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pmid:32265979
Integrated Analysis Identifies a Nine-microRNA Signature Biomarker for Diagnosis and Prognosis in Colorectal Cancer.
Ziyang Di · Maojun Di · Weihua Fu · Qiang Tang · Yanwei Liu · Peijie Lei · Xinsheng Gu · Tong Liu · Min Sun
Frontiers in genetics · 2020 doi:10.3389/fgene.2020.00192
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Experiment
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Complete file
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Abnormal expression of human microRNA-200a (hsa-miRNA-200a or miR-200a) has previously been characterized as a clinically noticeable biomarker in several cancers, but its role in CRC is still unclear.\nMETHODS: Three CRC miRNA expression datasets were integratively analyzed by Least Absolute Shrinkage and Selector Operation (LASSO) and Support Vector Machine-Recursive Feature Elimination (SVM-RFE) algorithms. Nine candidate miRNAs were identified and validated for diagnostic and prognostic capability with the prediction model. The potential roles of the tumor suppressor miR-200a-3p in invasion, migration, and epithelial-mesenchymal transition of CRC cells were elaborated by in vitro studies.\nRESULTS: Nine miRNAs (miR-492, miR-200a, miR-338, miR-29c, miR-101, miR-148a, miR-92a, miR-424, and miR-210) were identified as potentially useful diagnostic biomarkers in the clinic. The overall accuracy rate of the nine miRNAs in the diagnostic model was 0.94, 0.89, and 0.978 in the testing, validation, and independent validation dataset, respectively. CRC patients in the GSE29622 cohort were separated by the prognostic model into the low-risk score group and the high-risk score group. The area under the receiver operating characteristic curve (AUC) was 0.872 and 0.783 for predicting the 1- to 10-year survival of CRC patients. The performance of the prognostic model was validated by an independent TCGA-Colon Adenocarcinoma (COAD) dataset with AUC values between 0.911 and 0.796 in predicting 1- to 10-year survival. Nomograms comprising risk scores, tumor stage, and TNM staging were generated for predicting 1-, 3-, and 5-year overall survival (OS) in the GSE29622 and TCGA-COAD datasets. Colony formation, invasion, and migration in DLD1 and SW480 cells were suppressed by overexpression of miR-200a-3p. Inhibition of miR-200a-3p function contributed to abnormal colony formation, migration, invasion, and epithelial-mesenchymal transition (EMT). miR-200a-3p binding sites were located within the 3'-untranslated region (3'-UTR) of the Forkhead box protein A1 (FOXA1) mRNA.\nCONCLUSION: We developed and validated a diagnostic and prognostic prediction model for CRC. miR-200a-3p was determined to be a potential diagnostic and prognostic biomarker for CRC.", "claims": [{"id": "claim-method", "statement": "Fisher’s method was performed for statistically significant analysis to counterpoise the different stringencies of the methods.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32265979", "locator": "sections[4] \"Integrated Analysis of miRNA Expression Datasets\" paragraph 2", "quote": "Fisher’s method was performed for statistically significant analysis to counterpoise the different stringencies of the methods."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Publicly available datasets were analyzed in this study. This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32265979", "locator": "sections[25] \"Data Availability Statement\" paragraph 2", "quote": "Publicly available datasets were analyzed in this study. 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"GSM3180303", "GSM3180304", "GSM3180305", "GSM3180306", "GSM3180307", "GSM3180308", "GSM3180309", "GSM3180310", "GSM3180311", "GSM3180312", "GSM3180313", "GSM3180314", "GSM3180315", "GSM3180316", "GSM3180317", "GSM3180318", "GSM3180319", "GSM3180320", "GSM3180321", "GSM3180322", "GSM3180323", "GSM3180324", "GSM3180325", "GSM3180326", "GSM3180327", "GSM3180328", "GSM3180329", "GSM3180330", "GSM3180331", "GSM3180332", "GSM3180333", "GSM3180334", "GSM3180335", "GSM3180336", "GSM3180337", "GSM3180338", "GSM3180339", "GSM3180340", "GSM3180341", "GSM3180342", "GSM3180343", "GSM3180344", "GSM3180345", "GSM3180346", "GSM3180347", "GSM3180348", "GSM3180349", "GSM3180350", "GSM3180351", "GSM3180352", "GSM3180353", "GSM3180354", "GSM3180355", "GSM3180356", "GSM3180357", "GSM3180358", "GSM3180359", "GSM3180360", "GSM3180361", "GSM3180362", "GSM3180363", "GSM3180364", "GSM3180365", "GSM3180366", "GSM3180367", "GSM3180368", "GSM3180369", "GSM3180370", "GSM3180371", "GSM3180372", "GSM3180373", "GSM3180374", "GSM3180375", "GSM3180376", "GSM3180377", "GSM3180378", "GSM3180379", "GSM3180380", "GSM3180381", "GSM3180382", "GSM3180383", "GSM3180384", "GSM3180385", "GSM3180386", "GSM3180387", "GSM3180388", "GSM3180389", "GSM3180390", "GSM3180391", "GSM3180392", "GSM3180393", "GSM3180394", "GSM3180395", "GSM3180396", "GSM3180397", "GSM3180398", "GSM3180399", "GSM3180400", "GSM3180401", "GSM3180402", "GSM3180403", "GSM3180404", "GSM3180405", "GSM3180406", "GSM3180407", "GSM3180408", "GSM3180409", "GSM3180410", "GSM3180411", "GSM3180412", "GSM3180413", "GSM3180414", "GSM3180415", "GSM3180416", "GSM3180417", "GSM3180418", "GSM3180419", "GSM3180420", "GSM3180421", "GSM3180422", "GSM3180423", "GSM3180424", "GSM3180425", "GSM3180426", "GSM3180427", "GSM3180428", "GSM3180429", "GSM3180430", "GSM3180431", "GSM3180432", "GSM3180433", "GSM3180434", "GSM3180435", "GSM3180436", "GSM3180437", "GSM3180438", "GSM3180439", "GSM3180440", "GSM3180441", "GSM3180442", "GSM3180443", "GSM3180444", "GSM3180445", "GSM3180446", "GSM3180447", "GSM3180448", "GSM3180449", "GSM3180450", "GSM3180451", "GSM3180452", "GSM3180453", "GSM3180454", "GSM3180455", "GSM3180456", "GSM3180457", "GSM3180458", "GSM3180459", "GSM3180460", "GSM3180461", "GSM3180462", "GSM3180463", "GSM3180464", "GSM3180465", "GSM3180466", "GSM3180467", "GSM3180468", "GSM3180469", "GSM3180470", "GSM3180471", "GSM3180472", "GSM3180473", "GSM3180474", "GSM3180475", "GSM3180476", "GSM3180477", "GSM3180478", "GSM3180479", "GSM3180480", "GSM3180481", "GSM3180482", "GSM3180483", "GSM3180484", "GSM3180485", "GSM3180486", "GSM3180487", "GSM3180488", "GSM3180489", "GSM3180490", "GSM3180491", "GSM3180492", "GSM3180493", "GSM3180494", "GSM3180495", "GSM3180496", "GSM3180497", "GSM3180498", "GSM3180499", "GSM3180500", "GSM3180501", "GSM3180502", "GSM3180503", "GSM3180504", "GSM3180505", "GSM3180506", "GSM3180507", "GSM3180508", "GSM3180509", "GSM3180510", "GSM3180511", "GSM3180512", "GSM3180513", "GSM3180514", "GSM3180515", "GSM3180516", "GSM3180517", "GSM3180518", "GSM3180519", "GSM3180520", "GSM3180521", "GSM3180522", "GSM3180523", "GSM3180524", "GSM3180525", "GSM3180526", "GSM3180527", "GSM3180528", "GSM3180529", "GSM3180530", "GSM3180531", "GSM3180532", "GSM3180533", "GSM3180534", "GSM3180535", "GSM3180536", "GSM3180537", "GSM3180538", "GSM3180539", "GSM3180540", "GSM3180541", "GSM3180542", "GSM3180543", "GSM3180544", "GSM3180545", "GSM3180546", "GSM3180547", "GSM3180548", "GSM3180549", "GSM3180550", "GSM3180551", "GSM3180552", "GSM3180553", "GSM3180554", "GSM3180555", "GSM3180556", "GSM3180557", "GSM3180558", "GSM3180559", "GSM3180560", "GSM3180561", "GSM3180562", "GSM3180563", "GSM3180564", "GSM3180565", "GSM3180566", "GSM3180567", "GSM3180568", "GSM3180569", "GSM3180570", "GSM3180571", "GSM3180572", "GSM3180573", "GSM3180574", "GSM3180575", "GSM3180576", "GSM3180577", "GSM3180578", "GSM3180579", "GSM3180580", "GSM3180581", "GSM3180582", "GSM3180583", "GSM3180584", "GSM3180585", "GSM3180586", "GSM3180587", "GSM3180588", "GSM3180589", "GSM3180590", "GSM3180591", "GSM3180592", "GSM3180593", "GSM3180594", "GSM3180595", "GSM3180596", "GSM3180597", "GSM3180598", "GSM3180599", "GSM3180600", "GSM3180601", "GSM3180602", "GSM3180603", "GSM3180604", "GSM3180605", "GSM3180606", "GSM3180607", "GSM3180608", "GSM3180609", "GSM3180610", "GSM3180611", "GSM3180612", "GSM3180613", "GSM3180614", "GSM3180615", "GSM3180616", "GSM3180617", "GSM3180618", "GSM3180619", "GSM3180620", "GSM3180621", "GSM3180622", "GSM3180623", "GSM3180624", "GSM3180625", "GSM3180626", "GSM3180627", "GSM3180628", "GSM3180629", "GSM3180630", "GSM3180631", "GSM3180632", "GSM3180633", "GSM3180634", "GSM3180635", "GSM3180636", "GSM3180637", "GSM3180638", "GSM3180639", "GSM3180640", "GSM3180641", "GSM3180642", "GSM3180643", "GSM3180644", "GSM3180645", "GSM3180646", "GSM3180647", "GSM3180648", "GSM3180649", "GSM3180650", "GSM3180651", "GSM3180652", "GSM3180653", "GSM3180654", "GSM3180655", "GSM3180656", "GSM3180657", "GSM3180658", "GSM3180659", "GSM3180660", "GSM3180661", "GSM3180662", "GSM3180663", "GSM3180664", "GSM3180665", "GSM3180666", "GSM3180667", "GSM3180668", "GSM3180669", "GSM3180670", "GSM3180671", "GSM3180672", "GSM3180673", "GSM3180674", "GSM3180675", "GSM3180676", "GSM3180677", "GSM3180678", "GSM3180679", "GSM3180680", "GSM3180681", "GSM3180682", "GSM3180683", "GSM3180684", "GSM3180685", "GSM3180686", "GSM3180687", "GSM3180688", "GSM3180689", "GSM3180690", "GSM3180691", "GSM3180692", "GSM3180693", "GSM3180694", "GSM3180695", "GSM3180696", "GSM3180697", "GSM3180698", "GSM3180699", "GSM3180700", "GSM3180701", "GSM3180702", "GSM3180703", "GSM3180704", "GSM3180705", "GSM3180706", "GSM3180707", "GSM3180708", "GSM3180709", "GSM3180710", "GSM3180711", "GSM3180712", "GSM3180713", "GSM3180714", "GSM3180715", "GSM3180716", "GSM3180717", "GSM3180718", "GSM3180719", "GSM3180720", "GSM3180721", "GSM3180722", "GSM3180723", "GSM3180724", "GSM3180725", "GSM3180726", "GSM3180727", "GSM3180728", "GSM3180729", "GSM3180730", "GSM3180731", "GSM3180732", "GSM3180733", "GSM3180734", "GSM3180735", "GSM3180736", "GSM3180737", "GSM3180738", "GSM3180739", "GSM3180740", "GSM3180741", "GSM3180742", "GSM3180743", "GSM3180744", "GSM3180745", "GSM3180746", "GSM3180747", "GSM3180748", "GSM3180749", "GSM3180750", "GSM3180751", "GSM3180752", "GSM3180753", "GSM3180754", "GSM3180755", "GSM3180756", "GSM3180757", "GSM3180758", "GSM3180759", "GSM3180760", "GSM3180761", "GSM3180762", "GSM3180763", "GSM3180764", "GSM3180765", "GSM3180766", "GSM3180767", "GSM3180768", "GSM3180769", "GSM3180770", "GSM3180771", "GSM3180772", "GSM3180773", "GSM3180774", "GSM3180775", "GSM3180776", "GSM3180777", "GSM3180778", "GSM3180779", "GSM3180780", "GSM3180781", "GSM3180782", "GSM3180783", "GSM3180784", "GSM3180785", "GSM3180786", "GSM3180787", "GSM3180788", "GSM3180789", "GSM3180790", "GSM3180791", "GSM3180792", "GSM3180793", "GSM3180794", "GSM3180795", "GSM3180796", "GSM3180797", "GSM3180798", "GSM3180799", "GSM3180800", "GSM3180801", "GSM3180802", "GSM3180803", "GSM3180804", "GSM3180805", "GSM3180806", "GSM3180807", "GSM3180808", "GSM3180809", "GSM3180810", "GSM3180811", "GSM3180812", "GSM3180813", "GSM3180814", "GSM3180815", "GSM3180816", "GSM3180817", "GSM3180818", "GSM3180819", "GSM3180820", "GSM3180821", "GSM3180822", "GSM3180823", "GSM3180824", "GSM3180825", "GSM3180826", "GSM3180827", "GSM3180828", "GSM3180829", "GSM3180830", "GSM3180831", "GSM3180832", "GSM3180833", "GSM3180834", "GSM3180835", "GSM3180836", "GSM3180837", "GSM3180838", "GSM3180839", "GSM3180840", "GSM3180841", "GSM3180842", "GSM3180843", "GSM3180844", "GSM3180845", "GSM3180846", "GSM3180847", "GSM3180848", "GSM3180849", "GSM3180850", "GSM3180851", "GSM3180852", "GSM3180853", "GSM3180854", "GSM3180855", "GSM3180856", "GSM3180857", "GSM3180858", "GSM3180859", "GSM3180860", "GSM3180861", "GSM3180862", "GSM3180863", "GSM3180864", "GSM3180865", "GSM3180866", "GSM3180867", "GSM3180868", "GSM3180869", "GSM3180870", "GSM3180871", "GSM3180872", "GSM3180873", "GSM3180874", "GSM3180875", "GSM3180876", "GSM3180877", "GSM3180878", "GSM3180879", "GSM3180880", "GSM3180881", "GSM3180882", "GSM3180883", "GSM3180884", "GSM3180885", "GSM3180886", "GSM3180887", "GSM3180888", "GSM3180889", "GSM3180890", "GSM3180891", "GSM3180892", "GSM3180893", "GSM3180894", "GSM3180895", "GSM3180896", "GSM3180897", "GSM3180898", "GSM3180899", "GSM3180900", "GSM3180901", "GSM3180902", "GSM3180903", "GSM3180904", "GSM3180905", "GSM3180906", "GSM3180907", "GSM3180908", "GSM3180909", "GSM3180910", "GSM3180911", "GSM3180912", "GSM3180913", "GSM3180914", "GSM3180915", "GSM3180916", "GSM3180917", "GSM3180918", "GSM3180919", "GSM3180920", "GSM3180921", "GSM3180922", "GSM3180923", "GSM3180924", "GSM3180925", "GSM3180926", "GSM3180927", "GSM3180928", "GSM3180929", "GSM3180930", "GSM3180931", "GSM3180932", "GSM3180933", "GSM3180934", "GSM3180935", "GSM3180936", "GSM3180937", "GSM3180938", "GSM3180939", "GSM3180940", "GSM3180941", "GSM3180942", "GSM3180943", "GSM3180944", "GSM3180945", "GSM3180946", "GSM3180947", "GSM3180948", "GSM3180949", "GSM3180950", "GSM3180951", "GSM3180952", "GSM3180953", "GSM3180954", "GSM3180955", "GSM3180956", "GSM3180957", "GSM3180958", "GSM3180959", "GSM3180960", "GSM3180961", "GSM3180962", "GSM3180963", "GSM3180964", "GSM3180965", "GSM3180966", "GSM3180967", "GSM3180968", "GSM3180969", "GSM3180970", "GSM3180971", "GSM3180972", "GSM3180973", "GSM3180974", "GSM3180975", "GSM3180976", "GSM3180977", "GSM3180978", "GSM3180979", "GSM3180980", "GSM3180981", "GSM3180982", "GSM3180983", "GSM3180984", "GSM3180985", "GSM3180986", "GSM3180987", "GSM3180988", "GSM3180989", "GSM3180990", "GSM3180991", "GSM3180992", "GSM3180993", "GSM3180994", "GSM3180995", "GSM3180996", "GSM3180997", "GSM3180998", "GSM3180999", "GSM3181000", "GSM3181001", "GSM3181002", "GSM3181003", "GSM3181004", "GSM3181005", "GSM3181006", "GSM3181007", "GSM3181008", "GSM3181009", "GSM3181010", "GSM3181011", "GSM3181012", "GSM3181013", "GSM3181014", "GSM3181015", "GSM3181016", "GSM3181017", "GSM3181018", "GSM3181019", "GSM3181020", "GSM3181021", "GSM3181022", "GSM3181023", "GSM3181024", "GSM3181025", "GSM3181026", "GSM3181027", "GSM3181028", "GSM3181029", "GSM3181030", "GSM3181031", "GSM3181032", "GSM3181033", "GSM3181034", "GSM3181035", "GSM3181036", "GSM3181037", "GSM3181038", "GSM3181039", "GSM3181040", "GSM3181041", "GSM3181042", "GSM3181043", "GSM3181044", "GSM3181045", "GSM3181046", "GSM3181047", "GSM3181048", "GSM3181049", "GSM3181050", "GSM3181051", "GSM3181052", "GSM3181053", "GSM3181054", "GSM3181055", "GSM3181056", "GSM3181057", "GSM3181058", "GSM3181059", "GSM3181060", "GSM3181061", "GSM3181062", "GSM3181063", "GSM3181064", "GSM3181065", "GSM3181066", "GSM3181067", "GSM3181068", "GSM3181069", "GSM3181070", "GSM3181071", "GSM3181072", "GSM3181073", "GSM3181074", "GSM3181075", "GSM3181076", "GSM3181077", "GSM3181078", "GSM3181079", "GSM3181080", "GSM3181081", "GSM3181082", "GSM3181083", "GSM3181084", "GSM3181085", "GSM3181086", "GSM3181087", "GSM3181088", "GSM3181089", "GSM3181090", "GSM3181091", "GSM3181092", "GSM3181093", "GSM3181094", "GSM3181095", "GSM3181096", "GSM3181097", "GSM3181098", "GSM3181099", "GSM3181100", "GSM3181101", "GSM3181102", "GSM3181103", "GSM3181104", "GSM3181105", "GSM3181106", "GSM3181107", "GSM3181108", "GSM3181109", "GSM3181110", "GSM3181111", "GSM3181112", "GSM3181113", "GSM3181114", "GSM3181115", "GSM3181116", "GSM3181117", "GSM3181118", "GSM3181119", "GSM3181120", "GSM3181121", "GSM3181122", "GSM3181123", "GSM3181124", "GSM3181125", "GSM3181126", "GSM3181127", "GSM3181128", "GSM3181129", "GSM3181130", "GSM3181131", "GSM3181132", "GSM3181133", "GSM3181134", "GSM3181135", "GSM3181136", "GSM3181137", "GSM3181138", "GSM3181139", "GSM3181140", "GSM3181141", "GSM3181142", "GSM3181143", "GSM3181144", "GSM3181145", "GSM3181146", "GSM3181147", "GSM3181148", "GSM3181149", "GSM3181150", "GSM3181151", "GSM3181152", "GSM3181153", "GSM3181154", "GSM3181155", "GSM3181156", "GSM3181157", "GSM3181158", "GSM3181159", "GSM3181160", "GSM3181161", "GSM3181162", "GSM3181163", "GSM3181164", "GSM3181165", "GSM3181166", "GSM3181167", "GSM3181168", "GSM3181169", "GSM3181170", "GSM3181171", "GSM3181172", "GSM3181173", "GSM3181174", "GSM3181175", "GSM3181176", "GSM3181177", "GSM3181178", "GSM3181179", "GSM3181180", "GSM3181181", "GSM3181182", "GSM3181183", "GSM3181184", "GSM3181185", "GSM3181186", "GSM3181187", "GSM3181188", "GSM3181189", "GSM3181190", "GSM3181191", "GSM3181192", "GSM3181193", "GSM3181194", "GSM3181195", "GSM3181196", "GSM3181197", "GSM3181198", "GSM3181199", "GSM3181200", "GSM3181201", "GSM3181202", "GSM3181203", "GSM3181204", "GSM3181205", "GSM3181206", "GSM3181207", "GSM3181208", "GSM3181209", "GSM3181210", "GSM3181211", "GSM3181212", "GSM3181213", "GSM3181214", "GSM3181215", "GSM3181216", "GSM3181217", "GSM3181218", "GSM3181219", "GSM3181220", "GSM3181221", "GSM3181222", "GSM3181223", "GSM3181224", "GSM3181225", "GSM3181226", "GSM3181227", "GSM3181228", "GSM3181229", "GSM3181230", "GSM3181231", "GSM3181232", "GSM3181233", "GSM3181234", "GSM3181235", "GSM3181236", "GSM3181237", "GSM3181238", "GSM3181239", "GSM3181240", "GSM3181241", "GSM3181242", "GSM3181243", "GSM3181244", "GSM3181245", "GSM3181246", "GSM3181247", "GSM3181248", "GSM3181249", "GSM3181250", "GSM3181251", "GSM3181252", "GSM3181253", "GSM3181254", "GSM3181255", "GSM3181256", "GSM3181257", "GSM3181258", "GSM3181259", "GSM3181260", "GSM3181261", "GSM3181262", "GSM3181263", "GSM3181264", "GSM3181265", "GSM3181266", "GSM3181267", "GSM3181268", "GSM3181269", "GSM3181270", "GSM3181271", "GSM3181272", "GSM3181273", "GSM3181274", "GSM3181275", "GSM3181276", "GSM3181277", "GSM3181278", "GSM3181279", "GSM3181280", "GSM3181281", "GSM3181282", "GSM3181283", "GSM3181284", "GSM3181285", "GSM3181286", "GSM3181287", "GSM3181288", "GSM3181289", "GSM3181290", "GSM3181291", "GSM3181292", "GSM3181293", "GSM3181294", "GSM3181295", "GSM3181296", 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This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/).", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM734176", "GSM734177", "GSM734178", "GSM734179", "GSM734180", "GSM734181", "GSM734182", "GSM734183", "GSM734184", "GSM734185", "GSM734186", "GSM734187", "GSM734188", "GSM734189", "GSM734190", "GSM734191", "GSM734192", "GSM734193", "GSM734194", "GSM734195", "GSM734196", "GSM734197", "GSM734198", "GSM734199", "GSM734200", "GSM734201", "GSM734202", "GSM734203", "GSM734204", "GSM734205", "GSM734206", "GSM734207", "GSM734208", "GSM734209", "GSM734210", "GSM734211", "GSM734212", "GSM734213", "GSM734214", "GSM734215", "GSM734216", "GSM734217", "GSM734218", "GSM734219", "GSM734220", "GSM734221", "GSM734222", "GSM734223", "GSM734224", "GSM734225", "GSM734226", "GSM734227", "GSM734228", "GSM734229", "GSM734230", "GSM734231", "GSM734232", "GSM734233", "GSM734234", "GSM734235", "GSM734236", "GSM734237", "GSM734238", "GSM734239", "GSM734240"], "sample_count": 65, "group_sizes": null, "group_sizes_basis": null, "platform": "11162", "taxon": "Homo sapiens", "title": "Complementary Strand MicroRNAs Mediate Acquisition of Metastatic Potential in Colonic AdenocarcinomamRNA and microRNA profile in colon cancer", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE38389", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE38389", "version": null, "note": "Publicly available datasets were analyzed in this study. This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Publicly available datasets were analyzed in this study. This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/).", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM941048", "GSM941049", "GSM941050", "GSM941051", "GSM941052", "GSM941053", "GSM941054", "GSM941055", "GSM941056", "GSM941057", "GSM941058", "GSM941059", "GSM941060", "GSM941061", "GSM941062", "GSM941063", "GSM941064", "GSM941065", "GSM941066", "GSM941067", "GSM941068", "GSM941069", "GSM941070", "GSM941071", "GSM941072", "GSM941073", "GSM941074", "GSM941075", "GSM941076", "GSM941077", "GSM941078", "GSM941079", "GSM941080", "GSM941081", "GSM941082", "GSM941083", "GSM941084", "GSM941085", "GSM941086", "GSM941087", "GSM941088", "GSM941089", "GSM941090", "GSM941091", "GSM941092", "GSM941093", "GSM941094", "GSM941095", "GSM941096", "GSM941097", "GSM941098", "GSM941099", "GSM941100", "GSM941101", "GSM941102", "GSM941103", "GSM941104", "GSM941105", "GSM941106", "GSM941107", "GSM941108", "GSM941109", "GSM941110", "GSM941111", "GSM941112", "GSM941113", "GSM941114", "GSM941115", "GSM941116", "GSM941117", "GSM941118", "GSM941119", "GSM941120", "GSM941121", "GSM941122", "GSM941123", "GSM941124", "GSM941125", "GSM941126", "GSM941127", "GSM941128", "GSM941129", "GSM941130", "GSM941131", "GSM941132", "GSM941133", "GSM941134", "GSM941135", "GSM941136", "GSM941137", "GSM941138", "GSM941139", "GSM941140", "GSM941141", "GSM941142", "GSM941143", "GSM941144", "GSM941145", "GSM941146", "GSM941147", "GSM941148", "GSM941149", "GSM941150", "GSM941151", "GSM941152", "GSM941153", "GSM941154", "GSM941155", "GSM941156", "GSM941157", "GSM941158", "GSM941159", "GSM941160", "GSM941161", "GSM941162", "GSM941163", "GSM941164", "GSM941165", "GSM941166", "GSM941167", "GSM941168", "GSM941169", "GSM941170", "GSM941171", "GSM941172", "GSM941173", "GSM941174", "GSM941175", "GSM941176", "GSM941177", "GSM941178", "GSM941179", "GSM941180", "GSM941181", "GSM941182", "GSM941183", "GSM941184", "GSM941185", "GSM941186", "GSM941187"], "sample_count": 140, "group_sizes": null, "group_sizes_basis": null, "platform": "11039", "taxon": "Homo sapiens", "title": "The rectal cancer microRNAome - a comprehensive comparative analysis of microRNA expression in rectal cancer and matched normal mucosa", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE48267", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE48267", "version": null, "note": "Publicly available datasets were analyzed in this study. This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Publicly available datasets were analyzed in this study. This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/).", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1173638", "GSM1173639", "GSM1173640", "GSM1173641", "GSM1173642", "GSM1173643", "GSM1173644", "GSM1173645", "GSM1173646", "GSM1173647", "GSM1173648", "GSM1173649", "GSM1173650", "GSM1173651", "GSM1173652", "GSM1173653", "GSM1173654", "GSM1173655", "GSM1173656", "GSM1173657", "GSM1173658", "GSM1173659", "GSM1173660", "GSM1173661", "GSM1173662", "GSM1173663", "GSM1173664", "GSM1173665", "GSM1173666", "GSM1173667", "GSM1173668", "GSM1173669", "GSM1173670", "GSM1173671", "GSM1173672", "GSM1173673", "GSM1173674", "GSM1173675", "GSM1173676", "GSM1173677", "GSM1173678", "GSM1173679", "GSM1173680", "GSM1173681", "GSM1173682", "GSM1173683", "GSM1173684", "GSM1173685", "GSM1173686", "GSM1173687", "GSM1173688", "GSM1173689", "GSM1173690", "GSM1173691", "GSM1173692", "GSM1173693", "GSM1173694", "GSM1173695", "GSM1173696", "GSM1173697", "GSM1173698", "GSM1173699", "GSM1173700", "GSM1173701", "GSM1173702", "GSM1173703", "GSM1173704", "GSM1173705", "GSM1173706", "GSM1173707", "GSM1173708", "GSM1173709", "GSM1173710", "GSM1173711", "GSM1173712", "GSM1173713", "GSM1173714", "GSM1173715", "GSM1173716", "GSM1173717", "GSM1173718", "GSM1173719", "GSM1173720", "GSM1173721", "GSM1173722", "GSM1173723", "GSM1173724", "GSM1173725", "GSM1173726", "GSM1173727", "GSM1173728", "GSM1173729", "GSM1173730", "GSM1173731", "GSM1173732", "GSM1173733", "GSM1173734", "GSM1173735", "GSM1173736", "GSM1173737", "GSM1173738", "GSM1173739", "GSM1173740", "GSM1173741", "GSM1173742", "GSM1173743", "GSM1173744", "GSM1173745", "GSM1173746", "GSM1173747", "GSM1173748", "GSM1173749", "GSM1173750", "GSM1173751", "GSM1173752", "GSM1173753", "GSM1173754", "GSM1173755", "GSM1173756", "GSM1173757", "GSM1173758", "GSM1173759"], "sample_count": 122, "group_sizes": null, "group_sizes_basis": null, "platform": "10850", "taxon": "Homo sapiens", "title": "Differential Expression of miRNAs: Implication in Colon Cancer Racial Health Disparity", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE49246", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE49246", "version": null, "note": "Publicly available datasets were analyzed in this study. This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/).", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Publicly available datasets were analyzed in this study. This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/).", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1195876", "GSM1195877", "GSM1195878", "GSM1195879", "GSM1195880", "GSM1195881", "GSM1195882", "GSM1195883", "GSM1195884", "GSM1195885", "GSM1195886", "GSM1195887", "GSM1195888", "GSM1195889", "GSM1195890", "GSM1195891", "GSM1195892", "GSM1195893", "GSM1195894", "GSM1195895", "GSM1195896", "GSM1195897", "GSM1195898", "GSM1195899", "GSM1195900", 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"resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:32265979:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:3d77bf2e3439f82444a121c028789c4d42ea9436f4ff3c5ff056d85c9c824e99", "bytes": 1653, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[19]/table-wrap[1]#T1", "version": null, "note": "Univariate and multivariate analyses of clinicopathological factors and nine-miRNA classifier with OS in GSE29622 and TCGA COAD cohorts.", "structure": {"pmcid": "PMC7100107", "section_index": 19, "section_title": "Validation of Prognostic Performance of the Nine-miRNA Signature in TCGA-COAD", "row_count": 16, "column_count": 5}, "table": {"label": "TABLE 1", "caption": "Univariate and multivariate analyses of clinicopathological factors and nine-miRNA classifier with OS in GSE29622 and TCGA COAD cohorts.", "rows": [["", "Univariate analysisa", "Multivariate analysisb"], ["", "HR (95% Cl)", "P-value", "HR (95% CI)", "P-value"], ["GSE29622 testing set (n = 65)"], ["Gender (male vs. female)", "1.586 (0.682–3.687)", "0.284", "", ""], ["Pathologic T stage (T3–4 vs. T1–2)", "1.678 (0.394–7.141)", "0.484", "0.559 (0.099–3.162)", "0.511"], ["Pathologic N stage (N0 vs. N1 vs. N2)", "2.744 (1.562–4.820)", "<0.001", "1.322 (0.559–3.128)", "0.525"], ["Pathologic M stage (present vs. absent)", "5.059 (2.243–11.410)", "<0.001", "3.09 (1.231–7.757)", "0.016"], ["TNM stage (III and IV vs. I and II)", "5.290 (1.813–15.436)", "0.002", "2.331 (0.421–12.911)", "0.332"], ["Risk Score (continuous value)", "1.272 (1.159–1.396)", "<0.001", "1.232 (1.115–1.363)", "<0.001"], ["TCGA-COAD validation set (n = 406)"], ["Gender (male vs. female)", "1.299 (0.727–2.321)", "0.376", "", ""], ["Pathologic T stage (T3–4 vs. 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not downloaded", "asset:data:geo:GSE49246 licence not read"]}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "group_comparison", "specific": "anova", "label": "Group comparison", "dsl_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["two_or_more_groups_continuous"], "evidence": {"score": 0.8, "band": "high", "quote": "ANOVA"}}, {"id": "method-2", "family": "survival_analysis", "specific": "kaplan_meier", "label": "Survival analysis", "dsl_operations": ["survival_km"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "Kaplan-Meier"}}, {"id": "method-3", "family": "survival_analysis", "specific": "cox_proportional_hazards", "label": "Survival analysis", "dsl_operations": ["cox_ph"], "missing_operations": [], 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different stringencies of the methods."}}], "targets": [], "gaps": ["method.reader_named_unmapped"]}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: anova."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE48267", "GSE38389", "GSE49246", "GSE115513", "GSE29622"], "resolved_accessions": ["GSE48267", "GSE38389", "GSE49246", "GSE115513", "GSE29622"], "statements": ["Publicly available datasets were analyzed in this study. This data can be found at The Cancer Genome Atlas and Gene Expression Omnibus: GSE48267 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE48267); GSE38389 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38389); GSE- 28364 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28364); GSE49246 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49246); GSE115513 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115513); GSE29622 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29622); and TC GA-COAD (https://portal.gdc.cancer.gov/)."], "basis": "The paper names GSE48267, GSE38389, GSE49246, GSE115513, GSE29622 in Gene Expression Omnibus and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "assets": ["source:pmid:32265979", "data:geo:GSE115513", "asset:table:pmid:32265979:1"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE115513"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:19:07Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 36787, "completion_tokens": 2866, "cached_tokens": 12296}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:32265979", "type": "paper", "label": "pmid:32265979"}, {"id": "source:pmid:32265979", "type": "manuscript", "label": "PMID 32265979 full text"}, {"id": "data:geo:GSE115513", "type": "dataset", "label": "GEO GSE115513"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:32265979", "type": "paper", "label": "pmid:32265979"}, {"id": "source:pmid:32265979", "type": "manuscript", "label": "PMID 32265979 full text"}, {"id": "data:geo:GSE115513", "type": "dataset", "label": "GEO GSE115513"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-32265979", "type": "extraction", "used": ["source:pmid:32265979"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE115513", "type": "accession_resolution", "used": ["data:geo:GSE115513"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:32265979", "parent_hash": "sha256:361289ac15e8f413e1b25abfa84eccc5026a3d615e80b2f23436d0dd5596590f", "fork_of": null, "generation": 6}, "gaps": ["asset:data:geo:GSE115513 licence not read", "asset:data:geo:GSE115513 not downloaded", "asset:data:geo:GSE29622 licence not read", "asset:data:geo:GSE29622 not downloaded", "asset:data:geo:GSE38389 licence not read", "asset:data:geo:GSE38389 not downloaded", "asset:data:geo:GSE48267 licence not read", "asset:data:geo:GSE48267 not downloaded", "asset:data:geo:GSE49246 licence not read", "asset:data:geo:GSE49246 not downloaded", "execution.not_run", "method.reader_named_unmapped", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "data_generation", "definition_id": "transfection", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.99, "evidence": ["ally significant DE miRNAs. Cell Culture and Transfection of miR-200a-3p Mimic and Inhibitor Human col", "uangzhou, China). Cell culture and transient transfection were performed as described previously (Sun"], "order_basis": "paper_text_order:3100", "id": "assay:1"}, {"role": "data_generation", "definition_id": "microarray", "definition_version": "99e1195c7d6f", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"assay_lexicon": "99e1195c7d6f"}, "confidence": 0.93, "evidence": ["file. TABLE S1Characteristics of the public microarray datasets used in this study.Click here for a"], "order_basis": "paper_text_order:6653", "id": "assay:2"}, {"role": "analysis", "definition_id": "group_comparison", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["group_summary", "welch_t", "bootstrap_mean_difference", "group_comparison_anova"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 0.8, "evidence": ["ANOVA"], "order_basis": "consumes_earlier_output", "id": "assay:3"}]}