Expression Omnibus (https://www.ncbi.nlm.nih.gov/geo/), and the datasets for the colon cancer cohort from the First Affiliated Hospital of Guangxi Medical University used and/or analyzed during the current study are available from the corresponding author on reasonable request."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31545503"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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"taxon": "Homo sapiens", "title": "Gene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:31545503:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:71d02c829039749201ebbc212646205b2530f99fb55caeb05ba226551dc1a4b2", "bytes": 2412, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[16]/table-wrap[1]#tI-or-0-0-7326", "version": null, "note": "Clinical and pathological parameters of 212 patients with colon cancer.", "structure": {"pmcid": "PMC6787997", "section_index": 16, "section_title": "IHC of CXCL3 expression in CC tissue", "row_count": 59, "column_count": 5}, 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(0.367–6.221)", ""], ["Mass", "42", "NA", "1.203 (0.267–5.428)", ""], ["Missing", "6", "", "", ""], ["Tumor differentiation", "", "", "", "0.019"], ["Well", "10", "NA", "1", ""], ["Moderately", "160", "NA", "1.451 (0.352–5.993)", ""], ["Poor", "42", "NA", "3.076 (0.710–13.318)", ""], ["Tumor thrombus", "", "", "", "<0.0001"], ["No", "185", "NA", "1", ""], ["Yes", "26", "660", "4.571 (2.568–8.134)", ""], ["Missing", "1", "", "", ""], ["Tumor size (cm)", "", "", "", "0.236"], ["<5", "90", "NA", "1", ""], ["≥5", "116", "NA", "0.739 (0.447–1.221)", ""], ["Missing", "6", "", "", ""], ["Tumor number", "", "", "", "0.138"], ["One", "205", "NA", "1", ""], ["Two", "7", "1,917", "2.119 (0.768–5.844)", ""], ["Lymph node", "", "", "", "<0.0001"], ["Negative", "120", "NA", "1", ""], ["Positive", "91", "NA", "3.546 (2.075–6.061)", ""], ["Missing", "1", "", "", ""], ["Radical resection", "", "", "", "<0.0001"], ["Yes", "175", "NA", "1", ""], ["No", "37", "481", "11.536 (6.836–19.469)", ""], ["Tumor metastasis", "", "", "", "<0.0001"], ["No", "179", "NA", "1", ""], ["Yes", "33", "401", "14.344 (8.376–24.565)", ""], ["Nerve infiltration", "", "", "", "0.173"], ["No", "207", "NA", "1", ""], ["Yes", "4", "1,079", "2.572 (0.628–10.540)", ""], ["Missing", "1", "", "", ""], ["Postoperative chemotherapy", "", "", "", "0.833"], ["No", "69", "NA", "1", ""], ["Yes", "124", "NA", "1.061 (0.610–1.846)", ""], ["Missing", "19", "", "", ""], ["CXCL3", "", "", "", "0.730"], ["Negative", "122", "NA", "1", ""], ["Positive", "90", "NA", "0.914(0.548–1.524)", ""]], "row_count": 59, "column_count": 5, "numeric_cells": 105, "header_rows": 1, "locator": "section[16]/table-wrap[1]#tI-or-0-0-7326"}}, {"id": "asset:table:pmid:31545503:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:f6799202d73a98e9f33fcd5b7b3c65cd086d9e32578e90da9d8c50cf9e55155a", "bytes": 2251, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[18]/table-wrap[1]#tII-or-0-0-7326", "version": null, "note": "Clinical and pathological parameters of 585 patients with colon cancer from the GSE40967 cohort.", "structure": {"pmcid": "PMC6787997", "section_index": 18, "section_title": "Validation of the prognostic value of CXCL3 using the GEO database", "row_count": 55, "column_count": 5}, "table": {"label": "Table II.", "caption": "Clinical and pathological parameters of 585 patients with colon cancer from the GSE40967 cohort.", "rows": [["Variable", "No. of patients", "MST (months)", "OSa, HR (95% CI)b", "Log-rank P-valuec"], ["Sex", "", "", "", "0.066"], ["Male", "322", "112", "1", ""], ["Female", "263", "183", "0.765 (0.573–1.020)", ""], ["Age (years)", "", "", "", "0.010"], ["≤65", "228", "NA", "1", ""], [">65", "356", "105", "1.479 (1.094–1.999)", ""], ["Missing", "1", "", "", ""], ["TNM stage", "", "", "", "<0.0001"], ["0-II", "313", "183", "1", ""], ["III–IV", "270", "105", 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