Serine Incorporator 2 (SERINC2) Expression Predicts an Unfavorable Prognosis of Low-Grade Glioma (LGG): Evidence from Bioinformatics Analysis.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32642801", "kind": "science-record", "revision": 8, "content_hash": "sha256:eff1692b5e6795fa94776956bc169137c19f6ad62ff18d9f9381d76fa9af7040", "created_at": "2026-11-01T15:41:05Z", "updated_at": "2026-11-01T22:01:54Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Serine Incorporator 2 (SERINC2) Expression Predicts an Unfavorable Prognosis of Low-Grade Glioma (LGG): Evidence from Bioinformatics Analysis.", "doi": "10.1007/s12031-020-01620-w", "pmid": "32642801", "authors": ["Chunxiao Qi", "Lei Lei", "Jinqu Hu", "Gang Wang", "Jiyuan Liu", "Shaowu Ou"], "journal": "Journal of molecular neuroscience : MN", "year": 2020, "abstract": "Serine Incorporator 2 (SERINC2) is a transmembrane protein that incorporates serine into membrane lipids. The function of SERINC2 in tumors has been reported, but the role of SERINC2 in gliomas is not fully understood. RNA-sequencing data from The Cancer Genome Atlas (TCGA) (530 cases of low-grade glioma (LGG) and 173 cases of glioblastoma multiforme (GBM)) and microarray data from Gene Expression Omnibus (GEO) (Accession No. GSE16011, 284 cases gliomas were included) were acquired. Bioinformatics analysis was performed as the primary method to examine the function of SERINC2 and its correlated genes in glioma. SERINC2 was highly expressed in GBM compared with LGG and normal brain tissues. Elevated SERINC2 expression predicted shorter 5-, 10-, and 15-year overall survival (OS) of LGG patients and isocitrate dehydrogenase-1 (IDH-1) mutation-type LGG patients but had no effect on the OS of GBM patients. Cox regression analysis showed that SERINC2 was an independent factor in LGG OS. Methylation analysis found that 13 CpG methylation sites (methylation450k) correlated with SERINC2 expression in LGG. The mRNA expression level of SERINC2 was significant lower in the DNA deletion group than in the intact and amplification groups. A total of 390 copositive and 244 conegative correlation genes with SERINC2 were obtained from LGG in TCGA-LGG and GSE16011. Gene ontology (GO) category and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that the copositive correlation genes were primarily enriched in the mitotic process and cell cycle. Combining the results from the protein-protein interaction (PPI) network of SERINC2 correlation genes and CytoHubba led to the selection of 10 hub genes (CDC20, FN1, AURKB, AURKA, KIF2C, BIRC5, CCNB2, UBE2C, CCNA2, and CENPE). OncoLnc analysis confirmed that high expression levels of these hub genes were associated with poor OS in LGG. Our results suggested that aberrant SERINC2 expression existed in glioma and that its expression might be a potential prognostic marker in LGG patients. CDC20, FN1, AURKB, AURKA, KIF2C, BIRC5, CCNB2, UBE2C, CCNA2, and CENPE may be potential biomarkers and therapeutic targets for LGG.", "claims": [{"id": "claim-method", "statement": "Kaplan-Meier survival analysis was performed to compare the OS data in the two cohorts.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32642801", "locator": "sections[4] \"Statistical Analysis\" paragraph 2", "quote": "Kaplan-Meier survival analysis was performed to compare the OS data in the two cohorts."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The present study was based on RNA sequencing data from TCGA-LGG (530 cases, Illumina HiSeq 2000 RNA Sequencing platform) and TCGA-GBM (173 cases, Illumina HiSeq 2000 RNA Sequencing platform) and microarray data from GSE16011, which contains 8 cases of normal brain tissue as a control group, 159 cases of GBM, and 117 cases of low-grade gliomas (GPL8542 platform, Affymetrix GeneChip Human Genome U133 Plus 2.0 Array).", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32642801", "locator": "sections[3] \"Data Collection and Bioinformatics Analysis\" paragraph 2", "quote": "The present study was based on RNA sequencing data from TCGA-LGG (530 cases, Illumina HiSeq 2000 RNA Sequencing platform) and TCGA-GBM (173 cases, Illumina HiSeq 2000 RNA Sequencing platform) and microarray data from GSE16011, which contains 8 cases of normal brain tissue as a control group, 159 cases of GBM, and 117 cases of low-grade gliomas (GPL8542 platform, Affymetrix GeneChip Human Genome U133 Plus 2.0 Array)."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:32642801"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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