HLA-DPA1 gene is a potential predictor with prognostic values in multiple myeloma.

{"sci_version": "1.2", "schema": "https://corpus.bntrg.co.uk/sci/1.0/sci.schema.json", "id": "pmid:32972413", "kind": "science-record", "revision": 7, "content_hash": "sha256:5c0bbc0c1a3a8b49ce0986be2bf3b84b53a42374c3a3de9266a5bdd1ee832e90", "created_at": "2026-11-01T15:41:11Z", "updated_at": "2026-11-01T22:02:14Z", "generator": {"name": "corpus-assay-engine", "run_id": "reading-sci-2026-11-01"}, "paper": {"state": "complete", "title": "HLA-DPA1 gene is a potential predictor with prognostic values in multiple myeloma.", "doi": "10.1186/s12885-020-07393-0", "pmid": "32972413", "authors": ["Jie Yang", "Fei Wang", "Baoan Chen"], "journal": "BMC cancer", "year": 2020, "abstract": "BACKGROUND: Multiple myeloma (MM) is an incurable hematological tumor, which is closely related to hypoxic bone marrow microenvironment. However, the underlying mechanisms are still far from fully understood. We took integrated bioinformatics analysis with expression profile GSE110113 downloaded from National Center for Biotechnology Information-Gene Expression Omnibus (NCBI-GEO) database, and screened out major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) as a hub gene related to hypoxia in MM.\nMETHODS: Differentially expressed genes (DEGs) were filtrated with R package \"limma\". Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were performed using \"clusterProfiler\" package in R. Then, protein-protein interaction (PPI) network was established. Hub genes were screened out according to Maximal Clique Centrality (MCC). PrognoScan evaluated all the significant hub genes for survival analysis. ScanGEO was used for visualization of gene expression in different clinical studies. P and Cox p value < 0.05 was considered to be statistical significance.\nRESULTS: HLA-DPA1 was finally picked out as a hub gene in MM related to hypoxia. MM patients with down-regulated expression of HLA-DPA1 has statistically significantly shorter disease specific survival (DSS) (COX p = 0.005411). Based on the clinical data of GSE47552 dataset, HLA-DPA1 expression showed significantly lower in MM patients than that in healthy donors (HDs) (p = 0.017).\nCONCLUSION: We identified HLA-DPA1 as a hub gene in MM related to hypoxia. HLA-DPA1 down-regulated expression was associated with MM patients' poor outcome. Further functional and mechanistic studies are need to investigate HLA-DPA1 as potential therapeutic target.", "claims": [{"id": "claim-method", "statement": "The results are displayed with hazard ratio (HR) and Cox p value from a Log-rank test.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32972413", "locator": "sections[6] \"Survival analysis\" paragraph 2", "quote": "The results are displayed with hazard ratio (HR) and Cox p value from a Log-rank test."}], "state": "complete"}, {"id": "claim-data-access", "statement": "The dataset analysed during the current study are available in the NCBI-GEO repository, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE110113.", "kind": "methodological", "target": null, "evidence": [{"asset": "source:pmid:32972413", "locator": "sections[20] \"Availability of data and materials\" paragraph 2", "quote": "The dataset analysed during the current study are available in the NCBI-GEO repository, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE110113."}], "state": "complete"}], "gaps": []}, "experiment": {"state": "complete", "objective": null, "steps": [{"id": "read_published_estimate", "order": 1, "name": "Read the published estimate from the source", "kind": "other", "state": "complete", "blocked_on": null, "description": "The claim, method and evidence span published with the source article.", "duration_hours": null, "parameters": {}, "inputs": ["source:pmid:32972413"], "outputs": ["the published estimate and its evidence"], "instruments": [], "reagents": []}, {"id": "obtain_source_data", "order": 2, "name": "Obtain the source data from the named repository", "kind": "data-preparation", "state": "complete", "blocked_on": null, "description": "The GEO series accession resolves and its sample accessions are listed. 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