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pmid:32760766
Data on proteome of Mycoplasma hominis cultivated with arginine or thymidine as a carbon source.
Tatiana A Semashko · Daria V Evsyutina · Valentina G Ladygina · Aleksandr I Zubov · Irina V Rakovskaya · Sergey I Kovalchuk · Rustam H Ziganshin · Olga V Pobeguts
Data in brief · 2020 doi:10.1016/j.dib.2020.106034
Paper
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Experiment
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Data
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Analysis
partial
Execution
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Complete file
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This bacterium, like all other Mycoplasma species, is characterized by the reduced genome size, and, consequently, reduction of the main metabolic pathways. M. hominis cells cannot effectively use glucose as a carbon and energy source. Therefore, the main pathway of energy metabolism is the arginine dihydrolase pathway. However, several bacteria can use nucleosides as the sole energy source. Biochemical studies using Salmonella typhimurium have shown that three enzymes (thymidine phosphorylase, phosphopentose mutase and deoxyribose-phosphate aldolase) are involved in the thymidine catabolic pathway. All these enzymes are present in M. hominis. For understanding changes in the energy metabolism of M. hominis we performed shotgun proteome analysis of M. hominis cells in liquid medium with arginine or thymidine as a carbon source. LC-MS analysis was performed with an Ultimate 3000 Nano LC System (Thermo Fisher Scientific) coupled to a Q Exactive HF benchtop Orbitrap mass spectrometer (Thermo Fisher Scientific) via a nanoelectrospray source (Thermo Fisher Scientific). 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