Assessment of the Microbiome Role in Skin Protection Against UV Irradiation Via Network Analysis.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32802281", "kind": "science-record", "revision": 4, "content_hash": "sha256:fbc3941f179823bdb3a1a8527df94ec9682c0dbf1b197cff45b4950e2cca7d86", "created_at": "2026-11-01T17:33:58Z", "updated_at": "2026-11-01T22:02:02Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Assessment of the Microbiome Role in Skin Protection Against UV Irradiation Via Network Analysis.", "doi": "10.34172/jlms.2020.40", "pmid": "32802281", "authors": ["Mohammad Hossein Heidari", "Mohammadreza Razzaghi", "Alireza Akbarzadeh Baghban", "Mohammad Rostami-Nejad", "Mostafa Rezaei-Tavirani", "Mona Zamanian Azodi", "Alireza Zali", "Alireza Ahmadzadeh"], "journal": "Journal of lasers in medical sciences", "year": 2020, "abstract": "Introduction: Diverse microbiotas which have some contributions to gene expression reside in human skin. To identify the protective role of the skin microbiome against UV exposure, proteinprotein interaction (PPI) network analysis is used to assessment gene expression alteration. Methods: A microarray dataset, GEO accession number GSE117359, was considered in this respect. Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R. The top significant DEGs were assigned for network analysis via Cytoscape 3.7.2 and its applications. Results: A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes. The gene ontology analysis of Il6, Cxcl2, Cxcl1, TNF, Il10, Cxcl10, and Mmp9 showed that the crucial genes were highly enriched in the immune system. Conclusion: The skin microbiome plays a significant role in the protection of skin against UV irradiation and the role of TNF and IL6 is prominent in this regard.", "claims": [{"id": "claim-method", "statement": "Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32802281", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R."}], "state": "complete"}, {"id": "claim-data-access", "statement": "A microarray dataset, GEO accession number GSE117359, was considered in this respect.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32802281", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "A microarray dataset, GEO accession number GSE117359, was considered in this respect."}], "state": "complete"}, {"id": "claim-target-result", "statement": "A total of 28 genes were identified as significant DEGs.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:32802281", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "A microarray dataset, GEO accession number GSE117359, was considered in this respect."}, {"asset": "source:pmid:32802281", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R."}, {"asset": "source:pmid:32802281", "locator": "sections[0] \"Abstract\" paragraph 3", "quote": "A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "A total of 28 genes were identified as significant DEGs.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:32802281"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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