Potential mechanism of RRM2 for promoting Cervical Cancer based on weighted gene co-expression network analysis.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32922202", "kind": "science-record", "revision": 7, "content_hash": "sha256:6acd4c55239dc4063bdd914806a4cdba357de3f480f997ee40678a2a370cb9d4", "created_at": "2026-11-01T15:41:10Z", "updated_at": "2026-11-01T22:02:10Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Potential mechanism of RRM2 for promoting Cervical Cancer based on weighted gene co-expression network analysis.", "doi": "10.7150/ijms.47356", "pmid": "32922202", "authors": ["Jingtao Wang", "Yuexiong Yi", "Yurou Chen", "Yao Xiong", "Wei Zhang"], "journal": "International journal of medical sciences", "year": 2020, "abstract": "Cervical cancer is the most common gynecologic malignant tumor, with a high incidence in 50-55-year-olds. This study aims to investigate the potential molecular mechanism of RRM2 for promoting the development of cervical cancer based on The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). RRM2 was found to be significant upregulated in cervical tissue (P<0.05) by extracting the expression of RRM2 from TCGA, GSE63514, GSE7410, GSE7803 and GSE9750. Survival analysis indicated that the overall survival was significantly worse in the patients with high-expression of RRM2 (P<0.05). The top 1000 positively/negatively correlated genes with RRM2 by Pearson Correlation test were extracted. The gene co-expression network by Weighted Gene Co-Expression Network Analysis (WGCNA) with these genes and the clinical characteristics (lymphocyte infiltration, monocyte infiltration, necrosis, neutrophil infiltration, the number of normal/stromal/tumor cells and the number of tumor nuclei) was constructed. By screening the hub nodes from the co-expression network, results suggested that RRM2 may co-express with relevant genes to regulate the number of stromal/tumor cells and the process of lymphocyte infiltration to promote the progression of cervical cancer. RRM2 is likely to become a novel potential diagnostic and prognostic biomarker of cervical cancer and provide evidence to support the study of mechanisms for cervical cancer.", "claims": [{"id": "claim-method", "statement": "The comparison for each clinical characteristic between each classification in RRM2 expression was performed by student-t test.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32922202", "locator": "sections[4] \"Expression distribution of RRM2 in cervical cancer tissues and patients' characteristics\" paragraph 2", "quote": "The comparison for each clinical characteristic between each classification in RRM2 expression was performed by student-t test."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The datasets used and/or analyzed during the current study are available in TCGA and GEO.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32922202", "locator": "sections[21] \"Availability of data and materials\" paragraph 2", "quote": "The datasets used and/or analyzed during the current study are available in TCGA and GEO."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "partial", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:32922202"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE63514"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "blocked", "blocked_on": "method:student_t", "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:GSE63514"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": ["step:run_analysis blocked on method:student_t"]}, "data": {"state": "partial", "assets": [{"id": "source:pmid:32922202", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.7150/ijms.47356", "sha256": "sha256:948a72c472a06657176035c0c9dfc1f36498104a2d68ea5edc9414c0c3bc073a", "bytes": 39989, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.7150/ijms.47356", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC7484645", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:GSE63514", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63514", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE63514", "version": null, "note": "The datasets used and/or analyzed during the current study are available in TCGA and GEO.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets used and/or analyzed during the current study are available in TCGA and GEO.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1551311", "GSM1551312", "GSM1551313", "GSM1551314", "GSM1551315", "GSM1551316", "GSM1551317", "GSM1551318", "GSM1551319", "GSM1551320", "GSM1551321", "GSM1551322", "GSM1551323", "GSM1551324", "GSM1551325", "GSM1551326", "GSM1551327", "GSM1551328", "GSM1551329", "GSM1551330", "GSM1551331", "GSM1551332", "GSM1551333", "GSM1551334", "GSM1551335", "GSM1551336", "GSM1551337", "GSM1551338", "GSM1551339", "GSM1551340", "GSM1551341", "GSM1551342", "GSM1551343", "GSM1551344", "GSM1551345", "GSM1551346", "GSM1551347", "GSM1551348", "GSM1551349", "GSM1551350", "GSM1551351", "GSM1551352", "GSM1551353", "GSM1551354", "GSM1551355", "GSM1551356", "GSM1551357", "GSM1551358", "GSM1551359", "GSM1551360", "GSM1551361", "GSM1551362", "GSM1551363", "GSM1551364", "GSM1551365", "GSM1551366", "GSM1551367", "GSM1551368", "GSM1551369", "GSM1551370", "GSM1551371", "GSM1551372", "GSM1551373", "GSM1551374", "GSM1551375", "GSM1551376", "GSM1551377", "GSM1551378", "GSM1551379", "GSM1551380", "GSM1551381", "GSM1551382", "GSM1551383", "GSM1551384", "GSM1551385", "GSM1551386", "GSM1551387", "GSM1551388", "GSM1551389", "GSM1551390", "GSM1551391", "GSM1551392", "GSM1551393", "GSM1551394", "GSM1551395", "GSM1551396", "GSM1551397", "GSM1551398", "GSM1551399", "GSM1551400", "GSM1551401", "GSM1551402", "GSM1551403", "GSM1551404", "GSM1551405", "GSM1551406", "GSM1551407", "GSM1551408", "GSM1551409", "GSM1551410", "GSM1551411", "GSM1551412", "GSM1551413", "GSM1551414", "GSM1551415", "GSM1551416", "GSM1551417", "GSM1551418", "GSM1551419", "GSM1551420", "GSM1551421", "GSM1551422", "GSM1551423", "GSM1551424", "GSM1551425", "GSM1551426", "GSM1551427", "GSM1551428", "GSM1551429", "GSM1551430", "GSM1551431", "GSM1551432", "GSM1551433", "GSM1551434", "GSM1551435", "GSM1551436", "GSM1551437", "GSM1551438"], "sample_count": 128, "group_sizes": null, "group_sizes_basis": null, "platform": "570", "taxon": "Homo sapiens", "title": "Gene expression analysis of cervical cancer progression", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE7410", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE7410", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE7410", "version": null, "note": "The datasets used and/or analyzed during the current study are available in TCGA and GEO.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "The datasets used and/or analyzed during the current study are available in TCGA and GEO.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM178828", "GSM178829", "GSM178830", "GSM178831", "GSM178832", "GSM178833", "GSM178834", "GSM178835", "GSM178836", "GSM178837", "GSM178838", "GSM178839", "GSM178840", "GSM178841", "GSM178842", "GSM178843", "GSM178844", "GSM178845", "GSM178846", "GSM178847", "GSM178848", "GSM178849", "GSM178850", "GSM178851", "GSM178852", "GSM178853", "GSM178854", "GSM178855", "GSM178856", "GSM178857", "GSM178858", "GSM178859", "GSM178860", "GSM178861", "GSM178862", "GSM178863", "GSM178864", "GSM178865", "GSM178866", "GSM178867", "GSM178868", "GSM178869", "GSM178870", "GSM178871", "GSM178872"], "sample_count": 45, "group_sizes": null, "group_sizes_basis": null, "platform": "1708", "taxon": "Homo sapiens", "title": "Gene expression in early stage cervical cancer", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:32922202:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:380d091fa43adbe0d4d40c3aa976bba9909d048143e2e8fabf310243f2efba92", "bytes": 563, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[3]/table-wrap[1]#T1", "version": null, "note": "Basic characteristics of the four microarray datasets from GEO", "structure": {"pmcid": "PMC7484645", "section_index": 3, "section_title": "Raw data", "row_count": 5, "column_count": 7}, "table": {"label": "Table 1", "caption": "Basic characteristics of the four microarray datasets from GEO", "rows": [["Profile", "RNA type", "Platform", "Organism", "Sample size (T/N)", "Published Year", "Country"], ["GSE63514", "mRNA", "GPL570", "Homo sapiens", "28/24", "2015", "USA"], ["GSE7410", "mRNA", "GPL1708", "Homo sapiens", "40/5", "2008", "Netherlands"], ["GSE7803", "mRNA", "GPL96", "Homo sapiens", "3/10", "2007", "USA"], ["GSE9750", "mRNA", "GPL96", "Homo sapiens", "42/24", "2008", "USA"]], "row_count": 5, "column_count": 7, "numeric_cells": 16, "header_rows": 1, "locator": "section[3]/table-wrap[1]#T1"}}, {"id": "asset:table:pmid:32922202:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:9f68dfbc3550fd7cea9b63408cb47e740523445f1af7da785b8fd3b453b46591", "bytes": 584, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#T2", "version": null, "note": "Top 10 positively correlated genes with RRM2", "structure": {"pmcid": "PMC7484645", "section_index": 6, "section_title": "Co-expression analysis with RRM2", "row_count": 11, "column_count": 4}, "table": {"label": "Table 2", "caption": "Top 10 positively correlated genes with RRM2", "rows": [["Gene", "Cor.", "P value", "Sample size"], ["TCF19", "0.539", "2.51e-24", "304"], ["CDCA8", "0.519", "2.53e-22", "304"], ["CENPO", "0.505", "4.63e-21", "304"], ["CCNA2", "0.496", "2.68e-20", "304"], ["KIF2C", "0.493", "4.81e-20", "304"], ["KIF4A", "0.491", "8.28e-20", "304"], ["RACGAP1", "0.488", "1.41e-19", "304"], ["ORC1L", "0.486", "1.87e-19", "304"], ["KIFC1", "0.481", "4.77e-19", "304"], ["MELK", "0.474", "1.97e-18", "304"]], "row_count": 11, "column_count": 4, "numeric_cells": 31, "header_rows": 1, "locator": "section[13]/table-wrap[1]#T2"}}, {"id": "asset:table:pmid:32922202:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:88045a98060e662f8abf8bc255ce9633d26710978059419027e3319cdaae5109", "bytes": 612, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#T3", "version": null, "note": "Top 10 negatively correlated genes with RRM2", "structure": {"pmcid": "PMC7484645", "section_index": 6, "section_title": "Co-expression analysis with RRM2", "row_count": 11, "column_count": 4}, "table": {"label": "Table 3", "caption": "Top 10 negatively correlated genes with RRM2", "rows": [["Gene", "Cor.", "P value", "Sample size"], ["PCMTD1", "-0.374", "1.69e-11", "304"], ["TP53INP1", "-0.362", "7.19e-11", "304"], ["ZNF582", "-0.358", "1.32e-10", "304"], ["ZNF737", "-0.356", "1.55e-10", "304"], ["TMEM150A", "-0.345", "6.20e-10", "304"], ["ZNF248", "-0.343", "7.99e-10", "304"], ["LOC144571", "-0.339", "1.31e-09", "304"], ["FAM171A1", "-0.337", "1.57e-09", "304"], ["ZNF626", "-0.335", "2.05e-09", "304"], ["RNF170", "-0.334", "2.39e-09", "304"]], "row_count": 11, "column_count": 4, "numeric_cells": 39, "header_rows": 1, "locator": "section[13]/table-wrap[2]#T3"}}, {"id": "asset:table:pmid:32922202:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:9f68dfbc3550fd7cea9b63408cb47e740523445f1af7da785b8fd3b453b46591", "bytes": 584, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#T2", "version": null, "note": "Top 10 positively correlated genes with RRM2", "structure": {"pmcid": "PMC7484645", "section_index": 13, "section_title": "Co-expression analysis with RRM2", "row_count": 11, "column_count": 4}, "table": {"label": "Table 2", "caption": "Top 10 positively correlated genes with RRM2", "rows": [["Gene", "Cor.", "P value", "Sample size"], ["TCF19", "0.539", "2.51e-24", "304"], ["CDCA8", "0.519", "2.53e-22", "304"], ["CENPO", "0.505", "4.63e-21", "304"], ["CCNA2", "0.496", "2.68e-20", "304"], ["KIF2C", "0.493", "4.81e-20", "304"], ["KIF4A", "0.491", "8.28e-20", "304"], ["RACGAP1", "0.488", "1.41e-19", "304"], ["ORC1L", "0.486", "1.87e-19", "304"], ["KIFC1", "0.481", "4.77e-19", "304"], ["MELK", "0.474", "1.97e-18", "304"]], "row_count": 11, "column_count": 4, "numeric_cells": 31, "header_rows": 1, "locator": "section[13]/table-wrap[1]#T2"}}, {"id": "asset:table:pmid:32922202:5", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:88045a98060e662f8abf8bc255ce9633d26710978059419027e3319cdaae5109", "bytes": 612, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[2]#T3", "version": null, "note": "Top 10 negatively correlated genes with RRM2", "structure": {"pmcid": "PMC7484645", "section_index": 13, "section_title": "Co-expression analysis with RRM2", "row_count": 11, "column_count": 4}, "table": {"label": "Table 3", "caption": "Top 10 negatively correlated genes with RRM2", "rows": [["Gene", "Cor.", "P value", "Sample size"], ["PCMTD1", "-0.374", "1.69e-11", "304"], ["TP53INP1", "-0.362", "7.19e-11", "304"], ["ZNF582", "-0.358", "1.32e-10", "304"], ["ZNF737", "-0.356", "1.55e-10", "304"], ["TMEM150A", "-0.345", "6.20e-10", "304"], ["ZNF248", "-0.343", "7.99e-10", "304"], ["LOC144571", "-0.339", "1.31e-09", "304"], ["FAM171A1", "-0.337", "1.57e-09", "304"], ["ZNF626", "-0.335", "2.05e-09", "304"], ["RNF170", "-0.334", "2.39e-09", "304"]], "row_count": 11, "column_count": 4, "numeric_cells": 39, "header_rows": 1, "locator": "section[13]/table-wrap[2]#T3"}}], "gaps": ["asset:data:geo:GSE63514 not downloaded", "asset:data:geo:GSE63514 licence not read", "asset:data:geo:GSE7410 not downloaded", "asset:data:geo:GSE7410 licence not read"]}, "analysis": {"state": "partial", "methods": [{"id": "method-1", "family": "group_comparison", "specific": "student_t_test", "label": "Group comparison", "dsl_operations": [], "missing_operations": ["student_t"], "expressible": false, "parameters": {}, "data_shapes": ["two_or_more_groups_continuous"], "evidence": {"score": 1.0, "band": "verbatim", "quote": "The comparison for each clinical characteristic between each classification in RRM2 expression was performed by student-t test."}}, {"id": "method-2", "family": "survival_analysis", "specific": "log_rank_test", "label": "Survival analysis", "dsl_operations": ["logrank_test"], "missing_operations": [], "expressible": true, "parameters": {"p_value": "The P value obtained from a log-ran"}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "log-rank"}}, {"id": "method-3", "family": "correlation_analysis", "specific": "pearson", "label": "Correlation analysis", "dsl_operations": ["pearson_r"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["paired_numeric_columns"], "evidence": {"score": 0.7, "band": "medium", "quote": "Pearson Correlation"}}], "targets": [], "gaps": ["method.reader_differs_from_extractor", "method.student_t"]}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": false, "required_operations": [], "missing_operations": ["student_t"], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: student_t_test."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["GSE63514", "GSE7410", "GSE7803 and GSE9750"], "resolved_accessions": ["GSE63514", "GSE7410"], "statements": ["The datasets used and/or analyzed during the current study are available in TCGA and GEO."], "basis": "The paper names GSE63514, GSE7410 in Gene Expression Omnibus (GEO) and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": [], "assets": ["source:pmid:32922202", "data:geo:GSE63514", "asset:table:pmid:32922202:1", "asset:table:pmid:32922202:2", "asset:table:pmid:32922202:3", "asset:table:pmid:32922202:4", "asset:table:pmid:32922202:5"], "steps": []}, "must_build": {"dsl_operations": [{"operation": "student_t", "unlocks_papers": null, "priority": null}], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:GSE63514"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T18:22:32Z", "independence": "single_reader"}, "evidence_check": {"method": "verbatim", "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 32147, "completion_tokens": 1011, "cached_tokens": 256}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:32922202", "type": "paper", "label": "pmid:32922202"}, {"id": "source:pmid:32922202", "type": "manuscript", "label": "PMID 32922202 full text"}, {"id": "data:geo:GSE63514", "type": "dataset", "label": "GEO GSE63514"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:32922202", "type": "paper", "label": "pmid:32922202"}, {"id": "source:pmid:32922202", "type": "manuscript", "label": "PMID 32922202 full text"}, {"id": "data:geo:GSE63514", "type": "dataset", "label": "GEO GSE63514"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-32922202", "type": "extraction", "used": ["source:pmid:32922202"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-GSE63514", "type": "accession_resolution", "used": ["data:geo:GSE63514"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:32922202", "parent_hash": "sha256:bd39523f5fc3d01c0b6d1b08c8f04f120ede8b0475c4c1da5a314c1f29fbaecb", "fork_of": null, "generation": 6}, "gaps": ["asset:data:geo:GSE63514 licence not read", "asset:data:geo:GSE63514 not downloaded", "asset:data:geo:GSE7410 licence not read", "asset:data:geo:GSE7410 not downloaded", "execution.not_run", "method.reader_differs_from_extractor", "method.student_t", "review.human_critique", "review.independent_reader", "review.machine_critique", "step:run_analysis blocked on method:student_t"], "assays": [{"role": "analysis", "definition_id": "group_comparison", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": [], "support_state": "partial", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 1.0, "evidence": ["The comparison for each clinical characteristic between each classification in RRM2 expression was performed by student-t test."], "order_basis": "analysis_only", "id": "assay:1"}]}