Key genes associated with non-alcoholic fatty liver disease and acute myocardial infarction.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32594092", "kind": "science-record", "revision": 6, "content_hash": "sha256:f6cff8c55b21e3cbbed3652433edb5b901511d04cb348ce37662fd30d11287eb", "created_at": "2026-11-01T15:41:04Z", "updated_at": "2026-11-01T22:01:48Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Key genes associated with non-alcoholic fatty liver disease and acute myocardial infarction.", "doi": "10.12659/MSM.922492", "pmid": "32594092", "authors": ["Weiran Dai", "Yue Sun", "Zhiyuan Jiang", "Kuan Du", "Ning Xia", "Guoqiang Zhong"], "journal": "Medical science monitor : international medical journal of experimental and clinical research", "year": 2020, "abstract": "BACKGROUND With the increasing research on non-alcoholic fatty liver (NAFLD) and acute myocardial infarction (AMI), many evidences show a tight correlation between NAFLD and AMI, however the underlying pathophysiology is still not clear. This study was to identify the potential hub genes and pathways related to these two diseases via bioinformatic method. MATERIAL AND METHODS Gene Expression Omnibus (GEO) dataset GSE63067 of NAFLD patients and normal controls was downloaded from GEO database. The GSE60993 and GSE66360 datasets for AMI patients and healthy controls were also obtained. Differential expression genes (DEGs) of NAFLD and AMI datasets, accompanied with common genes between them were achieved. Further GO and KEGG enrichment analysis for common genes were performed. RESULTS To obtain the pathogenesis associated with both NAFLD and AMI, protein-protein interaction (PPI) network was constructed and the top ten hub genes (TLR2, LILRB2, CXCL1, FPR1, TLR4, TYROBP, MMP9, FCER1G, CLEC4D and CCR2) were selected with CONCLUSIONS The results of this study suggesting some novel genes may play an important role in the occurrence and progression NAFLD and AMI. But more experimental researches and clinical trials need to verify.", "claims": [{"id": "claim-method", "statement": "Using SPSS 22.0 (SPSS, Inc, Chicago, IL, USA), we constructed receiver operating characteristic (ROC) curves and calculated the area under the curve (AUC) of the hub genes to compare the AUC as the index of the model.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32594092", "locator": "sections[7] \"Statistical analysis\" paragraph 2", "quote": "Using SPSS 22.0 (SPSS, Inc, Chicago, IL, USA), we constructed receiver operating characteristic (ROC) curves and calculated the area under the curve (AUC) of the hub genes to compare the AUC as the index of the model."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The GSE63067 dataset contained the gene expression profiles of 11 NAFLD patients and 7 non-NAFLD controls.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32594092", "locator": "sections[3] \"Microarray data collection\" paragraph 2", "quote": "The GSE63067 dataset contained the gene expression profiles of 11 NAFLD patients and 7 non-NAFLD controls."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:32594092"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE60993"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE60993"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:32594092", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.12659/MSM.922492", "sha256": 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