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pmid:32306128
High MICB expression as a biomarker for good prognosis of colorectal cancer.
Qingyang Feng · Shanchao Yu · Yihao Mao · Meiling Ji · Ye Wei · Guodong He · Wenju Chang · Dexiang Zhu · Li Ren · Jianmin Xu
Journal of cancer research and clinical oncology · 2020 doi:10.1007/s00432-020-03159-0
Paper
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Experiment
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Data
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Analysis
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Execution
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Complete file
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However, the function of MHC class I chain-related B (MICB) molecule is not very clear. In this study, we explored the prognostic effect of MICB in colorectal cancer.\nMATERIAL AND METHODS: From 2008-05 to 2012-11, consecutive CRC patients of Zhongshan Hospital, Fudan University were retrospectively enrolled as primary cohort. The inclusion criteria were as follows: receiving primary radical resection, pathologically confirmed colorectal adenocarcinoma, no treatment before surgery, clinicopathological data available. Another cohort of CRC patients were collected from a public dataset GSE39582 of GEO database from 1987 to 2007 in the same criteria for validation. MICB was detected using immunochemistry and evaluated as prognostic biomarker. The cut-off value of MICB expression was calculated using X-tile software.\nRESULTS: Finally, 863 patients were enrolled in the primary cohort, and 556 patients were enrolled in the validation cohort. MICB expression was significantly associated with tumor size and primary histological type in primary cohort, and with primary tumor location and distant metastases in validation cohort. The survival analysis showed that patients with high MICB expression had significantly better overall survival in both primary (P = 0.002) and validation (P = 0.001) cohorts. The multivariate analysis also confirmed that high MICB expression was a significantly independent protective factor for overall survival in both primary (hazard ratio HR = 0.741, 95% CI 0.594-0.924) and validation (HR = 0.699, 95% CI 0.508-0.961) cohorts.\nCONCLUSION: For stage I-IV CRC patients, MICB was confirmed a novel independent prognostic factor. 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"platform": "570", "taxon": "Homo sapiens", "title": "Gene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [Expression]", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:32306128:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:e3aa2ef61e657a4b3ee3d0c60903a7756c16395edfd303d110057c1d4e5a5d8b", "bytes": 2186, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[7]/table-wrap[1]#Tab1", "version": null, "note": "Baseline clinicopathological characteristics of primary and validation cohorts", "structure": {"pmcid": "PMC7230058", "section_index": 7, "section_title": "Patient characteristics", "row_count": 51, 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"", "", "", "", ""], ["≤ 4.0", "478", "55.4", "", "", "", ""], ["> 4.0", "385", "44.6", "", "", "", ""], ["Primary histological type"], ["Non-mucinous", "732", "84.8", "", "", "", ""], ["Mucinous", "131", "15.2", "", "", "", ""], ["Primary differentiation"], ["Well/moderate", "584", "67.7", "", "", "", ""], ["Poor/anaplastic", "279", "32.3", "", "", "", ""], ["T stage", "T stage"], ["T1", "29", "3.4", "T1", "11", "2.0", "< 0.001"], ["T2", "120", "13.9", "T2", "44", "7.9", ""], ["T3", "207", "24.0", "T3", "362", "65.1", ""], ["T4", "507", "58.7", "T4", "119", "21.4", ""], ["", "", "", "Unknown", "20", "3.6", ""], ["N stage", "N stage"], ["N0", "457", "53.0", "N0", "294", "52.9", "0.502"], ["N1", "264", "30.6", "N1/N2", "242", "43.5", ""], ["N2", "142", "16.4", "Unknown", "20", "3.6", ""], ["Vascular invasion"], ["No", "761", "88.2", "", "", "", ""], ["Yes", "102", "11.8", "", "", "", ""], ["Nerve invasion"], ["No", "800", "92.7", "", "", "", ""], ["Yes", "63", "7.3", "", "", "", ""], 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"structure": {"pmcid": "PMC7230058", "section_index": 10, "section_title": "Association between MICB and clinical characteristics", "row_count": 46, "column_count": 4}, "table": {"label": "Table 2", "caption": "Relationship between MICB and clinical characteristics of primary cohort", "rows": [["Factors", "Primary cohort"], ["MICB expression"], ["Low (%)", "High (%)", "P"], ["All patients", "417", "446", ""], ["Age (years)"], ["≤ 60", "197 (47.2)", "218 (48.9)", "0.631"], ["> 60", "220 (52.8)", "228 (51.1)"], ["Gender", ""], ["Male", "240 (57.6)", "265 (59.4)", "0.579"], ["Female", "177 (42.4)", "181 (40.6)", ""], ["CEA (ng/ml)"], ["≤ 5", "222(53.2)", "228 (51.1)", "0.534"], ["> 5", "195(46.8)", "218 (48.9)"], ["Tumor location"], ["Right-sided colon", "119 (28.5)", "127 (28.5)", "0.937"], ["Left-sided colon", "107 (25.7)", "119 (26.7)"], ["Rectum", "191 (45.8)", "200 (44.8)"], ["Tumor size (cm)"], ["≤ 4.0", "227 (54.4)", "294 (65.9)", "0.001"], ["> 4.0", "190 (45.6)", "152 (34.1)"], 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"locator": "section[10]/table-wrap[1]#Tab2"}}, {"id": "asset:table:pmid:32306128:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:1f009e3876f7ea57acbead9edc95363271c4fb0b20870f4b479027fbb7019a6b", "bytes": 2114, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[11]/table-wrap[1]#Tab3", "version": null, "note": "Cox regression analyses for OS of primary cohort", "structure": {"pmcid": "PMC7230058", "section_index": 11, "section_title": "MICB as prognostic biomarkers", "row_count": 48, "column_count": 5}, "table": {"label": "Table 3", "caption": "Cox regression analyses for OS of primary cohort", "rows": [["Factors", "Overall survival"], ["Univariate analysis", "Multivariate analysis"], ["HR (95% CI)", "P", "HR (95% CI)", "P"], ["Age (years)"], ["≤ 60", "1 (reference)", "0.644", "", ""], ["> 60", "1.053 (0.845–1.312)", ""], ["Gender"], ["Male", "1 (reference)", "0.062", "1 (reference)", "0.339"], ["Female", "0.805 (0.641–1.011)", "0.893 (0.708–1.126)"], ["CEA (ng/ml)"], ["≤ 5", "1 (reference)", "< 0.001", "1 (reference)", "0.003"], ["> 5", "2.540 (2.017–3.197)", "1.441 (1.129–1.840)"], ["Tumor location"], ["Right-sided colon", "1 (reference)", "0.028", "1 (reference)", "0.183"], ["Left-sided colon", "1.000 (0.754–1.326)", "0.854 (0.640–1.139)"], ["Rectum", "0.737 (0.566–0.958)", "0.779 (0.596–1.017)"], ["Tumor size (cm)"], ["≤ 4.0", "1 (reference)", "0.168", "", ""], ["> 4.0", "1.167 (0.937–1.455)", ""], ["Primary histological type"], ["Non-mucinous", "1 (reference)", "0.984", "", ""], ["Mucinous", "0.997 (0.731–1.359)", ""], ["Primary differentiation"], ["Well/moderate", "1 (reference)", "< 0.001", "1 (reference)", "0.098"], ["Poor/anaplastic", "1.628 (1.301–2.038)", "1.213 (0.965–1.525)"], ["T stage"], ["T1/T2", "1 (reference)", "< 0.001", "1 (reference)", "0.062"], ["T3/T4", "3.198 (2.074–4.932)", "1.541 (0.978–2.429)"], ["N 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""], ["CEA (ng/ml)"], ["≤ 5", "1 (reference)", "< 0.001", "1 (reference)", "0.003"], ["> 5", "2.346 (1.641–3.354)", "1.747 (1.209–2.526)"], ["Tumor size (cm)"], ["≤ 4.0", "1 (reference)", "0.306", "", ""], ["> 4.0", "1.203 (0.845–1.714)", ""], ["Primary histological type"], ["Non-mucinous", "1 (reference)", "0.701", "", ""], ["Mucinous", "1.111 (0.648–1.906)", ""], ["Primary differentiation"], ["Well/moderate", "1 (reference)", "0.004", "1 (reference)", "0.098"], ["Poor/anaplastic", "1.667 (1.172–2.371)", "1.358 (0.945–1.951)"], ["T stage"], ["T1/T2", "1 (reference)", "< 0.001", "1 (reference)", "0.351"], ["T3/T4", "2.564 (1.538–4.275)", "1.305 (0.746–2.282)"], ["N stage"], ["N0", "1 (reference)", "< 0.001", "1 (reference)", "0.013"], ["N1/N2", "2.371 (1.652–3.404)", "1.606 (1.104–2.336)"], ["M stage"], ["M0", "1 (reference)", "< 0.001", "1 (reference)", "< 0.001"], ["M1", "5.494 (3.856–7.828)", "4.303 (2.976–6.223)"], ["Vascular invasion"], ["No", "1 (reference)", "0.360", "", ""], ["Yes", "1.269 (0.761–2.116)", ""], ["Nerve invasion"], ["No", "1 (reference)", "0.840", "", ""], ["Yes", "0.935 (0.490–1.785)", ""], ["TNM stage"], ["I", "1 (reference)", "< 0.001", "", ""], ["II", "1.595 (0.755–3.368)", ""], ["III", "2.559 (1.272–5.146)", ""], ["IV", "9.924 (5.058–19.473)", ""], ["MICB"], ["Low", "1 (reference)", "< 0.001", "1 (reference)", "< 0.001"], ["High", "0.492 (0.343–0.705)", "0.510 (0.356–0.733)"]], "row_count": 44, "column_count": 5, "numeric_cells": 67, "header_rows": 3, "locator": "section[12]/table-wrap[1]#Tab4"}}], "gaps": ["asset:data:geo:GSE39582 not downloaded", "asset:data:geo:GSE39582 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": "log_rank_test", "label": "Survival analysis", "dsl_operations": ["logrank_test"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "Kaplan–Meier analysis and Log-rank test were performed to evaluate the relationship between MICB expression and OS."}}, {"id": "method-2", "family": "survival_analysis", "specific": "cox_proportional_hazards", "label": "Survival analysis", "dsl_operations": ["cox_ph"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "cox regression"}}, {"id": "method-3", "family": "contingency_analysis", "specific": "chi_square", "label": "Categorical (contingency table) analysis", "dsl_operations": ["chi_square_test"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["categorical_cross_tabulation"], "evidence": {"score": 0.8, "band": "high", "quote": "Chi-square"}}], "targets": [], "gaps": []}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis 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The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE39582"], "resolved_accessions": ["GSE39582"], "statements": ["The datasets used and analyzed during the current study are available from the corresponding author on reasonable request."], "basis": "The paper names GSE39582 in Gene Expression Omnibus (GEO) repository and the accession resolves in the repository. 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