Corpus Engine Towards a reproducible .science file.
← All .science files

pmid:32963529

Bioinformatic Identification of Neuroblastoma Microenvironment-Associated Biomarkers with Prognostic Value.

Yi Wang · Huan Luo · Jing Cao · Chao Ma

Journal of oncology · 2020 doi:10.1155/2020/5943014

Paper

complete

Experiment

complete

Data

partial

Analysis

complete

Execution

absent

Execution evidence has not yet been added to this .science file. Explore its methods, data and open questions to plan the next step.
Record details sci_version · id · kind · revision · content_hash · schema · created_at · updated_at · generator
id
pmid:32963529
kind
science-record
content_hash
sha256:dac3e96cfa1ee4def1c3f5e8917013f629c21d2a09938301d295947b46f069a7
schema
https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json
created_at
2026-11-01T15:41:11Z
updated_at
2026-11-01T21:23:50Z
generator object · 2 fields
name
corpus-assay-engine
run_id
reading-sci-2026-11-01
paper object · 10 fields
state
complete
title
Bioinformatic Identification of Neuroblastoma Microenvironment-Associated Biomarkers with Prognostic Value.
doi
10.1155/2020/5943014
pmid
32963529
authors array · 4 items
[0]
Yi Wang
[1]
Huan Luo
[2]
Jing Cao
[3]
Chao Ma
journal
Journal of oncology
year
2020
abstract
The microenvironment plays a vital role in the tumor recurrence of neuroblastoma. This research aimed at exploring prognostic genes that are involved in neuroblastoma microenvironment. We used "estimate" R package to calculate the immune/stromal/ESTIMATE scores of each sample of ArrayExpress dataset E-MTAB-8248 based on the ESTIMATE algorithm. Then we found that immune/stromal/ESTIMATE scores were not correlated with age/chromosome 11q, but tumor stage, MYCN gene amplifications, and chromosome 1p. Samples were then divided into high- and low-score groups, and 280 common differentially expressed genes (DEGs) were identified. 64 potential prognostic genes were harvested through overall survival analysis from the common DEGs. 14 prognostic genes (ABCA6, SEPP1, SLAMF8, GPR171, ABCA9, ARHGAP15, IL7R, HLA-DPB1, GZMA, GPR183, CCL19, ITK, FGL2, and CD1C) were obtained after screening in two independent cohorts. GO and KEGG analysis discovered that common DEGs and 64 potential prognostic genes are mainly involved in T-cell activation, lymphocyte activation regulation, leukocyte migration, and the interaction of cytokines and cytokine receptors. Correlation analysis showed that all prognostic genes were negatively correlated with MYCN amplification. Cox analysis identified 5 independent prognostic genes (ARHGAP15, ABCA9, CCL19, SLAMF8, and CD1C).
claims array · 1 item
[0] object · 6 fields
id
claim-data-access
statement
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
kind
methodological
target
null
evidence array · 1 item
[0] object · 3 fields
asset
source:pmid:32963529
locator
sections[23] "Data Availability" paragraph 2
quote
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
state
complete
gaps array · 0 items
experiment object · 8 fields
state
complete
objective
null
steps array · 3 items
[0] object · 13 fields
id
read_published_estimate
order
1
name
Read the published estimate from the source
kind
other
state
complete
blocked_on
null
description
The claim, method and evidence span published with the source article.
parameters object · 0 fields
inputs array · 1 item
[0]
source:pmid:32963529
outputs array · 1 item
[0]
the published estimate and its evidence
instruments array · 0 items
reagents array · 0 items
[1] object · 13 fields
id
obtain_source_data
order
2
name
Obtain the source data from the named repository
kind
data-preparation
state
complete
blocked_on
null
description
The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.
parameters object · 0 fields
inputs array · 1 item
[0]
data:geo:E-MTAB-8248
outputs array · 1 item
[0]
the source data with its repository provenance
instruments array · 0 items
reagents array · 0 items
[2] object · 13 fields
id
run_analysis
order
3
name
Run the published analysis
kind
analysis
state
complete
blocked_on
null
description
Apply the paper's statistical method to the resolved series and compare the result with the published target.
parameters object · 1 field
p_value
E-MTAB-8248 cohort with p value tested in the log-rank
inputs array · 1 item
[0]
data:geo:E-MTAB-8248
outputs array · 1 item
[0]
the replicated result and its comparison
instruments array · 0 items
reagents array · 0 items
materials array · 0 items
instruments array · 0 items
reagents array · 0 items
conditions object · 0 fields
gaps array · 0 items
data object · 3 fields
state
partial
assets array · 9 items
[0] object · 15 fields
id
source:pmid:32963529
role
manuscript
format
xml
media_type
application/xml
uri
https://doi.org/10.1155/2020/5943014
sha256
sha256:f25c826ff4b3cf54b143a5ae37a1c0dc8c89acefa146a42956cbb24841b59cde
bytes
40029
access
open
state
resolved
reader
null
reader_status
reader_required
identifier
10.1155/2020/5943014
version
null
note
Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.
structure object · 4 fields
pmcid
PMC7501561
source
europe_pmc_fulltext
coverage
whole_body
text_hash_scope
rendered_section_body
[1] object · 15 fields
id
data:geo:E-MTAB-8248
role
raw
format
geo-series
media_type
application/vnd.ncbi.geo-series+json
uri
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=E-MTAB-8248
sha256
null
bytes
null
access
open
state
resolved
reader
null
reader_status
reader_required
identifier
E-MTAB-8248
version
null
note
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
structure object · 15 fields
repository
GEO
access_route
GEO accession URL
access_statement_verbatim
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
access_statement_kind
data_availability_statement
sample_accessions array · 0 items
sample_count
null
group_sizes
null
group_sizes_basis
null
platform
null
taxon
null
title
null
resolution_checked_at
2026-10-31T18:29:04Z
resolution_check
identifier_resolution_only_no_download_no_licence_read
downloaded
false
licence_read
false
[2] object · 15 fields
id
data:geo:GSE49710
role
raw
format
geo-series
media_type
application/vnd.ncbi.geo-series+json
uri
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49710
sha256
null
bytes
null
access
open
state
resolved
reader
null
reader_status
reader_required
identifier
GSE49710
version
null
note
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
structure object · 15 fields
repository
GEO
access_route
GEO accession URL
access_statement_verbatim
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
access_statement_kind
data_availability_statement
sample_accessions array · 498 items
[0]
GSM1205238
[1]
GSM1205239
[2]
GSM1205240
[3]
GSM1205241
[4]
GSM1205242
[5]
GSM1205243
[6]
GSM1205244
[7]
GSM1205245
[8]
GSM1205246
[9]
GSM1205247
[10]
GSM1205248
[11]
GSM1205249
[12]
GSM1205250
[13]
GSM1205251
[14]
GSM1205252
[15]
GSM1205253
[16]
GSM1205254
[17]
GSM1205255
[18]
GSM1205256
[19]
GSM1205257
[20]
GSM1205258
[21]
GSM1205259
[22]
GSM1205260
[23]
GSM1205261
[24]
GSM1205262
[25]
GSM1205263
[26]
GSM1205264
[27]
GSM1205265
[28]
GSM1205266
[29]
GSM1205267
[30]
GSM1205268
[31]
GSM1205269
[32]
GSM1205270
[33]
GSM1205271
[34]
GSM1205272
[35]
GSM1205273
[36]
GSM1205274
[37]
GSM1205275
[38]
GSM1205276
[39]
GSM1205277
[40]
GSM1205278
[41]
GSM1205279
[42]
GSM1205280
[43]
GSM1205281
[44]
GSM1205282
[45]
GSM1205283
[46]
GSM1205284
[47]
GSM1205285
[48]
GSM1205286
[49]
GSM1205287
[50]
GSM1205288
[51]
GSM1205289
[52]
GSM1205290
[53]
GSM1205291
[54]
GSM1205292
[55]
GSM1205293
[56]
GSM1205294
[57]
GSM1205295
[58]
GSM1205296
[59]
GSM1205297
[60]
GSM1205298
[61]
GSM1205299
[62]
GSM1205300
[63]
GSM1205301
[64]
GSM1205302
[65]
GSM1205303
[66]
GSM1205304
[67]
GSM1205305
[68]
GSM1205306
[69]
GSM1205307
[70]
GSM1205308
[71]
GSM1205309
[72]
GSM1205310
[73]
GSM1205311
[74]
GSM1205312
[75]
GSM1205313
[76]
GSM1205314
[77]
GSM1205315
[78]
GSM1205316
[79]
GSM1205317
[80]
GSM1205318
[81]
GSM1205319
[82]
GSM1205320
[83]
GSM1205321
[84]
GSM1205322
[85]
GSM1205323
[86]
GSM1205324
[87]
GSM1205325
[88]
GSM1205326
[89]
GSM1205327
[90]
GSM1205328
[91]
GSM1205329
[92]
GSM1205330
[93]
GSM1205331
[94]
GSM1205332
[95]
GSM1205333
[96]
GSM1205334
[97]
GSM1205335
[98]
GSM1205336
[99]
GSM1205337
[100]
GSM1205338
[101]
GSM1205339
[102]
GSM1205340
[103]
GSM1205341
[104]
GSM1205342
[105]
GSM1205343
[106]
GSM1205344
[107]
GSM1205345
[108]
GSM1205346
[109]
GSM1205347
[110]
GSM1205348
[111]
GSM1205349
[112]
GSM1205350
[113]
GSM1205351
[114]
GSM1205352
[115]
GSM1205353
[116]
GSM1205354
[117]
GSM1205355
[118]
GSM1205356
[119]
GSM1205357
[120]
GSM1205358
[121]
GSM1205359
[122]
GSM1205360
[123]
GSM1205361
[124]
GSM1205362
[125]
GSM1205363
[126]
GSM1205364
[127]
GSM1205365
[128]
GSM1205366
[129]
GSM1205367
[130]
GSM1205368
[131]
GSM1205369
[132]
GSM1205370
[133]
GSM1205371
[134]
GSM1205372
[135]
GSM1205373
[136]
GSM1205374
[137]
GSM1205375
[138]
GSM1205376
[139]
GSM1205377
[140]
GSM1205378
[141]
GSM1205379
[142]
GSM1205380
[143]
GSM1205381
[144]
GSM1205382
[145]
GSM1205383
[146]
GSM1205384
[147]
GSM1205385
[148]
GSM1205386
[149]
GSM1205387
[150]
GSM1205388
[151]
GSM1205389
[152]
GSM1205390
[153]
GSM1205391
[154]
GSM1205392
[155]
GSM1205393
[156]
GSM1205394
[157]
GSM1205395
[158]
GSM1205396
[159]
GSM1205397
[160]
GSM1205398
[161]
GSM1205399
[162]
GSM1205400
[163]
GSM1205401
[164]
GSM1205402
[165]
GSM1205403
[166]
GSM1205404
[167]
GSM1205405
[168]
GSM1205406
[169]
GSM1205407
[170]
GSM1205408
[171]
GSM1205409
[172]
GSM1205410
[173]
GSM1205411
[174]
GSM1205412
[175]
GSM1205413
[176]
GSM1205414
[177]
GSM1205415
[178]
GSM1205416
[179]
GSM1205417
[180]
GSM1205418
[181]
GSM1205419
[182]
GSM1205420
[183]
GSM1205421
[184]
GSM1205422
[185]
GSM1205423
[186]
GSM1205424
[187]
GSM1205425
[188]
GSM1205426
[189]
GSM1205427
[190]
GSM1205428
[191]
GSM1205429
[192]
GSM1205430
[193]
GSM1205431
[194]
GSM1205432
[195]
GSM1205433
[196]
GSM1205434
[197]
GSM1205435
[198]
GSM1205436
[199]
GSM1205437
[200]
GSM1205438
[201]
GSM1205439
[202]
GSM1205440
[203]
GSM1205441
[204]
GSM1205442
[205]
GSM1205443
[206]
GSM1205444
[207]
GSM1205445
[208]
GSM1205446
[209]
GSM1205447
[210]
GSM1205448
[211]
GSM1205449
[212]
GSM1205450
[213]
GSM1205451
[214]
GSM1205452
[215]
GSM1205453
[216]
GSM1205454
[217]
GSM1205455
[218]
GSM1205456
[219]
GSM1205457
[220]
GSM1205458
[221]
GSM1205459
[222]
GSM1205460
[223]
GSM1205461
[224]
GSM1205462
[225]
GSM1205463
[226]
GSM1205464
[227]
GSM1205465
[228]
GSM1205466
[229]
GSM1205467
[230]
GSM1205468
[231]
GSM1205469
[232]
GSM1205470
[233]
GSM1205471
[234]
GSM1205472
[235]
GSM1205473
[236]
GSM1205474
[237]
GSM1205475
[238]
GSM1205476
[239]
GSM1205477
[240]
GSM1205478
[241]
GSM1205479
[242]
GSM1205480
[243]
GSM1205481
[244]
GSM1205482
[245]
GSM1205483
[246]
GSM1205484
[247]
GSM1205485
[248]
GSM1205486
[249]
GSM1205487
[250]
GSM1205488
[251]
GSM1205489
[252]
GSM1205490
[253]
GSM1205491
[254]
GSM1205492
[255]
GSM1205493
[256]
GSM1205494
[257]
GSM1205495
[258]
GSM1205496
[259]
GSM1205497
[260]
GSM1205498
[261]
GSM1205499
[262]
GSM1205500
[263]
GSM1205501
[264]
GSM1205502
[265]
GSM1205503
[266]
GSM1205504
[267]
GSM1205505
[268]
GSM1205506
[269]
GSM1205507
[270]
GSM1205508
[271]
GSM1205509
[272]
GSM1205510
[273]
GSM1205511
[274]
GSM1205512
[275]
GSM1205513
[276]
GSM1205514
[277]
GSM1205515
[278]
GSM1205516
[279]
GSM1205517
[280]
GSM1205518
[281]
GSM1205519
[282]
GSM1205520
[283]
GSM1205521
[284]
GSM1205522
[285]
GSM1205523
[286]
GSM1205524
[287]
GSM1205525
[288]
GSM1205526
[289]
GSM1205527
[290]
GSM1205528
[291]
GSM1205529
[292]
GSM1205530
[293]
GSM1205531
[294]
GSM1205532
[295]
GSM1205533
[296]
GSM1205534
[297]
GSM1205535
[298]
GSM1205536
[299]
GSM1205537
[300]
GSM1205538
[301]
GSM1205539
[302]
GSM1205540
[303]
GSM1205541
[304]
GSM1205542
[305]
GSM1205543
[306]
GSM1205544
[307]
GSM1205545
[308]
GSM1205546
[309]
GSM1205547
[310]
GSM1205548
[311]
GSM1205549
[312]
GSM1205550
[313]
GSM1205551
[314]
GSM1205552
[315]
GSM1205553
[316]
GSM1205554
[317]
GSM1205555
[318]
GSM1205556
[319]
GSM1205557
[320]
GSM1205558
[321]
GSM1205559
[322]
GSM1205560
[323]
GSM1205561
[324]
GSM1205562
[325]
GSM1205563
[326]
GSM1205564
[327]
GSM1205565
[328]
GSM1205566
[329]
GSM1205567
[330]
GSM1205568
[331]
GSM1205569
[332]
GSM1205570
[333]
GSM1205571
[334]
GSM1205572
[335]
GSM1205573
[336]
GSM1205574
[337]
GSM1205575
[338]
GSM1205576
[339]
GSM1205577
[340]
GSM1205578
[341]
GSM1205579
[342]
GSM1205580
[343]
GSM1205581
[344]
GSM1205582
[345]
GSM1205583
[346]
GSM1205584
[347]
GSM1205585
[348]
GSM1205586
[349]
GSM1205587
[350]
GSM1205588
[351]
GSM1205589
[352]
GSM1205590
[353]
GSM1205591
[354]
GSM1205592
[355]
GSM1205593
[356]
GSM1205594
[357]
GSM1205595
[358]
GSM1205596
[359]
GSM1205597
[360]
GSM1205598
[361]
GSM1205599
[362]
GSM1205600
[363]
GSM1205601
[364]
GSM1205602
[365]
GSM1205603
[366]
GSM1205604
[367]
GSM1205605
[368]
GSM1205606
[369]
GSM1205607
[370]
GSM1205608
[371]
GSM1205609
[372]
GSM1205610
[373]
GSM1205611
[374]
GSM1205612
[375]
GSM1205613
[376]
GSM1205614
[377]
GSM1205615
[378]
GSM1205616
[379]
GSM1205617
[380]
GSM1205618
[381]
GSM1205619
[382]
GSM1205620
[383]
GSM1205621
[384]
GSM1205622
[385]
GSM1205623
[386]
GSM1205624
[387]
GSM1205625
[388]
GSM1205626
[389]
GSM1205627
[390]
GSM1205628
[391]
GSM1205629
[392]
GSM1205630
[393]
GSM1205631
[394]
GSM1205632
[395]
GSM1205633
[396]
GSM1205634
[397]
GSM1205635
[398]
GSM1205636
[399]
GSM1205637
[400]
GSM1205638
[401]
GSM1205639
[402]
GSM1205640
[403]
GSM1205641
[404]
GSM1205642
[405]
GSM1205643
[406]
GSM1205644
[407]
GSM1205645
[408]
GSM1205646
[409]
GSM1205647
[410]
GSM1205648
[411]
GSM1205649
[412]
GSM1205650
[413]
GSM1205651
[414]
GSM1205652
[415]
GSM1205653
[416]
GSM1205654
[417]
GSM1205655
[418]
GSM1205656
[419]
GSM1205657
[420]
GSM1205658
[421]
GSM1205659
[422]
GSM1205660
[423]
GSM1205661
[424]
GSM1205662
[425]
GSM1205663
[426]
GSM1205664
[427]
GSM1205665
[428]
GSM1205666
[429]
GSM1205667
[430]
GSM1205668
[431]
GSM1205669
[432]
GSM1205670
[433]
GSM1205671
[434]
GSM1205672
[435]
GSM1205673
[436]
GSM1205674
[437]
GSM1205675
[438]
GSM1205676
[439]
GSM1205677
[440]
GSM1205678
[441]
GSM1205679
[442]
GSM1205680
[443]
GSM1205681
[444]
GSM1205682
[445]
GSM1205683
[446]
GSM1205684
[447]
GSM1205685
[448]
GSM1205686
[449]
GSM1205687
[450]
GSM1205688
[451]
GSM1205689
[452]
GSM1205690
[453]
GSM1205691
[454]
GSM1205692
[455]
GSM1205693
[456]
GSM1205694
[457]
GSM1205695
[458]
GSM1205696
[459]
GSM1205697
[460]
GSM1205698
[461]
GSM1205699
[462]
GSM1205700
[463]
GSM1205701
[464]
GSM1205702
[465]
GSM1205703
[466]
GSM1205704
[467]
GSM1205705
[468]
GSM1205706
[469]
GSM1205707
[470]
GSM1205708
[471]
GSM1205709
[472]
GSM1205710
[473]
GSM1205711
[474]
GSM1205712
[475]
GSM1205713
[476]
GSM1205714
[477]
GSM1205715
[478]
GSM1205716
[479]
GSM1205717
[480]
GSM1205718
[481]
GSM1205719
[482]
GSM1205720
[483]
GSM1205721
[484]
GSM1205722
[485]
GSM1205723
[486]
GSM1205724
[487]
GSM1205725
[488]
GSM1205726
[489]
GSM1205727
[490]
GSM1205728
[491]
GSM1205729
[492]
GSM1205730
[493]
GSM1205731
[494]
GSM1205732
[495]
GSM1205733
[496]
GSM1205734
[497]
GSM1205735
sample_count
498
group_sizes
null
group_sizes_basis
null
platform
16876
taxon
Homo sapiens
title
RNA-Seq reveals an unprecedented complexity of the neuroblastoma transcriptome and is suitable for clinical endpoint prediction [microarray]
resolution_checked_at
2026-11-01T15:39:54Z
resolution_check
identifier_resolution_only_no_download_no_licence_read
downloaded
false
licence_read
false
[3] object · 15 fields
id
data:geo:GSE85047
role
raw
format
geo-series
media_type
application/vnd.ncbi.geo-series+json
uri
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85047
sha256
null
bytes
null
access
open
state
resolved
reader
null
reader_status
reader_required
identifier
GSE85047
version
null
note
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
structure object · 15 fields
repository
GEO
access_route
GEO accession URL
access_statement_verbatim
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
access_statement_kind
data_availability_statement
sample_accessions array · 283 items
[0]
GSM2256846
[1]
GSM2256847
[2]
GSM2256848
[3]
GSM2256849
[4]
GSM2256850
[5]
GSM2256851
[6]
GSM2256852
[7]
GSM2256853
[8]
GSM2256854
[9]
GSM2256855
[10]
GSM2256856
[11]
GSM2256857
[12]
GSM2256858
[13]
GSM2256859
[14]
GSM2256860
[15]
GSM2256861
[16]
GSM2256862
[17]
GSM2256863
[18]
GSM2256864
[19]
GSM2256865
[20]
GSM2256866
[21]
GSM2256867
[22]
GSM2256868
[23]
GSM2256869
[24]
GSM2256870
[25]
GSM2256871
[26]
GSM2256872
[27]
GSM2256873
[28]
GSM2256874
[29]
GSM2256875
[30]
GSM2256876
[31]
GSM2256877
[32]
GSM2256878
[33]
GSM2256879
[34]
GSM2256880
[35]
GSM2256881
[36]
GSM2256882
[37]
GSM2256883
[38]
GSM2256884
[39]
GSM2256885
[40]
GSM2256886
[41]
GSM2256887
[42]
GSM2256888
[43]
GSM2256889
[44]
GSM2256890
[45]
GSM2256891
[46]
GSM2256892
[47]
GSM2256893
[48]
GSM2256894
[49]
GSM2256895
[50]
GSM2256896
[51]
GSM2256897
[52]
GSM2256898
[53]
GSM2256899
[54]
GSM2256900
[55]
GSM2256901
[56]
GSM2256902
[57]
GSM2256903
[58]
GSM2256904
[59]
GSM2256905
[60]
GSM2256906
[61]
GSM2256907
[62]
GSM2256908
[63]
GSM2256909
[64]
GSM2256910
[65]
GSM2256911
[66]
GSM2256912
[67]
GSM2256913
[68]
GSM2256914
[69]
GSM2256915
[70]
GSM2256916
[71]
GSM2256917
[72]
GSM2256918
[73]
GSM2256919
[74]
GSM2256920
[75]
GSM2256921
[76]
GSM2256922
[77]
GSM2256923
[78]
GSM2256924
[79]
GSM2256925
[80]
GSM2256926
[81]
GSM2256927
[82]
GSM2256928
[83]
GSM2256929
[84]
GSM2256930
[85]
GSM2256931
[86]
GSM2256932
[87]
GSM2256933
[88]
GSM2256934
[89]
GSM2256935
[90]
GSM2256936
[91]
GSM2256937
[92]
GSM2256938
[93]
GSM2256939
[94]
GSM2256940
[95]
GSM2256941
[96]
GSM2256942
[97]
GSM2256943
[98]
GSM2256944
[99]
GSM2256945
[100]
GSM2256946
[101]
GSM2256947
[102]
GSM2256948
[103]
GSM2256949
[104]
GSM2256950
[105]
GSM2256951
[106]
GSM2256952
[107]
GSM2256953
[108]
GSM2256954
[109]
GSM2256955
[110]
GSM2256956
[111]
GSM2256957
[112]
GSM2256958
[113]
GSM2256959
[114]
GSM2256960
[115]
GSM2256961
[116]
GSM2256962
[117]
GSM2256963
[118]
GSM2256964
[119]
GSM2256965
[120]
GSM2256966
[121]
GSM2256967
[122]
GSM2256968
[123]
GSM2256969
[124]
GSM2256970
[125]
GSM2256971
[126]
GSM2256972
[127]
GSM2256973
[128]
GSM2256974
[129]
GSM2256975
[130]
GSM2256976
[131]
GSM2256977
[132]
GSM2256978
[133]
GSM2256979
[134]
GSM2256980
[135]
GSM2256981
[136]
GSM2256982
[137]
GSM2256983
[138]
GSM2256984
[139]
GSM2256985
[140]
GSM2256986
[141]
GSM2256987
[142]
GSM2256988
[143]
GSM2256989
[144]
GSM2256990
[145]
GSM2256991
[146]
GSM2256992
[147]
GSM2256993
[148]
GSM2256994
[149]
GSM2256995
[150]
GSM2256996
[151]
GSM2256997
[152]
GSM2256998
[153]
GSM2256999
[154]
GSM2257000
[155]
GSM2257001
[156]
GSM2257002
[157]
GSM2257003
[158]
GSM2257004
[159]
GSM2257005
[160]
GSM2257006
[161]
GSM2257007
[162]
GSM2257008
[163]
GSM2257009
[164]
GSM2257010
[165]
GSM2257011
[166]
GSM2257012
[167]
GSM2257013
[168]
GSM2257014
[169]
GSM2257015
[170]
GSM2257016
[171]
GSM2257017
[172]
GSM2257018
[173]
GSM2257019
[174]
GSM2257020
[175]
GSM2257021
[176]
GSM2257022
[177]
GSM2257023
[178]
GSM2257024
[179]
GSM2257025
[180]
GSM2257026
[181]
GSM2257027
[182]
GSM2257028
[183]
GSM2257029
[184]
GSM2257030
[185]
GSM2257031
[186]
GSM2257032
[187]
GSM2257033
[188]
GSM2257034
[189]
GSM2257035
[190]
GSM2257036
[191]
GSM2257037
[192]
GSM2257038
[193]
GSM2257039
[194]
GSM2257040
[195]
GSM2257041
[196]
GSM2257042
[197]
GSM2257043
[198]
GSM2257044
[199]
GSM2257045
[200]
GSM2257046
[201]
GSM2257047
[202]
GSM2257048
[203]
GSM2257049
[204]
GSM2257050
[205]
GSM2257051
[206]
GSM2257052
[207]
GSM2257053
[208]
GSM2257054
[209]
GSM2257055
[210]
GSM2257056
[211]
GSM2257057
[212]
GSM2257058
[213]
GSM2257059
[214]
GSM2257060
[215]
GSM2257061
[216]
GSM2257062
[217]
GSM2257063
[218]
GSM2257064
[219]
GSM2257065
[220]
GSM2257066
[221]
GSM2257067
[222]
GSM2257068
[223]
GSM2257069
[224]
GSM2257070
[225]
GSM2257071
[226]
GSM2257072
[227]
GSM2257073
[228]
GSM2257074
[229]
GSM2257075
[230]
GSM2257076
[231]
GSM2257077
[232]
GSM2257078
[233]
GSM2257079
[234]
GSM2257080
[235]
GSM2257081
[236]
GSM2257082
[237]
GSM2257083
[238]
GSM2257084
[239]
GSM2257085
[240]
GSM2257086
[241]
GSM2257087
[242]
GSM2257088
[243]
GSM2257089
[244]
GSM2257090
[245]
GSM2257091
[246]
GSM2257092
[247]
GSM2257093
[248]
GSM2257094
[249]
GSM2257095
[250]
GSM2257096
[251]
GSM2257097
[252]
GSM2257098
[253]
GSM2257099
[254]
GSM2257100
[255]
GSM2257101
[256]
GSM2257102
[257]
GSM2257103
[258]
GSM2257104
[259]
GSM2257105
[260]
GSM2257106
[261]
GSM2257107
[262]
GSM2257108
[263]
GSM2257109
[264]
GSM2257110
[265]
GSM2257111
[266]
GSM2257112
[267]
GSM2257113
[268]
GSM2257114
[269]
GSM2257115
[270]
GSM2257116
[271]
GSM2257117
[272]
GSM2257118
[273]
GSM2257119
[274]
GSM2257120
[275]
GSM2257121
[276]
GSM2257122
[277]
GSM2257123
[278]
GSM2257124
[279]
GSM2257125
[280]
GSM2257126
[281]
GSM2257127
[282]
GSM2257128
sample_count
283
group_sizes
null
group_sizes_basis
null
platform
5175
taxon
Homo sapiens
title
Gene expression data from primary neuroblastoma tumors
resolution_checked_at
2026-11-01T15:39:55Z
resolution_check
identifier_resolution_only_no_download_no_licence_read
downloaded
false
licence_read
false
[4] object · 16 fields
id
asset:table:pmid:32963529:1
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:f9e9abe6b35dedd70c04d557939fd52d06f3dd2b46b27915faefc80c2536ae86
bytes
1401
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[10]/table-wrap[1]#tab1
version
null
note
Genes identified in this study as prognostic markers.
structure object · 5 fields
pmcid
PMC7501561
section_index
10
section_title
2.8. Screening for Prognostic Genes in Two Independent Cohorts
row_count
16
column_count
6
table object · 8 fields
label
Table 1
caption
Genes identified in this study as prognostic markers.
rows array · 16 items
[0] array · 4 items
[0]
Gene
[1]
Kaplan–Meier analysis (p value)
[2]
Prognostic correlation
[3]
Regulation in TME
[1] array · 3 items
[0]
E-MTAB-8248
[1]
GSE85047
[2]
GSE49710
[2] array · 6 items
[0]
ABCA6
[1]
0.048329644
[2]
0.000456
[3]
1.38E − 11
[4]
Positively
[5]
Upregulated
[3] array · 6 items
[0]
SEPP1
[1]
0.043655597
[2]
0.000644
[3]
4.85E − 05
[4]
Positively
[5]
Upregulated
[4] array · 6 items
[0]
SLAMF8
[1]
0.016798116
[2]
0.00237
[3]
1.44E − 09
[4]
Positively
[5]
Upregulated
[5] array · 6 items
[0]
GPR171
[1]
0.013243245
[2]
0.006901
[3]
3.27E − 07
[4]
Positively
[5]
Upregulated
[6] array · 6 items
[0]
ABCA9
[1]
0.04278403
[2]
0.007713
[3]
5.43E − 09
[4]
Positively
[5]
Upregulated
[7] array · 6 items
[0]
ARHGAP15
[1]
0.013917259
[2]
0.010945
[3]
1.6E − 05
[4]
Positively
[5]
Upregulated
[8] array · 6 items
[0]
IL7R
[1]
0.001138517
[2]
0.012055
[3]
1.44E − 07
[4]
Positively
[5]
Upregulated
[9] array · 6 items
[0]
HLA-DPB1
[1]
0.014579249
[2]
0.020717
[3]
2.25E − 05
[4]
Positively
[5]
Upregulated
[10] array · 6 items
[0]
GZMA
[1]
0.00900038
[2]
0.023614
[3]
0.000124
[4]
Positively
[5]
Upregulated
[11] array · 6 items
[0]
GPR183
[1]
0.010691506
[2]
0.024086
[3]
4.64E − 06
[4]
Positively
[5]
Upregulated
[12] array · 6 items
[0]
CCL19
[1]
0.013557588
[2]
0.034966
[3]
8.77E − 07
[4]
Positively
[5]
Upregulated
[13] array · 6 items
[0]
ITK
[1]
0.016816901
[2]
0.044203
[3]
2.78E − 06
[4]
Positively
[5]
Upregulated
[14] array · 6 items
[0]
FGL2
[1]
0.007567598
[2]
0.045289
[3]
2E − 06
[4]
Positively
[5]
Upregulated
[15] array · 6 items
[0]
CD1C
[1]
0.013928199
[2]
0.047954
[3]
2.7E − 09
[4]
Positively
[5]
Upregulated
locator
section[10]/table-wrap[1]#tab1
[5] object · 16 fields
id
asset:table:pmid:32963529:2
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:9813141f308db4585b851b7b04e1ea235702341bec04ab14f68753266e37836c
bytes
1281
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[13]/table-wrap[1]#tab2
version
null
note
Clinical characteristics of cohorts involved in the study.
structure object · 5 fields
pmcid
PMC7501561
section_index
13
section_title
3.1. Characteristics of Cohorts Included in This Study
row_count
27
column_count
4
table object · 8 fields
label
Table 2
caption
Clinical characteristics of cohorts involved in the study.
rows array · 27 items
[0] array · 4 items
[0]
Characteristics
[1]
E-MTAB-8248, n = 223
[2]
GSE85047, n = 283
[3]
GSE49710, n = 498
[1] array · 4 items
[0]
Age (months)
[1]
[2]
[3]
[2] array · 4 items
[0]
≤18
[1]
103 (46.19%)
[2]
144 (50.88%)
[3]
300 (60.24%)
[3] array · 4 items
[0]
>18
[1]
120 (53.81%)
[2]
134 (47.35%)
[3]
198 (39.76%)
[4] array · 4 items
[0]
Unknown
[1]
0
[2]
5 (1.77%)
[3]
0
[5] array · 4 items
[0]
Gender
[1]
[2]
[3]
[6] array · 4 items
[0]
Female
[1]
NA
[2]
NA
[3]
211 (42.37%)
[7] array · 4 items
[0]
Male
[1]
NA
[2]
NA
[3]
287 (57.63%)
[8] array · 4 items
[0]
MYCN
[1]
[2]
[3]
[9] array · 4 items
[0]
Amplified
[1]
46 (20.63%)
[2]
55 (19.43%)
[3]
92 (18.47%)
[10] array · 4 items
[0]
Nonamplified
[1]
176 (78.92%)
[2]
222 (78.45%)
[3]
401 (80.52%)
[11] array · 4 items
[0]
Unknown
[1]
1 (0.45%)
[2]
6 (2.12%)
[3]
5 (1%)
[12] array · 4 items
[0]
Stage (INSS)
[1]
[2]
[3]
[13] array · 4 items
[0]
1
[1]
29 (13%)
[2]
50 (17.67%)
[3]
121 (24.3%)
[14] array · 4 items
[0]
2
[1]
39 (17.49%)
[2]
36 (12.72%)
[3]
78 (15.66%)
[15] array · 4 items
[0]
3
[1]
36 (16.14%)
[2]
43 (15.19%)
[3]
63 (12.65%)
[16] array · 4 items
[0]
4
[1]
89 (39.91%)
[2]
124 (43.82%)
[3]
183 (36.75%)
[17] array · 4 items
[0]
4s
[1]
30 (13.45%)
[2]
27 (9.54%)
[3]
53 (10.64%)
[18] array · 4 items
[0]
Unknown
[1]
0
[2]
3 (1.06%)
[3]
0
[19] array · 4 items
[0]
1p status
[1]
[2]
[3]
[20] array · 4 items
[0]
Del/im
[1]
67 (30.04%)
[2]
NA
[3]
NA
[21] array · 4 items
[0]
Normal
[1]
137 (61.43%)
[2]
NA
[3]
NA
[22] array · 4 items
[0]
Unknown
[1]
19 (8.52%)
[2]
NA
[3]
NA
[23] array · 4 items
[0]
11q status
[1]
[2]
[3]
[24] array · 4 items
[0]
Del
[1]
18 (8.07%)
[2]
NA
[3]
NA
[25] array · 4 items
[0]
Normal
[1]
46 (20.63%)
[2]
NA
[3]
NA
[26] array · 4 items
[0]
Unknown
[1]
159 (71.3%)
[2]
NA
[3]
NA
locator
section[13]/table-wrap[1]#tab2
[6] object · 16 fields
id
asset:table:pmid:32963529:3
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:3db032ff51acf820991fd1522850003391f399af01e6de794efbe40e0f2149f2
bytes
864
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[20]/table-wrap[1]#tab3
version
null
note
The correlations between prognostic genes and the status of MYCN status tested by Spearman correlation.
structure object · 5 fields
pmcid
PMC7501561
section_index
20
section_title
3.8. Identification of the Independent Prognostic Value of Prognostic Genes
row_count
15
column_count
3
table object · 8 fields
label
Table 3
caption
The correlations between prognostic genes and the status of MYCN status tested by Spearman correlation.
rows array · 15 items
[0] array · 3 items
[0]
Gene
[1]
R
[2]
p value
[1] array · 3 items
[0]
ABCA6
[1]
−0.433035927
[2]
5.96E − 24
[2] array · 3 items
[0]
SEPP1
[1]
−0.43773706
[2]
1.71E − 24
[3] array · 3 items
[0]
SLAMF8
[1]
−0.485479
[2]
1.62E − 30
[4] array · 3 items
[0]
GPR171
[1]
−0.449936802
[2]
6.05E − 26
[5] array · 3 items
[0]
ABCA9
[1]
−0.371500185
[2]
1.40E − 17
[6] array · 3 items
[0]
ARHGAP15
[1]
−0.452056568
[2]
3.34E − 26
[7] array · 3 items
[0]
IL7R
[1]
−0.457452749
[2]
7.23E − 27
[8] array · 3 items
[0]
HLA-DPB1
[1]
−0.418455553
[2]
2.55E − 22
[9] array · 3 items
[0]
GZMA
[1]
−0.411284919
[2]
1.51E − 21
[10] array · 3 items
[0]
GPR183
[1]
−0.415347624
[2]
5.55E − 22
[11] array · 3 items
[0]
CCL19
[1]
−0.462592772
[2]
1.64E − 27
[12] array · 3 items
[0]
ITK
[1]
−0.483115504
[2]
3.40E − 30
[13] array · 3 items
[0]
FGL2
[1]
−0.459540146
[2]
3.97E − 27
[14] array · 3 items
[0]
CD1C
[1]
−0.466033388
[2]
5.99E − 28
locator
section[20]/table-wrap[1]#tab3
[7] object · 16 fields
id
asset:table:pmid:32963529:4
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:008ce78bd10e585894b88f1978275f17953794aec2e704ea0815cef6bdd2a28c
bytes
2161
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[20]/table-wrap[2]#tab4
version
null
note
The Cox analysis on prognostic genes and MYCN in the GSE49710 cohort.
structure object · 5 fields
pmcid
PMC7501561
section_index
20
section_title
3.8. Identification of the Independent Prognostic Value of Prognostic Genes
row_count
17
column_count
9
table object · 8 fields
label
Table 4
caption
The Cox analysis on prognostic genes and MYCN in the GSE49710 cohort.
rows array · 17 items
[0] array · 3 items
[0]
Variable
[1]
Univariate Cox analysis
[2]
Multivariate Cox analysis∗
[1] array · 8 items
[0]
Coef
[1]
HR (95% CI)
[2]
z
[3]
p value
[4]
Coef
[5]
HR (95% CI)
[6]
z
[7]
p value
[2] array · 9 items
[0]
ABCA6
[1]
−0.345
[2]
0.708 (0.651–0.77)
[3]
−8.1
[4]
5.38E − 16
[5]
0.0186
[6]
1.02 (0.776–1.34)
[7]
0.134
[8]
0.894
[3] array · 9 items
[0]
SEPP1
[1]
−0.392
[2]
0.676 (0.602–0.759)
[3]
−6.64
[4]
3.11E − 11
[5]
−0.0928
[6]
0.911 (0.644–1.29)
[7]
−0.524
[8]
0.6
[4] array · 9 items
[0]
SLAMF8
[1]
−0.505
[2]
0.603 (0.537–0.677)
[3]
−8.54
[4]
1.29E − 17
[5]
−0.274
[6]
0.76 (0.586–0.986)
[7]
−2.07
[8]
0.0389
[5] array · 9 items
[0]
GPR171
[1]
−0.415
[2]
0.66 (0.582–0.749)
[3]
−6.44
[4]
1.21E − 10
[5]
−0.108
[6]
0.898 (0.581–1.39)
[7]
−0.484
[8]
0.629
[6] array · 9 items
[0]
ABCA9
[1]
−0.387
[2]
0.679 (0.613–0.753)
[3]
−7.34
[4]
2.10E − 13
[5]
−0.303
[6]
0.738 (0.574–0.95)
[7]
−2.36
[8]
0.0183
[7] array · 9 items
[0]
ARHGAP15
[1]
−0.393
[2]
0.675 (0.598–0.763)
[3]
−6.31
[4]
2.77E − 10
[5]
0.583
[6]
1.79 (1.22–2.62)
[7]
3
[8]
0.00272
[8] array · 9 items
[0]
IL7R
[1]
−0.375
[2]
0.687 (0.617–0.765)
[3]
−6.86
[4]
7.05E − 12
[5]
−0.112
[6]
0.894 (0.624–1.28)
[7]
−0.607
[8]
0.544
[9] array · 9 items
[0]
HLA-DPB1
[1]
−0.403
[2]
0.668 (0.588–0.759)
[3]
−6.21
[4]
5.40E − 10
[5]
0.0422
[6]
1.04 (0.735–1.48)
[7]
0.236
[8]
0.813
[10] array · 9 items
[0]
GZMA
[1]
−0.305
[2]
0.737 (0.666–0.816)
[3]
−5.86
[4]
4.62E − 09
[5]
0.216
[6]
1.24 (0.993–1.55)
[7]
1.89
[8]
0.0581
[11] array · 9 items
[0]
GPR183
[1]
−0.387
[2]
0.679 (0.604–0.763)
[3]
−6.51
[4]
7.63E − 11
[5]
−0.0716
[6]
0.931 (0.746–1.16)
[7]
−0.633
[8]
0.527
[12] array · 9 items
[0]
CCL19
[1]
−0.184
[2]
0.832 (0.783–0.884)
[3]
−5.94
[4]
2.81E − 09
[5]
0.147
[6]
1.16 (1.01–1.33)
[7]
2.09
[8]
0.0362
[13] array · 9 items
[0]
ITK
[1]
−0.35
[2]
0.705 (0.641–0.775)
[3]
−7.25
[4]
4.04E − 13
[5]
−0.125
[6]
0.883 (0.662–1.18)
[7]
−0.85
[8]
0.395
[14] array · 9 items
[0]
FGL2
[1]
−0.383
[2]
0.682 (0.612–0.76)
[3]
−6.95
[4]
3.66E − 12
[5]
0.0172
[6]
1.02 (0.677–1.53)
[7]
0.0827
[8]
0.934
[15] array · 9 items
[0]
CD1C
[1]
−0.356
[2]
0.701 (0.64–0.767)
[3]
−7.68
[4]
1.65E − 14
[5]
−0.235
[6]
0.791 (0.633–0.989)
[7]
−2.06
[8]
0.0393
[16] array · 9 items
[0]
MYCN amplification
[1]
2.05
[2]
7.8 (5.26–11.5)
[3]
10.2
[4]
1.19E − 24
[5]
1.7
[6]
5.45 (3.22–9.21)
[7]
6.33
[8]
2.48E − 10
locator
section[20]/table-wrap[2]#tab4
[8] object · 16 fields
id
asset:table:pmid:32963529:5
role
table
format
jats-table
media_type
application/vnd.jats.table+json
uri
null
sha256
sha256:503e7e438806afce2656613be4da4ee6ee96b2c38917fce4903758087e86460f
bytes
490
access
open
state
verified
reader
read_table
reader_status
available
identifier
section[20]/table-wrap[3]#tab5
version
null
note
Prognostic genes identified related to the tumor microenvironment in neuroblastoma.
structure object · 5 fields
pmcid
PMC7501561
section_index
20
section_title
3.8. Identification of the Independent Prognostic Value of Prognostic Genes
row_count
6
column_count
2
table object · 8 fields
label
Table 5
caption
Prognostic genes identified related to the tumor microenvironment in neuroblastoma.
rows array · 6 items
[0] array · 2 items
[0]
Categories#
[1]
Gene symbols$
[1] array · 2 items
[0]
Molecular function
[1]
ABCA6, ABCA9, IL7R [15], GPR183, CCL19 [16]
[2] array · 2 items
[0]
Extracellular region
[1]
SEPP1, GZMA [17], FGL2
[3] array · 2 items
[0]
Plasma membrane
[1]
GPR171, HLA-DPB1, CD1C
[4] array · 2 items
[0]
Signal transduction
[1]
ARHGAP15, ITK
[5] array · 2 items
[0]
Membrane
[1]
SLAMF8
locator
section[20]/table-wrap[3]#tab5
gaps array · 6 items
[0]
asset:data:geo:E-MTAB-8248 not downloaded
[1]
asset:data:geo:E-MTAB-8248 licence not read
[2]
asset:data:geo:GSE49710 not downloaded
[3]
asset:data:geo:GSE49710 licence not read
[4]
asset:data:geo:GSE85047 not downloaded
[5]
asset:data:geo:GSE85047 licence not read
analysis object · 4 fields
state
complete
methods array · 2 items
[0] object · 10 fields
id
method-1
family
survival_analysis
specific
log_rank_test
label
Survival analysis
dsl_operations array · 1 item
[0]
logrank_test
missing_operations array · 0 items
parameters object · 1 field
p_value
E-MTAB-8248 cohort with p value tested in the log-rank
data_shapes array · 1 item
[0]
time_to_event_with_censoring
evidence object · 3 fields
score
0.8
band
high
quote
log-rank
[1] object · 10 fields
id
method-2
family
network_analysis
specific
pathway_enrichment
label
Network / pathway analysis
dsl_operations array · 1 item
[0]
pathway_enrich
missing_operations array · 0 items
parameters object · 0 fields
data_shapes array · 1 item
[0]
edge_list
evidence object · 3 fields
score
0.8
band
high
quote
pathway enrichment
targets array · 0 items
gaps array · 0 items
capability object · 3 fields
state
complete
requirements array · 1 item
[0] object · 6 fields
capability_id
capability:computational_analysis
label
Computational analysis platform
assay_families array · 9 items
[0]
meta_analysis
[1]
machine_learning
[2]
survival_analysis
[3]
statistical_regression
[4]
pca
[5]
molecular_docking
[6]
network_analysis
[7]
differential_expression
[8]
gwas
candidate
Automated Assays Laravel application and simulated adapters
gaps array · 0 items
readiness object · 8 fields
state
complete
tier
R1
blocked_on
nothing:replicable_now
axes object · 3 fields
method object · 5 fields
tier
R1
expressible
true
required_operations array · 1 item
[0]
logrank_test
missing_operations array · 0 items
basis
The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: log_rank_test.
capability object · 4 fields
tier
R1
capability_id
capability:computational_analysis
availability_state
owned
basis
The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here.
data object · 6 fields
tier
R1
reachable
true
accessions array · 3 items
[0]
E-MTAB-8248
[1]
GSE85047
[2]
GSE49710
resolved_accessions array · 3 items
[0]
E-MTAB-8248
[1]
GSE85047
[2]
GSE49710
statements array · 1 item
[0]
Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.
basis
The paper names E-MTAB-8248, GSE85047, GSE49710 in ArrayExpress and the accession resolves in the repository. No dataset was downloaded and no licence was read.
can_run object · 3 fields
dsl_operations array · 1 item
[0]
logrank_test
assets array · 7 items
[0]
source:pmid:32963529
[1]
data:geo:E-MTAB-8248
[2]
asset:table:pmid:32963529:1
[3]
asset:table:pmid:32963529:2
[4]
asset:table:pmid:32963529:3
[5]
asset:table:pmid:32963529:4
[6]
asset:table:pmid:32963529:5
steps array · 1 item
[0]
run_analysis
must_build object · 5 fields
dsl_operations array · 0 items
converters array · 0 items
readers array · 0 items
capabilities array · 0 items
data_gaps array · 1 item
[0]
data:geo:E-MTAB-8248
gaps array · 0 items
review object · 5 fields
state
partial
machine_critique object · 5 fields
kind
extraction_review
reader object · 5 fields
model
MiniMax-M3.1-Flash
provider
minimax
provider_family
minimax
read_at
2026-10-31T19:11:09Z
independence
single_reader
evidence_check object · 2 fields
method
absent
availability
verbatim
calls
3
usage object · 3 fields
prompt_tokens
33335
completion_tokens
1517
cached_tokens
784
stages array · 1 item
[0] object · 4 fields
id
extraction
state
complete
reader
MiniMax-M3.1-Flash
provider
minimax
gaps array · 3 items
[0]
review.independent_reader
[1]
review.machine_critique
[2]
review.human_critique
execution object · 5 fields
state
absent
status
not_run
mode
null
runs array · 0 items
gaps array · 1 item
[0]
execution.not_run
provenance object · 7 fields
entities array · 3 items
[0] object · 3 fields
id
pmid:32963529
type
paper
label
pmid:32963529
[1] object · 3 fields
id
source:pmid:32963529
type
manuscript
label
PMID 32963529 full text
[2] object · 3 fields
id
data:geo:E-MTAB-8248
type
dataset
label
GEO E-MTAB-8248
activities array · 3 items
[0] object · 4 fields
id
activity-reading-sci-2026-11-01
type
classification
used array · 3 items
[0] object · 3 fields
id
pmid:32963529
type
paper
label
pmid:32963529
[1] object · 3 fields
id
source:pmid:32963529
type
manuscript
label
PMID 32963529 full text
[2] object · 3 fields
id
data:geo:E-MTAB-8248
type
dataset
label
GEO E-MTAB-8248
agent
agent:corpus-assay-engine
[1] object · 4 fields
id
activity-read-32963529
type
extraction
used array · 1 item
[0]
source:pmid:32963529
agent
agent:minimax-reader
[2] object · 4 fields
id
activity-resolve-E-MTAB-8248
type
accession_resolution
used array · 1 item
[0]
data:geo:E-MTAB-8248
agent
agent:corpus-assay-engine
agents array · 2 items
[0] object · 3 fields
id
agent:corpus-assay-engine
type
software
label
Corpus assay engine
[1] object · 3 fields
id
agent:minimax-reader
type
software
label
MiniMax literature reader
source_run_id
reading-sci-2026-11-01
dsl_catalogue_fingerprint
343fb30756ba6ec3
capability_table_fingerprint
2cb3e42f047d2ecf
snapshot_id
ba34b49490d9bfaf
lineage object · 4 fields
parent_id
pmid:32963529
parent_hash
sha256:c899e03045477ae253833fa7e90bfc025c1d71481f865a527a00a120f5f605a9
fork_of
null
gaps array · 10 items
[0]
asset:data:geo:E-MTAB-8248 licence not read
[1]
asset:data:geo:E-MTAB-8248 not downloaded
[2]
asset:data:geo:GSE49710 licence not read
[3]
asset:data:geo:GSE49710 not downloaded
[4]
asset:data:geo:GSE85047 licence not read
[5]
asset:data:geo:GSE85047 not downloaded
[6]
execution.not_run
[7]
review.human_critique
[8]
review.independent_reader
[9]
review.machine_critique
assays array · 1 item
[0] object · 11 fields
role
analysis
definition_id
survival_analysis
definition_version
f2132e96ae6c7a4e
required_operations array · 1 item
[0]
logrank_test
support_state
supported
source_hashes object · 1 field
dsl_catalogue
f2132e96ae6c7a4e
evidence array · 1 item
[0]
log-rank
order_basis
analysis_only
id
assay:1
Complete file
{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32963529", "kind": "science-record", "revision": 6, "content_hash": "sha256:dac3e96cfa1ee4def1c3f5e8917013f629c21d2a09938301d295947b46f069a7", "created_at": "2026-11-01T15:41:11Z", "updated_at": "2026-11-01T21:23:50Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "Bioinformatic Identification of Neuroblastoma Microenvironment-Associated Biomarkers with Prognostic Value.", "doi": "10.1155/2020/5943014", "pmid": "32963529", "authors": ["Yi Wang", "Huan Luo", "Jing Cao", "Chao Ma"], "journal": "Journal of oncology", "year": 2020, "abstract": "The microenvironment plays a vital role in the tumor recurrence of neuroblastoma. This research aimed at exploring prognostic genes that are involved in neuroblastoma microenvironment. We used \"estimate\" R package to calculate the immune/stromal/ESTIMATE scores of each sample of ArrayExpress dataset E-MTAB-8248 based on the ESTIMATE algorithm. Then we found that immune/stromal/ESTIMATE scores were not correlated with age/chromosome 11q, but tumor stage, MYCN gene amplifications, and chromosome 1p. Samples were then divided into high- and low-score groups, and 280 common differentially expressed genes (DEGs) were identified. 64 potential prognostic genes were harvested through overall survival analysis from the common DEGs. 14 prognostic genes (ABCA6, SEPP1, SLAMF8, GPR171, ABCA9, ARHGAP15, IL7R, HLA-DPB1, GZMA, GPR183, CCL19, ITK, FGL2, and CD1C) were obtained after screening in two independent cohorts. GO and KEGG analysis discovered that common DEGs and 64 potential prognostic genes are mainly involved in T-cell activation, lymphocyte activation regulation, leukocyte migration, and the interaction of cytokines and cytokine receptors. Correlation analysis showed that all prognostic genes were negatively correlated with MYCN amplification. Cox analysis identified 5 independent prognostic genes (ARHGAP15, ABCA9, CCL19, SLAMF8, and CD1C).", "claims": [{"id": "claim-data-access", "statement": "Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32963529", "locator": "sections[23] \"Data Availability\" paragraph 2", "quote": "Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:32963529"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. This lane did not download the dataset or read its licence.", "duration_hours": null, "parameters": {}, "inputs": ["data:geo:E-MTAB-8248"], "outputs": ["the source data with its repository provenance"], "instruments": [], "reagents": []}, {"id": "run_analysis", "order": 3, "name": "Run the published analysis", "kind": "analysis", "state": "complete", "blocked_on": null, "description": "Apply the paper's statistical method to the resolved series and compare the result with the published target.", "duration_hours": null, "parameters": {"p_value": "E-MTAB-8248 cohort with p value tested in the log-rank"}, "inputs": ["data:geo:E-MTAB-8248"], "outputs": ["the replicated result and its comparison"], "instruments": [], "reagents": []}], "materials": [], "instruments": [], "reagents": [], "conditions": {}, "gaps": []}, "data": {"state": "partial", "assets": [{"id": "source:pmid:32963529", "role": "manuscript", "format": "xml", "media_type": "application/xml", "uri": "https://doi.org/10.1155/2020/5943014", "sha256": "sha256:f25c826ff4b3cf54b143a5ae37a1c0dc8c89acefa146a42956cbb24841b59cde", "bytes": 40029, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "10.1155/2020/5943014", "version": null, "note": "Full article fetched from PMC; the checksum covers the rendered section body, not the original XML bytes.", "structure": {"pmcid": "PMC7501561", "source": "europe_pmc_fulltext", "coverage": "whole_body", "text_hash_scope": "rendered_section_body"}}, {"id": "data:geo:E-MTAB-8248", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=E-MTAB-8248", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "E-MTAB-8248", "version": null, "note": "Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.", "access_statement_kind": "data_availability_statement", "sample_accessions": [], "sample_count": null, "group_sizes": null, "group_sizes_basis": null, "platform": null, "taxon": null, "title": null, "resolution_checked_at": "2026-10-31T18:29:04Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE49710", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE49710", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE49710", "version": null, "note": "Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM1205238", "GSM1205239", "GSM1205240", "GSM1205241", "GSM1205242", "GSM1205243", "GSM1205244", "GSM1205245", "GSM1205246", "GSM1205247", "GSM1205248", "GSM1205249", "GSM1205250", "GSM1205251", "GSM1205252", "GSM1205253", "GSM1205254", "GSM1205255", "GSM1205256", "GSM1205257", "GSM1205258", "GSM1205259", "GSM1205260", "GSM1205261", "GSM1205262", "GSM1205263", "GSM1205264", "GSM1205265", "GSM1205266", "GSM1205267", "GSM1205268", "GSM1205269", "GSM1205270", "GSM1205271", "GSM1205272", "GSM1205273", "GSM1205274", "GSM1205275", "GSM1205276", "GSM1205277", "GSM1205278", "GSM1205279", "GSM1205280", "GSM1205281", "GSM1205282", "GSM1205283", "GSM1205284", "GSM1205285", "GSM1205286", "GSM1205287", "GSM1205288", "GSM1205289", "GSM1205290", "GSM1205291", "GSM1205292", "GSM1205293", "GSM1205294", "GSM1205295", "GSM1205296", "GSM1205297", "GSM1205298", "GSM1205299", "GSM1205300", "GSM1205301", "GSM1205302", "GSM1205303", "GSM1205304", "GSM1205305", "GSM1205306", "GSM1205307", "GSM1205308", "GSM1205309", "GSM1205310", "GSM1205311", "GSM1205312", "GSM1205313", "GSM1205314", "GSM1205315", "GSM1205316", "GSM1205317", "GSM1205318", "GSM1205319", "GSM1205320", "GSM1205321", "GSM1205322", "GSM1205323", "GSM1205324", "GSM1205325", "GSM1205326", "GSM1205327", "GSM1205328", "GSM1205329", "GSM1205330", "GSM1205331", "GSM1205332", "GSM1205333", "GSM1205334", "GSM1205335", "GSM1205336", "GSM1205337", "GSM1205338", "GSM1205339", "GSM1205340", "GSM1205341", "GSM1205342", "GSM1205343", "GSM1205344", "GSM1205345", "GSM1205346", "GSM1205347", "GSM1205348", "GSM1205349", "GSM1205350", "GSM1205351", "GSM1205352", "GSM1205353", "GSM1205354", "GSM1205355", "GSM1205356", "GSM1205357", "GSM1205358", "GSM1205359", "GSM1205360", "GSM1205361", "GSM1205362", "GSM1205363", "GSM1205364", "GSM1205365", "GSM1205366", "GSM1205367", "GSM1205368", "GSM1205369", "GSM1205370", "GSM1205371", "GSM1205372", "GSM1205373", "GSM1205374", "GSM1205375", "GSM1205376", "GSM1205377", "GSM1205378", "GSM1205379", "GSM1205380", "GSM1205381", "GSM1205382", "GSM1205383", "GSM1205384", "GSM1205385", "GSM1205386", "GSM1205387", "GSM1205388", "GSM1205389", "GSM1205390", "GSM1205391", "GSM1205392", "GSM1205393", "GSM1205394", "GSM1205395", "GSM1205396", "GSM1205397", "GSM1205398", "GSM1205399", "GSM1205400", "GSM1205401", "GSM1205402", "GSM1205403", "GSM1205404", "GSM1205405", "GSM1205406", "GSM1205407", "GSM1205408", "GSM1205409", "GSM1205410", "GSM1205411", "GSM1205412", "GSM1205413", "GSM1205414", "GSM1205415", "GSM1205416", "GSM1205417", "GSM1205418", "GSM1205419", "GSM1205420", "GSM1205421", "GSM1205422", "GSM1205423", "GSM1205424", "GSM1205425", "GSM1205426", "GSM1205427", "GSM1205428", "GSM1205429", "GSM1205430", "GSM1205431", "GSM1205432", "GSM1205433", "GSM1205434", "GSM1205435", "GSM1205436", "GSM1205437", "GSM1205438", "GSM1205439", "GSM1205440", "GSM1205441", "GSM1205442", "GSM1205443", "GSM1205444", "GSM1205445", "GSM1205446", "GSM1205447", "GSM1205448", "GSM1205449", "GSM1205450", "GSM1205451", "GSM1205452", "GSM1205453", "GSM1205454", "GSM1205455", "GSM1205456", "GSM1205457", "GSM1205458", "GSM1205459", "GSM1205460", "GSM1205461", "GSM1205462", "GSM1205463", "GSM1205464", "GSM1205465", "GSM1205466", "GSM1205467", "GSM1205468", "GSM1205469", "GSM1205470", "GSM1205471", "GSM1205472", "GSM1205473", "GSM1205474", "GSM1205475", "GSM1205476", "GSM1205477", "GSM1205478", "GSM1205479", "GSM1205480", "GSM1205481", "GSM1205482", "GSM1205483", "GSM1205484", "GSM1205485", "GSM1205486", "GSM1205487", "GSM1205488", "GSM1205489", "GSM1205490", "GSM1205491", "GSM1205492", "GSM1205493", "GSM1205494", "GSM1205495", "GSM1205496", "GSM1205497", "GSM1205498", "GSM1205499", "GSM1205500", "GSM1205501", "GSM1205502", "GSM1205503", "GSM1205504", "GSM1205505", "GSM1205506", "GSM1205507", "GSM1205508", "GSM1205509", "GSM1205510", "GSM1205511", "GSM1205512", "GSM1205513", "GSM1205514", "GSM1205515", "GSM1205516", "GSM1205517", "GSM1205518", "GSM1205519", "GSM1205520", "GSM1205521", "GSM1205522", "GSM1205523", "GSM1205524", "GSM1205525", "GSM1205526", "GSM1205527", "GSM1205528", "GSM1205529", "GSM1205530", "GSM1205531", "GSM1205532", "GSM1205533", "GSM1205534", "GSM1205535", "GSM1205536", "GSM1205537", "GSM1205538", "GSM1205539", "GSM1205540", "GSM1205541", "GSM1205542", "GSM1205543", "GSM1205544", "GSM1205545", "GSM1205546", "GSM1205547", "GSM1205548", "GSM1205549", "GSM1205550", "GSM1205551", "GSM1205552", "GSM1205553", "GSM1205554", "GSM1205555", "GSM1205556", "GSM1205557", "GSM1205558", "GSM1205559", "GSM1205560", "GSM1205561", "GSM1205562", "GSM1205563", "GSM1205564", "GSM1205565", "GSM1205566", "GSM1205567", "GSM1205568", "GSM1205569", "GSM1205570", "GSM1205571", "GSM1205572", "GSM1205573", "GSM1205574", "GSM1205575", "GSM1205576", "GSM1205577", "GSM1205578", "GSM1205579", "GSM1205580", "GSM1205581", "GSM1205582", "GSM1205583", "GSM1205584", "GSM1205585", "GSM1205586", "GSM1205587", "GSM1205588", "GSM1205589", "GSM1205590", "GSM1205591", "GSM1205592", "GSM1205593", "GSM1205594", "GSM1205595", "GSM1205596", "GSM1205597", "GSM1205598", "GSM1205599", "GSM1205600", "GSM1205601", "GSM1205602", "GSM1205603", "GSM1205604", "GSM1205605", "GSM1205606", "GSM1205607", "GSM1205608", "GSM1205609", "GSM1205610", "GSM1205611", "GSM1205612", "GSM1205613", "GSM1205614", "GSM1205615", "GSM1205616", "GSM1205617", "GSM1205618", "GSM1205619", "GSM1205620", "GSM1205621", "GSM1205622", "GSM1205623", "GSM1205624", "GSM1205625", "GSM1205626", "GSM1205627", "GSM1205628", "GSM1205629", "GSM1205630", "GSM1205631", "GSM1205632", "GSM1205633", "GSM1205634", "GSM1205635", "GSM1205636", "GSM1205637", "GSM1205638", "GSM1205639", "GSM1205640", "GSM1205641", "GSM1205642", "GSM1205643", "GSM1205644", "GSM1205645", "GSM1205646", "GSM1205647", "GSM1205648", "GSM1205649", "GSM1205650", "GSM1205651", "GSM1205652", "GSM1205653", "GSM1205654", "GSM1205655", "GSM1205656", "GSM1205657", "GSM1205658", "GSM1205659", "GSM1205660", "GSM1205661", "GSM1205662", "GSM1205663", "GSM1205664", "GSM1205665", "GSM1205666", "GSM1205667", "GSM1205668", "GSM1205669", "GSM1205670", "GSM1205671", "GSM1205672", "GSM1205673", "GSM1205674", "GSM1205675", "GSM1205676", "GSM1205677", "GSM1205678", "GSM1205679", "GSM1205680", "GSM1205681", "GSM1205682", "GSM1205683", "GSM1205684", "GSM1205685", "GSM1205686", "GSM1205687", "GSM1205688", "GSM1205689", "GSM1205690", "GSM1205691", "GSM1205692", "GSM1205693", "GSM1205694", "GSM1205695", "GSM1205696", "GSM1205697", "GSM1205698", "GSM1205699", "GSM1205700", "GSM1205701", "GSM1205702", "GSM1205703", "GSM1205704", "GSM1205705", "GSM1205706", "GSM1205707", "GSM1205708", "GSM1205709", "GSM1205710", "GSM1205711", "GSM1205712", "GSM1205713", "GSM1205714", "GSM1205715", "GSM1205716", "GSM1205717", "GSM1205718", "GSM1205719", "GSM1205720", "GSM1205721", "GSM1205722", "GSM1205723", "GSM1205724", "GSM1205725", "GSM1205726", "GSM1205727", "GSM1205728", "GSM1205729", "GSM1205730", "GSM1205731", "GSM1205732", "GSM1205733", "GSM1205734", "GSM1205735"], "sample_count": 498, "group_sizes": null, "group_sizes_basis": null, "platform": "16876", "taxon": "Homo sapiens", "title": "RNA-Seq reveals an unprecedented complexity of the neuroblastoma transcriptome and is suitable for clinical endpoint prediction [microarray]", "resolution_checked_at": "2026-11-01T15:39:54Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "data:geo:GSE85047", "role": "raw", "format": "geo-series", "media_type": "application/vnd.ncbi.geo-series+json", "uri": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85047", "sha256": null, "bytes": null, "access": "open", "state": "resolved", "reader": null, "reader_status": "reader_required", "identifier": "GSE85047", "version": null, "note": "Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.", "structure": {"repository": "GEO", "access_route": "GEO accession URL", "access_statement_verbatim": "Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/.", "access_statement_kind": "data_availability_statement", "sample_accessions": ["GSM2256846", "GSM2256847", "GSM2256848", "GSM2256849", "GSM2256850", "GSM2256851", "GSM2256852", "GSM2256853", "GSM2256854", "GSM2256855", "GSM2256856", "GSM2256857", "GSM2256858", "GSM2256859", "GSM2256860", "GSM2256861", "GSM2256862", "GSM2256863", "GSM2256864", "GSM2256865", "GSM2256866", "GSM2256867", "GSM2256868", "GSM2256869", "GSM2256870", "GSM2256871", "GSM2256872", "GSM2256873", "GSM2256874", "GSM2256875", "GSM2256876", "GSM2256877", "GSM2256878", "GSM2256879", "GSM2256880", "GSM2256881", "GSM2256882", "GSM2256883", "GSM2256884", "GSM2256885", "GSM2256886", "GSM2256887", "GSM2256888", "GSM2256889", "GSM2256890", "GSM2256891", "GSM2256892", "GSM2256893", "GSM2256894", "GSM2256895", "GSM2256896", "GSM2256897", "GSM2256898", "GSM2256899", "GSM2256900", "GSM2256901", "GSM2256902", "GSM2256903", "GSM2256904", "GSM2256905", "GSM2256906", "GSM2256907", "GSM2256908", "GSM2256909", "GSM2256910", "GSM2256911", "GSM2256912", "GSM2256913", "GSM2256914", "GSM2256915", "GSM2256916", "GSM2256917", "GSM2256918", "GSM2256919", "GSM2256920", "GSM2256921", "GSM2256922", "GSM2256923", "GSM2256924", "GSM2256925", "GSM2256926", "GSM2256927", "GSM2256928", "GSM2256929", "GSM2256930", "GSM2256931", "GSM2256932", "GSM2256933", "GSM2256934", "GSM2256935", "GSM2256936", "GSM2256937", "GSM2256938", "GSM2256939", "GSM2256940", "GSM2256941", "GSM2256942", "GSM2256943", "GSM2256944", "GSM2256945", "GSM2256946", "GSM2256947", "GSM2256948", "GSM2256949", "GSM2256950", "GSM2256951", "GSM2256952", "GSM2256953", "GSM2256954", "GSM2256955", "GSM2256956", "GSM2256957", "GSM2256958", "GSM2256959", "GSM2256960", "GSM2256961", "GSM2256962", "GSM2256963", "GSM2256964", "GSM2256965", "GSM2256966", "GSM2256967", "GSM2256968", "GSM2256969", "GSM2256970", "GSM2256971", "GSM2256972", "GSM2256973", "GSM2256974", "GSM2256975", "GSM2256976", "GSM2256977", "GSM2256978", "GSM2256979", "GSM2256980", "GSM2256981", "GSM2256982", "GSM2256983", "GSM2256984", "GSM2256985", "GSM2256986", "GSM2256987", "GSM2256988", "GSM2256989", "GSM2256990", "GSM2256991", "GSM2256992", "GSM2256993", "GSM2256994", "GSM2256995", "GSM2256996", "GSM2256997", "GSM2256998", "GSM2256999", "GSM2257000", "GSM2257001", "GSM2257002", "GSM2257003", "GSM2257004", "GSM2257005", "GSM2257006", "GSM2257007", "GSM2257008", "GSM2257009", "GSM2257010", "GSM2257011", "GSM2257012", "GSM2257013", "GSM2257014", "GSM2257015", "GSM2257016", "GSM2257017", "GSM2257018", "GSM2257019", "GSM2257020", "GSM2257021", "GSM2257022", "GSM2257023", "GSM2257024", "GSM2257025", "GSM2257026", "GSM2257027", "GSM2257028", "GSM2257029", "GSM2257030", "GSM2257031", "GSM2257032", "GSM2257033", "GSM2257034", "GSM2257035", "GSM2257036", "GSM2257037", "GSM2257038", "GSM2257039", "GSM2257040", "GSM2257041", "GSM2257042", "GSM2257043", "GSM2257044", "GSM2257045", "GSM2257046", "GSM2257047", "GSM2257048", "GSM2257049", "GSM2257050", "GSM2257051", "GSM2257052", "GSM2257053", "GSM2257054", "GSM2257055", "GSM2257056", "GSM2257057", "GSM2257058", "GSM2257059", "GSM2257060", "GSM2257061", "GSM2257062", "GSM2257063", "GSM2257064", "GSM2257065", "GSM2257066", "GSM2257067", "GSM2257068", "GSM2257069", "GSM2257070", "GSM2257071", "GSM2257072", "GSM2257073", "GSM2257074", "GSM2257075", "GSM2257076", "GSM2257077", "GSM2257078", "GSM2257079", "GSM2257080", "GSM2257081", "GSM2257082", "GSM2257083", "GSM2257084", "GSM2257085", "GSM2257086", "GSM2257087", "GSM2257088", "GSM2257089", "GSM2257090", "GSM2257091", "GSM2257092", "GSM2257093", "GSM2257094", "GSM2257095", "GSM2257096", "GSM2257097", "GSM2257098", "GSM2257099", "GSM2257100", "GSM2257101", "GSM2257102", "GSM2257103", "GSM2257104", "GSM2257105", "GSM2257106", "GSM2257107", "GSM2257108", "GSM2257109", "GSM2257110", "GSM2257111", "GSM2257112", "GSM2257113", "GSM2257114", "GSM2257115", "GSM2257116", "GSM2257117", "GSM2257118", "GSM2257119", "GSM2257120", "GSM2257121", "GSM2257122", "GSM2257123", "GSM2257124", "GSM2257125", "GSM2257126", "GSM2257127", "GSM2257128"], "sample_count": 283, "group_sizes": null, "group_sizes_basis": null, "platform": "5175", "taxon": "Homo sapiens", "title": "Gene expression data from primary neuroblastoma tumors", "resolution_checked_at": "2026-11-01T15:39:55Z", "resolution_check": "identifier_resolution_only_no_download_no_licence_read", "downloaded": false, "licence_read": false}}, {"id": "asset:table:pmid:32963529:1", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:f9e9abe6b35dedd70c04d557939fd52d06f3dd2b46b27915faefc80c2536ae86", "bytes": 1401, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[10]/table-wrap[1]#tab1", "version": null, "note": "Genes identified in this study as prognostic markers.", "structure": {"pmcid": "PMC7501561", "section_index": 10, "section_title": "2.8. Screening for Prognostic Genes in Two Independent Cohorts", "row_count": 16, "column_count": 6}, "table": {"label": "Table 1", "caption": "Genes identified in this study as prognostic markers.", "rows": [["Gene", "Kaplan–Meier analysis (p value)", "Prognostic correlation", "Regulation in TME"], ["E-MTAB-8248", "GSE85047", "GSE49710"], ["ABCA6", "0.048329644", "0.000456", "1.38E − 11", "Positively", "Upregulated"], ["SEPP1", "0.043655597", "0.000644", "4.85E − 05", "Positively", "Upregulated"], ["SLAMF8", "0.016798116", "0.00237", "1.44E − 09", "Positively", "Upregulated"], ["GPR171", "0.013243245", "0.006901", "3.27E − 07", "Positively", "Upregulated"], ["ABCA9", "0.04278403", "0.007713", "5.43E − 09", "Positively", "Upregulated"], ["ARHGAP15", "0.013917259", "0.010945", "1.6E − 05", "Positively", "Upregulated"], ["IL7R", "0.001138517", "0.012055", "1.44E − 07", "Positively", "Upregulated"], ["HLA-DPB1", "0.014579249", "0.020717", "2.25E − 05", "Positively", "Upregulated"], ["GZMA", "0.00900038", "0.023614", "0.000124", "Positively", "Upregulated"], ["GPR183", "0.010691506", "0.024086", "4.64E − 06", "Positively", "Upregulated"], ["CCL19", "0.013557588", "0.034966", "8.77E − 07", "Positively", "Upregulated"], ["ITK", "0.016816901", "0.044203", "2.78E − 06", "Positively", "Upregulated"], ["FGL2", "0.007567598", "0.045289", "2E − 06", "Positively", "Upregulated"], ["CD1C", "0.013928199", "0.047954", "2.7E − 09", "Positively", "Upregulated"]], "row_count": 16, "column_count": 6, "numeric_cells": 49, "header_rows": 2, "locator": "section[10]/table-wrap[1]#tab1"}}, {"id": "asset:table:pmid:32963529:2", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:9813141f308db4585b851b7b04e1ea235702341bec04ab14f68753266e37836c", "bytes": 1281, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[13]/table-wrap[1]#tab2", "version": null, "note": "Clinical characteristics of cohorts involved in the study.", "structure": {"pmcid": "PMC7501561", "section_index": 13, "section_title": "3.1. Characteristics of Cohorts Included in This Study", "row_count": 27, "column_count": 4}, "table": {"label": "Table 2", "caption": "Clinical characteristics of cohorts involved in the study.", "rows": [["Characteristics", "E-MTAB-8248, n = 223", "GSE85047, n = 283", "GSE49710, n = 498"], ["Age (months)", "", "", ""], ["≤18", "103 (46.19%)", "144 (50.88%)", "300 (60.24%)"], [">18", "120 (53.81%)", "134 (47.35%)", "198 (39.76%)"], ["Unknown", "0", "5 (1.77%)", "0"], ["Gender", "", "", ""], ["Female", "NA", "NA", "211 (42.37%)"], ["Male", "NA", "NA", "287 (57.63%)"], ["MYCN", "", "", ""], ["Amplified", "46 (20.63%)", "55 (19.43%)", "92 (18.47%)"], ["Nonamplified", "176 (78.92%)", "222 (78.45%)", "401 (80.52%)"], ["Unknown", "1 (0.45%)", "6 (2.12%)", "5 (1%)"], ["Stage (INSS)", "", "", ""], ["1", "29 (13%)", "50 (17.67%)", "121 (24.3%)"], ["2", "39 (17.49%)", "36 (12.72%)", "78 (15.66%)"], ["3", "36 (16.14%)", "43 (15.19%)", "63 (12.65%)"], ["4", "89 (39.91%)", "124 (43.82%)", "183 (36.75%)"], ["4s", "30 (13.45%)", "27 (9.54%)", "53 (10.64%)"], ["Unknown", "0", "3 (1.06%)", "0"], ["1p status", "", "", ""], ["Del/im", "67 (30.04%)", "NA", "NA"], ["Normal", "137 (61.43%)", "NA", "NA"], ["Unknown", "19 (8.52%)", "NA", "NA"], ["11q status", "", "", ""], ["Del", "18 (8.07%)", "NA", "NA"], ["Normal", "46 (20.63%)", "NA", "NA"], ["Unknown", "159 (71.3%)", "NA", "NA"]], "row_count": 27, "column_count": 4, "numeric_cells": 56, "header_rows": 1, "locator": "section[13]/table-wrap[1]#tab2"}}, {"id": "asset:table:pmid:32963529:3", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:3db032ff51acf820991fd1522850003391f399af01e6de794efbe40e0f2149f2", "bytes": 864, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[20]/table-wrap[1]#tab3", "version": null, "note": "The correlations between prognostic genes and the status of MYCN status tested by Spearman correlation.", "structure": {"pmcid": "PMC7501561", "section_index": 20, "section_title": "3.8. Identification of the Independent Prognostic Value of Prognostic Genes", "row_count": 15, "column_count": 3}, "table": {"label": "Table 3", "caption": "The correlations between prognostic genes and the status of MYCN status tested by Spearman correlation.", "rows": [["Gene", "R", "p value"], ["ABCA6", "−0.433035927", "5.96E − 24"], ["SEPP1", "−0.43773706", "1.71E − 24"], ["SLAMF8", "−0.485479", "1.62E − 30"], ["GPR171", "−0.449936802", "6.05E − 26"], ["ABCA9", "−0.371500185", "1.40E − 17"], ["ARHGAP15", "−0.452056568", "3.34E − 26"], ["IL7R", "−0.457452749", "7.23E − 27"], ["HLA-DPB1", "−0.418455553", "2.55E − 22"], ["GZMA", "−0.411284919", "1.51E − 21"], ["GPR183", "−0.415347624", "5.55E − 22"], ["CCL19", "−0.462592772", "1.64E − 27"], ["ITK", "−0.483115504", "3.40E − 30"], ["FGL2", "−0.459540146", "3.97E − 27"], ["CD1C", "−0.466033388", "5.99E − 28"]], "row_count": 15, "column_count": 3, "numeric_cells": 32, "header_rows": 1, "locator": "section[20]/table-wrap[1]#tab3"}}, {"id": "asset:table:pmid:32963529:4", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:008ce78bd10e585894b88f1978275f17953794aec2e704ea0815cef6bdd2a28c", "bytes": 2161, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[20]/table-wrap[2]#tab4", "version": null, "note": "The Cox analysis on prognostic genes and MYCN in the GSE49710 cohort.", "structure": {"pmcid": "PMC7501561", "section_index": 20, "section_title": "3.8. Identification of the Independent Prognostic Value of Prognostic Genes", "row_count": 17, "column_count": 9}, "table": {"label": "Table 4", "caption": "The Cox analysis on prognostic genes and MYCN in the GSE49710 cohort.", "rows": [["Variable", "Univariate Cox analysis", "Multivariate Cox analysis∗"], ["Coef", "HR (95% CI)", "z", "p value", "Coef", "HR (95% CI)", "z", "p value"], ["ABCA6", "−0.345", "0.708 (0.651–0.77)", "−8.1", "5.38E − 16", "0.0186", "1.02 (0.776–1.34)", "0.134", "0.894"], ["SEPP1", "−0.392", "0.676 (0.602–0.759)", "−6.64", "3.11E − 11", "−0.0928", "0.911 (0.644–1.29)", "−0.524", "0.6"], ["SLAMF8", "−0.505", "0.603 (0.537–0.677)", "−8.54", "1.29E − 17", "−0.274", "0.76 (0.586–0.986)", "−2.07", "0.0389"], ["GPR171", "−0.415", "0.66 (0.582–0.749)", "−6.44", "1.21E − 10", "−0.108", "0.898 (0.581–1.39)", "−0.484", "0.629"], ["ABCA9", "−0.387", "0.679 (0.613–0.753)", "−7.34", "2.10E − 13", "−0.303", "0.738 (0.574–0.95)", "−2.36", "0.0183"], ["ARHGAP15", "−0.393", "0.675 (0.598–0.763)", "−6.31", "2.77E − 10", "0.583", "1.79 (1.22–2.62)", "3", "0.00272"], ["IL7R", "−0.375", "0.687 (0.617–0.765)", "−6.86", "7.05E − 12", "−0.112", "0.894 (0.624–1.28)", "−0.607", "0.544"], ["HLA-DPB1", "−0.403", "0.668 (0.588–0.759)", "−6.21", "5.40E − 10", "0.0422", "1.04 (0.735–1.48)", "0.236", "0.813"], ["GZMA", "−0.305", "0.737 (0.666–0.816)", "−5.86", "4.62E − 09", "0.216", "1.24 (0.993–1.55)", "1.89", "0.0581"], ["GPR183", "−0.387", "0.679 (0.604–0.763)", "−6.51", "7.63E − 11", "−0.0716", "0.931 (0.746–1.16)", "−0.633", "0.527"], ["CCL19", "−0.184", "0.832 (0.783–0.884)", "−5.94", "2.81E − 09", "0.147", "1.16 (1.01–1.33)", "2.09", "0.0362"], ["ITK", "−0.35", "0.705 (0.641–0.775)", "−7.25", "4.04E − 13", "−0.125", "0.883 (0.662–1.18)", "−0.85", "0.395"], ["FGL2", "−0.383", "0.682 (0.612–0.76)", "−6.95", "3.66E − 12", "0.0172", "1.02 (0.677–1.53)", "0.0827", "0.934"], ["CD1C", "−0.356", "0.701 (0.64–0.767)", "−7.68", "1.65E − 14", "−0.235", "0.791 (0.633–0.989)", "−2.06", "0.0393"], ["MYCN amplification", "2.05", "7.8 (5.26–11.5)", "10.2", "1.19E − 24", "1.7", "5.45 (3.22–9.21)", "6.33", "2.48E − 10"]], "row_count": 17, "column_count": 9, "numeric_cells": 126, "header_rows": 2, "locator": "section[20]/table-wrap[2]#tab4"}}, {"id": "asset:table:pmid:32963529:5", "role": "table", "format": "jats-table", "media_type": "application/vnd.jats.table+json", "uri": null, "sha256": "sha256:503e7e438806afce2656613be4da4ee6ee96b2c38917fce4903758087e86460f", "bytes": 490, "access": "open", "state": "verified", "reader": "read_table", "reader_status": "available", "identifier": "section[20]/table-wrap[3]#tab5", "version": null, "note": "Prognostic genes identified related to the tumor microenvironment in neuroblastoma.", "structure": {"pmcid": "PMC7501561", "section_index": 20, "section_title": "3.8. Identification of the Independent Prognostic Value of Prognostic Genes", "row_count": 6, "column_count": 2}, "table": {"label": "Table 5", "caption": "Prognostic genes identified related to the tumor microenvironment in neuroblastoma.", "rows": [["Categories#", "Gene symbols$"], ["Molecular function", "ABCA6, ABCA9, IL7R [15], GPR183, CCL19 [16]"], ["Extracellular region", "SEPP1, GZMA [17], FGL2"], ["Plasma membrane", "GPR171, HLA-DPB1, CD1C"], ["Signal transduction", "ARHGAP15, ITK"], ["Membrane", "SLAMF8"]], "row_count": 6, "column_count": 2, "numeric_cells": 4, "header_rows": 1, "locator": "section[20]/table-wrap[3]#tab5"}}], "gaps": ["asset:data:geo:E-MTAB-8248 not downloaded", "asset:data:geo:E-MTAB-8248 licence not read", "asset:data:geo:GSE49710 not downloaded", "asset:data:geo:GSE49710 licence not read", "asset:data:geo:GSE85047 not downloaded", "asset:data:geo:GSE85047 licence not read"]}, "analysis": {"state": "complete", "methods": [{"id": "method-1", "family": "survival_analysis", "specific": "log_rank_test", "label": "Survival analysis", "dsl_operations": ["logrank_test"], "missing_operations": [], "expressible": true, "parameters": {"p_value": "E-MTAB-8248 cohort with p value tested in the log-rank"}, "data_shapes": ["time_to_event_with_censoring"], "evidence": {"score": 0.8, "band": "high", "quote": "log-rank"}}, {"id": "method-2", "family": "network_analysis", "specific": "pathway_enrichment", "label": "Network / pathway analysis", "dsl_operations": ["pathway_enrich"], "missing_operations": [], "expressible": true, "parameters": {}, "data_shapes": ["edge_list"], "evidence": {"score": 0.8, "band": "high", "quote": "pathway enrichment"}}], "targets": [], "gaps": []}, "capability": {"state": "complete", "requirements": [{"capability_id": "capability:computational_analysis", "label": "Computational analysis platform", "assay_families": ["meta_analysis", "machine_learning", "survival_analysis", "statistical_regression", "pca", "molecular_docking", "network_analysis", "differential_expression", "gwas"], "availability_state": "owned", "tier_unlocked": "R1", "candidate": "Automated Assays Laravel application and simulated adapters"}], "gaps": []}, "readiness": {"state": "complete", "tier": "R1", "blocking_axis": "none", "blocked_on": "nothing:replicable_now", "axes": {"method": {"tier": "R1", "expressible": true, "required_operations": ["logrank_test"], "missing_operations": [], "basis": "The paper names the method it used and the corpus's method extractor maps it onto the DSL catalogue: log_rank_test."}, "capability": {"tier": "R1", "capability_id": "capability:computational_analysis", "availability_state": "owned", "basis": "The computational analysis is owned. The physical bench the paper used is not, so a physical validation cannot be run here."}, "data": {"tier": "R1", "reachable": true, "accessions": ["E-MTAB-8248", "GSE85047", "GSE49710"], "resolved_accessions": ["E-MTAB-8248", "GSE85047", "GSE49710"], "statements": ["Publicly available datasets were analyzed in this study. These data can be found as follows: ArrayExpress: https://www.ebi.ac.uk/arrayexpress/, and GEO: https://www.ncbi.nlm.nih.gov/geo/."], "basis": "The paper names E-MTAB-8248, GSE85047, GSE49710 in ArrayExpress and the accession resolves in the repository. No dataset was downloaded and no licence was read."}}, "can_run": {"dsl_operations": ["logrank_test"], "assets": ["source:pmid:32963529", "data:geo:E-MTAB-8248", "asset:table:pmid:32963529:1", "asset:table:pmid:32963529:2", "asset:table:pmid:32963529:3", "asset:table:pmid:32963529:4", "asset:table:pmid:32963529:5"], "steps": ["run_analysis"]}, "must_build": {"dsl_operations": [], "converters": [], "readers": [], "capabilities": [], "data_gaps": ["data:geo:E-MTAB-8248"]}, "gaps": []}, "review": {"state": "partial", "machine_critique": {"kind": "extraction_review", "reader": {"model": "MiniMax-M3.1-Flash", "provider": "minimax", "provider_family": "minimax", "read_at": "2026-10-31T19:11:09Z", "independence": "single_reader"}, "evidence_check": {"method": "absent", "availability": "verbatim"}, "calls": 3, "usage": {"prompt_tokens": 33335, "completion_tokens": 1517, "cached_tokens": 784}}, "human_critique": null, "stages": [{"id": "extraction", "state": "complete", "reader": "MiniMax-M3.1-Flash", "provider": "minimax"}], "gaps": ["review.independent_reader", "review.machine_critique", "review.human_critique"]}, "execution": {"state": "absent", "status": "not_run", "mode": null, "runs": [], "gaps": ["execution.not_run"]}, "provenance": {"entities": [{"id": "pmid:32963529", "type": "paper", "label": "pmid:32963529"}, {"id": "source:pmid:32963529", "type": "manuscript", "label": "PMID 32963529 full text"}, {"id": "data:geo:E-MTAB-8248", "type": "dataset", "label": "GEO E-MTAB-8248"}], "activities": [{"id": "activity-reading-sci-2026-11-01", "type": "classification", "used": [{"id": "pmid:32963529", "type": "paper", "label": "pmid:32963529"}, {"id": "source:pmid:32963529", "type": "manuscript", "label": "PMID 32963529 full text"}, {"id": "data:geo:E-MTAB-8248", "type": "dataset", "label": "GEO E-MTAB-8248"}], "agent": "agent:corpus-assay-engine"}, {"id": "activity-read-32963529", "type": "extraction", "used": ["source:pmid:32963529"], "agent": "agent:minimax-reader"}, {"id": "activity-resolve-E-MTAB-8248", "type": "accession_resolution", "used": ["data:geo:E-MTAB-8248"], "agent": "agent:corpus-assay-engine"}], "agents": [{"id": "agent:corpus-assay-engine", "type": "software", "label": "Corpus assay engine"}, {"id": "agent:minimax-reader", "type": "software", "label": "MiniMax literature reader"}], "source_run_id": "reading-sci-2026-11-01", "dsl_catalogue_fingerprint": "343fb30756ba6ec3", "capability_table_fingerprint": "2cb3e42f047d2ecf", "snapshot_id": "ba34b49490d9bfaf"}, "lineage": {"parent_id": "pmid:32963529", "parent_hash": "sha256:c899e03045477ae253833fa7e90bfc025c1d71481f865a527a00a120f5f605a9", "fork_of": null, "generation": 5}, "gaps": ["asset:data:geo:E-MTAB-8248 licence not read", "asset:data:geo:E-MTAB-8248 not downloaded", "asset:data:geo:GSE49710 licence not read", "asset:data:geo:GSE49710 not downloaded", "asset:data:geo:GSE85047 licence not read", "asset:data:geo:GSE85047 not downloaded", "execution.not_run", "review.human_critique", "review.independent_reader", "review.machine_critique"], "assays": [{"role": "analysis", "definition_id": "survival_analysis", "definition_version": "f2132e96ae6c7a4e", "definition_digest": null, "required_operations": ["logrank_test"], "support_state": "supported", "source_hashes": {"dsl_catalogue": "f2132e96ae6c7a4e"}, "confidence": 0.8, "evidence": ["log-rank"], "order_basis": "analysis_only", "id": "assay:1"}]}