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pmid:32626531
Application of cAMP-dependent catalytic subunit β (PRKACB) Low Expression in Predicting Worse Overall Survival: A Potential Therapeutic Target for Colorectal Carcinoma.
Xiaoya Yao · Weixian Hu · Jie Zhang · Chengzhi Huang · Haibi Zhao · Xueqing Yao
Journal of Cancer · 2020 doi:10.7150/jca.46156
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Experiment
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Complete file
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However, the prognostic value of PRKACB expression in colorectal cancer (CRC) patients remains controversial. In this analysis, PRKACB expression in CRC tumors was evaluated across the GEO, TCGA, and Oncomine databases, and a PRKACB survival analysis was performed based on the TCGA profile. We detected PRKACB in 7 GEO series (GSE110225, GSE32323, GSE44076, GSE9348, GSE41328, GSE21510, GSE68468) and TCGA spectra (all P <0.05). A meta-analysis performed in the Oncomine database revealed that PRKACB was significantly up-regulated in neoplastic tissues compared to normal tissues (all P <0.05). A Kaplan-Meier analysis demonstrated that lower PRKACB expression in tumors was significantly associated with poorer overall survival (OS) in patients with CRC (P <0.05). A subgroup analysis showed that low expression of PRKACB correlated with poor 1-, 3-, and 5-year OS (all P <0.05). Furthermore, in males (P = 0.0083), whites (P = 0.0463), and non-mucinous adenocarcinoma patients (P = 0.0108), the down-regulation of PRKACB expression was more significant for the OS prognostic value. 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"column_count": 5}, "table": {"label": "Table 2", "caption": "Characteristics of CRC patients between PRKACB high and low groups", "rows": [["", "", "High groups (n=166)", "Low groups (n=165)", "P"], ["Gender✱", "Male (n=185)", "78", "107", "0.001"], ["", "Female (n=146)", "88", "58", ""], ["Age, median(IQR), years✱", "", "61.5(21.75)", "66(17)", "0.022"], ["", "≤60 (n=139)", "80", "59", ""], ["", ">60 (n=192)", "86", "106", ""], ["BMI, kg/m2", "<18.5 (n=4)", "1", "3", "0.836"], ["", "18.5-24.99 (n=86)", "44", "42", ""], ["", "25-29.99 (n=104)", "53", "51", ""], ["", ">29.99 (n=60)", "29", "31", ""], ["Tumor Stage", "T1 (n=10)", "4", "6", "0.849"], ["", "T2 (n=49)", "24", "25", ""], ["", "T3 (n=231)", "115", "116", ""], ["", "T4 (n=40)", "22", "18", ""], ["", "Tis (n=1)", "1", "0", ""], ["Lymph Node Stage", "N0 (n=188)", "91", "97", "0.513"], ["", "N1 (n=87)", "46", "41", ""], ["", "N2 (n=54)", "29", "25", ""], ["", "NX (n=2)", "0", "2", ""], ["Metastasis Stage", "M0 (n=228)", "111", "117", "0.143"], ["", "M1 (n=40)", "26", "14", ""], ["", "MX (n=59)", "28", "31", ""], ["AJCC stage", "I (n=52)", "25", "27", "0.213"], ["", "II (n=125)", "61", "64", ""], ["", "III (n=99)", "47", "52", ""], ["", "IV (n=41)", "27", "14", ""], ["Lymphovascular invasion", "YES (n=89)", "43", "46", "0.910"], ["", "NO (n=206)", "101", "105", ""], ["Perineural Invasion", "YES (n=51)", "30", "21", "0.196"], ["", "NO (n=153)", "74", "79", ""], ["Vascular invasion", "YES (n=61)", "31", "30", "0.674"], ["", "NO (n=226)", "108", "118", ""], ["Race Category", "WHITE (n=232)", "112", "120", "0.479"], ["", "BLACK OR AFRICAN AMERICAN (n=56)", "28", "28", ""], ["", "ASIAN (n=12)", "8", "4", ""], ["", "AMERICAN INDIAN OR ALASKA NATIVE (n=1)", "1", "0", ""], ["Person Neoplasm Status", "TUMOR FREE (n=221)", "115", "106", "0.845"], ["", "WITH TUMOR (n=71)", "36", "35", ""]], "row_count": 38, "column_count": 5, "numeric_cells": 124, "header_rows": 1, "locator": "section[13]/table-wrap[1]#T2"}}], "gaps": 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