Identification of nine key genes by bioinformatics analysis for predicting poor prognosis in smoking-induced lung adenocarcinoma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32346404", "kind": "science-record", "revision": 5, "content_hash": "sha256:e92122c8444566a0b402a6f7ba6fbe703a3d9a64c32ef4e1eba9e327f84d7fe5", "created_at": "2026-11-01T15:41:00Z", "updated_at": "2026-11-01T21:23:10Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Identification of nine key genes by bioinformatics analysis for predicting poor prognosis in smoking-induced lung adenocarcinoma.", "doi": "10.2217/lmt-2020-0009", "pmid": "32346404", "authors": ["Chuanli Ren", "Weixiu Sun", "Xu Lian", "Chongxu Han"], "journal": "Lung cancer management", "year": 2020, "abstract": "AIM: To screen and identify key genes related to the development of smoking-induced lung adenocarcinoma (LUAD).\nMATERIALS & METHODS: We obtained data from the GEO chip dataset GSE31210. The differentially expressed genes were screened by GEO2R. The protein interaction network of differentially expressed genes was constructed by STRING and Cytoscape. Finally, core genes were screened. The overall survival time of patients with the core genes was analyzed by Kaplan-Meier method. Gene ontology and Kyoto encyclopedia of genes and genomes bioaccumulation was calculated by DAVID.\nRESULTS: Functional enrichment analysis indicated that nine key genes were actively involved in the biological process of smoking-related LUAD.\nCONCLUSION: 23 core genes and nine key genes among them were correlated with adverse prognosis of LUAD induced by smoking.", "claims": [{"id": "claim-method", "statement": "The overall survival time of patients with the core genes was analyzed by Kaplan–Meier method.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32346404", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "The overall survival time of patients with the core genes was analyzed by Kaplan–Meier method."}], "state": "complete"}, {"id": "claim-data-access", "statement": "Gene expression profile data GSE31210 were downloaded from the GEO database [7], which is the Affymetrix human genome U1332.0 chip [HGU133_Plus_2] (Agilent GPL570 platform). The GSE31210 dataset included 246 lung tissues, 226 fresh frozen tissue specimens of LUAD primary lung adenocarcinoma ADCs of pathological stage I–II and 20 normal lung tissues.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32346404", "locator": "sections[4] \"Data acquisition & genetic screening\" paragraph 2", "quote": "Gene expression profile data GSE31210 were downloaded from the GEO database [7], which is the Affymetrix human genome U1332.0 chip [HGU133_Plus_2] (Agilent GPL570 platform). The GSE31210 dataset included 246 lung tissues, 226 fresh frozen tissue specimens of LUAD primary lung adenocarcinoma ADCs of pathological stage I–II and 20 normal lung tissues."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:32346404"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE31210"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE31210"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:32346404", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.2217/lmt-2020-0009", "sha256": "sha256:eae54d595d124fa0f4ab99c966a2693279c589882af7d61f175865e323063c21", "bytes": 25928, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.2217/lmt-2020-0009", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC7186853", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE31210", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE31210", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE31210", "version": null, "note": "Gene expression profile data GSE31210 were downloaded from the GEO database [7], which is the Affymetrix human genome U1332.0 chip [HGU133_Plus_2] (Agilent GPL570 platform). 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