Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:31889939", "kind": "science-record", "revision": 6, "content_hash": "sha256:93e0771d7f854241d5286034e6cbb98850df7c5ffc7c962931dc01dff5495bd1", "created_at": "2026-11-01T15:40:54Z", "updated_at": "2026-11-01T21:22:46Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Quantitative proteome analysis of Merkel cell carcinoma cell lines using SILAC.", "doi": "10.1186/s12014-019-9263-z", "pmid": "31889939", "authors": ["Ulana Kotowski", "Boban M Erović", "Julia Schnöll", "Victoria Stanek", "Stefan Janik", "Martin Steurer", "Goran Mitulović"], "journal": "Clinical proteomics", "year": 2019, "abstract": "BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin with growing incidence. To better understand the biology of this malignant disease, immortalized cell lines are used in research for in vitro experiments. However, a comprehensive quantitative proteome analysis of these cell lines has not been performed so far.\nMETHODS: Stable isotope labelling by amino acids in cell culture (SILAC) was applied to six MCC cell lines (BroLi, MKL-1, MKL-2, PeTa, WaGa, and MCC13). Following tryptic digest of labelled proteins, peptides were analysed by mass spectrometry. Proteome patterns of MCC cell lines were compared to the proteome profile of an immortalized keratinocyte cell line (HaCaT).\nRESULTS: In total, 142 proteins were upregulated and 43 proteins were downregulated. Altered proteins included mitoferrin-1, histone H2A type 1-H, protein-arginine deiminase type-6, heterogeneous nuclear ribonucleoproteins A2/B1, protein SLX4IP and clathrin light chain B. Furthermore, several proteins of the histone family and their variants were highly abundant in MCC cell lines.\nCONCLUSIONS: The results of this study present a new protein map of MCC and provide deeper insights in the biology of MCC. Data are available via ProteomeXchange with identifier PXD008181.", "claims": [{"id": "claim-method", "statement": "p-values where corrected for multitesting according to Benjamini Hochberg.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31889939", "locator": "sections[7] \"Term enrichment analysis\" paragraph 2", "quote": "p-values where corrected for multitesting according to Benjamini Hochberg."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Data availabilityThe mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD008181 and 10.6019/pxd008181.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:31889939", "locator": "sections[21] \"notes\" paragraph 1", "quote": "Data availabilityThe mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD008181 and 10.6019/pxd008181."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:31889939"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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the PRIDE partner repository with the dataset identifier PXD008181 and 10.6019/pxd008181.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Data availabilityThe mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD008181 and 10.6019/pxd008181.", "access_statement_kind": "data_availability_statement", "sample_accessions": [], "sample_count": null, "group_sizes": null, "group_sizes_basis": null, "platform": null, "taxon": null, "title": "Proteome analysis of Merkel cell carcinoma cell lines using SILAC", "resolution_checked_at": "2026-10-31T18:35:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:31889939:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:9b82ce6553dfb8722e11b5460dfdbba731469cc9f96035d764052283d6982536", "bytes": 9681, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[6]/table-wrap[1]#Tab1", "version": null, "note": "An overview of upregulated proteins identified in Merkel cell carcinoma cell lines", "structure": {"pmcid": "PMC6921584", "section_index": 6, "section_title": "Nano-HPLC separation and MS detection", "row_count": 143, "column_count": 5}, "table": {"label": "Table 1", "caption": "An overview of upregulated proteins identified in Merkel cell carcinoma cell lines", "rows": [["Cell line", "UniProt entry name", "Protein name", "Gene symbol", "Ratio (H/L)"], ["BroLi", "MFRN1_HUMAN", "Mitoferrin-1", "SLC25A37", "9.64"], ["SF01_HUMAN", "Splicing factor 1", "SF1", "1.92"], ["N4BP1_HUMAN", "NEDD4-binding protein 1", "N4BP1", "1.65"], ["MKL-1", "H2A1H_HUMAN", "Histone H2A type 1-H", "HIST1H2AH", "5.25"], ["HMGN2_HUMAN", "Non-histone chromosomal protein HMG-17", "HMGN2", "3.86"], ["C2C2L_HUMAN", "C2 domain-containing protein 2-like", "C2CD2L", "3.63"], ["DPY30_HUMAN", "Protein dpy-30 homolog", "DPY30", "3.56"], ["STON1_HUMAN", "Stonin-1", "STON1", "3.18"], ["PREX2_HUMAN", "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein", "PREX2", "3.11"], ["CCAR1_HUMAN", "Cell division cycle and apoptosis regulator protein 1", "CCAR1", "2.96"], ["RFC1_HUMAN", "Replication factor C subunit 1", "RFC1", "2.89"], ["ATPB_HUMAN", "ATP synthase subunit beta, mitochondrial", "ATP5B", "2.87"], ["ROAA_HUMAN", "Heterogeneous nuclear ribonucleoprotein A/B", "HNRNPAB", "2.64"], ["DJB14_HUMAN", "DnaJ homolog subfamily B member 14", "DNAJB14", "2.53"], ["SF3B1_HUMAN", "Splicing factor 3B subunit 1", "SF3B1", "2.47"], ["RL29_HUMAN", "60S ribosomal protein L29", "RPL29", "2.44"], ["HNRPM_HUMAN", "Heterogeneous nuclear ribonucleoprotein M", "HNRNPM", "2.39"], ["SUMO4_HUMAN", "Small ubiquitin-related modifier 4", "SUMO4", "2.38"], ["NDUS7_HUMAN", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NDUFS7", "2.29"], ["HSP7C_HUMAN", "Heat shock cognate 71 kDa protein", "HSPA8", "2.19"], ["CH60_HUMAN", "60 kDa heat shock protein, mitochondrial", "HSPD1", "2.10"], ["BSDC1_HUMAN", "BSD domain-containing protein 1", "BSDC1", "2.06"], ["RS30_HUMAN", "40S ribosomal protein S30", "FAU", "2.01"], ["MXRA5_HUMAN", "Matrix-remodeling-associated protein 5", "MXRA5", "1.96"], ["ROA2_HUMAN", "Heterogeneous nuclear ribonucleoproteins A2/B1", "HNRNPA2B1", "1.89"], ["ROA1_HUMAN", "Heterogeneous nuclear ribonucleoprotein A1", "HNRNPA1", "1.89"], ["ROA3_HUMAN", "Heterogeneous nuclear ribonucleoprotein A3", "HNRNPA3", "1.89"], ["NPM_HUMAN", "Nucleophosmin", "NPM1", "1.80"], ["CH10_HUMAN", "10 kDa heat shock protein, mitochondrial", "HSPE1", "1.70"], ["STK24_HUMAN", "Serine/threonine-protein kinase 24", "STK24", "1.70"], ["HNRPC_HUMAN", "Heterogeneous nuclear ribonucleoproteins C1/C2", "HNRNPC", "1.66"], ["H2B1O_HUMAN", "Histone H2B type 1-O", "HIST1H2BO", "1.60"], ["PABP1_HUMAN", "Polyadenylate-binding protein 1", "PABPC1", "1.58"], ["I23O2_HUMAN", "Indoleamine 2,3-dioxygenase 2", "IDO2", "1.54"], ["MKL-2", "PADI6_HUMAN", "Protein-arginine deiminase type-6", "PADI6 PAD6", "9.47"], ["CTL2_HUMAN", "Choline transporter-like protein 2", "SLC44A2", "6.74"], ["SRSF3_HUMAN", "Serine/arginine-rich splicing factor 3", "SRSF3", "5.87"], ["HMGN2_HUMAN", "Non-histone chromosomal protein HMG-17", "HMGN2", "5.10"], ["PABP1_HUMAN", "Polyadenylate-binding protein 1", "PABPC1", "4.02"], ["NDUS7_HUMAN", "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial", "NDUFS7", "3.84"], ["H2B1H_HUMAN", "Histone H2B type 1-H", "HIST1H2BH", "3.15"], ["COF1_HUMAN", "Cofilin-1", "CFL1", "2.30"], ["LRRT3_HUMAN", "Leucine-rich repeat transmembrane neuronal protein 3", "LRRTM3", "2.27"], ["CH10_HUMAN", "10 kDa heat shock protein, mitochondrial", "HSPE1", "2.20"], ["ACM2_HUMAN", "Muscarinic acetylcholine receptor M2", "CHRM2", "2.14"], ["S38AA_HUMAN", "Putative sodium-coupled neutral amino acid transporter 10", "SLC38A10", "2.14"], ["ROA1_HUMAN", "Heterogeneous nuclear ribonucleoprotein A1", "HNRNPA1", "2.08"], ["WDR62_HUMAN", "WD repeat-containing protein 62", "WDR62", "2.02"], ["ROA2_HUMAN", "Heterogeneous nuclear ribonucleoproteins A2/B1", "HNRNPA2B1", "2.01"], ["STMN1_HUMAN", "Stathmin", "STMN1", "1.80"], ["TM266_HUMAN", "Transmembrane protein 266", "TMEM266", "1.77"], ["H2B2E_HUMAN", "Histone H2B type 2-E", "HIST2H2BE", "1.66"], ["TBA1A_HUMAN", "Tubulin alpha-1A chain", "TUBA1A", "1.64"], ["TBA1B_HUMAN", "Tubulin alpha-1B chain", "TUBA1B", "1.64"], ["HNRPK_HUMAN", "Heterogeneous nuclear ribonucleoprotein K", "HNRNPK", "1.60"], ["PRDX2_HUMAN", "Peroxiredoxin-2", "PRDX2", "1.50"], ["PeTa", "ROA2_HUMAN", "Heterogeneous nuclear ribonucleoproteins A2/B1", "HNRNPA2B1", "4.46"], ["ROA3_HUMAN", "Heterogeneous nuclear ribonucleoprotein A3", "HNRNPA3", "4.46"], ["H2A1B_HUMAN", "Histone H2A type 1-B/E", "HIST1H2AB", "4.23"], ["H2AJ_HUMAN", "Histone H2A.J", "H2AFJ", "4.23"], ["ROA1_HUMAN", "Heterogeneous nuclear ribonucleoprotein A1", "HNRNPA1", "2.98"], ["NIBL1_HUMAN", "Niban-like protein 1", "FAM129B", "2.97"], ["CTL2_HUMAN", "Choline transporter-like protein 2", "SLC44A2", "2.96"], ["REPS2_HUMAN", "RalBP1-associated Eps domain-containing protein 2", "REPS2", "2.72"], ["URGCP_HUMAN", "Up-regulator of cell proliferation", "URGCP", "2.69"], ["H14_HUMAN", "Histone H1.4", "HIST1H1E", "2.67"], ["H33_HUMAN", "Histone H3.3", "H3F3A", "2.39"], ["K0895_HUMAN", "Uncharacterized protein KIAA0895", "KIAA0895", "2.36"], ["H15_HUMAN", "Histone H1.5", "HIST1H1B", "2.17"], ["H2B1N_HUMAN", "Histone H2B type 1-N", "HIST1H2BN", "1.91"], ["H2B2E_HUMAN", "Histone H2B type 2-E", "HIST2H2BE", "1.90"], ["PRDX2_HUMAN", "Peroxiredoxin-2", "PRDX2", "1.80"], ["WaGa", "SLX4I_HUMAN", "Protein SLX4IP", "SLX4IP", "33.84"], ["TMM56_HUMAN", "Transmembrane protein 56", "TMEM56", "8.88"], ["S38AA_HUMAN", "Putative sodium-coupled neutral amino acid transporter 10", "SLC38A10", "6.38"], ["COQ6_HUMAN", "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial", "COQ6", "4.57"], ["NEK5_HUMAN", "Serine/threonine-protein kinase Nek5", "NEK5", "4.36"], ["PEX16_HUMAN", "Peroxisomal membrane protein PEX16", "PEX16", "4.33"], ["PEAK1_HUMAN", "Pseudopodium-enriched atypical kinase 1", "PEAK1", "3.95"], ["PCBP2_HUMAN", "Poly(rC)-binding protein 2", "PCBP2", "3.83"], ["HS71A_HUMAN", "Heat shock 70 kDa protein 1A", "HSPA1A", "3.66"], ["FBX41_HUMAN", "F-box only protein 41", "FBXO41", "3.59"], ["HNRPC_HUMAN", "Heterogeneous nuclear ribonucleoproteins C1/C2", "HNRNPC", "3.55"], ["HMMR_HUMAN", "Hyaluronan mediated motility receptor", "HMMR", "3.37"], ["SMYD5_HUMAN", "SET and MYND domain-containing protein 5", "SMYD5", "3.27"], ["MBNL2_HUMAN", "Muscleblind-like protein 2", "MBNL2", "2.47"], ["H4_HUMAN", "Histone H4", "HIST1H4A", "2.45"], ["HNF4A_HUMAN", "Hepatocyte nuclear factor 4-alpha", "HNF4A", "2.35"], ["ASPG_HUMAN", "N(4)-(beta-N-acetylglucosaminyl)-l-asparaginase", "AGA", "2.20"], ["H2B1O_HUMAN", "Histone H2B type 1-O", "HIST1H2BO", "1.99"], ["H2B1D_HUMAN", "Histone H2B type 1-D", "HIST1H2BD", "1.97"], ["TBB5_HUMAN", "Tubulin beta chain", "TUBB", "1.89"], ["UGGG1_HUMAN", "UDP-glucose:glycoprotein glucosyltransferase 1", "UGGT1", "1.80"], ["UB2J1_HUMAN", "Ubiquitin-conjugating enzyme E2 J1", "UBE2J1", "1.80"], ["RLA2_HUMAN", "60S acidic ribosomal protein P2", "RPLP2", "1.77"], ["SF01_HUMAN", "Splicing factor 1", "SF1", "1.71"], ["HNRL2_HUMAN", "Heterogeneous nuclear ribonucleoprotein U-like protein 2", "HNRNPUL2", "1.71"], ["ROAA_HUMAN", "Heterogeneous nuclear ribonucleoprotein A/B", "HNRNPAB", "1.70"], ["POP1_HUMAN", "Ribonucleases P/MRP protein subunit POP1", "POP1", "1.69"], ["PRDX2_HUMAN", "Peroxiredoxin-2", "PRDX2", "1.68"], ["CE57L_HUMAN", "Centrosomal protein CEP57L1", "CEP57L1", "1.67"], ["CCDC6_HUMAN", "Coiled-coil domain-containing protein 6", "CCDC6", "1.67"], ["KCTD9_HUMAN", "BTB/POZ domain-containing protein KCTD9", "KCTD9", "1.66"], ["ADCY1_HUMAN", "Adenylate cyclase type 1", "ADCY1", "1.59"], ["S35E2_HUMAN", "Solute carrier family 35 member E2", "SLC35E2", "1.55"], ["ATP5J_HUMAN", "ATP synthase-coupling factor 6, mitochondrial", "ATP5J", "1.51"], ["ATPA_HUMAN", "ATP synthase subunit alpha, mitochondrial", "ATP5A1", "1.50"], ["MCC13", "CLCB_HUMAN", "Clathrin light chain B", "CLTB", "4.71"], ["HSPB1_HUMAN", "Heat shock protein beta-1", "HSPB1", "3.23"], ["SNX4_HUMAN", "Sorting nexin-4", "SNX4", "2.83"], ["RL23A_HUMAN", "60S ribosomal protein L23a", "RPL23A", "2.82"], ["PROF1_HUMAN", "Profilin-1", "PFN1", "2.51"], ["H2B1C_HUMAN", "Histone H2B type 1-C/E/F/G/I", "HIST1H2BC", "2.47"], ["ZN407_HUMAN", "Zinc finger protein 407", "ZNF407", "2.44"], ["H2B1K_HUMAN", "Histone H2B type 1-K", "HIST1H2BK", "2.42"], ["OPRD_HUMAN", "Delta-type opioid receptor", "OPRD1", "2.42"], ["HGB1A_HUMAN", "Putative high mobility group protein B1-like 1", "HMGB1P1", "2.35"], ["PSME1_HUMAN", "Proteasome activator complex subunit 1", "PSME1", "2.29"], ["PRDX1_HUMAN", "Peroxiredoxin-1", "PRDX1", "2.22"], ["CAC1G_HUMAN", "Voltage-dependent T-type calcium channel subunit alpha-1G", "CACNA1G", "2.20"], ["H2B2F_HUMAN", "Histone H2B type 2-F", "HIST2H2BF", "2.18"], ["K2C5_HUMAN", "Keratin, type II cytoskeletal 5", "KRT5", "2.17"], ["RL4_HUMAN", "60S ribosomal protein L4", "RPL4", "2.15"], ["LDHB_HUMAN", "l-Lactate dehydrogenase B chain", "LDHB", "2.14"], ["MT1E_HUMAN", "Metallothionein-1E", "MT1E", "2.14"], ["ILRL2_HUMAN", "Interleukin-1 receptor-like 2", "IL1RL2", "1.94"], ["MYPC2_HUMAN", "Myosin-binding protein C, fast-type", "MYBPC2", "1.93"], ["NONO_HUMAN", "Non-POU domain-containing octamer-binding protein", "NONO", "1.84"], ["LMNA_HUMAN", "Prelamin-A/C", "LMNA", "1.82"], ["K2C8_HUMAN", "Keratin, type II cytoskeletal 8", "KRT8", "1.66"], ["NUCL_HUMAN", "Nucleolin", "NCL", "1.64"], ["PDLI1_HUMAN", "PDZ and LIM domain protein 1", "PDLIM1", "1.64"], ["RLA1_HUMAN", "60S acidic ribosomal protein P1", "RPLP1", "1.64"], ["BAF_HUMAN", "Barrier-to-autointegration factor", "BANF1", "1.63"], ["NPM_HUMAN", "Nucleophosmin", "NPM1", "1.61"], ["HNRPK_HUMAN", "Heterogeneous nuclear ribonucleoprotein K", "HNRNPK", "1.61"], ["YBOX1_HUMAN", "Nuclease-sensitive element-binding protein 1", "YBX1", "1.60"], ["H2AJ_HUMAN", "Histone H2A.J", "H2AFJ", "1.56"], ["RL34_HUMAN", "60S ribosomal protein L34", "RPL34", "1.55"], ["ROA1_HUMAN", "Heterogeneous nuclear ribonucleoprotein A1", "HNRNPA1", "1.52"], ["RS28_HUMAN", "40S ribosomal protein S28", "RPS28", "1.52"], ["CQ047_HUMAN", "Uncharacterized protein C17orf47", "C17orf47", "1.52"]], "row_count": 143, "column_count": 5, "numeric_cells": 298, "header_rows": 1, "locator": "section[6]/table-wrap[1]#Tab1"}}, {"id": "asset:table:pmid:31889939:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:efe7594ff6b0d8d66d9d8527f147edfa0088750865b0fe80f40fecb9a9ace355", "bytes": 3066, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[9]/table-wrap[1]#Tab2", "version": null, "note": "An overview of downregulated proteins identified in Merkel cell carcinoma cell lines", "structure": {"pmcid": "PMC6921584", "section_index": 9, "section_title": "Differentially expressed proteins in MCC cell lines and the control cell line", "row_count": 44, "column_count": 5}, "table": {"label": "Table 2", "caption": "An overview of downregulated proteins identified in Merkel cell carcinoma cell lines", "rows": [["Cell line", "UniProt entry name", "Protein name", "Gene symbol", "Ratio (H/L)"], ["BroLi", "H10_HUMAN", "Histone H1.0", "H1F0", "0.45"], ["MGAP_HUMAN", "MAX gene-associated protein", "MGA", "0.17"], ["MKL-1", "ASXL1_HUMAN", "Putative Polycomb group protein ASXL1", "ASXL1", "0.48"], ["TBB5_HUMAN", "Tubulin beta chain", "TUBB TUBB5", "0.48"], ["TAF2_HUMAN", "Transcription initiation factor TFIID subunit 2", "TAF2", "0.45"], ["FBLN2_HUMAN", "Fibulin-2", "FBLN2", "0.45"], ["PRDX2_HUMAN", "Peroxiredoxin-2", "PRDX2", "0.44"], ["SEPT5_HUMAN", "Septin-5", "Sep-05", "0.44"], ["FUS_HUMAN", "RNA-binding protein FUS", "FUS", "0.44"], ["BICD2_HUMAN", "Protein bicaudal D homolog 2", "BICD2", "0.43"], ["SRRT_HUMAN", "Serrate RNA effector molecule homolog", "SRRT", "0.41"], ["MAK_HUMAN", "Serine/threonine-protein kinase MAK", "MAK", "0.40"], ["CBX5_HUMAN", "Chromobox protein homolog 5", "CBX5", "0.36"], ["CHSP1_HUMAN", "Calcium-regulated heat-stable protein 1", "CARHSP1", "0.34"], ["NUCB2_HUMAN", "Nucleobindin-2", "NUCB2", "0.31"], ["TPIS_HUMAN", "Triosephosphate isomerase", "TPI1", "0.26"], ["TRI13_HUMAN", "E3 ubiquitin-protein ligase TRIM13", "TRIM13", "0.22"], ["L37A3_HUMAN", "Leucine-rich repeat-containing protein 37A3", "LRRC37A3", "0.08"], ["CMGA_HUMAN", "Chromogranin-A", "CHGA", "0.03"], ["KCTD9_HUMAN", "BTB/POZ domain-containing protein KCTD9", "KCTD9", "0.02"], ["1433Z_HUMAN", "14-3-3 protein zeta/delta", "YWHAZ", "0.02"], ["MKL-2", "ALAT1_HUMAN", "Alanine aminotransferase 1", "GPT", "0.49"], ["GRP75_HUMAN", "Stress-70 protein, mitochondrial", "HSPA9", "0.40"], ["ULK2_HUMAN", "Serine/threonine-protein kinase ULK2", "ULK2", "0.34"], ["NUCL_HUMAN", "Nucleolin", "NCL", "0.24"], ["1433Z_HUMAN", "14-3-3 protein zeta/delta", "YWHAZ", "0.04"], ["PeTa", "KCTD9_HUMAN", "BTB/POZ domain-containing protein KCTD9", "KCTD9", "0.45"], ["WaGa", "TMX1_HUMAN", "Thioredoxin-related transmembrane protein 1", "TMX1", "0.39"], ["RS30_HUMAN", "40S ribosomal protein S30", "FAU", "0.38"], ["CPLX3_HUMAN", "Complexin-3", "CPLX", "0.37"], ["CA052_HUMAN", "UPF0690 protein C1orf52", "C1orf52", "0.27"], ["RSMB_HUMAN", "Small nuclear ribonucleoprotein-associated proteins B and B’", "SNRPB", "0.23"], ["RS28_HUMAN", "40S ribosomal protein S28", "RPS28", "0.22"], ["CQ047_HUMAN", "Uncharacterized protein C17orf47", "C17orf47", 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