← All .science files
pmid:31598161
Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) overexpression in tumors predicts worse overall survival in hepatocellular carcinoma.
Jia Shi · Lixiang Chen · Yi Chen · Yunfei Lu · Xiaorong Chen · Zongguo Yang
Journal of Cancer · 2019 doi:10.7150/jca.32768
Paper
complete
Experiment
complete
Data
partial
Analysis
partial
Execution
absent
Execution evidence has not yet been added to this .science file. Explore its methods, data and open questions to plan the next step.
Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
paper object · 10 fields
authors array · 6 items
claims array · 2 items
[0] object · 6 fields
evidence array · 1 item
[0] object · 3 fields
[1] object · 6 fields
evidence array · 1 item
[0] object · 3 fields
gaps array · 0 items
experiment object · 8 fields
steps array · 3 items
[0] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
[1] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
[2] object · 13 fields
parameters object · 0 fields
inputs array · 1 item
outputs array · 1 item
instruments array · 0 items
reagents array · 0 items
materials array · 0 items
instruments array · 0 items
reagents array · 0 items
conditions object · 0 fields
gaps array · 0 items
data object · 3 fields
assets array · 8 items
[0] object · 15 fields
structure object · 4 fields
[1] object · 15 fields
structure object · 15 fields
sample_accessions array · 488 items
[2] object · 15 fields
structure object · 15 fields
sample_accessions array · 557 items
[3] object · 15 fields
structure object · 15 fields
sample_accessions array · 6 items
[4] object · 15 fields
structure object · 15 fields
sample_accessions array · 134 items
[5] object · 15 fields
structure object · 15 fields
sample_accessions array · 140 items
[6] object · 16 fields
structure object · 5 fields
table object · 8 fields
rows array · 8 items
[0] array · 5 items
[1] array · 5 items
[2] array · 5 items
[3] array · 5 items
[4] array · 5 items
[5] array · 5 items
[6] array · 5 items
[7] array · 5 items
[7] object · 16 fields
structure object · 5 fields
table object · 8 fields
rows array · 66 items
[0] array · 3 items
[1] array · 2 items
[2] array · 4 items
[3] array · 4 items
[4] array · 4 items
[5] array · 3 items
[6] array · 3 items
[7] array · 3 items
[8] array · 3 items
[9] array · 3 items
[10] array · 4 items
[11] array · 3 items
[12] array · 3 items
[13] array · 3 items
[14] array · 4 items
[15] array · 4 items
[16] array · 4 items
[17] array · 3 items
[18] array · 3 items
[19] array · 3 items
[20] array · 4 items
[21] array · 4 items
[22] array · 4 items
[23] array · 3 items
[24] array · 3 items
[25] array · 3 items
[26] array · 4 items
[27] array · 4 items
[28] array · 4 items
[29] array · 3 items
[30] array · 3 items
[31] array · 3 items
[32] array · 3 items
[33] array · 4 items
[34] array · 4 items
[35] array · 3 items
[36] array · 3 items
[37] array · 3 items
[38] array · 3 items
[39] array · 4 items
[40] array · 4 items
[41] array · 3 items
[42] array · 3 items
[43] array · 3 items
[44] array · 4 items
[45] array · 4 items
[46] array · 3 items
[47] array · 3 items
[48] array · 3 items
[49] array · 3 items
[50] array · 4 items
[51] array · 4 items
[52] array · 4 items
[53] array · 4 items
[54] array · 3 items
[55] array · 3 items
[56] array · 3 items
[57] array · 3 items
[58] array · 4 items
[59] array · 4 items
[60] array · 4 items
[61] array · 3 items
[62] array · 3 items
[63] array · 3 items
[64] array · 3 items
[65] array · 4 items
gaps array · 10 items
analysis object · 4 fields
methods array · 5 items
[0] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
evidence object · 3 fields
[1] object · 10 fields
dsl_operations array · 0 items
missing_operations array · 1 item
parameters object · 0 fields
data_shapes array · 1 item
[2] object · 10 fields
dsl_operations array · 0 items
missing_operations array · 1 item
parameters object · 0 fields
data_shapes array · 1 item
[3] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
[4] object · 10 fields
dsl_operations array · 1 item
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
targets array · 0 items
gaps array · 1 item
capability object · 3 fields
requirements array · 1 item
[0] object · 6 fields
assay_families array · 9 items
gaps array · 0 items
readiness object · 8 fields
axes object · 3 fields
method object · 5 fields
required_operations array · 1 item
missing_operations array · 0 items
capability object · 4 fields
data object · 6 fields
accessions array · 6 items
resolved_accessions array · 5 items
statements array · 1 item
can_run object · 3 fields
dsl_operations array · 1 item
assets array · 4 items
steps array · 1 item
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 0 items
capabilities array · 0 items
data_gaps array · 1 item
gaps array · 0 items
review object · 5 fields
machine_critique object · 5 fields
reader object · 5 fields
evidence_check object · 2 fields
usage object · 3 fields
stages array · 1 item
[0] object · 4 fields
gaps array · 3 items
provenance object · 7 fields
entities array · 3 items
activities array · 3 items
[0] object · 4 fields
used array · 3 items
[0] object · 3 fields
[1] object · 3 fields
[2] object · 3 fields
[1] object · 4 fields
agents array · 2 items
lineage object · 4 fields
gaps array · 15 items
assays array · 1 item
[0] object · 11 fields
required_operations array · 1 item
source_hashes object · 1 field
evidence array · 1 item
Complete file
{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:31598161", "kind": "science-record", "revision": 8, "content_hash": "sha256:64071819efb850f6028574e28b29bc6ae65ea8630bca0d3acdf360cc8e3d07de", "created_at": "2026-11-01T15:40:50Z", "updated_at": "2026-11-01T22:00:53Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) overexpression in tumors predicts worse overall survival in hepatocellular carcinoma.", "doi": "10.7150/jca.32768", "pmid": "31598161", "authors": ["Jia Shi", "Lixiang Chen", "Yi Chen", "Yunfei Lu", "Xiaorong Chen", "Zongguo Yang"], "journal": "Journal of Cancer", "year": 2019, "abstract": "Overexpression of AKR1B10 correlated with tumorigenesis of many human malignancies; however, the prognostic value of AKR1B10 expression in patients with hepatocellular carcinoma (HCC) still remains controversial. In this analysis, AKR1B10 expression in HCC tumors were evaluated in GEO, TCGA and Oncomine databases, and a survival analysis of AKR1B10 based on TCGA profile was performed. We found that AKR1B10 was significantly overexpressed in tumors compared with nontumors in 7 GEO series (GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502, GSE77314) and TCGA profile (all P < 0.05). Meta-analysis in Oncomine database revealed that AKR1B10 was significantly upregulated in cirrhosis, liver cell dysplasia and HCC compared with normal tissues (all P < 0.05). Kaplan-Meier analysis demonstrated that high AKR1B10 in tumors were significantly associated with worse overall survival (OS) in HCC patients (P < 0.05). Subgroup analysis showed that AKR1B10 overexpression were associated with poor 1-year, 3-year and 5-year OS (all P < 0.05). In addition, prognostic values of AKR1B10 upregulation for OS were more significant in HCC with hepatitis-virus-free (P = 0.00055), White race (P = 0.0029) and alcohol-free (P = 0.013), and both in male and female (P = 0.014 and P = 0.034, respectively). In conclusion: AKR1B10 was upregulated in tumors and correlated with worse OS in HCC patients.", "claims": [{"id": "claim-method", "statement": "Using hash and survival packages in R program, we performed Kaplan-Meier analysis of AKR1B10 and OS in HCC patients, which showed that AKR1B10 overexpression in tumor tissues was significantly associated with poor OS in HCC patients (log rank P = 0.004, Figure 3A).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31598161", "locator": "sections[10] \"Associations between AKR1B10 and OS in HCC patients\" paragraph 2", "quote": "Using hash and survival packages in R program, we performed Kaplan-Meier analysis of AKR1B10 and OS in HCC patients, which showed that AKR1B10 overexpression in tumor tissues was significantly associated with poor OS in HCC patients (log rank P = 0.004, Figure 3A)."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31598161", "locator": "sections[3] \"Data resource and Description\" paragraph 2", "quote": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31598161"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE14520"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE14520"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:31598161", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.7150/jca.32768", "sha256": "sha256:929a46db16730c391a3180f9010c54817effd5467d86be79f992d318f88fc406", "bytes": 25159, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.7150/jca.32768", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC6775506", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE14520", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14520", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE14520", "version": null, "note": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM362947", "GSM362948", "GSM362949", "GSM362950", "GSM362951", "GSM362952", "GSM362953", "GSM362954", "GSM362955", "GSM362956", "GSM362957", "GSM362958", "GSM362959", "GSM362960", "GSM362961", "GSM362962", "GSM362963", "GSM362964", "GSM362965", "GSM362966", "GSM362967", "GSM362968", "GSM362969", "GSM362970", "GSM362971", "GSM362972", "GSM362973", "GSM362974", "GSM362975", "GSM362976", "GSM362977", "GSM362978", "GSM362979", "GSM362980", "GSM362981", "GSM362982", "GSM362983", "GSM362984", "GSM362985", "GSM362986", "GSM362987", "GSM362988", "GSM362989", "GSM362990", "GSM362991", "GSM362992", "GSM362993", "GSM362994", "GSM362995", "GSM362996", "GSM362997", "GSM362998", "GSM362999", "GSM363000", "GSM363001", "GSM363002", "GSM363003", "GSM363004", "GSM363005", "GSM363006", "GSM363007", "GSM363008", "GSM363009", "GSM363010", "GSM363011", "GSM363012", "GSM363013", "GSM363014", "GSM363015", "GSM363016", "GSM363017", "GSM363018", "GSM363019", "GSM363020", "GSM363021", "GSM363022", "GSM363023", "GSM363024", "GSM363025", "GSM363026", "GSM363027", "GSM363028", "GSM363029", "GSM363030", "GSM363031", "GSM363032", "GSM363033", "GSM363034", "GSM363035", "GSM363036", "GSM363037", "GSM363038", "GSM363039", "GSM363040", "GSM363041", "GSM363042", "GSM363043", "GSM363044", "GSM363045", "GSM363046", "GSM363047", "GSM363048", "GSM363049", "GSM363050", "GSM363051", "GSM363052", "GSM363053", "GSM363054", "GSM363055", "GSM363056", "GSM363057", "GSM363058", "GSM363059", "GSM363060", "GSM363061", "GSM363062", "GSM363063", "GSM363064", "GSM363065", "GSM363066", "GSM363067", "GSM363068", "GSM363069", "GSM363070", "GSM363071", "GSM363072", "GSM363073", "GSM363074", "GSM363075", "GSM363076", "GSM363077", "GSM363078", "GSM363079", "GSM363080", "GSM363081", "GSM363082", "GSM363083", "GSM363084", "GSM363085", "GSM363086", "GSM363087", "GSM363088", "GSM363089", "GSM363090", "GSM363091", "GSM363092", "GSM363093", "GSM363094", "GSM363095", "GSM363096", "GSM363097", "GSM363098", "GSM363099", "GSM363100", "GSM363101", "GSM363102", "GSM363103", "GSM363104", "GSM363105", "GSM363106", "GSM363107", "GSM363108", "GSM363109", "GSM363110", "GSM363111", "GSM363112", "GSM363113", "GSM363114", "GSM363115", "GSM363116", "GSM363117", "GSM363118", "GSM363119", "GSM363120", "GSM363121", "GSM363122", "GSM363123", "GSM363124", "GSM363125", "GSM363126", "GSM363127", "GSM363128", "GSM363129", "GSM363130", "GSM363131", "GSM363132", "GSM363133", "GSM363134", "GSM363135", "GSM363136", "GSM363137", "GSM363138", "GSM363139", "GSM363140", "GSM363141", "GSM363142", "GSM363143", "GSM363144", "GSM363145", "GSM363146", "GSM363147", "GSM363148", "GSM363149", "GSM363150", "GSM363151", "GSM363152", "GSM363153", "GSM363154", "GSM363155", "GSM363156", "GSM363157", "GSM363158", "GSM363159", "GSM363160", "GSM363161", "GSM363162", "GSM363163", "GSM363164", "GSM363165", "GSM363166", "GSM363167", "GSM363168", "GSM363169", "GSM363170", "GSM363171", "GSM363172", "GSM363173", "GSM363174", "GSM363175", "GSM363176", "GSM363177", "GSM363178", "GSM363179", "GSM363180", "GSM363181", "GSM363182", "GSM363183", "GSM363184", "GSM363185", "GSM363186", "GSM363187", "GSM363188", "GSM363189", "GSM363190", "GSM363191", "GSM363192", "GSM363193", "GSM363194", "GSM363195", "GSM363196", "GSM363197", "GSM363198", "GSM363199", "GSM363200", "GSM363201", "GSM363202", "GSM363203", "GSM363204", "GSM363205", "GSM363206", "GSM363207", "GSM363208", "GSM363209", "GSM363210", "GSM363211", "GSM363212", "GSM363213", "GSM363214", "GSM363215", "GSM363216", "GSM363217", "GSM363218", "GSM363219", "GSM363220", "GSM363221", "GSM363222", "GSM363223", "GSM363224", "GSM363225", "GSM363226", "GSM363227", "GSM363228", "GSM363229", "GSM363230", "GSM363231", "GSM363232", "GSM363233", "GSM363234", "GSM363235", "GSM363236", "GSM363237", "GSM363238", "GSM363239", "GSM363240", "GSM363241", "GSM363242", "GSM363243", "GSM363244", "GSM363245", "GSM363246", "GSM363247", "GSM363248", "GSM363249", "GSM363250", "GSM363251", "GSM363252", "GSM363253", "GSM363254", "GSM363255", "GSM363256", "GSM363257", "GSM363258", "GSM363259", "GSM363260", "GSM363261", "GSM363262", "GSM363263", "GSM363264", "GSM363265", "GSM363266", "GSM363267", "GSM363268", "GSM363269", "GSM363270", "GSM363271", "GSM363272", "GSM363273", "GSM363274", "GSM363275", "GSM363276", "GSM363277", "GSM363278", "GSM363279", "GSM363280", "GSM363281", "GSM363282", "GSM363283", "GSM363284", "GSM363285", "GSM363286", "GSM363287", "GSM363288", "GSM363289", "GSM363290", "GSM363291", "GSM363292", "GSM363293", "GSM363294", "GSM363295", "GSM363296", "GSM363297", "GSM363298", "GSM363299", "GSM363300", "GSM363301", "GSM363302", "GSM363303", "GSM363304", "GSM363305", "GSM363306", "GSM363307", "GSM363308", "GSM363309", "GSM363310", "GSM363311", "GSM363312", "GSM363313", "GSM363314", "GSM363315", "GSM363316", "GSM363317", "GSM363318", "GSM363319", "GSM363320", "GSM363321", "GSM363322", "GSM363323", "GSM363324", "GSM363325", "GSM363326", "GSM363327", "GSM363328", "GSM363329", "GSM363330", "GSM363331", "GSM363332", "GSM363333", "GSM363334", "GSM363335", "GSM363336", "GSM363337", "GSM363338", "GSM363339", "GSM363340", "GSM363341", "GSM363342", "GSM363343", "GSM363344", "GSM363345", "GSM363346", "GSM363347", "GSM363348", "GSM363349", "GSM363350", "GSM363351", "GSM363352", "GSM363353", "GSM363354", "GSM363355", "GSM363356", "GSM363357", "GSM363358", "GSM363359", "GSM363360", "GSM363361", "GSM363362", "GSM363363", "GSM363364", "GSM363365", "GSM363366", "GSM363367", "GSM363368", "GSM363369", "GSM363370", "GSM363371", "GSM363372", "GSM363373", "GSM363374", "GSM363375", "GSM363376", "GSM363378", "GSM363380", "GSM363381", "GSM363382", "GSM363384", "GSM363386", "GSM363388", "GSM363391", "GSM363393", "GSM363397", "GSM363400", "GSM363402", "GSM363404", "GSM363407", "GSM363417", "GSM363420", "GSM363421", "GSM363422", "GSM363423", "GSM363424", "GSM363425", "GSM363426", "GSM363427", "GSM363428", "GSM363429", "GSM363430", "GSM363431", "GSM363432", "GSM363433", "GSM363434", "GSM363435", "GSM363436", "GSM363437", "GSM363438", "GSM363439", "GSM363440", "GSM363441", "GSM363442", "GSM363443", "GSM363444", "GSM363445", "GSM363446", "GSM363447", "GSM363448", "GSM363449", "GSM363450", "GSM363451", "GSM712532", "GSM712533", "GSM712534", "GSM712535", "GSM712536", "GSM712537", "GSM712538", "GSM712539", "GSM712540", "GSM712541", "GSM712542"], "sample_count": 488, "group_sizes": null, "group_sizes_basis": null, "platform": "3921;571", "taxon": "Homo sapiens", "title": "Gene expression data of human hepatocellular carcinoma (HCC)", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE25097", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE25097", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE25097", "version": null, "note": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM616704", "GSM616705", "GSM616706", "GSM616707", "GSM616708", "GSM616709", "GSM616710", "GSM616711", "GSM616712", "GSM616713", "GSM616714", "GSM616715", "GSM616716", "GSM616717", "GSM616718", "GSM616719", "GSM616720", "GSM616721", "GSM616722", "GSM616723", "GSM616724", "GSM616725", "GSM616726", "GSM616727", "GSM616728", "GSM616729", "GSM616730", "GSM616731", "GSM616732", "GSM616733", "GSM616734", "GSM616735", "GSM616736", "GSM616737", "GSM616738", "GSM616739", "GSM616740", "GSM616741", "GSM616742", "GSM616743", "GSM616744", "GSM616745", "GSM616746", "GSM616747", "GSM616748", "GSM616749", "GSM616750", "GSM616751", "GSM616752", "GSM616753", "GSM616754", "GSM616755", "GSM616756", "GSM616757", "GSM616758", "GSM616759", "GSM616760", "GSM616761", "GSM616762", "GSM616763", "GSM616764", "GSM616765", "GSM616766", "GSM616767", "GSM616768", "GSM616769", "GSM616770", "GSM616771", "GSM616772", "GSM616773", "GSM616774", "GSM616775", "GSM616776", "GSM616777", "GSM616778", "GSM616779", "GSM616780", "GSM616781", "GSM616782", "GSM616783", "GSM616784", "GSM616785", "GSM616786", "GSM616787", "GSM616788", "GSM616789", "GSM616790", "GSM616791", "GSM616792", "GSM616793", "GSM616794", "GSM616795", "GSM616796", "GSM616797", "GSM616798", "GSM616799", "GSM616800", "GSM616801", "GSM616802", "GSM616803", "GSM616804", "GSM616805", "GSM616806", "GSM616807", "GSM616808", "GSM616809", "GSM616810", "GSM616811", "GSM616812", "GSM616813", "GSM616814", "GSM616815", "GSM616816", "GSM616817", "GSM616818", "GSM616819", "GSM616820", "GSM616821", "GSM616822", "GSM616823", "GSM616824", "GSM616825", "GSM616826", "GSM616827", "GSM616828", "GSM616829", "GSM616830", "GSM616831", "GSM616832", "GSM616833", "GSM616834", "GSM616835", "GSM616836", "GSM616837", "GSM616838", "GSM616839", "GSM616840", "GSM616841", "GSM616842", "GSM616843", "GSM616844", "GSM616845", "GSM616846", "GSM616847", "GSM616848", "GSM616849", "GSM616850", "GSM616851", "GSM616852", "GSM616853", "GSM616854", "GSM616855", "GSM616856", "GSM616857", "GSM616858", "GSM616859", "GSM616860", "GSM616861", "GSM616862", "GSM616863", "GSM616864", "GSM616865", "GSM616866", "GSM616867", "GSM616868", "GSM616869", "GSM616870", "GSM616871", "GSM616872", "GSM616873", "GSM616874", "GSM616875", "GSM616876", "GSM616877", "GSM616878", "GSM616879", "GSM616880", "GSM616881", "GSM616882", "GSM616883", "GSM616884", "GSM616885", "GSM616886", "GSM616887", "GSM616888", "GSM616889", "GSM616890", "GSM616891", "GSM616892", "GSM616893", "GSM616894", "GSM616895", "GSM616896", "GSM616897", "GSM616898", "GSM616899", "GSM616900", "GSM616901", "GSM616902", "GSM616903", "GSM616904", "GSM616905", "GSM616906", "GSM616907", "GSM616908", "GSM616909", "GSM616910", "GSM616911", "GSM616912", "GSM616913", "GSM616914", "GSM616915", "GSM616916", "GSM616917", "GSM616918", "GSM616919", "GSM616920", "GSM616921", "GSM616922", "GSM616923", "GSM616924", "GSM616925", "GSM616926", "GSM616927", "GSM616928", "GSM616929", "GSM616930", "GSM616931", "GSM616932", "GSM616933", "GSM616934", "GSM616935", "GSM616936", "GSM616937", "GSM616938", "GSM616939", "GSM616940", "GSM616941", "GSM616942", "GSM616943", "GSM616944", "GSM616945", "GSM616947", "GSM616948", "GSM616950", "GSM616952", "GSM616953", "GSM616955", "GSM616957", "GSM616959", "GSM616961", "GSM616963", "GSM616965", "GSM616966", "GSM616968", "GSM616970", "GSM616972", "GSM616973", "GSM616975", "GSM616977", "GSM616978", "GSM616980", "GSM616982", "GSM616984", "GSM616986", "GSM616987", "GSM616989", "GSM616990", "GSM616992", "GSM616994", "GSM616995", "GSM616996", "GSM616997", "GSM616998", "GSM616999", "GSM617000", "GSM617001", "GSM617002", "GSM617003", "GSM617004", "GSM617005", "GSM617006", "GSM617007", "GSM617008", "GSM617009", "GSM617010", "GSM617011", "GSM617012", "GSM617013", "GSM617304", "GSM617305", "GSM617306", "GSM617307", "GSM617308", "GSM617309", "GSM617310", "GSM617311", "GSM617312", "GSM617313", "GSM617314", "GSM617315", "GSM617316", "GSM617317", "GSM617318", "GSM617319", "GSM617320", "GSM617321", "GSM617322", "GSM617323", "GSM617324", "GSM617325", "GSM617326", "GSM617327", "GSM617328", "GSM617329", "GSM617330", "GSM617331", "GSM617332", "GSM617333", "GSM617334", "GSM617335", "GSM617336", "GSM617337", "GSM617338", "GSM617339", "GSM617340", "GSM617341", "GSM617342", "GSM617343", "GSM617344", "GSM617345", "GSM617346", "GSM617347", "GSM617348", "GSM617349", "GSM617350", "GSM617351", "GSM617352", "GSM617353", "GSM617354", "GSM617355", "GSM617356", "GSM617357", "GSM617358", "GSM617359", "GSM617360", "GSM617361", "GSM617362", "GSM617363", "GSM617364", "GSM617365", "GSM617366", "GSM617367", "GSM617368", "GSM617369", "GSM617370", "GSM617371", "GSM617372", "GSM617373", "GSM617374", "GSM617375", "GSM617376", "GSM617377", "GSM617378", "GSM617379", "GSM617380", "GSM617381", "GSM617382", "GSM617383", "GSM617384", "GSM617385", "GSM617386", "GSM617387", "GSM617388", "GSM617389", "GSM617390", "GSM617391", "GSM617392", "GSM617393", "GSM617394", "GSM617395", "GSM617396", "GSM617397", "GSM617398", "GSM617399", "GSM617400", "GSM617401", "GSM617402", "GSM617403", "GSM617404", "GSM617405", "GSM617406", "GSM617407", "GSM617408", "GSM617409", "GSM617410", "GSM617411", "GSM617412", "GSM617413", "GSM617414", "GSM617415", "GSM617416", "GSM617417", "GSM617418", "GSM617419", "GSM617420", "GSM617421", "GSM617422", "GSM617423", "GSM617424", "GSM617425", "GSM617426", "GSM617427", "GSM617428", "GSM617429", "GSM617430", "GSM617431", "GSM617432", "GSM617433", "GSM617434", "GSM617435", "GSM617436", "GSM617437", "GSM617438", "GSM617439", "GSM617440", "GSM617441", "GSM617442", "GSM617443", "GSM617444", "GSM617445", "GSM617446", "GSM617447", "GSM617448", "GSM617449", "GSM617450", "GSM617451", "GSM617452", "GSM617453", "GSM617454", "GSM617455", "GSM617456", "GSM617457", "GSM617458", "GSM617459", "GSM617460", "GSM617461", "GSM617462", "GSM617463", "GSM617464", "GSM617465", "GSM617466", "GSM617467", "GSM617468", "GSM617469", "GSM617470", "GSM617471", "GSM617472", "GSM617473", "GSM617474", "GSM617475", "GSM617476", "GSM617477", "GSM617478", "GSM617479", "GSM617480", "GSM617481", "GSM617482", "GSM617483", "GSM617484", "GSM617485", "GSM617486", "GSM617487", "GSM617488", "GSM617489", "GSM617490", "GSM617491", "GSM617492", "GSM617493", "GSM617494", "GSM617495", "GSM617496", "GSM617497", "GSM617498", "GSM617499", "GSM617500", "GSM617501", "GSM617502", "GSM617503", "GSM617504", "GSM617505", "GSM617506", "GSM617507", "GSM617508", "GSM617509", "GSM617510", "GSM617511", "GSM617512", "GSM617513", "GSM617514", "GSM617515", "GSM617516", "GSM617517", "GSM617518", "GSM617519", "GSM617520", "GSM617521", "GSM617522", "GSM617523", "GSM617524", "GSM617525", "GSM617526", "GSM617527", "GSM617528", "GSM617529", "GSM617530", "GSM617531", "GSM617532", "GSM617533", "GSM617534", "GSM617535", "GSM617536", "GSM617537", "GSM617538", "GSM617539", "GSM617540", "GSM617541", "GSM617542", "GSM617543", "GSM617544", "GSM617545", "GSM617546", "GSM617547", "GSM617548", "GSM617549", "GSM617550", "GSM617551", "GSM617552", "GSM617553", "GSM617554", "GSM617555", "GSM617556", "GSM617557", "GSM617558", "GSM617559", "GSM617560", "GSM617561", "GSM617562", "GSM617563", "GSM617564", "GSM617565", "GSM617566", "GSM617567", "GSM617568", "GSM617569", "GSM617570", "GSM617571"], "sample_count": 557, "group_sizes": null, "group_sizes_basis": null, "platform": "10687", "taxon": "Homo sapiens", "title": "Study of gene expression of human liver Hepatocellular carcinoma", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE33006", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE33006", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE33006", "version": null, "note": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM818276", "GSM818277", "GSM818278", "GSM818279", "GSM818280", "GSM818281"], "sample_count": 6, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene expression profiles from the hepatocellular carcinoma (HCC) tissues", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE45436", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE45436", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE45436", "version": null, "note": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM1100370", "GSM1100371", "GSM1100372", "GSM1100373", "GSM1100374", "GSM1100375", "GSM1100376", "GSM1100377", "GSM1100378", "GSM1100379", "GSM1100380", "GSM1100381", "GSM1100382", "GSM1100383", "GSM1100384", "GSM1100385", "GSM1100386", "GSM1100387", "GSM1100388", "GSM1100389", "GSM1100390", "GSM1100391", "GSM1100392", "GSM1100393", "GSM1100394", "GSM1100395", "GSM1100396", "GSM1100397", "GSM1100398", "GSM1100399", "GSM1100400", "GSM1100401", "GSM1100402", "GSM1100403", "GSM1100404", "GSM1100405", "GSM1100406", "GSM1100407", "GSM1100408", "GSM1100409", "GSM1100410", "GSM1100411", "GSM1100412", "GSM1100413", "GSM1100414", "GSM1100415", "GSM1100416", "GSM1100417", "GSM1100418", "GSM1100419", "GSM1100420", "GSM1100421", "GSM1100422", "GSM1100423", "GSM1100424", "GSM1100425", "GSM1100426", "GSM1100427", "GSM1100428", "GSM1100429", "GSM1100430", "GSM1100431", "GSM1100432", "GSM1100433", "GSM1100434", "GSM1100435", "GSM1100436", "GSM1100437", "GSM1100438", "GSM1100439", "GSM1100440", "GSM1100441", "GSM1100442", "GSM1100443", "GSM1100444", "GSM1100445", "GSM1100446", "GSM1100447", "GSM1100448", "GSM1100449", "GSM1100450", "GSM1100451", "GSM1100452", "GSM1100453", "GSM1100454", "GSM1100455", "GSM1100456", "GSM1104153", "GSM1104154", "GSM1104155", "GSM1104156", "GSM1104157", "GSM1104158", "GSM1104159", "GSM1104160", "GSM1104161", "GSM1104162", "GSM1104163", "GSM1104164", "GSM1104165", "GSM1104166", "GSM1104167", "GSM1104168", "GSM1104169", "GSM1104170", "GSM1104171", "GSM1104172", "GSM1104173", "GSM1104174", "GSM1104175", "GSM1104176", "GSM1104177", "GSM1104178", "GSM1104179", "GSM1104180", "GSM1104181", "GSM1104182", "GSM1104183", "GSM1104184", "GSM1104185", "GSM1104186", "GSM1104187", "GSM1104188", "GSM1104189", "GSM1104190", "GSM1104191", "GSM1104192", "GSM1104193", "GSM1104194", "GSM1104195", "GSM1104196", "GSM1104197", "GSM1104198", "GSM1104199"], "sample_count": 134, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene expression profiles of human hepatocellular carcinoma", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE55092", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE55092", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE55092", "version": null, "note": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/).", "access_statement_kind": "repository_route_statement", "sample_accessions": ["GSM1329321", "GSM1329322", "GSM1329323", "GSM1329324", "GSM1329325", "GSM1329326", "GSM1329327", "GSM1329328", "GSM1329329", "GSM1329330", "GSM1329331", "GSM1329332", "GSM1329333", "GSM1329334", "GSM1329335", "GSM1329336", "GSM1329337", "GSM1329338", "GSM1329339", "GSM1329340", "GSM1329341", "GSM1329342", "GSM1329343", "GSM1329344", "GSM1329345", "GSM1329346", "GSM1329347", "GSM1329348", "GSM1329349", "GSM1329350", "GSM1329351", "GSM1329352", "GSM1329353", "GSM1329354", "GSM1329355", "GSM1329356", "GSM1329357", "GSM1329358", "GSM1329359", "GSM1329360", "GSM1329361", "GSM1329362", "GSM1329363", "GSM1329364", "GSM1329365", "GSM1329366", "GSM1329367", "GSM1329368", "GSM1329369", "GSM1329370", "GSM1329371", "GSM1329372", "GSM1329373", "GSM1329374", "GSM1329375", "GSM1329376", "GSM1329377", "GSM1329378", "GSM1329379", "GSM1329380", "GSM1329381", "GSM1329382", "GSM1329383", "GSM1329384", "GSM1329385", "GSM1329386", "GSM1329387", "GSM1329388", "GSM1329389", "GSM1329390", "GSM1329391", "GSM1329392", "GSM1329393", "GSM1329394", "GSM1329395", "GSM1329396", "GSM1329397", "GSM1329398", "GSM1329399", "GSM1329400", "GSM1329401", "GSM1329402", "GSM1329403", "GSM1329404", "GSM1329405", "GSM1329406", "GSM1329407", "GSM1329408", "GSM1329409", "GSM1329410", "GSM1329411", "GSM1329412", "GSM1329413", "GSM1329414", "GSM1329415", "GSM1329416", "GSM1329417", "GSM1329418", "GSM1329419", "GSM1329420", "GSM1329421", "GSM1329422", "GSM1329423", "GSM1329424", "GSM1329425", "GSM1329426", "GSM1329427", "GSM1329428", "GSM1329429", "GSM1329430", "GSM1329431", "GSM1329432", "GSM1329433", "GSM1329434", "GSM1329435", "GSM1329436", "GSM1329437", "GSM1329438", "GSM1329439", "GSM1329440", "GSM1329441", "GSM1329442", "GSM1329443", "GSM1329444", "GSM1329445", "GSM1329446", "GSM1329447", "GSM1329448", "GSM1329449", "GSM1329450", "GSM1329451", "GSM1329452", "GSM1329453", "GSM1329454", "GSM1329455", "GSM1329456", "GSM1329457", "GSM1329458", "GSM1329459", "GSM1329460"], "sample_count": 140, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Viral Expression and Molecular Profiling in Liver Tissue versus Microdissected Hepatocytes in Hepatitis B Virus - Associated Hepatocellular Carcinoma", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:31598161:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:6171c1436da8913f022e86643e5a4e8c211aa8b2a975cd2e05e6faa5ec09706a", "bytes": 921, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[3]/table-wrap[1]#T1", "version": null, "note": "Details of GEO series included in this analysis", "structure": {"pmcid": "PMC6775506", "section_index": 3, "section_title": "Data resource and Description", "row_count": 8, "column_count": 5}, "table": {"label": "Table 1", "caption": "Details of GEO series included in this analysis", "rows": [["GEO series", "Contributor(s)", "Tumor", "Nontumor", "Platform"], ["GSE14520", "Roessler S et al, 2009", "222", "212", "Affymetrix Human Genome U133A 2.0 Array / Affymetrix HT Human Genome U133A Array"], ["GSE25097", "Zhang C, 2010", "268", "243", "Rosetta/Merck Human RSTA Affymetrix 1.0 microarray, Custom CDF"], ["GSE33006", "Huang Y et al, 2011", "3", "3", "Affymetrix Human Genome U133 Plus 2.0 Array"], ["GSE45436", "Hsieh J, 2013", "97", "37", "Affymetrix Human Genome U133 Plus 2.0 Array"], ["GSE55092", "Melis M et al, 2014", "49", "91", "Affymetrix Human Genome U133 Plus 2.0 Array"], ["GSE60502", "Kao KJ, 2014", "18", "18", "Affymetrix Human Genome U133A Array"], ["GSE77314", "Hou G et al, 2016", "50", "50", "Illumina Genome Analyzer (Homo sapiens)"]], "row_count": 8, "column_count": 5, "numeric_cells": 34, "header_rows": 1, "locator": "section[3]/table-wrap[1]#T1"}}, {"id": "asset:table:pmid:31598161:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:2a47ef7cdf9619ab5d0f873d18acbeb8c4edef0d028a35235d5d0eda1675c9b7", "bytes": 2894, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[11]/table-wrap[1]#T2", "version": null, "note": "Characteristics of HCC patients between AKR1B10 high and low groups", "structure": {"pmcid": "PMC6775506", "section_index": 11, "section_title": "Association between AKR1B10 and clinico-pathological features in HCC patients", "row_count": 66, "column_count": 4}, "table": {"label": "Table 2", "caption": "Characteristics of HCC patients between AKR1B10 high and low groups", "rows": [["Variables", "AKR1B10 expression level", "P value"], ["Low (n = 180)", "High (n = 181)"], ["Gender, male (%)", "106 (58.9)", "138 (76.2)", "< 0.001"], ["Age, median (IQR), years", "59.5 (20)", "62 (15)", "0.031"], ["BMI, kg/m2, n (%)", "", "", "0.132"], ["<18.5", "14 (7.8)", "7 (3.9)"], ["18.5~24.99", "79 (43.9)", "73 (40.3)"], ["25~29.99", "36 (20.0)", "52 (28.9)"], [">30", "35 (19.4)", "32 (17.7)"], ["NA", "16 (8.9)", "17 (9.4)"], ["Race, n (%)", "", "", "0.36"], ["Asian", "77 (42.8)", "79 (43.6)"], ["White", "91 (50.6)", "85 (47.0)"], ["Black or African American", "7 (3.9)", "10 (5.5)"], ["American Indian or Alaska Native", "2 (1.1)", "0 (0)", ""], ["NA", "3 (1.6)", "7 (3.9)", ""], ["Tumor status, n (%)", "", "", "0.923"], ["With tumor", "53 (29.4)", "56 (30.9)"], ["Tumor free", "115 (63.9)", "112 (61.9)"], ["NA", "12 (6.7)", "13 (7.2)"], ["Family history of cancer, n (%)", "54 (30.0)", "78 (43.1)", "0.01"], ["Hepatocarcinoma risk factors*, n (%)", "", "", "0.006"], ["Hepatitis virus infection", "55 (30.6)", "56 (30.9)", ""], ["Alcohol consumption", "48 (26.7)", "67 (37.0)"], ["Non-alcoholic fatty liver disease", "6 (3.3)", "6 (3.3)"], ["No risk factors", "54 (30.0)", "32 (17.7)"], ["Other", "8 (4.4)", "10 (5.5)", ""], ["NA", "9 (5.0)", "10 (5.5)", ""], ["Neoplasm histologic grade, n (%)", "", "", "0.054"], ["G1", "35 (19.4)", "18 (9.9)"], ["G2", "76 (42.2)", "95 (52.5)"], ["G3", "60 (33.3)", "61 (33.7)"], ["G4", "6 (3.3)", "5 (2.8)"], ["NA", "3 (1.7)", "2 (1.1)", ""], ["AJCC stage, n (%)", "", "", "0.203"], ["I", "84 (46.7)", "83 (45.9)"], ["II", "35 (19.4)", "47 (26.0)"], ["III", "48 (26.7)", "33 (18.2)"], ["IV", "4 (2.2)", "3 (1.7)"], ["NA", "9 (5.0)", "15 (8.3)", ""], ["Vascular invasion, n (%)", "", "", "0.999"], ["Macro", "8 (4.4)", "8 (4.4)"], ["Micro", "44 (24.4)", "45 (24.9)"], ["None", "99 (55.0)", "101 (55.8)"], ["NA", "29 (16.1)", "27 (14.9)", ""], ["Child-pugh classification, n (%)", "", "", "0.525"], ["A", "101 (56.1)", "111 (61.3)"], ["B", "9 (5.0)", "12 (6.6)"], ["C", "1 (0.6)", "0 (0)"], ["NA", "69 (38.3)", "58 (32.0)"], ["AFP > 400ng/ml, n (%)", "39 (21.7)", "25 (13.8)", "0.051"], ["Platelet, median (IQR), ×103/mm3", "204.5 (182)", "178 (136)", "0.066"], ["New tumor event after initial treatment, n (%)", "46 (25.6)", "47 (26.0)", "0.929"], ["Ishak fibrosis status, n (%)", "", "", "0.036"], ["No fibrosis", "44 (24.4)", "28 (15.5)"], ["Portal fibrosis", "10 (5.6)", "21 (11.6)"], ["Fibrous speta", "11 (6.1)", "17 (9.4)"], ["Nodular Formation/Incomplete Cirrhosis", "3 (1.7)", "6 (3.3)"], ["Cirrhosis", "30 (16.7)", "40 (22.1)", ""], ["NA", "82 (45.6)", "69 (38.1)", ""], ["Hepatic inflammation, n (%)", "", "", "0.033"], ["None", "69 (38.3)", "45 (24.9)"], ["Mild", "43 (23.9)", "54 (29.8)"], ["Severe", "7 (3.9)", "11 (6.1)"], ["NA", "61 (33.9)", "71 (39.2)"], ["Follow up, median (IQR), years", "0.378 (1.8)", "0.334 (1.3)", "0.453"]], "row_count": 66, "column_count": 4, "numeric_cells": 134, "header_rows": 2, "locator": "section[11]/table-wrap[1]#T2"}}], "gaps": ["asset:data:geo:GSE14520 not downloaded", "asset:data:geo:GSE14520 licence not read", "asset:data:geo:GSE25097 not downloaded", "asset:data:geo:GSE25097 licence not read", "asset:data:geo:GSE33006 not downloaded", "asset:data:geo:GSE33006 licence not read", "asset:data:geo:GSE45436 not downloaded", "asset:data:geo:GSE45436 licence not read", "asset:data:geo:GSE55092 not downloaded", "asset:data:geo:GSE55092 licence not read"]}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": "kaplan_meier", "label": "Survival analysis", "dsl_operations": ["survival_km"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "Using hash and survival packages in R program, we performed Kaplan-Meier analysis of AKR1B10 and OS in HCC patients, which showed that AKR1B10 overexpression in tumor tissues was significantly associated with poor OS in HCC patients (log rank P = 0.004, Figure 3A)."}}, {"id": "method-2", "family": "group_comparison", "specific": "student_t_test", "label": "Group comparison", "dsl_operations": [], "missing_operations": ["student_t"], "expressible": false, "parameters": {}, "data_shapes": ["two_or_more_groups_continuous"], "evidence": {"score": 0.8, "band": "high", "quote": "student t test"}}, {"id": "method-3", "family": "group_comparison", "specific": "mann_whitney", "label": "Group comparison", "dsl_operations": [], "missing_operations": ["group_comparison_mann_whitney"], "expressible": false, "parameters": {}, "data_shapes": ["two_or_more_groups_continuous"], "evidence": {"score": 0.8, "band": "high", "quote": "Mann-Whitney"}}, {"id": "method-4", "family": "survival_analysis", "specific": "log_rank_test", "label": "Survival analysis", "dsl_operations": ["logrank_test"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "log rank"}}, {"id": "method-5", "family": "contingency_analysis", "specific": "chi_square", "label": "Categorical (contingency table) analysis", "dsl_operations": ["chi_square_test"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["categorical_cross_tabulation"], "evidence": {"score": 0.8, "band": "high", "quote": "Chi-square"}}], "targets": [], "gaps": ["method.reader_differs_from_extractor"]}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["survival_km"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: kaplan_meier."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE14520", "GSE25097", "GSE33006", "GSE45436", "GSE55092", "GSE60502 and GSE77314"], "resolved_accessions": ["GSE14520", "GSE25097", "GSE33006", "GSE45436", "GSE55092"], "statements": ["Seven expression microarray series GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502 and GSE77314 containing HCC tumor and nontumor samples were downloaded from the Gene Expression Omnibus dataset (GEO, https://www.ncbi.nlm.nih.gov/geo/)."], "basis": "The paper names GSE14520, GSE25097, GSE33006, GSE45436, GSE55092 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["survival_km"], "assets": ["source:pmid:31598161", "data:geo:GSE14520", "asset:table:pmid:31598161:1", "asset:table:pmid:31598161:2"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE14520"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:16:26Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": null}, "calls": 3, "usage": {"prompt_tokens": 22826, "completion_tokens": 2550, "cached_tokens": 7863}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:31598161", "type": "paper", "label": "pmid:31598161"}, {"id": "source:pmid:31598161", "type": "manuscript", "label": "PMID 31598161 full text"}, {"id": "data:geo:GSE14520", "type": "dataset", "label": "GEO GSE14520"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:31598161", "type": "paper", "label": "pmid:31598161"}, {"id": "source:pmid:31598161", "type": "manuscript", "label": "PMID 31598161 full text"}, {"id": "data:geo:GSE14520", "type": "dataset", "label": "GEO GSE14520"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-31598161", "type": "extraction", "used": ["source:pmid:31598161"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE14520", "type": "accession_resolution", "used": ["data:geo:GSE14520"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:31598161", "parent_hash": "sha256:d35747e7999d17fc1dabddfab3b7c45a76139e0aba466f729908ce7b08abc31a", "fork_of": null, "generation": 7}, "gaps": ["asset:data:geo:GSE14520 licence not read", "asset:data:geo:GSE14520 not downloaded", "asset:data:geo:GSE25097 licence not read", "asset:data:geo:GSE25097 not downloaded", "asset:data:geo:GSE33006 licence not read", "asset:data:geo:GSE33006 not downloaded", "asset:data:geo:GSE45436 licence not read", "asset:data:geo:GSE45436 not downloaded", "asset:data:geo:GSE55092 licence not read", "asset:data:geo:GSE55092 not downloaded", "execution.not_run", "method.reader_differs_from_extractor", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["survival_km"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["Using hash and survival packages in R program, we performed Kaplan-Meier analysis of AKR1B10 and OS in HCC patients, which showed that AKR1B10 overexpression in tumor tissues was significantly associated with poor OS in HCC patients (log rank P = 0.004, Figure 3A)."], "order_basis": "analysis_only", "id": "assay:1"}]}