Intratumoral Adipocyte-High Breast Cancer Enrich for Metastatic and Inflammation-Related Pathways but Associated with Less Cancer Cell Proliferation.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32796516", "kind": "science-record", "revision": 8, "content_hash": "sha256:03420770f0d31985252267742028819ddef0fe702bb368023f14163f6d90734a", "created_at": "2026-11-01T15:41:07Z", "updated_at": "2026-11-01T22:02:02Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Intratumoral Adipocyte-High Breast Cancer Enrich for Metastatic and Inflammation-Related Pathways but Associated with Less Cancer Cell Proliferation.", "doi": "10.3390/ijms21165744", "pmid": "32796516", "authors": ["Yoshihisa Tokumaru", "Masanori Oshi", "Eriko Katsuta", "Li Yan", "Jing Li Huang", "Masayuki Nagahashi", "Nobuhisa Matsuhashi", "Manabu Futamura", "Kazuhiro Yoshida", "Kazuaki Takabe"], "journal": "International journal of molecular sciences", "year": 2020, "abstract": "Cancer-associated adipocytes are known to cause inflammation, leading to cancer progression and metastasis. The clinicopathological and transcriptomic data from 2256 patients with breast cancer were obtained based on three cohorts: The Cancer Genome Atlas (TCGA), GSE25066, and a study by Yau et al. For the current study, we defined the adipocyte, which is calculated by utilizing a computational algorithm, xCell, as \"intratumoral adipocyte\". These intratumoral adipocytes appropriately reflected mature adipocytes in a bulk tumor. The amount of intratumoral adipocytes demonstrated no relationship with survival. Intratumoral adipocyte-high tumors significantly enriched for metastasis and inflammation-related gene sets and are associated with a favorable tumor immune microenvironment, especially in the ER+/HER2- subtype. On the other hand, intratumoral adipocyte-low tumors significantly enriched for cell cycle and cell proliferation-related gene sets. Correspondingly, intratumoral adipocyte-low tumors are associated with advanced pathological grades and inversely correlated with MKI67 expression. In conclusion, a high amount of intratumoral adipocytes in breast cancer was associated with inflammation, metastatic pathways, cancer stemness, and favorable tumor immune microenvironment. However, a low amount of adipocytes was associated with a highly proliferative tumor in ER-positive breast cancer. This cancer biology may explain the reason why patient survival did not differ by the amount of adipocytes.", "claims": [{"id": "claim-method", "statement": "Kaplan–Meier survival analysis was performed with greyzoneSurv packages in R for the survival analysis.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32796516", "locator": "sections[16] \"4.4. Statistical Analysis\" paragraph 2", "quote": "Kaplan–Meier survival analysis was performed with greyzoneSurv packages in R for the survival analysis."}], "state": "complete"}, {"id": "claim-data-access", "statement": "A total of 1090 patient clinicopathological and gene expression data of The Cancer Genome Atlas (TCGA) Pan-Cancer study (TCGA PanCancer Atlas) was obtained through cBioPortal as previously described [17,19,40,41,48,60,61].", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32796516", "locator": "sections[13] \"4.1. 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