Neuroprotective Properties of Photobiomodulation in Retinal Regeneration in Rats: Perspectives From Interaction Levels.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32802288", "kind": "science-record", "revision": 4, "content_hash": "sha256:46ddc0423e9aad5b11845f00a45558b180ab8b116dd22243501ba9035943e224", "created_at": "2026-11-01T17:33:58Z", "updated_at": "2026-11-01T22:02:02Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Neuroprotective Properties of Photobiomodulation in Retinal Regeneration in Rats: Perspectives From Interaction Levels.", "doi": "10.34172/jlms.2020.47", "pmid": "32802288", "authors": ["Vahid Mansouri", "Mohammadreza Razzaghi", "Mohammad Rostami-Nejad", "Majid Rezaei-Tavirani", "Mohammad Hossein Heidari", "Saeed Safari", "Babak Arjmand", "Mostafa Rezaei-Tavirani", "Alireza Zali", "Mostafa Hamdieh"], "journal": "Journal of lasers in medical sciences", "year": 2020, "abstract": "Introduction: Photobiomodulation (PBM) is known as low-level laser (or light) therapy and is applied in different fields of medicine. However, it is required that its molecular and cellular mechanism be investigated. This study aims to assess the neuroprotective properties of PBM in the rat retina. Methods: GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment. Results: The 78 produced DEGs by light-damage in the rat retina were protected via PBM pretreatment action. Among these determined DEGs, 53 individuals were included in the main connected component of the constructed protein-protein interaction (PPI) network. Ccl2, Icam1, Cxcl10, Timp1, and Fos were determined as hub nodes. Eight clusters including 26 regulated biochemical pathways by PBM pretreatment were identified. The critical DEGs based on the action maps were introduced. Conclusion: The finding indicates that PBM treatment protects rat retina against light damage via the prevention of Fos, Ccl2, Icam1, Cxcl10, and Myc dysregulation.", "claims": [{"id": "claim-method", "statement": "GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32802288", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment."}], "state": "complete"}, {"id": "claim-data-access", "statement": "GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32802288", "locator": "sections[0] \"Abstract\" paragraph 2", "quote": "GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment."}], "state": "complete"}, {"id": "claim-target-result", "statement": "The finding indicates that PBM treatment protects rat retina against light damage via the prevention of Fos, Ccl2, Icam1, Cxcl10, and Myc dysregulation.", "kind": "qualitative", "target": null, "evidence": [{"asset": "source:pmid:32802288", "locator": "sections[0] \"Abstract\" paragraph 4", "quote": "The finding indicates that PBM treatment protects rat retina against light damage via the prevention of Fos, Ccl2, Icam1, Cxcl10, and Myc dysregulation."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": "The finding indicates that PBM treatment protects rat retina against light damage via the prevention of Fos, Ccl2, Icam1, Cxcl10, and Myc dysregulation.", "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:32802288"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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